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WDR91 Gene

protein-coding   GIFtS: 38

GC07M129171
WD repeat domain 91
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
WD repeat domain 911 2
HSPC0491
WD repeat-containing protein 912
OTTHUMP000002079862

External Ids:    HGNC: 249971   Entrez Gene: 290622   Ensembl: ENSG000001058757   UniProtKB: A4D1P63   

Export aliases for WDR91 gene to outside databases

Previous GC identifers: GC07M134521 GC07M134868


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WDR91
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for WDR91

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WDR91 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

WDR91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR91 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M129171:  view genomic region     (about GC identifiers)

Start:
129,171,252 bp from pter
End:
129,198,944 bp from pter
Size:
27,693 bases
Orientation:
minus strand

1 alternative location:
Chr7- 134,868,590-134,896,316     
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NT_079596.2  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: WDR91_HUMAN, A4D1P6 (See protein sequence)
Recommended Name: WD repeat-containing protein 91  
Size: 747 amino acids; 83344 Da
Sequence caution: Sequence=AAF29021.1; Type=Frameshift; Positions=136, 161, 166, 381, 392, 400, 405, 424, 442, 448,
458, 462, 501, 505, 508, 605, 626, 646, 712, 736;
Secondary accessions: A6NK54 Q6FI65 Q6MZQ1 Q6P4I1 Q96AE5 Q96G63 Q9H062 Q9H9B6 Q9NVG7 Q9NZY6
Alternative splicing: 3 isoforms:  A4D1P6-1   A4D1P6-2   A4D1P6-3   

Explore the universe of human proteins at neXtProt for WDR91: NX_A4D1P6 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_054868.3  

    ENSEMBL proteins: 
    ENSP00000346466 ENSP00000317639 ENSP00000392555 ENSP00000340877 ENSP00000414251 


    Human Recombinant Proteins 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WDR91 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR019782 WD40_repeat_2
     IPR011046 WD40_repeat-like_dom
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry A4D1P6

    ProtoNet protein and cluster: A4D1P6

    UniProtKB/Swiss-Prot: WDR91_HUMAN, A4D1P6
    Similarity: Contains 7 WD repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    OriGene basic RS shRNA (see all 2): WDR91
    OriGene siRNA: WDR91
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WDR91 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WDR91 
    2 SABiosciences Assays for microRNAs that regulate WDR91:
    hsa-miR-200c hsa-miR-429

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    OriGene GFP tagged cDNA clones in CMV expression vector: WDR91
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    OriGene untagged cDNA clones in CMV expression vector: WDR91
    OriGene 3'-UTR clone: WDR91 
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    Cell
    Lines:
      
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    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for WDR91 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR91

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR91


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for WDR91
    Sigma-Aldrich shRNA for WDR91
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): WDR91
    OriGene shRNA RFP (see all 2): WDR91
    OriGene basic RS shRNA (see all 2): WDR91
    OriGene siRNA: WDR91
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WDR91 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WDR91 
    2 SABiosciences Assays for microRNAs that regulate WDR91:
    hsa-miR-200c hsa-miR-429
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: WDR91
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: WDR91
    OriGene untagged cDNA clones in CMV expression vector: WDR91
    OriGene 3'-UTR Clone: WDR91 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WDR91 
    Primers: OriGene genome-wide validated SYBR primer pairs: WDR91
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WDR91: PPH23048A

    REFSEQ mRNAs for WDR91 gene: 

    NM_014149.3  

    Additional cDNA sequence: 

    AF161534.1 AK001606.1 AK074466.1 AK123659.1 AK124765.1 AL136940.1 BC009939.2 BC017246.2 
    BC063394.1 CR533561.1 

    8 DOTS entries:

    DT.91803517  DT.313756  DT.99940492  DT.100812528  DT.95288074  DT.92428297  DT.100644760  DT.121122784 

    24/152 AceView cDNA sequences (see all 152):

    BM679286 AI568570 AA341667 AI823447 AA341589 BI766832 BC017246 AK022935 
    AI872196 BE349973 BX421732 AW025588 N62857 AA336926 BU631036 AK124765 
    NM_014149 AA127645 BM681874 AU130906 AK001606 CK300109 AW173485 AW873003 

    Unigene Cluster for WDR91:

    WD repeat domain 91
    Hs.459858  [show with all ESTs]
    Unigene Representative Sequence: AK124765


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for WDR91 (see all 10)

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
    SP1:                                                                    -                       -                             -           -     -               
    SP2:                                                                    -                       -                             -           -     -               
    SP3:              -     -     -                                         -                                                                                       
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                                          -           -                     

    ExUns: 13a · 13b ^ 14 ^ 15
    SP1:                        
    SP2:  -     -               
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for WDR91
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354475(uc003vsp.2) ENST00000497853 ENST00000326099 ENST00000485942
    ENST00000474411 ENST00000423565(uc010lmq.2) ENST00000344400(uc010lmr.2)
    ENST00000479698 ENST00000466182 ENST00000431482 ENST00000462707 ENST00000476775


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    WDR91 expression in normal and diseased human tissues

    1  / 2

    8 probe-sets matching WDR91 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51081_at2 U95-B 1 0.94 1.00 0.84 0.75 -- -- -- -- --
    63387_at2 U95-C 1 0.69 1.00 0.92 1.25 -- -- -- -- --
    218971_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    222799_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --
    230888_at2 U133-B 1 0.82 1.00 -- -- -- -- -- -- --
    218971_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    222799_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    230888_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    WDR91 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    WDR91 gene expression
    WDR91 gene electronic northern expression
    WDR91 gene sage expression
    About these images

    CGAP SAGE TAG: AAACAAAAAA

    SOURCE GeneReport for Unigene cluster: Hs.459858
    Primers: OriGene genome-wide validated SYBR primer pairs: WDR91
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WDR91: PPH23048A
        SABiosciences Custom PCR Arrays for WDR91 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for WDR91 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR911   -- WD repeat domain 91 89.53(n)
    93.49(a)
    482705  XM_539821.2  XP_539821.2 
    chimpanzee
    (Pan troglodytes)
    WDR911   -- WD repeat domain 91 99.55(n)
    99.46(a)
    463749  XM_519399.2  XP_519399.2 
    cow
    (Bos taurus)
    WDR911   -- WD repeat domain 91 90.25(n)
    93.88(a)
    540606  NM_001046483.1  NP_001039948.1 
    rat
    (Rattus norvegicus)
    Wdr911   -- WD repeat domain 91 87.37(n)
    92.34(a)
    312225  XM_231599.4  XP_231599.4 
    mouse
    (Mus musculus)
    Wdr911 , 5 6 (15.19 cM)5
    WD repeat domain 911, 5 87.72(n)1
    92.47(a)1
    1012401  NM_001013366.11  NP_001013384.11 
     AI9876835  AK0353455  (see all 11)
    About this table        Species with no ortholog for WDR91

    ENSEMBL Gene Tree for WDR91 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/303 NCBI SNPs in WDR91 are shown (see all 303)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs83451,2
    C,F,A,134870201(+) tagccC/TgTCTT 1 -- ut31 ese316Minor allele frequency- T:0.27MN NS EA NA 1384
    rs104571,2
    C,F,A,H,134868824(+) ACAGAG/ATCACT 1 -- ut3122Minor allele frequency- A:0.26MN EA NS NA 3107
    rs119041,2
    C,134868954(+) AATAAC/TTATTT 1 -- ut312Minor allele frequency- T:0.01MN WA 186
    rs1425081,2
    C,F,A,134887640(+) ATGGCT/AGCTAA 1 -- int112Minor allele frequency- A:0.19NA EA 1485
    rs1425091,2
    C,F,A,134887656(+) AGTTTG/TTTTGC 1 -- int119Minor allele frequency- T:0.36NA NS MN EA 1202
    rs1425101,2
    C,F,A,134887857(+) TTTACG/CCAACC 1 -- int119Minor allele frequency- C:0.38NA EA NS MN 1175
    rs2925491,2
    C,A,H,134869048(+) CTTTGA/GTACCA 1 -- ut319Minor allele frequency- G:0.29MN NA EA 534
    rs2925501,2
    C,A,134869918(+) tgcccG/Agcccc 1 -- ut313Minor allele frequency- A:0.00NA 6
    rs2925521,2
    C,F,A,134870447(+) AGTTCG/AGGGCC 1 -- ut3115Minor allele frequency- A:0.09MN NS EA NA 1008
    rs2925531,2
    C,F,A,134871348(+) CACACC/TGGTTG 1 -- int115Minor allele frequency- T:0.42NS EA NA 1010
    About this table

    HapMap Linkage Disequilibrium images for WDR91 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WDR91: --

    QIAGEN SeqTarget long-range PCR primers for resequencing WDR91 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/14 PubMed articles for WDR91 gene, integrated from 7 sources (see all 14):
    (articles sorted by number of sources associating them with WDR91)
    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29062 HGNC: 24997 AceView: HSPC049 Ensembl:ENSG00000105875 euGenes: HUgn29062
    ECgene: WDR91 H-InvDB: WDR91

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for WDR91 gene:
    Search GeneIP for patents involving WDR91

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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