Aliases &
Descriptions
for WTIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| Wilms tumor 1 interacting protein1 2 | | WT1-interacting protein2 3 | | Wilms tumor protein 1-interacting protein2 |
Export aliases for WTIP gene to outside databasesPrevious GC identifers: GC19P039665 GC19P039663 GC19P034971 |
Summaries
for WTIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2Function: May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. Incase of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that repressesWT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered geneexpression and a less differentiated phenotype (By similarity)
|
Genomic Views
for WTIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WTIP gene promoter:
MEF-2A RSRFC4 FOXC1 ATF-2 c-Jun FOXJ2 (long isoform) Pax-2 POU2F1 ZID Nkx3-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WTIP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for WTIP  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11WTIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P031481: view genomic region
(about GC identifiers)
Start:
|
31,480,314 bp from pter |
End:
|
31,499,023 bp from pter |
Size:
|
18,710 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 34,971,874-34,992,085 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for WTIP gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2 (See
protein sequence)Recommended Name: Wilms tumor protein 1-interacting protein Size: 654 amino acids; 67454 Da
Subunit: Interacts with CD2AP and WT1 (By similarity)
Subcellular location: Cell junction, adherens junction (By similarity). Nucleus (By similarity). Note=Translocates fromcell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes (By similarity)Explore the universe of human proteins at neXtProt for WTIP: NX_A6NIX2
REFSEQ proteins: NP_001073905.1
ENSEMBL proteins: ENSP00000270288
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
WTIP for ontologies About GeneDecksing
Antibodies for WTIP:
Assays for WTIP: |
Protein
Domains/
Families
for WTIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WTIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NIX2ProtoNet protein and cluster: A6NIX2 UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2Similarity: Belongs to the zyxin/ajuba familySimilarity: Contains 3 LIM zinc-binding domains |
Gene Function
for WTIP gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2Function: May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. Incase of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that repressesWT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered geneexpression and a less differentiated phenotype (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
About this table
WTIP for ontologies About GeneDecksing
|
Pathways & Interactions
for WTIP gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for WTIP
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WTIP
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- |
About this table
WTIP for ontologies About GeneDecksing
|
Drugs & Compounds
for WTIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WTIP
|
Transcripts
for WTIP gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for WTIP gene: NM_001080436.1 Additional cDNA sequence: AK130059.1 BC030216.1 4 DOTS entries: DT.40290983 DT.212492 DT.99948993 DT.91876490 1 AceView cDNA sequence: BM711847
 highest scoring ESTs for WTIP:AI435456 AK130059 BC030216 CF541375 AA024536 AA025297 AA029233 AA293179 AA293180 AA410720 Unigene Cluster for WTIP: Wilms tumor 1 interacting protein Hs.585010 [show with all ESTs]Unigene Representative Sequence: NM_001080436
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000270288(uc002nvm.2)
|
Expression
for WTIP gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| WTIP expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching WTIP gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 56841_at2, 3
|
U95-B |
1 |
0.69 |
1.00 |
1.00 |
1.00 |
AI435456 |
0.80 |
1.00 |
0.91 |
1 |
| 227411_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
BF111298 |
0.60 |
1.00 |
0.82 |
1 |
| 227411_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
WTIP for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGTGTTCCTG
SOURCE GeneReport for Unigene cluster: Hs.585010
SABiosciences Custom PCR Arrays for WTIP
|
Orthologs
for WTIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WTIP gene from 4 species
About this table Species with no ortholog for WTIP
ENSEMBL Gene Tree for WTIP (if available) |
Paralogs
for WTIP gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WTIP gene
- TRIP62 FBLIM12 LPP2 LOC1002886952 LIMS3-LOC4408952 LIMS12 ZYX2 JUB2
- LIMS22 LIMD12
WTIP for paralogs About GeneDecksing
|
Genomic Variants
for WTIP gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for WTIP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for WTIP
5 CNVs: 50131 50130 73360 50129 50128
1 Indel: 40276 | | QIAGEN SeqTarget long-range PCR primers for resequencing WTIP |
|
Disorders & Mutations
for WTIP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for WTIP gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WTIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for WTIP gene integrated from 7 sources:
(articles sorted by number of sources associating them with WTIP)- A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PubMed id 14736876)1, 3, 7 Srichai M.B....Sedor J.R. (2004)
- LIM protein Ajuba functions as a nuclear receptor cor epressor and negatively regulates retinoic acid signaling. (PubMed id 20133701)1 Hou Z....Rauscher F.J. (2010)
- Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PubMed id 20086015)1 Kim J.H....Sedor J.R. (2010)
- The LIM domain protein Wtip interacts with the recept or tyrosine kinase Ror2 and inhibits canonical Wnt signalling. (PubMed id 19785987)1 van Wijk N.V....Stricker S. (2009)
- Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. (PubMed id 18331720)1 Langer E.M....Longmore G.D. (2008)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment. (PubMed id 15798086)7 Rico M....Sedor J.R. (2005)
|
External Searches for WTIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WTIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WTIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WTIP gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WTIP gene:
Search GeneIP for patents involving WTIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WTIP gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for WTIP |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for WTIP |
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