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WEE1 Gene

protein-coding   GIFtS: 62

GC11P009266
WEE1 homolog (S. pombe)
(Previous name: wee1+ (S. pombe) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for WEE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
WEE1 homolog (S. pombe)1 2     WEE1A2
Wee1A kinase2 3     wee1-like protein kinase2
WEE1hu2 3     WEE1+ homolog2
wee1+ (S. pombe) homolog1     DKFZp686I181662
FLJ164462     EC 2.7.10.23

External Ids:    HGNC: 127611   Entrez Gene: 74652   Ensembl: ENSG000001664837   UniProtKB: P302913   

Export aliases for WEE1 gene to outside databases

Previous GC identifers: GC11P010605 GC11P010164 GC11P009633 GC11P009558 GC11P009550


Summaries
for WEE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WEE1:
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases.
This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the
transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
(provided by RefSeq)

UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2
phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1
phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching
a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively
on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur

Gene Wiki entry for WEE1 (Wee1-like protein kinase)

Genomic Views
for WEE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WEE1 gene promoter:
         NF-kappaB1   NF-kappaB   p53   MIF-1   RFX1   Sp1   Hlf   E4BP4   Sox9   FOXF2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for WEE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WEE1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3-p15.1   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3-p15.1

WEE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WEE1 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009266:  view genomic region     (about GC identifiers)

Start:
 9,266,900 bp from pter
End:
 9,282,930 bp from pter
Size:
 16,031 bases
Orientation:
 plus strand

1 alternative location:
Chr11+ 9,595,430-9,611,531     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

Proteins
for WEE1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291 (See protein sequence)
Recommended Name: Wee1-like protein kinase  
Size: 646 amino acids; 71597 Da
Cofactor: Binds 2 magnesium ions per subunit
Subcellular location: Nucleus
PDB structures from and Proteopedia :
1X8B (3D)    2IN6 (3D)    2IO6 (3D)    2Z2W (3D)    3BI6 (3D)    3BIZ (3D)    3CQE (3D)    3CR0 (3D)    

Explore the universe of human proteins at neXtProt for WEE1: NX_P30291 

Post-translational modifications:

  • Phosphorylated during M and G1 phases. Also autophosphorylated1
  • Ubiquitinated and degraded at the onset of G2/M phase (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001137448.1  NP_003381.1  


    ENSEMBL proteins: 
    ENSP00000402084 ENSP00000299613 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant WEE1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for WEE1 
    Novus Biologicals Proteins for WEE1
    Novus Biologicals Lysate for WEE1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm TAS--
    About this table

    WEE1 for ontologies           About GeneDecksing



    Antibodies for WEE1: 
    Millipore Mono- and Polyclonal Antibodies for the study of WEE1
    Sigma-Aldrich Antibodies for WEE1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for WEE1 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for WEE1 
    Novus Biologicals Antibodies for WEE1
    Epitomics antibodies for WEE1

    Assays for WEE1: 
    Millipore Kits and Assays for the Analysis of WEE1
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WEE1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WEE1 

    Protein Domains/
    Families
    for WEE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WEE1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR017164 Wee1-like_protein_kinase

    Graphical View of Domain Structure for InterPro Entry P30291

    ProtoNet protein and cluster: P30291

    UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily
    Similarity: Contains 1 protein kinase domain


    Gene Function
    for WEE1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
    Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
    cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2
    phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1
    phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching
    a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively
    on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Synthesis is increased during S and G2 phases, presumably by an increase in transcription; activity
    is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased synthesis
    combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into mitosis,
    although N-terminal phosphorylation might also regulate the protein stability via protection from proteolysis or might
    regulate the subcellular location
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Inhib.
    RNA:            		Millipore RNAi Products for the Analysis of WEE1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for WEE1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for WEE1
    Sigma-Aldrich shRNA Panels and shRNA for WEE1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): WEE1
    OriGene shRNA RFP (see all 2): WEE1
    OriGene basic RS shRNA (see all 2): WEE1
    OriGene siRNA (see all 2): WEE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WEE1 
    miRNA:Sigma-Aldrich microRNA Mimics for WEE1
    Sigma-Aldrich microRNA target validation systems for WEE1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WEE1 
    8/15 SABiosciences Assays for microRNAs that regulate WEE1 (see all 15):
    hsa-miR-768-3p hsa-miR-300 hsa-miR-15a hsa-miR-381 hsa-miR-503 hsa-miR-545 hsa-miR-497 hsa-miR-646

    Gene
    Editing:    		Sigma-Aldrich CompoZr Knockout ZFN for WEE1 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene 3'-UTR clone (see all 2): WEE1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WEE1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for WEE1 

    Genatlas biochemistry entry for WEE1:
    wee1 tyrosine kinase,yeast wee1 homolog,involved in cell cycle regulation

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0004713 protein tyrosine kinase activity TAS7774574
    About this table

    WEE1 for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Wee1 (no phenotypes)


    WEE1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WEE1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    WEE1 for pathways           About GeneDecksing

    2 Millipore Pathways for WEE1
        Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of SCF complex in cell cycle regulation

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  WEE1
        Mitotic Roles of Polo-Like Kinase
    Cell Cycle: G2/M DNA Damage Checkpoint Regulation
    Hereditary Breast Cancer Signaling

    1 Cell Signaling Technology (CST) Pathway for WEE1
        Cell Cycle Control: G2/M DNA Damage Checkpoint

    1 Kegg Pathway  (Kegg details for WEE1):
        hsa04110 Cell cycle

        SABiosciences Custom Pathway-Focused PCR Arrays for WEE1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for WEE1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WEE1

    5/19 Interacting proteins for WEE1 (ENSP000002996133 P302911, 2) via UniProtKB, MINT, and/or STRING (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW11Q9UKB11STRING: ENSP00000265094 EBI-914695,EBI-355189
    PLK1P533501STRING: ENSP00000300093 EBI-914695,EBI-476768
    BTRCQ9Y2971EBI-914695,EBI-307461
    YWHABP319462MINT-16603 MINT-16602 MINT-50988
    YWHAZP631042MINT-3294834 MINT-3294458 MINT-3295375
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    GO:0000086 G2/M transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    About this table

    WEE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WEE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    WEE1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WEE1
    4 Novoseek chemical compound relationships for WEE1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 53.8 24 14711880 (2), 7813446 (2), 1384126 (1), 15558017 (1) (see all 19)
    berberine 36.1 5 16619512 (4), 16440412 (1)
    curcumin 31 3 17201156 (1), 14534529 (1), 16596191 (1)
    oxygen 0 1 17201156 (1)
    About this table



    Transcripts
    for WEE1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Millipore RNAi Products for the Analysis of WEE1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for WEE1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for WEE1
    Sigma-Aldrich shRNA Panels and shRNA for WEE1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): WEE1
    OriGene shRNA RFP (see all 2): WEE1
    OriGene basic RS shRNA (see all 2): WEE1
    OriGene siRNA (see all 2): WEE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WEE1 
    miRNA: Sigma-Aldrich microRNA Mimics for WEE1
    Sigma-Aldrich microRNA target validation systems for WEE1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WEE1 
    8/15 SABiosciences Assays for microRNAs that regulate WEE1 (see all 15):
    hsa-miR-768-3p hsa-miR-300 hsa-miR-15a hsa-miR-381 hsa-miR-503 hsa-miR-545 hsa-miR-497 hsa-miR-646
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): WEE1
    OriGene 3'-UTR Clone (see all 2): WEE1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WEE1 
    Primers: OriGene genome-wide validated SYBR primer pairs: WEE1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WEE1: PPH00445A

    REFSEQ mRNAs for WEE1 gene (2 alternative transcripts): 

    NM_001143976.1  NM_003390.3  

    Additional cDNA sequence: 

    AK122837.1 BC051831.1 BC070052.1 U10564.1 X62048.1 

    8 DOTS entries:

    DT.315661  DT.95290127  DT.92432867  DT.95373536  DT.100036218  DT.100787721  DT.120680022  DT.120680029 

    24/226 AceView cDNA sequences (see all 226):

    BQ962642 AU280199 BU689760 CB113055 CA487773 BX641032 AI799425 AW630943 
    AA554199 BQ009495 T28628 T63333 AK122837 BU161880 BG611243 BC070052 
    BC051831 BE349189 AU118534 BU689831 AW949527 AU126299 BF478052 BX117974 

    highest scoring ESTs for WEE1:

    U10564 X62048 AA039639 AA557209 AA748047 AA889156 AA939340 AI474983 AI811720 AI861843 

    Unigene Cluster for WEE1:

    WEE1 homolog (S. pombe)
    Hs.249441  [show with all ESTs]
    Unigene Representative Sequence: BC070052


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450114(uc001mhu.2 uc001mhs.2) ENST00000299613(uc001mht.2)


    Expression
    for WEE1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    WEE1 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching WEE1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    2033_s_at2, 3 U95-A 1 1.00 1.00 0.70 0.97 U10564 1.00 0.87 0.94 1
    36909_at2, 3 U95-A 1 1.00 1.00 0.92 1.04 X62048 1.00 0.87 0.94 1
    215711_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    212533_at2, 3 U133-A 1 1.00 1.00 -- -- X62048 1.00 0.87 0.94 1
    215711_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212533_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    WEE1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    WEE1 gene expression
    WEE1 gene electronic northern expression
    WEE1 gene sage expression
    About these images

    CGAP SAGE TAG: TTTGCACTTG

    SOURCE GeneReport for Unigene cluster: Hs.249441

    Expression variation in blood from EXPOLDB for WEE1

    Primers: OriGene genome-wide validated SYBR primer pairs: WEE1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WEE1: PPH00445A
        SABiosciences Custom PCR Arrays for WEE1 


    Orthologs
    for WEE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for WEE1 gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 WEE11   -- WEE1 homolog (S. pombe) 93.19(n)
    97.06(a)    		 476847  XM_534051.2  XP_534051.2 
    chimpanzee
    (Pan troglodytes)    		 WEE11   -- WEE1 homolog (S. pombe) 99.23(n)
    99.54(a)    		 466440  XM_521839.2  XP_521839.2 
    cow
    (Bos taurus)    		 WEE11   -- WEE1 homolog (S. pombe) 92.52(n)
    96.75(a)    		 540322  XM_593176.3  XP_593176.2 
    rat
    (Rattus norvegicus)    		 Wee11   -- wee 1 homolog (S. pombe) 88.51(n)
    91.93(a)    		 308937  NM_001012742.1  NP_001012760.1 
    mouse
    (Mus musculus)    		 Wee11 , 5 7 (57.70 cM)5
    		 WEE 1 homolog 1 (S. pombe)5
    WEE 1 homolog (S. pombe)1    		 87.16(n)1
    90.84(a)1    		 223901  NM_009516.31  NP_033542.21 
     AI4652275  AK0112125  (see all 14)
    About this table        Species with no ortholog for WEE1

    ENSEMBL Gene Tree for WEE1 (if available)

    Paralogs
    for WEE1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for WEE1 gene
    WEE22  PKMYT12  

    WEE1 for paralogs           About GeneDecksing


    Pseudogenes
    2 related pseudogenes



    Genomic Variants
    for WEE1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/153 NCBI SNPs in WEE1 are shown (see all 153)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs105341,2
    		--9611008(-) AAAAAC/AAGACT 2 -- ut311Minor allele frequency- A:0.00MN 184
    rs10494031,2
    		C,F,A,9610805(+) TGATGA/GAAAGC 2 -- ut3110Minor allele frequency- G:0.19MN NS EA NA WA 816
    rs23055001,2
    		--9607979(+) AAAAAC/TTGTTT 2 -- int10--------
    rs37638681,2
    		C,H,9594888(-) ACGCAC/GCCCCC 2 -- ng518Minor allele frequency- G:0.35MN NA EA 354
    rs37638691,2
    		C,A,H,9594827(-) AGCGCT/CTCCGG 2 -- ng516Minor allele frequency- C:0.26MN NA 264
    rs37638701,2
    		C,F,9594761(-) GAGGCC/AGCTTC 2 -- ng512Minor allele frequency- A:0.15EA NA 90
    rs37638711,2
    		C,9594235(-) TTTTTA/TTTTTT 2 -- ng510--------
    rs37638721,2
    		C,F,A,9593427(-) ACATCG/AGTGGA 1 -- ng5110Minor allele frequency- A:0.28EA NS NA WA 2120
    rs38706351,2
    		C,A,H,9602076(-) CCGATG/ATCGGG 2 -- int13Minor allele frequency- A:0.17NA WA 6
    rs38790771,2
    		--9598638(-) AAGCTC/TAAACT 2 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for WEE1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WEE1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing WEE1 

    Disorders & Mutations
    for WEE1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WEE1 for disorders           About GeneDecksing

    OMIM: 193525

    6 Novoseek disease relationships for WEE1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 40.1 1 7842740 (1)
    cancer 18.8 7 19500427 (2), 20159553 (1), 11585773 (1), 15735666 (1)
    tumors 3.68 7 14760118 (1), 19288185 (1), 19887545 (1), 14726685 (1) (see all 7)
    leukemia 0 2 16619512 (1), 18351645 (1)
    cancer lung 0 2 14760118 (2)
    immunodeficiency 0 1 16968670 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: WEE1 (3 documents)
    Tumor Gene Database (TGDB): WEE1

    Export disorders and mutations for WEE1 gene to outside databases

    Medical News
    for WEE1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for WEE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/190 PubMed articles for WEE1 gene, integrated from 7 sources (see all 190):
    (articles sorted by number of sources associating them with WEE1)
    1. Wee1(+)-like gene in human cells. (PubMed id 1840647)1, 2, 3 Igarashi M.... Okayama H. (1991)
    2. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (PubMed id 7743995)1, 2, 7 Watanabe N.... Hunter T. (1995)
    3. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. (PubMed id 8428596)1, 2, 7 McGowan C.H. and Russell P. (1993)
    4. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PubMed id 11528126)1, 2, 7 Cichutek A.... Zabel B.U. (2001)
    5. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. (PubMed id 15837193)1, 2, 7 Squire C.J.... Baker E.N. (2005)
    6. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. (PubMed id 15150265)1, 2 Lu R.... Nakanishi M. (2004)
    9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    10. A bifunctional regulatory element in human somatic We e1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. (PubMed id 19858290)1, 7 Li C....Enders G.H. (2010)

    External Searches for WEE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing WEE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7465 HGNC: 12761 AceView: WEE1 Ensembl:ENSG00000166483 euGenes: HUgn7465
    ECgene: WEE1 Kegg: 7465 H-InvDB: WEE1

    Other Databases showing WEE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WEE1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for WEE1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WEE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for WEE1 gene:
    Search GeneIP for patents involving WEE1

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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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