Aliases &
Descriptions
for WSB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| WD repeat and SOCS box-containing 11 2 | | DKFZp564B04821 | | SWIP11 2 3 | | DKFZp564A1221 | | WSB-12 3 | | WD repeat and SOCS box-containing protein 12 | | SOCS box-containing WD protein SWiP-12 3 | | |
Export aliases for WSB1 gene to outside databasesPrevious GC identifers: GC17P025476 GC17P027520 GC17P025766 GC17P022645 GC17P025621 |
Summaries
for WSB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WSB1:
This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chickproteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternativelyspliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizestype II iodothyronine deiodinase/DIO2
Gene Wiki entry for WSB1 |
Genomic Views
for WSB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WSB1 gene promoter:
NF-1 SRF STAT5B STAT4 STAT3 STAT2 STAT1beta STAT1alpha STAT1 STAT6
Other transcription factors
Search SABiosciences Chromatin IP Primers for WSB1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WSB1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.1 Ensembl cytogenetic band: 17q11.1 HGNC cytogenetic band: 17q11.2WSB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P021829: view genomic region
(about GC identifiers)
Start:
|
21,828,401 bp from pter |
End:
|
21,847,944 bp from pter |
Size:
|
19,544 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 25,621,106-25,640,657 |
RefSeq DNA sequence:- NC_000017.10 NT_010799.15
|
Proteins
for WSB1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7 (See
protein sequence)Recommended Name: WD repeat and SOCS box-containing protein 1 Size: 421 amino acids; 47432 Da
Subunit: Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5,RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex whichcontains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2
Secondary accessions: Q9NRB1 Q9UBH9 Q9UG25 Q9UNN6Alternative splicing: 3 isoforms: Q9Y6I7-1 Q9Y6I7-2 Q9Y6I7-3 Explore the universe of human proteins at neXtProt for WSB1: NX_Q9Y6I7
REFSEQ proteins (2 alternative transcripts):
NP_056441.6 NP_599027.1
ENSEMBL proteins: ENSP00000262394 ENSP00000327055 ENSP00000416112 ENSP00000400197
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
WSB1 for ontologies About GeneDecksing
Antibodies for WSB1:
Assays for WSB1: |
Protein
Domains/
Families
for WSB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WSB1 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9Y6I7ProtoNet protein and cluster: Q9Y6I7 1 Blocks protein family: IPB001496 SOCS protein
UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin ligase complexes (By similarity)Similarity: Contains 1 SOCS box domainSimilarity: Contains 6 WD repeats |
Gene Function
for WSB1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizestype II iodothyronine deiodinase/DIO2
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
WSB1 for ontologies About GeneDecksing
|
Pathways & Interactions
for WSB1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for WSB1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WSB1
2 Interacting proteins for WSB1 (Q9Y6I71) via UniProtKB, MINT, and/or STRING About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0023034 | intracellular signaling pathway |
-- | -- |
About this table
WSB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for WSB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WSB1
|
Transcripts
for WSB1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for WSB1 gene (2 alternative transcripts): NM_015626.8 NM_134265.2 Additional cDNA sequence: AF069313.2 AF072880.1 AF106683.1 AF106684.1 AF112205.1 AF147442.1 AF240696.1 AK057082.1 AK074917.1 AK222576.1 AK294516.1 AK300262.1 AK307114.1 AL110243.1 BC005226.1 BC021110.1 24/36 DOTS entries (see all 36): DT.86999091 DT.95292242 DT.92337392 DT.120948116 DT.86835765 DT.99939174 DT.92452701 DT.100038369 DT.75147874 DT.100828087 DT.120948113 DT.120948026 DT.95170822 DT.120948121 DT.120948094 DT.70101335 DT.97768910 DT.92452698 DT.120948048 DT.120948096 DT.120948124 DT.120948000 DT.120948046 DT.120948097 24/687 AceView cDNA sequences (see all 687): BM728927 CB989643 AI567193 AA330250 AI217464 AI051496 BV180039 BI089428 BU740046 AI560167 AI376804 CD558985 AI027468 AI435971 NM_134265 AI745109 AI933011 AA347583 BM476888 AL702944 N42589 AA353527 AI565018 AA464828
 highest scoring ESTs for WSB1:AA004838 AA310066 AA317575 AA343008 AA357871 AA369708 AA376663 AA401856 AA532758 AA809069 Unigene Cluster for WSB1: WD repeat and SOCS box-containing 1 Hs.446017 [show with all ESTs]Unigene Representative Sequence: NM_015626
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WSB1 (see all 17)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | · |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
| ExUns: | 8e | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | - | | - | | - | | | | | | | | | | |
| SP2: | - | | - | | - | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | |
| SP4: | - | | - | | - | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for WSB1
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262394(uc002gzd.1 uc002gze.1) ENST00000467843(uc010vzz.1 uc010crf.1 uc002gzf.1)
ENST00000348811 ENST00000487603 ENST00000427287(uc010vzy.1) ENST00000452005
|
Expression
for WSB1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WSB1 expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching WSB1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40928_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
W26496 |
0.60 |
1.00 |
0.82 |
1 |
| 210561_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AL110243 |
0.80 |
1.00 |
0.91 |
1 |
| 201294_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
N24643 |
0.60 |
1.00 |
0.82 |
1 |
| 201296_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_015626 |
0.60 |
1.00 |
0.82 |
1 |
| 201295_s_at2, 3
|
U133-A |
1 |
0.36 |
1.00 |
-- |
-- |
BF111821 |
0.60 |
1.00 |
0.82 |
1 |
| 210561_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201294_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201296_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201295_s_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
WSB1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GATTTAAAAA
SOURCE GeneReport for Unigene cluster: Hs.446017
Expression variation in blood from EXPOLDB for WSB1 SABiosciences Custom PCR Arrays for WSB1
|
Orthologs
for WSB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WSB1 gene from 5/9 species (see all 9)
About this table Species with no ortholog for WSB1
ENSEMBL Gene Tree for WSB1 (if available) |
Paralogs
for WSB1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WSB1 gene
- WSB22 WDR882 WDR382 PRPF42 WDSUB12 APAF12 KATNB12
WSB1 for paralogs About GeneDecksing
|
Genomic Variants
for WSB1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WSB1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for WSB1
8 CNVs: 77565 88407 88406 77563 77564 88410 88408 88409 | | QIAGEN SeqTarget long-range PCR primers for resequencing WSB1 |
|
Disorders & Mutations
for WSB1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WSB1 for disorders About GeneDecksing
OMIM: 610091
Human Genome Epidemiology (HuGE) Navigator: WSB1 (2 documents)
Export disorders and mutations for WSB1 gene to outside databases
|
Medical News
for WSB1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WSB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/28 PubMed articles for WSB1 gene, integrated from 7 sources (see all 28):
(articles sorted by number of sources associating them with WSB1)- SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. (PubMed id 10354473)1, 2, 3 Vasiliauskas D.... Stern C.D. (1999)
- The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. (PubMed id 15965468)1, 2 Dentice M.... Bianco A.C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A whole genome association study of mother-to-child t ransmission of HIV in Malawi. (PubMed id 20487506)1 Joubert B.R....Meshnick S.R. (2010)
- The WSB1 gene is involved in pancreatic cancer progression. (PubMed id 18575577)1 Archange C....Iovanna J.L. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. (PubMed id 18093972)1 Choi D.W....Choi C.Y. (2008)
|
External Searches for WSB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WSB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WSB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WSB1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WSB1 gene:
Search GeneIP for patents involving WSB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WSB1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for WSB1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for WSB1 |
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