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WDFY3 Gene

protein-coding   GIFtS: 49

GC04M081332
WD repeat and FYVE domain containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for WDFY3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
WD repeat and FYVE domain containing 31 2     Autophagy-linked FYVE protein2 3
KIAA09931 2 3     WD repeat and FYVE domain-containing protein 32
ALFY1 2     MGC164612
ZFYVE251 2     Alfy3

External Ids:    HGNC: 207511   Entrez Gene: 230012   Ensembl: ENSG000001636257   UniProtKB: Q8IZQ13   

Export aliases for WDFY3 gene to outside databases

Previous GC identifers: GC04M085884 GC04M086049 GC04M085947 GC04M085809 GC04M085590


Summaries
for WDFY3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WDFY3:
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate
clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where
it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated
proteins. However, it is not necessary for starvation-induced macroautophagy. (provided by RefSeq)

Gene Wiki entry for WDFY3

Genomic Views
for WDFY3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDFY3 gene promoter:
         GR-alpha   GR-beta   GCNF-2   GCNF-1   POU2F2B   POU2F2C   POU2F2   POU2F1   oct-B3   oct-B2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for WDFY3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WDFY3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.3

WDFY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDFY3 gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M081332:  view genomic region     (about GC identifiers)

Start:
 81,332,682 bp from pter
End:
 81,629,739 bp from pter
Size:
 297,058 bases
Orientation:
 minus strand

1 alternative location:
Chr4- 85,590,704-85,887,544     
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  

Proteins
for WDFY3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1 (See protein sequence)
Recommended Name: WD repeat and FYVE domain-containing protein 3  
Size: 3526 amino acids; 395258 Da
Subcellular location: Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Co-localizes with autophagic
structures in starved cells
Sequence caution: Sequence=AAH13377.1; Type=Erroneous initiation; Sequence=AAH15214.2; Type=Erroneous initiation;
Sequence=BAB71020.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC04455.1; Type=Erroneous
initiation;
Secondary accessions: Q4W5K5 Q6P0Q5 Q8N1T2 Q8NAV6 Q96BS7 Q96D33 Q96N85 Q9Y2J7
Alternative splicing: 2 isoforms:  Q8IZQ1-1   Q8IZQ1-2   

Explore the universe of human proteins at neXtProt for WDFY3: NX_Q8IZQ1 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_055806.2  

    ENSEMBL proteins: 
    ENSP00000398156 ENSP00000318466 ENSP00000421499 ENSP00000422741 ENSP00000425699 ENSP00000424987 
    ENSP00000295888 ENSP00000426813 ENSP00000392872 ENSP00000422256 ENSP00000421214 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for WDFY3 
    Novus Biologicals Protein for WDFY3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635 nuclear envelope IDA15292400
    GO:0005737 cytoplasm ----
    GO:0005776colocalizes with autophagic vacuole IDA15292400
    GO:0016020 membrane IEA--
    GO:0019898 extrinsic to membrane IDA15292400
    About this table

    WDFY3 for ontologies           About GeneDecksing



    Antibodies for WDFY3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WDFY3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for WDFY3 
    Novus Biologicals Antibodies for WDFY3
    Browse antibodies at Epitomics

    Assays for WDFY3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WDFY3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WDFY3 

    Protein Domains/
    Families
    for WDFY3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WDFY3 for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR019782 WD40_repeat_2
     IPR000409 Beige_BEACH
     IPR011989 ARM-like
     IPR019775 WD40_repeat_CS
     IPR013320 ConA-like_subgrp

    Graphical View of Domain Structure for InterPro Entry Q8IZQ1

    ProtoNet protein and cluster: Q8IZQ1

    2 Blocks protein families:
    IPB000306 Zn-finger
    IPB000409 Beige/BEACH domain


    UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1
    Similarity: Contains 1 BEACH domain
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 5 WD repeats


    Gene Function
    for WDFY3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for WDFY3
    Sigma-Aldrich shRNA for WDFY3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): WDFY3
    OriGene shRNA RFP (see all 4): WDFY3
    OriGene basic RS shRNA (see all 4): WDFY3
    OriGene siRNA (see all 3): WDFY3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WDFY3 
    miRNA:Sigma-Aldrich microRNA Mimics for WDFY3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WDFY3 
    8/20 SABiosciences Assays for microRNAs that regulate WDFY3 (see all 20):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-575 hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-1208

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): WDFY3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): WDFY3
    OriGene untagged cDNA clones in CMV expression vector (see all 4): WDFY3
    OriGene 3'-UTR clone (see all 3): WDFY3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WDFY3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for WDFY3 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ----
    GO:0005488 binding ----
    GO:0005515 protein binding IPI--
    GO:0005545 phosphatidylinositol binding IDA15292400
    GO:0008270 zinc ion binding IEA--
    About this table

    WDFY3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for WDFY3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    WDFY3 for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  WDFY3
        Keratan Sulfate Biosynthesis
    N-Glycan Biosynthesis

        SABiosciences Custom Pathway-Focused PCR Arrays for WDFY3 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for WDFY3
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDFY3

    Drugs & Compounds
    for WDFY3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDFY3


    Transcripts
    for WDFY3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for WDFY3
    Sigma-Aldrich shRNA for WDFY3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): WDFY3
    OriGene shRNA RFP (see all 4): WDFY3
    OriGene basic RS shRNA (see all 4): WDFY3
    OriGene siRNA (see all 3): WDFY3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WDFY3 
    miRNA: Sigma-Aldrich microRNA Mimics for WDFY3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WDFY3 
    8/20 SABiosciences Assays for microRNAs that regulate WDFY3 (see all 20):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-575 hsa-miR-301a hsa-miR-519a hsa-miR-144 hsa-miR-1208
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): WDFY3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): WDFY3
    OriGene untagged cDNA clones in CMV expression vector (see all 4): WDFY3
    OriGene 3'-UTR Clone (see all 3): WDFY3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WDFY3 
    Primers: OriGene genome-wide validated SYBR primer pairs: WDFY3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WDFY3: PPH10982A

    REFSEQ mRNAs for WDFY3 gene: 

    NM_014991.4  

    Additional cDNA sequence: 

    AB023210.2 AF131845.1 AK055806.1 AK092394.1 AK094910.1 BC015214.1 BC065502.1 BC150246.1 
    BX648077.1 BX648153.1 EF491804.1 EF491819.1 

    13 DOTS entries:

    DT.455599  DT.100779276  DT.95169174  DT.97808164  DT.121227189  DT.95256526  DT.100746625  DT.100779275 
    DT.40265912  DT.40283706  DT.91705863  DT.92005579  DT.95215555 

    24/206 AceView cDNA sequences (see all 206):

    AI423502 AI868798 AI632805 BE466483 CA314071 BU683585 AK055806 AW873534 
    AB023210 AI554250 BF002955 AI796438 BQ024448 AI373668 AW614563 BQ960724 
    AF131845 BE348236 BC065502 BM661628 AW262575 AA973044 AK094910 BX648077 

    highest scoring ESTs for WDFY3:

    BE503740 AI393222 AI962188 AA031778 AA031868 AA149197 AA149198 AA321218 AA635168 AA677526 

    Unigene Cluster for WDFY3:

    WD repeat and FYVE domain containing 3
    Hs.480116  [show with all ESTs]
    Unigene Representative Sequence: NM_014991


    GeneLoc Exon Structure

    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504990 ENST00000454012 ENST00000425179 ENST00000322366(uc003hpc.2 uc003hpe.1 uc003hpd.2)
    ENST00000513327 ENST00000502713 ENST00000509172 ENST00000512267 ENST00000514711
    ENST00000505923 ENST00000426414(uc003hpf.2) ENST00000504839 ENST00000295888
    ENST00000514071 ENST00000427028 ENST00000514687 ENST00000504351 ENST00000509825


    Expression
    for WDFY3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    WDFY3 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching WDFY3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32769_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB023210 0.80 0.80 0.80 1
    212606_at2, 3 U133-A 1 1.00 1.00 -- -- AL536319 0.20 1.00 0.72 1
    212598_at2, 3 U133-A 1 1.00 1.00 -- -- BE348236 0.60 1.00 0.82 1
    212602_at2, 3 U133-A 1 1.00 1.00 -- -- AI806395 0.60 1.00 0.82 1
    238660_at2, 3 U133-B 1 0.27 1.00 -- -- AI732512 0.40 1.00 0.76 1
    212606_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212598_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212602_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    238660_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    WDFY3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    WDFY3 gene expression
    WDFY3 gene electronic northern expression
    WDFY3 gene sage expression
    About these images

    CGAP SAGE TAG: ATTAAATGCA

    SOURCE GeneReport for Unigene cluster: Hs.480116

    Expression variation in blood from EXPOLDB for WDFY3

    UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1
    Tissue specificity: Ubiquitous

    Primers: OriGene genome-wide validated SYBR primer pairs: WDFY3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WDFY3: PPH10982A
        SABiosciences Custom PCR Arrays for WDFY3 


    Orthologs
    for WDFY3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for WDFY3 gene from 5/14 species (see all 14)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 WDFY31   -- WD repeat and FYVE domain containing 3 93.2(n)
    98.1(a)    		 487841  XM_544963.2  XP_544963.2 
    chimpanzee
    (Pan troglodytes)    		 WDFY31   -- WD repeat and FYVE domain containing 3 99.71(n)
    99.83(a)    		 461201  XM_001151618.1  XP_001151618.1 
    cow
    (Bos taurus)    		 WDFY31   -- WD repeat and FYVE domain containing 3 91.22(n)
    97.84(a)    		 537096  XM_617252.3  XP_617252.3 
    rat
    (Rattus norvegicus)    		 Wdfy31   -- WD repeat and FYVE domain containing 3 84.89(n)
    95.72(a)    		 305164  XM_223196.4  XP_223196.4 
    mouse
    (Mus musculus)    		 Wdfy31 , 5 5 (48.95 cM)5
    		 WD repeat and FYVE domain containing 31, 5 86.45(n)1
    96.47(a)1    		 721451  NM_172882.21  NP_766470.21 
     AB0932775  AI8428525  (see all 24)
    About this table        Species with no ortholog for WDFY3

    ENSEMBL Gene Tree for WDFY3 (if available)

    Paralogs
    for WDFY3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for WDFY3 gene
    NSMAF2  LYST2  WDFY42  

    WDFY3 for paralogs           About GeneDecksing



    Genomic Variants
    for WDFY3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1586 NCBI SNPs in WDFY3 are shown (see all 1586)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs8945331,2
    		C,F,A,85664294(+) TAGCAC/TATATA 1 -- int18Minor allele frequency- T:0.14MN NS EA WA 822
    rs9367501,2
    		--85786205(+) cctgtC/Ttaatt 1 -- int10--------
    rs9702081,2
    		C85679239(+) ACTCAG/AGATAC 1 -- int14Minor allele frequency- A:0.00NA EA NS 372
    rs9702091,2
    		--85679592(+) gacaaA/Ggtctt 1 -- int10--------
    rs9702101,2
    		--85679611(+) gctcaA/Ggctgg 1 -- int10--------
    rs10617271,2
    		C85592348(-) CATTTG/TGTACA 2 -- ut311Minor allele frequency- T:0.00MN 184
    rs10800561,2
    		--85597444(+) cactaG/Tcattg 1 -- int10--------
    rs13852631,2
    		C,F,O,85704974(+) AGTTAT/CGTGAA 1 -- int16Minor allele frequency- C:0.41NS EA WA NA 432
    rs14636071,2
    		C,F,O,85695218(+) AAAGTG/AAGTGA 1 -- int15Minor allele frequency- A:0.15NS NA WA 308
    rs14734561,2
    		C,F,A,85713072(+) AAGCTG/AAACAA 1 -- int14Minor allele frequency- A:0.24EA NS WA 348
    About this table

    HapMap Linkage Disequilibrium images for WDFY3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WDFY3: --

    QIAGEN SeqTarget long-range PCR primers for resequencing WDFY3 

    Disorders & Mutations
    for WDFY3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WDFY3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: WDFY3 (1 document)

    Export disorders and mutations for WDFY3 gene to outside databases

    Medical News
    for WDFY3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for WDFY3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for WDFY3 gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with WDFY3)
    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. (PubMed id 15292400)1, 2 Simonsen A.... Stenmark H. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. p62/SQSTM1 and ALFY interact to facilitate the format ion of p62 bodies/ALIS and their degradation by autophagy. (PubMed id 20168092)1 Clausen T.H....Johansen T. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. A master conductor for aggregate clearance by autopha gy. (PubMed id 20493804)1 Deretic V. (2010)
    9. The selective macroautophagic degradation of aggregat ed proteins requires the PI3P-binding protein Alfy. (PubMed id 20417604)1 Filimonenko M....Yamamoto A. (2010)
    10. Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)2 Imami K.... Ishihama Y. (2008)

    External Searches for WDFY3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing WDFY3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23001 HGNC: 20751 AceView: WDFY3 Ensembl:ENSG00000163625 euGenes: HUgn23001
    ECgene: WDFY3 H-InvDB: WDFY3

    Other Databases showing WDFY3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0993

    Specialized Databases showing WDFY3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for WDFY3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for WDFY3 gene:
    Search GeneIP for patents involving WDFY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for WDFY3 gene

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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in WDFY3 promoter
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     SABiosciences Custom PCR Arrays for WDFY3
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     ELISAs and CLIAs for WDFY3
           

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