Aliases &
Descriptions
for WDR7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| WD repeat domain 71 2 | | TGF-beta resistance-associated protein TRAG2 3 | | TRAG1 2 3 5 | | OTTHUMP000001635962 | | KIAA05411 2 3 5 | | TGF-beta resistance associated2 | | Rabconnectin-3 beta2 3 | | WD repeat-containing protein 72 |
Export aliases for WDR7 gene to outside databasesPrevious GC identifers: GC18P054428 GC18P054221 GC18P054103 GC18P052488 GC18P052490 GC18P054318 |
Summaries
for WDR7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR7:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit ofrabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activatingprotein; these proteins are regulators of Rab3 small G protein family members involved in control of thecalcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding differentisoforms have been described. (provided by RefSeq)
|
Genomic Views
for WDR7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR7 gene promoter:
AP-1 GCNF-2 GCNF-1 HNF-4alpha2 COUP-TF1 RFX1 TGIF deltaCREB CREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.31 Ensembl cytogenetic band: 18q21.31 HGNC cytogenetic band: 18q21.31WDR7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P051029: view genomic region
(about GC identifiers)
Start:
|
51,029,979 bp from pter |
End:
|
51,409,374 bp from pter |
Size:
|
379,396 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr18+ 54,318,616-54,698,828 |
RefSeq DNA sequence:- NC_000018.9 NT_025028.14
|
Proteins
for WDR7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WDR7_HUMAN, Q9Y4E6 (See
protein sequence)Recommended Name: WD repeat-containing protein 7 Size: 1490 amino acids; 163810 Da
Sequence caution: Sequence=BAA25467.2; Type=Erroneous initiation;
Secondary accessions: A7E2C8 Q86UX5 Q86VP2 Q96PS7Alternative splicing: 2 isoforms: Q9Y4E6-1 Q9Y4E6-2 Explore the universe of human proteins at neXtProt for WDR7: NX_Q9Y4E6
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_056100.2 NP_443066.2
ENSEMBL proteins: ENSP00000409365 ENSP00000254442 ENSP00000350187 ENSP00000381357
Human Recombinant Proteins
Antibodies for WDR7:
Assays for WDR7: |
Protein
Domains/
Families
for WDR7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR7 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y4E6ProtoNet protein and cluster: Q9Y4E6 UniProtKB/Swiss-Prot: WDR7_HUMAN, Q9Y4E6Similarity: Contains 9 WD repeats |
Gene Function
for WDR7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
-- | -- |
About this table
WDR7 for ontologies About GeneDecksing
|
Pathways & Interactions
for WDR7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for WDR7
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR7
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
-- | -- |
About this table
WDR7 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WDR7
|
Transcripts
for WDR7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for WDR7 gene (2 alternative transcripts): NM_015285.2 NM_052834.2 Additional cDNA sequence: AB011113.2 AF188125.1 AK057141.1 AY099325.1 BC050352.1 BC131558.1 BC150282.1 10 DOTS entries: DT.416774 DT.91858889 DT.100815998 DT.121105384 DT.121105445 DT.121105472 DT.40107935 DT.95112950 DT.121105361 DT.95231232 24/121 AceView cDNA sequences (see all 121): BM673086 AI247807 BF740230 AU132411 CD652969 CA437096 F10381 NM_015285 AY099325 AW999512 AI985465 AB011113 NM_052834 AI677922 AI342825 AF188125 BX096682 AA295837 BM474139 AA927074 AI298987 CB129832 AA777452 BM758657
 highest scoring ESTs for WDR7:AB011113 AA004758 AA218543 AA218741 AA295837 AA295838 AA677076 AA694022 AA702151 AA703274 Unigene Cluster for WDR7: WD repeat domain 7 Hs.465213 [show with all ESTs]Unigene Representative Sequence: NM_015285
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WDR7
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for WDR7
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444065 ENST00000254442(uc002lgk.1) ENST00000357574(uc010dpk.1 uc002lgl.1)
ENST00000398311
|
Expression
for WDR7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WDR7 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching WDR7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 41430_at2, 3
|
U95-A |
1 |
0.69 |
1.00 |
0.60 |
1.34 |
AB011113 |
1.00 |
0.90 |
0.95 |
1 |
| 68981_at2
|
U95-D |
1 |
0.44 |
1.00 |
0.54 |
0.68 |
-- |
-- |
-- |
-- |
-- |
| 212880_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
AB011113 |
1.00 |
0.90 |
0.95 |
1 |
| 237122_at2
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212880_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 237122_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
WDR7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACGTGACACC
SOURCE GeneReport for Unigene cluster: Hs.465213
SABiosciences Custom PCR Arrays for WDR7
|
Orthologs
for WDR7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDR7 gene from 5/11 species (see all 11)
About this table Species with no ortholog for WDR7
ENSEMBL Gene Tree for WDR7 (if available) |
Paralogs
for WDR7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WDR7 gene
- WDR722
WDR7 for paralogs About GeneDecksing
|
Genomic Variants
for WDR7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 18 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WDR7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for WDR7
5 CNVs: 50010 50012 9782 50011 50013
9 Indels: 88868 77896 77898 40234 88869 77897 88867 77900 77899 | | QIAGEN SeqTarget long-range PCR primers for resequencing WDR7 |
|
Disorders & Mutations
for WDR7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR7 for disorders About GeneDecksing
OMIM: 613473
Human Genome Epidemiology (HuGE) Navigator: WDR7 (2 documents)
Export disorders and mutations for WDR7 gene to outside databases
|
Medical News
for WDR7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WDR7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for WDR7 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with WDR7)- Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. (PubMed id 10828621)1, 3, 7 Sanders S....Thorgeirsson S.S. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)- dependent exocytosis of neurotransmitter. (PubMed id 12786944)1, 2 Kawabe H.... Takai Y. (2003)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1 Baranzini S.E....Oksenberg J.R. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Interactions between inner membrane proteins in donor and recipient cells limit conjugal DNA transfer. (PubMed id 15935784)7 Marrero J. and Waldor M.K. (2005)
|
External Searches for WDR7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR7 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WDR7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WDR7 gene:
Search GeneIP for patents involving WDR7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for WDR7 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for WDR7 |
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