Aliases &
Descriptions
for XAGE1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| X antigen family, member 1B1 2 | | cancer/testis antigen family 12, member 1b2 | | Protein XAGE-12 3 | | XAGE1D2 | | Cancer/testis antigen 12.12 3 | | CT12.1B2 | | CT12.12 3 | | cancer/testis associated protein2 | | GAGED22 3 | | XAGE1C2 | | CT12.1b1 | | XAGE1E2 | | G antigen family D member 22 | | CTP92 | | OTTHUMP000000395672 | | XAGE13 | | XAGE1A2 | | |
Export aliases for XAGE1B gene to outside databasesPrevious GC identifers: GC0XU900702 GC0XM052272 GC0XP052530 GC0XM052561 |
Summaries
for XAGE1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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|
Entrez Gene summary for XAGE1B:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma,alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signaland shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequencesimilarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene,in addition to alternative transcription start sites, results in multiple transcript variants. (provided by RefSeq)
|
Genomic Views
for XAGE1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for XAGE1B
Other transcription factors
Search SABiosciences Chromatin IP Primers for XAGE1B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22XAGE1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP052239: view genomic region
(about GC identifiers)
Start:
|
52,235,228 bp from pter |
End:
|
52,243,954 bp from pter |
Size:
|
8,727 bases |
Orientation:
|
plus strand |
|
Proteins
for XAGE1B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64 (See
protein sequence)Recommended Name: G antigen family D member 2 Size: 160 amino acids; 17751 Da
Sequence caution: Sequence=AAG01401.1; Type=Erroneous initiation;
Secondary accessions: A6NJ94 Q5JPN8 Q5JPP0 Q5JPP3 Q8WWG5 Q8WWG6 Q969J6Alternative splicing: 3 isoforms: Q9HD64-3 Q9HD64-2 Q9HD64-4 Explore the universe of human proteins at neXtProt for XAGE1B: NX_Q9HD64
REFSEQ proteins (2 alternative transcripts):
NP_001091063.2 NP_001091065.1
ENSEMBL proteins: ENSP00000430130 ENSP00000364766 ENSP00000382704 ENSP00000388178 ENSP00000364763
Human Recombinant Proteins
Antibodies for XAGE1B:
Assays for XAGE1B: |
Protein
Domains/
Families
for XAGE1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HD64 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64Similarity: Belongs to the GAGE family |
Gene Function
for XAGE1B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for XAGE1B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for XAGE1B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE1B
|
Drugs & Compounds
for XAGE1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for XAGE1B
|
Transcripts
for XAGE1B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for XAGE1B gene (2 alternative transcripts): NM_001097594.2 NM_001097596.2
GeneLoc Exon Structure
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494039 ENST00000518075 ENST00000375616 ENST00000399805 ENST00000375612(uc004dqh.2)
ENST00000437949(uc004dqf.2 uc004dqg.2) ENST00000519579 ENST00000375613
|
Expression
for XAGE1B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| XAGE1B expression in normal and diseased human tissues
1 / 2 3 probe-sets matching XAGE1B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 56998_at2
|
U95-B |
5 |
0.75 |
0.20 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 220057_at2
|
U133-A |
5 |
0.64 |
0.20 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 220057_at2
|
U133Plus2 |
5 |
0.64 |
0.20 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
XAGE1B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers:highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma,small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing'ssarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample
SABiosciences Custom PCR Arrays for XAGE1B
|
Orthologs
for XAGE1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for XAGE1B (if available) |
Paralogs
for XAGE1B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for XAGE1B gene
- XAGE1C1 2 XAGE1E2 XAGE1D2 XAGE1A2
XAGE1B for paralogs About GeneDecksing
|
Genomic Variants
for XAGE1B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for XAGE1B
14 CNVs: 83524 73977 83525 83526 96688 73976 67978 96689 83523 83522 96685 96687 96684 96686
1 Inversion: 37381 |
Disorders & Mutations
for XAGE1B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
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|
XAGE1B for disorders About GeneDecksing
OMIM: 300743
Export disorders and mutations for XAGE1B gene to outside databases
|
Medical News
for XAGE1B gene(Possibly Related Articles in
Doctor's Guide)
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| -- |
Publications
for XAGE1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for XAGE1B gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with XAGE1B)- Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PubMed id 12479262)1, 2 Egland K.A.... Pastan I. (2002)
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)
- XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PubMed id 10987281)1, 2 Liu X.F.... Pastan I. (2000)
- Epigenetic modulation of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem cells: implications for cance r therapy. (PubMed id 19498007)1 Gjerstorff M....Ditzel H. (2009)
- Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens. (PubMed id 18752338)1 Kikuchi E....Nishimura M. (2008)
- Identification of prostate cancer antigens by automat ed high-throughput filter immunoscreening. (PubMed id 18045611)1 AlsA...Gaudernack G. (2008)
- Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PubMed id 17335148)1 Sato S....Nakayama E. (2007)
- HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells. (PubMed id 17704638)1 Morishita Y....Nakayama E. (2007)
- Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. (PubMed id 17332921)1 Shimono M....Nakayama E. (2007)
- Characterization of preexisting humoral immunity specific for two cancer-testis antigens overexpressed at the mRNA level in non-small cell lung cancer. (PubMed id 16468707)1 Watanabe Y....Henderson R. (2006)
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External Searches for XAGE1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing XAGE1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XAGE1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XAGE1B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for XAGE1B gene:
Search GeneIP for patents involving XAGE1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XAGE1B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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