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WNT9B Gene

protein-coding GIFtS: 52

GC17P040307

wingless-type MMTV integration site family, member 9B
(Previous names: wingless-type MMTV integration site family, member 15 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: WNT15)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
wingless-type MMTV integration site family, member 9B¹ ²		Protein Wnt-14b² ³
WNT14B¹ ² ³		protein Wnt-9b²
WNT15² ³ ⁵		Protein Wnt-15³
wingless-type MMTV integration site family, member 15¹ ²

External Ids:	HGNC: 12779¹	Entrez Gene: 7484²	Ensembl: ENSG00000158955⁷	UniProtKB: O14905³

Export aliases for WNT9B gene to outside databases

Previous GC identifers: GC17P047327 GC17P045271 GC17P045403 GC17P042283 GC17P044910

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT9B:

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have

been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the

teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of

NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21

region. (provided by RefSeq)

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT9B gene promoter:
         HNF-4alpha2   p53   c-Myb   SRF   MIF-1   RFX1   GCNF-2   GCNF-1   FAC1   PPAR-gamma1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for WNT9B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WNT9B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21

WNT9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT9B gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040307: view genomic region (about GC identifiers)

Start:	40,307,364 bp from pter
End:	40,332,821 bp from pter
Size:	25,458 bases
Orientation:	plus strand

1 alternative location:

Chr17+ 44,910,712-44,962,485

RefSeq DNA sequence:

NC_000017.10 NT_010783.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905 (See protein sequence)

Recommended Name: Protein Wnt-9b precursor

Size: 357 amino acids; 39001 Da

Subunit: Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or

LRP6. Interacts directly in the complex with LRP6

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q6UXT4 Q96Q09

Explore the universe of human proteins at neXtProt for WNT9B: NX_O14905

REFSEQ proteins: NP_003387.1

ENSEMBL proteins:

ENSP00000377105 ENSP00000290015 ENSP00000366039

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: WNT9B
	GenScript Custom Purified and Recombinant Proteins Services for WNT9B
	Novus Biologicals Protein for WNT9B
	Novus Biologicals Lysate for WNT9B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	9441749
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	ISS	--
GO:0005886	plasma membrane	ISS	--

About this table

WNT9B for ontologies About GeneDecksing

Antibodies for WNT9B:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WNT9B
	R&D Systems Antibodies for WNT9B (Wnt-9b)
	OriGene Antibodies: WNT9B
	GenScript Custom Superior Antibodies Services for WNT9B
	Novus Biologicals Antibodies for WNT9B
	Browse antibodies at Epitomics

Assays for WNT9B:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT9B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WNT9B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT9B for domains About GeneDecksing

3 InterPro domains/families:

IPR005816 Wnt_grthfactor

IPR005817 Wnt_SF

IPR018161 Wnt_grthfactor_CS

Graphical View of Domain Structure for InterPro Entry O14905

ProtoNet protein and cluster: O14905

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905

Similarity: Belongs to the Wnt family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for WNT9B Sigma-Aldrich shRNA Panels and shRNA for WNT9B
		OriGene 29mer shRNA kits in GFP-retroviral vector: WNT9B OriGene shRNA RFP: WNT9B OriGene basic RS shRNA: WNT9B OriGene siRNA: WNT9B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WNT9B

miRNA:		Sigma-Aldrich microRNA Mimics for WNT9B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WNT9B
		Search SABiosciences for Assays for microRNAs that regulate WNT9B

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: WNT9B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: WNT9B OriGene untagged cDNA clones in CMV expression vector: WNT9B Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: WNT9B
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for WNT9B

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein-coupled receptor binding	ISS	--
GO:0004871	signal transducer activity	IEA	--
GO:0005201	extracellular matrix structural constituent	NAS	--

About this table

WNT9B for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wnt9b):

craniofacial	digestive/alimentary	embryogenesis	lethality-prenatal/perinatal	no phenotypic analysis
renal/urinary system	reproductive system

WNT9B for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

WNT9B for pathways About GeneDecksing

2 Millipore Pathways for WNT9B

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/11 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for WNT9B (see all 11)

	Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
	Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza
	Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
	Human Embryonic Stem Cell Pluripotency
	Colorectal Cancer Metastasis Signaling

5 Kegg Pathways (Kegg details for WNT9B):

	hsa04310 Wnt signaling pathway
	hsa04340 Hedgehog signaling pathway
	hsa04916 Melanogenesis
	hsa05200 Pathways in cancer
	hsa05217 Basal cell carcinoma

SABiosciences Pathway-Focused PCR Array including WNT9B: PAHS-078A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for WNT9B

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WNT9B

5/35 Interacting proteins for WNT9B (ENSP00000290015³) via UniProtKB, MINT, and/or STRING (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CER1	ENSP00000370297³	STRING: ENSP00000370297
FZD1	ENSP00000287934³	STRING: ENSP00000287934
FZD10	ENSP00000229030³	STRING: ENSP00000229030
FZD2	ENSP00000323901³	STRING: ENSP00000323901
FZD3	ENSP00000240093³	STRING: ENSP00000240093

About this table

5/37 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 37):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001658	branching involved in ureteric bud morphogenesis	ISS	--
GO:0001701	in utero embryonic development	--	--
GO:0001822	kidney development	--	--
GO:0001932	regulation of protein phosphorylation	--	--
GO:0003339	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS	--

About this table

WNT9B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

WNT9B for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT9B
1 Novoseek chemical compound relationship for WNT9B gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	34.8	4	11604992 (2), 11786923 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for WNT9B Sigma-Aldrich shRNA Panels and shRNA for WNT9B
		OriGene 29mer shRNA kits in GFP-retroviral vector: WNT9B OriGene shRNA RFP: WNT9B OriGene basic RS shRNA: WNT9B OriGene siRNA: WNT9B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WNT9B

miRNA:		Sigma-Aldrich microRNA Mimics for WNT9B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WNT9B
		Search SABiosciences for Assays for microRNAs that regulate WNT9B

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: WNT9B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: WNT9B OriGene untagged cDNA clones in CMV expression vector: WNT9B Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: WNT9B

Primers:		OriGene genome-wide validated SYBR primer pairs: WNT9B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for WNT9B: PPH02775A

REFSEQ mRNAs for WNT9B gene:

NM_003396.1

Additional cDNA sequence:

AB063483.1 AK127268.1 AK127615.1 AY358217.1 BC064534.1

5 DOTS entries:

DT.95204679 DT.99983080 DT.404939 DT.101974831 DT.92014147

16 AceView cDNA sequences:

NM_003396 AB063483 AK127268 AA317825 BX503643 Z43167 BX107965 Z39248

AY358217 AW967102 AK127615 BM545100 R12603 AW023308 R09965 BF921697

highest scoring ESTs for WNT9B:

Z39248 AB063483 AK127268 AK127615 AY358217 BX503643 Z43167 AW023308 BC064534 BM545100

Unigene Cluster for WNT9B:

Wingless-type MMTV integration site family, member 9B

Hs.326420 [show with all ESTs]

Unigene Representative Sequence: AK127268

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393461(uc002ikx.1) ENST00000290015(uc002ikw.1) ENST00000376843

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

WNT9B expression in normal and diseased human tissues

¹ / ² / ³

1 probe-set matching WNT9B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1552973_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

WNT9B gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.326420

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905

Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain

Primers:		OriGene genome-wide validated SYBR primer pairs: WNT9B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for WNT9B: PPH02775A

SABiosciences Expression via Pathway-Focused PCR Array including WNT9B: PAHS-078A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WNT9B gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WNT9B¹	--	wingless-type MMTV integration site family, member more	90.75(n) 95.22(a)	490919 XM_548042.2 XP_548042.2
chimpanzee (Pan troglodytes)	WNT9B¹	--	wingless-type MMTV integration site family, member more	99.4(n) 99.7(a)	468296 XM_523685.2 XP_523685.2
cow (Bos taurus)	WNT9B¹	--	wingless-type MMTV integration site family, member more	90.82(n) 94.66(a)	541243 XM_615247.3 XP_615247.3
rat (Rattus norvegicus)	Wnt9b¹	--	wingless-type MMTV integration site family, member more	87.45(n) 92.42(a)	303586 XM_221015.4 XP_221015.4
mouse (Mus musculus)	Wnt9b^{1 , 5}	11 (67.47 cM)⁵	wingless-type MMTV integration site 9B^{1, 5}	86.7(n)¹ 92.98(a)¹	22412¹ NM_011719.3¹ NP_035849.2¹ AB073819⁵ AF031169⁵ (see all 10)

About this table Species with no ortholog for WNT9B

ENSEMBL Gene Tree for WNT9B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WNT9B gene

WNT10B² WNT16² WNT11² WNT10A² WNT9A²

WNT9B for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs754474^1,2	C,F,A,	44953856(-)	`ATGTAC/GACCAG`	2	V	syn¹ ref¹		8		NS EA NA WA	584
rs881148^1,2		44942787(+)	`TGGGGA/GACGAG`	1	--	int¹		0	--	--	--	--
rs1443311^1,2	C,F,O,	44934971(-)	`tcctaG/Cacagt`	1	--	int¹		10		NS EA NA WA	770
rs1530364^1,2	C,F,O,A,	44951777(+)	`TGGCAG/AGTTTA`	1	--	int¹		22		NS EA NA WA	1638
rs2120202^1,2	C,A	44933307(-)	`GAGGCC/TGAGGT`	1	--	int¹		2		NA WA	4
rs2165845^1,2	C,F,A,	44933338(-)	`GTGGCA/TCACAC`	1	--	int¹		1		NA	72
rs2165846^1,2	C,F,O,A,H,	44941366(+)	`GGGACG/ATCTCT`	1	--	int¹		16		NS EA NA WA	1220
rs4305134^1,2	--	44936124(+)	`accttC/Ttggac`	1	--	int¹		0	--	--	--	--
rs4305135^1,2	--	44936250(+)	`CTGGTC/TTCAAA`	1	--	int¹		0	--	--	--	--
rs4480865^1,2	H	44943665(+)	`CCCCGC/TTACTG`	1	--	int¹		4		NS EA	416

About this table

HapMap Linkage Disequilibrium images for WNT9B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WNT9B
2 CNVs: 34570 4038

QIAGEN SeqTarget long-range PCR primers for resequencing WNT9B

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT9B for disorders About GeneDecksing

OMIM: 602864

4 Novoseek disease relationships for WNT9B gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic cancer	39.7	1	11713592 (1)
cancer	10.6	5	11713592 (3), 11604992 (1)
breast cancer	8.08	1	11713592 (1)
tumors	0	1	11713592 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: WNT9B (5 documents)

Export disorders and mutations for WNT9B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/23 PubMed articles for WNT9B gene, integrated from 7 sources (see all 23):
(articles sorted by number of sources associating them with WNT9B)

Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)^{1, 2, 3} Bergstein I.... Brown A.M.C. (1997)
Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PubMed id 11604992)^{1, 2, 7} Kirikoshi H.... Katoh M. (2001)
Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PubMed id 11713592)^{1, 3, 7} Kirikoshi H....Katoh M. (2001)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)¹ Nikopensius T....Metspalu A. (2010)
Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)¹ Menezes R....Vieira A.R. (2010)
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling co mplex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)² Bourhis E....Hannoush R.N. (2010)
Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome. (PubMed id 19171330)¹ Ravel C....Siffroi J.P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7484	HGNC: 12779	AceView: WNT9B	Ensembl:ENSG00000158955	euGenes: HUgn7484
ECgene: WNT9B	Kegg: 7484	H-InvDB: WNT9B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for WNT9B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT9B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for WNT9B gene:
Search GeneIP for patents involving WNT9B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Predesigned and custom siRNAs for WNT9B		Antibodies for WNT9B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WNT9B		microRNA Mimics for WNT9B
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies for WNT9B (Wnt-9b)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WNT9B
	SeqTarget long-range PCR primers for resequencing WNT9B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WNT9B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WNT9B

	GenScript Custom Purified and Recombinant Proteins Services for WNT9B		GenScript cDNA clones with any tag delivered in your preferred vector for WNT9B
	GenScript Custom Assay Services for WNT9B		GenScript Custom Superior Antibodies Services for WNT9B
	GenScript Custom overexpressing Cell Line Services for WNT9B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in WNT9B promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Browse antibodies at Epitomics

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ELISAs and CLIAs for WNT9B

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

WNT9B gene at Home site.

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WNT9B Gene

protein-coding GIFtS: 52

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WNT9B Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor WNT9B gene

Summariesfor WNT9B gene

Genomic Viewsfor WNT9B gene

Proteinsfor WNT9B gene

Protein Domains/Familiesfor WNT9B gene

Gene Functionfor WNT9B gene

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Publicationsfor WNT9B gene

External Searches for WNT9B gene

Genome Databases showing WNT9B gene

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Specialized Databases showing WNT9B gene

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Aliases &
Descriptions
for WNT9B gene

Summaries
for WNT9B gene

Genomic Views
for WNT9B gene

Proteins
for WNT9B gene

Protein Domains/
Families
for WNT9B gene

Gene Function
for WNT9B gene

Pathways & Interactions
for WNT9B gene

Drugs & Compounds
for WNT9B gene

Transcripts
for WNT9B gene

Expression
for WNT9B gene

Orthologs
for WNT9B gene

Paralogs
for WNT9B gene

Genomic Variants
for WNT9B gene

Disorders & Mutations
for WNT9B gene

Medical News
for WNT9B gene

Publications
for WNT9B gene

Intellectual Property
for WNT9B gene

Products
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