WFIKKN1 Gene
protein-coding GIFtS: 48
GC16P000602
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WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
(Previous name: chromosome 16 open reading frame 12 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C16orf12)
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Aliases &
Descriptions
for WFIKKN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 11 2 | | C16orf122 3 | | WFIKKN1 2 3 5 | | chromosome 16 open reading frame 121 | | RJD21 2 | | MGC1266512 | | Growth and differentiation factor-associated serum protein 22 3 | | WAP, FS, Ig, KU, and NTR-containing protein2 | | WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing protein2 3 | | MGC1266552 | | GASP-22 3 | | WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 12 | | hGASP-22 3 | | GASP23 |
Export aliases for WFIKKN1 gene to outside databasesPrevious GC identifers: GC16P000622 GC16P000623 GC16P000680 |
Summaries
for WFIKKN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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|
Entrez Gene summary for WFIKKN1:
This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, animmunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently ininhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitorand may control the action of multiple types of serine proteases as well as metalloproteinases. (provided by RefSeq)
UniProtKB/Swiss-Prot: WFKN1_HUMAN, Q96NZ8Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease-and metalloprotease-inhibitor activity (By similarity)
Gene Wiki entry for WFIKKN1 |
Genomic Views
for WFIKKN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFIKKN1 gene promoter:
deltaCREB CREB CUTL1 PPAR-gamma1 PPAR-gamma2 COUP-TF1 HNF-4alpha2 MAZR ER-alpha MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFIKKN1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WFIKKN1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13WFIKKN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P000602: view genomic region
(about GC identifiers)
Start:
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602,311 bp from pter |
End:
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605,379 bp from pter |
Size:
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3,069 bases |
Orientation:
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plus strand |
1 alternative location:
RefSeq DNA sequence:- NC_000016.9 NT_010393.16
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Proteins
for WFIKKN1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WFKN1_HUMAN, Q96NZ8 (See
protein sequence)Recommended Name: WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 precursor Size: 548 amino acids; 58798 Da
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=AAK61237.1; Type=Erroneous gene model prediction; Sequence=BAC11566.1; Type=Frameshift;Positions=147;
PDB structure from  and Proteopedia  :2DDI (3D)
2DDJ (3D)
Secondary accessions: Q7LDW0 Q8NBQ1 Q96S20Explore the universe of human proteins at neXtProt for WFIKKN1: NX_Q96NZ8
REFSEQ proteins: NP_444514.1
ENSEMBL proteins: ENSP00000324763
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
WFIKKN1 for ontologies About GeneDecksing
Antibodies for WFIKKN1:
Assays for WFIKKN1: |
Protein
Domains/
Families
for WFIKKN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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WFIKKN1 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry Q96NZ8ProtoNet protein and cluster: Q96NZ8 4 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB008197 4-disulphide core signature IPB011497 Protease inhibitor IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: WFKN1_HUMAN, Q96NZ8Domain: The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity towardchymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase ortissue plasminogen activatorSimilarity: Belongs to the WFIKKN familySimilarity: Contains 2 BPTI/Kunitz inhibitor domainsSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Kazal-like domainSimilarity: Contains 1 NTR domainSimilarity: Contains 1 WAP domain |
Gene Function
for WFIKKN1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: WFKN1_HUMAN, Q96NZ8Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease-and metalloprotease-inhibitor activity (By similarity)
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 18596030 | | GO:0008191 | metalloendopeptidase inhibitor activity |
IEA | -- | | GO:0030414 | peptidase inhibitor activity |
IEA | -- |
About this table
WFIKKN1 for ontologies About GeneDecksing
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Pathways & Interactions
for WFIKKN1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for WFIKKN1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFIKKN1
5/7 Interacting proteins for WFIKKN1 (Q96NZ81, 2) via UniProtKB, MINT, and/or STRING (see all 7)About this table
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Drugs & Compounds
for WFIKKN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WFIKKN1
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Transcripts
for WFIKKN1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
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REFSEQ mRNAs for WFIKKN1 gene: NM_053284.2 Additional cDNA sequence: AF422194.1 AK075356.1 AK314757.1 BC101602.1 BC101606.1 2 DOTS entries: DT.102842640 DT.97765902 24/243 AceView cDNA sequences (see all 243): AI631038 BM997982 BQ717538 BU527649 BM728190 AW166046 BX383974 AI819096 CB853381 CD674470 NM_053284 BM052895 BQ059400 AI479516 BM703680 BX280326 BQ233405 BX282685 AW005486 BQ027275 BQ685517 BM666257 CB215738 BF593711
 highest scoring ESTs for WFIKKN1:AF422194 AI819096 AK075356 AW182905 BX280326 CN425793 CN425795 CN425796 CN425797 CN425798 Unigene Cluster for WFIKKN1: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Hs.345818 [show with all ESTs]Unigene Representative Sequence: AK075356
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000319070(uc002chs.1 uc002cht.1)
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Expression
for WFIKKN1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WFIKKN1 expression in normal and diseased human tissues
1 / 2 / 3 1 probe-set matching WFIKKN1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1552811_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGTGAGGTGC
SOURCE GeneReport for Unigene cluster: Hs.345818
UniProtKB/Swiss-Prot: WFKN1_HUMAN, Q96NZ8Tissue specificity: Expressed in pancreas, kidney, liver, placenta, and lung
SABiosciences Custom PCR Arrays for WFIKKN1
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Orthologs
for WFIKKN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for WFIKKN1 gene from 5/7 species (see all 7)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
WFIKKN11 |
-- |
WAP, follistatin/kazal, immunoglobulin, kunitz and more |
86.23(n)
87.93(a) |
490094 XM_547215.2 XP_547215.2 |
cow
(Bos taurus) |
WFIKKN11 |
-- |
WAP, follistatin/kazal, immunoglobulin, kunitz and more |
85.62(n)
87.2(a) |
540233 XM_592519.3 XP_592519.1 |
rat
(Rattus norvegicus) |
Wfikkn11 |
-- |
WAP, FS, Ig, KU, and NTR-containing protein 1 |
82.24(n)
87.59(a) |
363555 XM_343870.3 XP_343871.2 |
mouse
(Mus musculus) |
Wfikkn11 , 5 |
17 (12.97 cM)5
|
WAP, FS, Ig, KU, and NTR-containing protein 11, 5 |
82.24(n)1
87.77(a)1 |
2150011 XM_128578.51 XP_128578.41
AA3875165 BC0264605 (see all 8) |
chicken
(Gallus gallus) |
WFIKKN11 |
-- |
WAP, follistatin/kazal, immunoglobulin, kunitz and more |
76.09(n)
69.13(a) |
429301 XM_426858.2 XP_426858.2 |
About this table Species with no ortholog for WFIKKN1
ENSEMBL Gene Tree for WFIKKN1 (if available) |
Paralogs
for WFIKKN1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WFIKKN1 gene
- WFDC62 WFIKKN22 SPINT32 ENSG000002491392 WFDC82 SPINLW12
WFIKKN1 for paralogs About GeneDecksing
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Genomic Variants
for WFIKKN1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WFIKKN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for WFIKKN1
10 CNVs: 49727 53069 29986 49728 3987 29982 5329 29983 4914 29985 | | QIAGEN SeqTarget long-range PCR primers for resequencing WFIKKN1 |
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Disorders & Mutations
for WFIKKN1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WFIKKN1 for disorders About GeneDecksing
OMIM: 608021
Export disorders and mutations for WFIKKN1 gene to outside databases
|
Medical News
for WFIKKN1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WFIKKN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for WFIKKN1 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with WFIKKN1)- A human protein containing multiple types of protease-inhibitory modules. (PubMed id 11274388)1, 2, 3, 7 Trexler M.... Patthy L. (2001)
- Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PubMed id 11928817)1, 3, 7 Trexler M.... Patthy L. (2002)
- Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein. (PubMed id 16791741)1, 2 Liepinsh E.... Otting G. (2006)
- Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein. (PubMed id 12709070)1, 2 Nagy A....Patthy L. (2003)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PubMed id 18596030)1, 7 Kondas K....Patthy L. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Regulation of myostatin in vivo by growth and differentiation factor- associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PubMed id 12595574)2 Hill J.J.... Wolfman N.M. (2003)
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External Searches for WFIKKN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing WFIKKN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing WFIKKN1 gene
(According to HUGE)
About This Section
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Specialized Databases showing WFIKKN1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for WFIKKN1 gene:
Search GeneIP for patents involving WFIKKN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFIKKN1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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