Aliases &
Descriptions
for WDFY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| WD repeat and FYVE domain containing 21 2 | | WD40- and FYVE domain-containing protein 22 3 | | ZFYVE221 2 3 | | RP11-147H23.12 | | WD40 and FYVE domain containing 21 2 | | propeller-FYVE protein2 | | Zinc finger FYVE domain-containing protein 222 3 | | WD repeat and FYVE domain-containing protein 22 | | WDF22 3 | | PROF2 |
Export aliases for WDFY2 gene to outside databasesPrevious GC identifers: GC13P046146 GC13P051095 GC13P049956 GC13P051056 GC13P052158 |
Summaries
for WDFY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDFY2:
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene isunknown. An alternatively spliced transcript variant of this gene may exist. (provided by RefSeq)
|
Genomic Views
for WDFY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDFY2 gene promoter:
TGIF deltaCREB CREB FOXO3b FOXO3a FAC1 CUTL1 Hlf Sp1 MEF-2A
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDFY2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.12WDFY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P032948: view genomic region
(about GC identifiers)
Start:
|
32,948,174 bp from pter |
End:
|
33,125,829 bp from pter |
Size:
|
177,656 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr13+ 52,158,644-52,334,135 |
RefSeq DNA sequence:- NC_000013.10 NT_024524.14
|
Proteins
for WDFY2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WDFY2_HUMAN, Q96P53 (See
protein sequence)Recommended Name: WD repeat and FYVE domain-containing protein 2 Size: 400 amino acids; 45154 Da
Secondary accessions: B1AL86 Q96CS1Explore the universe of human proteins at neXtProt for WDFY2: NX_Q96P53
REFSEQ proteins: NP_443182.1
ENSEMBL proteins: ENSP00000298125
Human Recombinant Proteins
Antibodies for WDFY2:
Assays for WDFY2: |
Protein
Domains/
Families
for WDFY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDFY2 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry Q96P53ProtoNet protein and cluster: Q96P53 1 Blocks protein family: IPB000306 Zn-finger
UniProtKB/Swiss-Prot: WDFY2_HUMAN, Q96P53Similarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 7 WD repeats |
Gene Function
for WDFY2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
WDFY2 for ontologies About GeneDecksing
|
Pathways & Interactions
for WDFY2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for WDFY2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDFY2
|
Drugs & Compounds
for WDFY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WDFY2
|
Transcripts
for WDFY2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for WDFY2 gene: NM_052950.3 Additional cDNA sequence: AF411978.1 AK054833.1 AK058149.1 AK093224.1 AK309815.1 AK311177.1 BC014004.2 CR612847.1 17 DOTS entries: DT.312154 DT.95343339 DT.100022742 DT.97816844 DT.100660634 DT.100751290 DT.312155 DT.120769969 DT.40238189 DT.86838664 DT.120769966 DT.120769981 DT.40132095 DT.75148371 DT.95370092 DT.99932067 DT.91927360 24/137 AceView cDNA sequences (see all 137): AA703241 AW614396 CB217004 AI040673 AA701982 CR612847 AA864300 BX363773 T87542 BU102054 BU520776 AI057330 AI417133 BM672061 CD358198 BU689194 BC014004 AA004280 BQ888546 BX099703 AI567388 BM987220 BM804744 BQ574560
 highest scoring ESTs for WDFY2:AA703241 AA845630 AA701982 AA716631 AA864300 AF411978 AI057330 AI240613 AK058149 AL562744 Unigene Cluster for WDFY2: WD repeat and FYVE domain containing 2 Hs.208550 [show with all ESTs]Unigene Representative Sequence: NM_052950
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298125(uc010ads.1 uc010adt.1 uc001vfp.2) ENST00000460145
|
Expression
for WDFY2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WDFY2 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching WDFY2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 58323_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.96 |
0.71 |
AA703241 |
1.00 |
1.00 |
1.00 |
1 |
| 75991_at2, 3
|
U95-D |
1 |
0.44 |
1.00 |
0.61 |
1.29 |
AA845630 |
1.00 |
1.00 |
1.00 |
1 |
| 227490_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
T87542 |
0.80 |
1.00 |
0.91 |
1 |
| 227490_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
WDFY2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCACAGTGG
SOURCE GeneReport for Unigene cluster: Hs.208550
SABiosciences Custom PCR Arrays for WDFY2
|
Orthologs
for WDFY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDFY2 gene from 5/10 species (see all 10)
About this table Species with no ortholog for WDFY2
ENSEMBL Gene Tree for WDFY2 (if available) |
Paralogs
for WDFY2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WDFY2 gene
- WDFY12 HGS2
WDFY2 for paralogs About GeneDecksing
|
Genomic Variants
for WDFY2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 13 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WDFY2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WDFY2
2 CNVs: 35172 4804 | | QIAGEN SeqTarget long-range PCR primers for resequencing WDFY2 |
|
Disorders & Mutations
for WDFY2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDFY2 for disorders About GeneDecksing
OMIM: 610418
Export disorders and mutations for WDFY2 gene to outside databases
|
Medical News
for WDFY2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WDFY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for WDFY2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with WDFY2)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PubMed id 16873553)1, 7 Hayakawa A....Corvera S. (2006)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. (PubMed id 17313651)1 Fritzius T....Moelling K. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. (PubMed id 16792529)1 Fritzius T....Moelling K. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for WDFY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDFY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDFY2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDFY2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WDFY2 gene:
Search GeneIP for patents involving WDFY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDFY2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for WDFY2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for WDFY2 |
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