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WFIKKN2 Gene

protein-coding   GIFtS: 48

GC17P044279
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for WFIKKN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 21 2     hGASP-12 3
WFIKKNRP1 2 3 5     WAP, FS, Ig, two KU and NTR module related protein2
Growth and differentiation factor-associated serum protein 12 3     WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 22
GASP-12 3     multivalent protease inhibitor protein2
WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related
protein2 3
     GASP13
WFIKKN-related protein2 3     

External Ids:    HGNC: 309161   Entrez Gene: 1248572   Ensembl: ENSG000001737147   UniProtKB: Q8TEU83   

Export aliases for WFIKKN2 gene to outside databases

Previous GC identifers: GC17P046267 GC17P048912


Summaries
for WFIKKN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WFIKKN2:
The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an
NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein.
The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of
multiple types of proteases. (provided by RefSeq)

UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease-
and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By
similarity)


Genomic Views
for WFIKKN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WFIKKN2 gene promoter:
         PPAR-gamma2   PPAR-gamma1   ATF6   Max1   Arnt   GATA-1   FOXO1a   Max   c-Myc   SRF   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for WFIKKN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21

WFIKKN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFIKKN2 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P044279:  view genomic region     (about GC identifiers)

Start:
 44,279,935 bp from pter
End:
 44,287,032 bp from pter
Size:
 7,098 bases
Orientation:
 plus strand

1 alternative location:
Chr17+ 48,912,011-48,919,709     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

Proteins
for WFIKKN2 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8 (See protein sequence)
Recommended Name: WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2 precursor  
Size: 576 amino acids; 63941 Da
Subunit: Interacts with both mature and propeptide myostatin/MSTN
Subcellular location: Secreted (By similarity)
Secondary accessions: Q6UXZ9

Explore the universe of human proteins at neXtProt for WFIKKN2: NX_Q8TEU8 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_783165.1  

    ENSEMBL proteins: 
    ENSP00000405889 ENSP00000311184 ENSP00000376918 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for WFIKKN2 (GASP-1/WFIKKNRP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for WFIKKN2 
    Novus Biologicals Protein for WFIKKN2
    Novus Biologicals Lysate for WFIKKN2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    WFIKKN2 for ontologies           About GeneDecksing



    Antibodies for WFIKKN2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WFIKKN2
    R&D Systems Antibodies for WFIKKN2 (GASP-1/WFIKKNRP)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for WFIKKN2 
    Novus Biologicals Antibody for WFIKKN2
    Browse antibodies at Epitomics

    Assays for WFIKKN2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for WFIKKN2 (GASP-1/WFIKKNRP)
    GenScript Custom Assay Services for WFIKKN2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WFIKKN2 

    Protein Domains/
    Families
    for WFIKKN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WFIKKN2 for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR003598 Ig_sub2
     IPR008993 TIMP-like_OB-fold
     IPR002350 Prot_inh_Kazal
     IPR013098 Ig_I-set
     IPR002223 Prot_inh_Kunz-m

    Graphical View of Domain Structure for InterPro Entry Q8TEU8

    ProtoNet protein and cluster: Q8TEU8

    4 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB008197 4-disulphide core signature
    IPB011497 Protease inhibitor
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
    Similarity: Belongs to the WFIKKN family
    Similarity: Contains 2 BPTI/Kunitz inhibitor domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 NTR domain
    Similarity: Contains 1 WAP domain


    Gene Function
    for WFIKKN2 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
    Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease-
    and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By
    similarity)

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for WFIKKN2
    Sigma-Aldrich shRNA for WFIKKN2
    OriGene 29mer shRNA kits in GFP-retroviral vector: WFIKKN2
    OriGene shRNA RFP: WFIKKN2
    OriGene basic RS shRNA: WFIKKN2
    OriGene siRNA: WFIKKN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WFIKKN2 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WFIKKN2 
    1 SABiosciences Assays for microRNA that regulate WFIKKN2:
    hsa-miR-608

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: WFIKKN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: WFIKKN2
    OriGene untagged cDNA clones in CMV expression vector: WFIKKN2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WFIKKN2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for WFIKKN2 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867 serine-type endopeptidase inhibitor activity IEA--
    GO:0005515 protein binding IPI18596030
    GO:0008191 metalloendopeptidase inhibitor activity IEA--
    GO:0030414 peptidase inhibitor activity IEA--
    About this table

    WFIKKN2 for ontologies           About GeneDecksing


    Pathways & Interactions
    for WFIKKN2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for WFIKKN2 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFIKKN2

    5/7 Interacting proteins for WFIKKN2 (Q8TEU81, 2) via UniProtKB, MINT, and/or STRING (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDF11O953901EBI-2363745,EBI-2363776
    BMP2P126432MINT-8044372
    BMP3P126452MINT-8044382
    BMP4P126442MINT-8044135
    BMP8BP348202MINT-8044393
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179 transforming growth factor beta receptor signaling pathway IEA--
    About this table

    WFIKKN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WFIKKN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WFIKKN2


    Transcripts
    for WFIKKN2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for WFIKKN2
    Sigma-Aldrich shRNA for WFIKKN2
    OriGene 29mer shRNA kits in GFP-retroviral vector: WFIKKN2
    OriGene shRNA RFP: WFIKKN2
    OriGene basic RS shRNA: WFIKKN2
    OriGene siRNA: WFIKKN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WFIKKN2 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WFIKKN2 
    1 SABiosciences Assays for microRNA that regulate WFIKKN2:
    hsa-miR-608
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: WFIKKN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: WFIKKN2
    OriGene untagged cDNA clones in CMV expression vector: WFIKKN2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for WFIKKN2 
    Primers: OriGene genome-wide validated SYBR primer pairs: WFIKKN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WFIKKN2: PPH14479A

    REFSEQ mRNAs for WFIKKN2 gene: 

    NM_175575.5  

    Additional cDNA sequence: 

    AF468657.1 AK127743.1 AK131196.1 AK298172.1 AK312821.1 AY358142.1 BC140842.1 BC140844.1 

    1 DOTS entry:

    DT.101979443 

    24/26 AceView cDNA sequences (see all 26):

    AF468657 NM_175575 BX108923 BQ954191 F27556 BX461258 AK127743 AI919298 
    AL537450 CA394579 BX433163 AW468704 BX464797 AI833106 AL540240 BX452077 
    AY358142 AA364422 AI932781 BX424452 CD671934 AL540239 BG221308 AL537449 

    highest scoring ESTs for WFIKKN2:

    AF468657 AI833106 AK127743 AK131196 AL537450 AY358142 CA394579 AA364422 AI919298 AI932781 

    Unigene Cluster for WFIKKN2:

    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
    Hs.211475  [show with all ESTs]
    Unigene Representative Sequence: NM_175575


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426127 ENST00000311378(uc010dbu.2 uc002isv.3) ENST00000393226


    Expression
    for WFIKKN2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    WFIKKN2 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching WFIKKN2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    87091_at2, 3 U95-E 1 0.44 1.00 1.00 1.00 AI833106 0.80 1.00 0.91 1
    241358_at2, 3 U133-B 1 0.64 1.00 -- -- AI833106 0.80 1.00 0.91 1
    1554773_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    241358_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    WFIKKN2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    WFIKKN2 gene expression
    WFIKKN2 gene electronic northern expression
    WFIKKN2 gene sage expression
    About these images

    CGAP SAGE TAG: GGCAATAGCA

    SOURCE GeneReport for Unigene cluster: Hs.211475

    UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
    Tissue specificity: Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily
    expressed in brain, skeletal muscle, thymus and kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: WFIKKN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for WFIKKN2: PPH14479A
        SABiosciences Custom PCR Arrays for WFIKKN2 


    Orthologs
    for WFIKKN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for WFIKKN2 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 WFIKKN21   -- WAP, follistatin/kazal, immunoglobulin, kunitz and more 90.24(n)
    94.25(a)    		 491086  XM_548206.2  XP_548206.2 
    cow
    (Bos taurus)    		 WFIKKN21   -- WAP, follistatin/kazal, immunoglobulin, kunitz and more 88.83(n)
    92.32(a)    		 531979  NM_001076885.1  NP_001070353.1 
    rat
    (Rattus norvegicus)    		 Wfikkn21   -- WAP, follistatin/kazal, immunoglobulin, kunitz and more 86.55(n)
    93.51(a)    		 287631  XM_220855.4  XP_220855.1 
    mouse
    (Mus musculus)    		 Wfikkn21 , 5 11 (58.90 cM)5
    		 WAP, follistatin/kazal, immunoglobulin, kunitz and more1, 5 87.08(n)1
    93.16(a)1    		 2785071  NM_181819.11  NP_861540.11 
     AK0119775  AY1004505  (see all 7)
    chicken
    (Gallus gallus)    		 WFIKKN21   -- WAP, follistatin/kazal, immunoglobulin, kunitz and more 73.67(n)
    78.99(a)    		 422097  XM_420100.2  XP_420100.2 
    About this table        Species with no ortholog for WFIKKN2

    ENSEMBL Gene Tree for WFIKKN2 (if available)

    Paralogs
    for WFIKKN2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for WFIKKN2 gene
    WFDC62  SPINT32  ENSG000002491392  WFDC82  SPINLW12  WFIKKN12  

    WFIKKN2 for paralogs           About GeneDecksing



    Genomic Variants
    for WFIKKN2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/99 NCBI SNPs in WFIKKN2 are shown (see all 99)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs38038841,2
    		C,F,A,H,48919039(+) CTGCAC/TTGGTT 1 -- ut31 ese318Minor allele frequency- T:0.48EA NA NS WA 854
    rs38882131,2
    		C,F,A,48911989(-) ctgccC/Tatgtc 1 -- ng5112Minor allele frequency- T:0.44NA EA WA 360
    rs44205711,2
    		C,F,48913571(+) GGAGCC/TGTCGG 1 -- int11Minor allele frequency- T:0.04NA 72
    rs46115021,2
    		C,F,A,48910781(+) CCAGGT/CTGGGT 1 -- ng5110Minor allele frequency- C:0.44NS EA NA WA 430
    rs72070281,2
    		C,F,A,H,48916052(+) TTTCCC/GGTGAA 1 -- int126Minor allele frequency- G:0.48NA NS EA WA 1632
    rs72072941,2
    		C,F,A,H,48915844(+) CTGCCG/AAGTGG 1 -- int118Minor allele frequency- A:0.42NS EA NA WA 1002
    rs72121521,2
    		C,F,A,H,48916231(+) GATCAC/TCTCGG 1 -- int116Minor allele frequency- T:0.48NS EA NA WA 688
    rs72141601,2
    		C,A,H48913913(+) GTGAGA/GCGGAC 1 -- int12Minor allele frequency- G:0.00NA 6
    rs72153111,2
    		C,A,H48913914(+) TGAGGT/CGGACC 1 -- int12Minor allele frequency- C:0.00NA 6
    rs72157821,2
    		C,A,H48913892(+) GTGGGG/ATCCAG 1 -- int14Minor allele frequency- A:0.00NA WA 10
    About this table

    HapMap Linkage Disequilibrium images for WFIKKN2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WFIKKN2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing WFIKKN2 

    Disorders & Mutations
    for WFIKKN2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WFIKKN2 for disorders           About GeneDecksing

    OMIM: 610895


    Export disorders and mutations for WFIKKN2 gene to outside databases

    Medical News
    for WFIKKN2 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for WFIKKN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/12 PubMed articles for WFIKKN2 gene, integrated from 7 sources (see all 12):
    (articles sorted by number of sources associating them with WFIKKN2)
    1. Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PubMed id 11928817)1, 2, 3, 7 Trexler M.... Patthy L. (2002)
    2. Regulation of myostatin in vivo by growth and differentiation factor- associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PubMed id 12595574)1, 2 Hill J.J.... Wolfman N.M. (2003)
    3. Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein. (PubMed id 12709070)1, 3 Nagy A....Patthy L. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PubMed id 18596030)1, 7 Kondas K....Patthy L. (2008)
    6. Effects of oral creatine and resistance training on s erum myostatin and GASP-1. (PubMed id 20026378)1 Saremi A....Omidfar K. (2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
    10. Current status of tissue kallikrein inhibitors: importance in cancer. (PubMed id 17621876)7 Bhoola K.D....Thompson P.J. (2007)

    External Searches for WFIKKN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WFIKKN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124857 HGNC: 30916 AceView: WFIKKN2 Ensembl:ENSG00000173714 euGenes: HUgn124857
    ECgene: WFIKKN2 H-InvDB: WFIKKN2

    Other Databases showing WFIKKN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WFIKKN2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for WFIKKN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for WFIKKN2 gene:
    Search GeneIP for patents involving WFIKKN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     ELISAs and CLIAs for WFIKKN2
           

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