Aliases &
Descriptions
for WDR72 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| WD repeat domain 721 2 | | MGC1266632 | | FLJ387361 2 | | OTTHUMP000001627712 | | AI2A32 5 | | MGC1266652 | | WD repeat-containing protein 722 | | |
Export aliases for WDR72 gene to outside databasesPrevious GC identifers: GC15M051595 GC15M053805 |
Summaries
for WDR72 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR72 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR72 gene promoter:
GCNF-2 GCNF-1 CUTL1 MEF-2A FOXD1 POU3F2 (N-Oct-5b) POU3F2 POU3F2 (N-Oct-5a) RORalpha1 Max1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR72
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.3 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q21.3WDR72 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M030638: view genomic region
(about GC identifiers)
Start:
|
30,636,351 bp from pter |
End:
|
30,882,318 bp from pter |
Size:
|
245,968 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 53,805,938-54,055,075 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for WDR72 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WDR72_HUMAN, Q3MJ13 (See
protein sequence)Recommended Name: WD repeat-containing protein 72 Size: 1102 amino acids; 123425 Da
Secondary accessions: Q7Z3I3 Q8N8X2Explore the universe of human proteins at neXtProt for WDR72: NX_Q3MJ13
REFSEQ proteins: NP_877435.2
ENSEMBL proteins: ENSP00000379619 ENSP00000353699
Human Recombinant Proteins
Antibodies for WDR72:
Assays for WDR72: |
Protein
Domains/
Families
for WDR72 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR72 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q3MJ13ProtoNet protein and cluster: Q3MJ13 UniProtKB/Swiss-Prot: WDR72_HUMAN, Q3MJ13Similarity: Contains 8 WD repeats |
Gene Function
for WDR72 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- |
About this table
WDR72 for ontologies About GeneDecksing
|
Pathways & Interactions
for WDR72 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for WDR72
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR72
|
Drugs & Compounds
for WDR72 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WDR72
|
Transcripts
for WDR72 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for WDR72 gene: NM_182758.2 Additional cDNA sequence: AK096055.1 AK123805.1 AK125130.1 AK310211.1 AK311300.1 BC058026.1 BC101614.1 BC101616.1 BX537884.1 BX648571.1 BX648751.1 7 DOTS entries: DT.97797773 DT.99935718 DT.207656 DT.205929 DT.100745586 DT.121056441 DT.91751155 24/68 AceView cDNA sequences (see all 68): AI796711 AI984341 BQ186335 BX103738 AA923056 AW269363 AI733060 BU681294 BX951021 AA856602 AI732846 AW662716 AI628599 AI932894 AA625553 BM552062 BC058026 CA312303 AK123805 AW182649 BG431098 CB163886 BU508756 AI628810
 highest scoring ESTs for WDR72:AA205598 AI791550 AK096055 BX537884 BX648571 AA205625 AA570161 AA625553 AA862938 AI474738 Unigene Cluster for WDR72: WD repeat domain 72 Hs.122125 [show with all ESTs]Unigene Representative Sequence: NM_182758
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WDR72
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for WDR72
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396328(uc010bfh.1) ENST00000360509(uc002acj.2 uc010bfi.1)
|
Expression
for WDR72 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WDR72 expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching WDR72 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 71002_at2, 3
|
U95-D |
1 |
1.00 |
1.00 |
0.97 |
1.11 |
AI791550 |
0.80 |
1.00 |
0.91 |
1 |
| 47110_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.98 |
1.13 |
AA205598 |
0.80 |
1.00 |
0.91 |
1 |
| 70579_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.90 |
0.95 |
AA205625 |
0.60 |
1.00 |
0.82 |
1 |
| 73684_at2
|
U95-E |
1 |
0.31 |
1.00 |
0.82 |
0.89 |
-- |
-- |
-- |
-- |
-- |
| 227174_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
Z98443 |
0.60 |
1.00 |
0.82 |
1 |
| 236741_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
AW299463 |
0.40 |
1.00 |
0.76 |
1 |
| 227174_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 236741_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1563874_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
WDR72 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.122125
SABiosciences Custom PCR Arrays for WDR72
|
Orthologs
for WDR72 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDR72 gene from 5/6 species (see all 6)
About this table Species with no ortholog for WDR72
ENSEMBL Gene Tree for WDR72 (if available) |
Paralogs
for WDR72 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WDR72 gene
- WDR72
WDR72 for paralogs About GeneDecksing
|
Genomic Variants
for WDR72 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WDR72 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for WDR72
3 CNVs: 66803 53379 32036
1 Indel: 66802 | | QIAGEN SeqTarget long-range PCR primers for resequencing WDR72 |
|
Disorders & Mutations
for WDR72 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR72 for disorders About GeneDecksing
OMIM: 613214 disorders: 613211 UniProtKB/Swiss-Prot: WDR72_HUMAN, Q3MJ13
Defects in WDR72 are the cause of amelogenesis imperfecta hypomaturation type 2A3 (AI2A3) [MIM:613211]. Adefect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agarjelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamelHuman Gene Mutation Database (HGMD): WDR72
Human Genome Epidemiology (HuGE) Navigator: WDR72 (3 documents)
Export disorders and mutations for WDR72 gene to outside databases
|
Medical News
for WDR72 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WDR72 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for WDR72 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with WDR72)- Mutations in the beta propeller WDR72 cause autosomal -recessive hypomaturation amelogenesis imperfecta. (PubMed id 19853237)1, 2 El-Sayed W....Mighell A.J. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
- A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)1 Paterson A.D....Bull S.B. (2010)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)2 Yu L.-R.... Veenstra T.D. (2007)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
|
External Searches for WDR72 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR72 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR72 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR72 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WDR72 gene:
Search GeneIP for patents involving WDR72
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR72 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for WDR72 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for WDR72 |
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