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WRAP53 Gene

protein-coding GIFtS: 45

GC17P007483

WD repeat containing, antisense to TP53
(Previous name: WD repeat domain 79 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: WDR79)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
WD repeat containing, antisense to TP53¹ ²		WD40 repeat-containing protein encoding RNA antisense to p53² ³
TCAB1¹ ² ³ ⁵		WD-encoding RNA antisense to p53²
WDR79² ³ ⁵		OTTHUMP00000166047²
WD repeat domain 79¹ ²		WD40 protein Wrap53²
FLJ10385¹ ²		telomerase Cajal body protein 1²
WD repeat-containing protein 79² ³

External Ids:	HGNC: 25522¹	Entrez Gene: 55135²	Ensembl: ENSG00000141499⁷	UniProtKB: Q9BUR4³

Export aliases for WRAP53 gene to outside databases

Previous GC identifers: GC17P007534 GC17P007589

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4

Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the

replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex,

it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for

telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in

the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA

levels and in p53 induction upon DNA damage

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for WRAP53
Other transcription factors

Search SABiosciences Chromatin IP Primers for WRAP53

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WRAP53

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

WRAP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WRAP53 gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P007483: view genomic region (about GC identifiers)

Start:	7,482,804 bp from pter
End:	7,500,156 bp from pter
Size:	17,353 bases
Orientation:	plus strand

1 alternative location:

Chr17+ 7,589,389-7,606,820

RefSeq DNA sequence:

NC_000017.10 NT_010718.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4 (See protein sequence)

Recommended Name: Telomerase Cajal body protein 1

Size: 548 amino acids; 59309 Da

Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2,

GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC)

Subcellular location: Nucleus, Cajal body. Cytoplasm

Secondary accessions: B3KPR9 Q08ET9 Q9NW09

Explore the universe of human proteins at neXtProt for WRAP53: NX_Q9BUR4

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001137462.1 NP_001137463.1 NP_001137464.1 NP_060551.2

ENSEMBL proteins:

ENSP00000408862 ENSP00000411061 ENSP00000379727 ENSP00000324203 ENSP00000397219

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: WRAP53 OriGene Protein Over-expression Lysate: WRAP53
	GenScript Custom Purified and Recombinant Proteins Services for WRAP53
	Novus Biologicals Proteins for WRAP53
	Novus Biologicals Lysates for WRAP53
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005697	telomerase holoenzyme complex	IDA	19179534
GO:0005737	cytoplasm	IEA	--
GO:0015030	Cajal body	IDA	19179534

About this table

WRAP53 for ontologies About GeneDecksing

Antibodies for WRAP53:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WRAP53
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	GenScript Custom Superior Antibodies Services for WRAP53
	Novus Biologicals Antibodies for WRAP53
	Browse antibodies at Epitomics

Assays for WRAP53:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WRAP53
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WRAP53

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WRAP53 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR019782 WD40_repeat_2

IPR011046 WD40_repeat-like_dom

IPR019781 WD40_repeat_sg

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry Q9BUR4

ProtoNet protein and cluster: Q9BUR4

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4

Similarity: Contains 6 WD repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4

Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the

replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex,

it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for

telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in

the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA

levels and in p53 induction upon DNA damage

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for WRAP53 Sigma-Aldrich shRNA for WRAP53
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): WRAP53 OriGene shRNA RFP (see all 4): WRAP53 OriGene basic RS shRNA (see all 4): WRAP53 OriGene siRNA (see all 4): WRAP53
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WRAP53

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WRAP53
		Search SABiosciences for Assays for microRNAs that regulate WRAP53

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): WRAP53 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): WRAP53 OriGene untagged cDNA clones in CMV expression vector: WRAP53 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for WRAP53
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for WRAP53

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	19179534
GO:0005515	protein binding	IPI	19179534

About this table

WRAP53 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for WRAP53

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WRAP53

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032203	telomere formation via telomerase	IMP	19179534
GO:0051973	positive regulation of telomerase activity	IDA	19179534

About this table

WRAP53 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WRAP53

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for WRAP53 Sigma-Aldrich shRNA for WRAP53
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): WRAP53 OriGene shRNA RFP (see all 4): WRAP53 OriGene basic RS shRNA (see all 4): WRAP53 OriGene siRNA (see all 4): WRAP53
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WRAP53

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WRAP53
		Search SABiosciences for Assays for microRNAs that regulate WRAP53

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): WRAP53 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): WRAP53 OriGene untagged cDNA clones in CMV expression vector: WRAP53 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for WRAP53

Primers:		OriGene genome-wide validated SYBR primer pairs: WRAP53 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for WRAP53: PPH20714A

REFSEQ mRNAs for WRAP53 gene (4 alternative transcripts):

NM_001143990.1 NM_001143991.1 NM_001143992.1 NM_018081.2

Additional cDNA sequence:

AK001247.1 AK056669.1 AK092370.1 AK225273.1 AK225411.1 AK303246.1 AY766322.1 AY766323.1

BC002336.2 CR603263.1 CR615409.1 CR616746.1 CR617478.1 CR622832.1 CR624035.1 DQ431240.1

DQ431241.1

14 DOTS entries:

DT.40276076 DT.445840 DT.100712946 DT.120961418 DT.100791809 DT.100791797 DT.101967939 DT.100791800

DT.100762063 DT.92432271 DT.100791798 DT.100791802 DT.92469229 DT.97855928

24/201 AceView cDNA sequences (see all 201):

BM824406 CB138697 CR624035 CA417092 BQ644183 BM423498 BM552657 AK092370

BM725682 BU849179 CR622832 BM678289 CR615409 BM723308 CR616746 CA487183

CA426678 CR617478 BC002336 BG109721 BM926273 BQ651069 CF264929 CF142453

Unigene Cluster for WRAP53:

WD repeat containing, antisense to TP53

Hs.437460 [show with all ESTs]

Unigene Representative Sequence: AK056669

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for WRAP53

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:															-
SP3:															-

About this scheme

ECgene alternative splicing isoforms for WRAP53
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000451908 ENST00000457584 ENST00000396463 ENST00000498311(uc002giq.2)

ENST00000463804 ENST00000316024(uc010vui.1 uc002gip.2 uc002gir.2 uc010cnl.2)

ENST00000431639(uc010vuh.1) ENST00000467699(uc010vuj.1) ENST00000498114

ENST00000471973

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

WRAP53 expression in normal and diseased human tissues

¹ / ²

5 probe-sets matching WRAP53 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44563_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
220258_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
44563_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
220258_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
44563_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

WRAP53 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

WRAP53 gene electronic northern expression

About these images

CGAP SAGE TAG: AGGGGGAGCA

SOURCE GeneReport for Unigene cluster: Hs.437460

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4

Tissue specificity: Expressed in all tissues and cell lines examined

Primers:		OriGene genome-wide validated SYBR primer pairs: WRAP53 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for WRAP53: PPH20714A

SABiosciences Custom PCR Arrays for WRAP53

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WRAP53 gene from 5/12 species (see all 12)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR79¹	--	WD repeat domain 79	85.1(n) 84.06(a)	607892 XM_844744.1 XP_849837.1
chimpanzee (Pan troglodytes)	WDR79¹	--	WD repeat domain 79	99.33(n) 98.91(a)	455213 XM_001172037.1 XP_001172037.1
cow (Bos taurus)	WDR79¹	--	WD repeat domain 79	87.59(n) 84.17(a)	509631 NM_001035073.1 NP_001030245.1
rat (Rattus norvegicus)	Wdr79¹	--	WD repeat domain 79	82.73(n) 81.14(a)	287432 NM_001007610.1 NP_001007611.1
mouse (Mus musculus)	Wrap53⁵ Wdr79¹	11 (42.81 cM)⁵	WD repeat containing, antisense to TP53⁵ WD repeat domain 79¹	82.22(n)¹ 80.57(a)¹	216853¹ NM_144824.2¹ NP_659073.1¹ AI451102⁵ AI854620⁵ (see all 14)

About this table Species with no ortholog for WRAP53

ENSEMBL Gene Tree for WRAP53 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1046823^1,2	--	7606379(+)	`GCCTGG/TCAATG`	8	G V	ref¹ mis¹		1		MN	184
rs4559962^1,2	C,A,	7594710(-)	`aaaaaA/CaCCTC`	4	--	int¹		1		WA	2
rs4968205^1,2	--	7597781(+)	`gtctcA/Gaactc`	4	--	int¹		0	--	--	--	--
rs6503050^1,2	C,A,	7593509(+)	`ggatcC/Tgccca`	4	--	int¹		1		WA	2
rs6503051^1,2	C,A,	7593540(+)	`gggatC/Tacagg`	4	--	int¹		1		WA	2
rs6503052^1,2	C,A,	7596993(+)	`atcgcG/Accact`	4	--	int¹		2		NA WA	4
rs7210452^1,2	H	7598648(+)	`GTGTAC/GTGAGT`	4	--	int¹		4		NS EA	416
rs7212296^1,2	C,A	7594485(+)	`tcatgC/Tcactg`	4	--	int¹		0	--	--	--	--
rs7223380^1,2	C,A	7602643(+)	`ctgagG/Acacaa`	4	--	int¹		1		NS	120
rs7223712^1,2	C	7597939(+)	`ccaagA/Gtggga`	4	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for WRAP53 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WRAP53: --

QIAGEN SeqTarget long-range PCR primers for resequencing WRAP53

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WRAP53 for disorders About GeneDecksing

OMIM: 612661

Human Gene Mutation Database (HGMD): WRAP53
Human Genome Epidemiology (HuGE) Navigator: WRAP53 (0 documents)

Export disorders and mutations for WRAP53 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/27 PubMed articles for WRAP53 gene, integrated from 7 sources (see all 27):
(articles sorted by number of sources associating them with WRAP53)

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)^{1, 2, 3} Venteicher A.S.... Artandi S.E. (2009)
Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. (PubMed id 19250907)^{1, 2, 3} Mahmoudi S....Farnebo M. (2009)
The p53 tumor suppressor: a master regulator of diver se cellular processes and therapeutic target in cancer. (PubMed id 20494116)^{1, 3} Farnebo M....Wiman K.G. (2010)
TCAB1: driving telomerase to Cajal bodies. (PubMed id 19342896)^{1, 3} Venteicher A.S. and Artandi S.E. (2009)
Wrap53, a novel regulator of p53. (PubMed id 19571673)^{1, 3} Farnebo M. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
The diversity profile of TP53 is influenced by positi ve selection on the immediately upstream locus WDR79. (PubMed id 19797907)¹ Alonso S....de la RA_a C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55135	HGNC: 25522	AceView: FLJ10385	Ensembl:ENSG00000141499	euGenes: HUgn55135
ECgene: WRAP53	H-InvDB: WRAP53

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for WRAP53 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for WRAP53 gene:
Search GeneIP for patents involving WRAP53

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WRAP53		Antibodies for WRAP53
	Super-pooled esiRNAs for WRAP53		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WRAP53		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of WRAP53
	SeqTarget long-range PCR primers for resequencing WRAP53
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WRAP53
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of WRAP53

	GenScript Custom Purified and Recombinant Proteins Services for WRAP53		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for WRAP53
	GenScript Custom Assay Services for WRAP53		GenScript Custom Superior Antibodies Services for WRAP53
	GenScript Custom overexpressing Cell Line Services for WRAP53		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

WRAP53 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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WRAP53 Gene

protein-coding GIFtS: 45

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WRAP53 Gene

protein-coding GIFtS: 45

Aliases & Descriptionsfor WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

Expression
for WRAP53 gene

Orthologs
for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene

Publications
for WRAP53 gene

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for WRAP53 gene

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for WRAP53 gene