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XPO1 Gene

protein-coding   GIFtS: 60

GC02M061445
exportin 1 (CRM1 homolog, yeast)
(Previous names: exportin 1 (CRM1, yeast, homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
exportin 1 (CRM1 homolog, yeast)1 2     DKFZp686B18232
CRM11 2 3 5     OTTHUMP000002014942
exportin 1 (CRM1, yeast, homolog)1 2     exportin-12
emb1 2     OTTHUMP000002014962
Chromosome region maintenance 1 protein homolog2 3     exp12
Exportin-1 (required for chromosome region maintenance)2     Exp13
CRM1, yeast, homolog2     

External Ids:    HGNC: 128251   Entrez Gene: 75142   Ensembl: ENSG000000828987   UniProtKB: O149803   

Export aliases for XPO1 gene to outside databases

Previous GC identifers: GC02M061833 GC02M061662 GC02M061679 GC02M061616 GC02M061704


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPO1:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport.
Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several
cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates
NFAT and AP-1. (provided by RefSeq)

UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES)
and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to
the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is
mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling
of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the
cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric
distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport
from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1,
HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts
with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization

Gene Wiki entry for XPO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPO1 gene promoter:
         p53   C/EBPbeta   NF-kappaB1   NF-kappaB   STAT1   c-Myc   Max   AhR   Arnt   Max1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for XPO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for XPO1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

XPO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO1 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061445:  view genomic region     (about GC identifiers)

Start:
61,445,666 bp from pter
End:
61,506,245 bp from pter
Size:
60,580 bases
Orientation:
minus strand

1 alternative location:
Chr2- 61,704,984-61,765,761     
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980 (See protein sequence)
Recommended Name: Exportin-1  
Size: 1071 amino acids; 123386 Da
Subunit: Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity).
Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export
complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal
subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also
found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts
presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the
nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm
Miscellaneous: Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor
PDB structure from and Proteopedia :
1W9C (3D)    3GB8 (3D)    
Secondary accessions: A6NL14 A8K1K5 Q63HP8 Q68CP3 Q99433

Explore the universe of human proteins at neXtProt for XPO1: NX_O14980 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003391.1  

    ENSEMBL proteins: 
    ENSP00000384863 ENSP00000413853 ENSP00000406819 ENSP00000388927 ENSP00000407170 ENSP00000393484 
    ENSP00000385559 ENSP00000408190 ENSP00000390843 ENSP00000399583 ENSP00000394951 ENSP00000385942 
    ENSP00000406428 ENSP00000412478 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: XPO1
    GenScript Custom Purified and Recombinant Proteins Services for XPO1 
    Novus Biologicals Protein for XPO1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776 kinetochore IDA17363900
    GO:0005634 nucleus IEA--
    GO:0005635 nuclear envelope TAS9368044
    GO:0005642 annulate lamellae IDA12210765
    GO:0005654 nucleoplasm TAS--
    About this table

    XPO1 for ontologies           About GeneDecksing



    Antibodies for XPO1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XPO1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for XPO1 
    Novus Biologicals Antibodies for XPO1
    Browse antibodies at Epitomics

    Assays for XPO1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for XPO1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for XPO1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    XPO1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR014877 Exportin-1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O14980

    ProtoNet protein and cluster: O14980

    2 Blocks protein families:
    IPB001494 Importin-beta
    IPB013598 Exportin 1-like


    UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
    Similarity: Belongs to the exportin family
    Similarity: Contains 10 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
    Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES)
    and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to
    the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is
    mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling
    of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the
    cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric
    distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport
    from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1,
    HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts
    with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for XPO1
    Sigma-Aldrich shRNA for XPO1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): XPO1
    OriGene shRNA RFP (see all 2): XPO1
    OriGene basic RS shRNA (see all 2): XPO1
    OriGene siRNA: XPO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of XPO1 
    miRNA:Sigma-Aldrich microRNA Mimics for XPO1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of XPO1 
    8/17 SABiosciences Assays for microRNAs that regulate XPO1 (see all 17):
    hsa-miR-142-3p hsa-miR-30c hsa-miR-320a hsa-miR-513a-5p hsa-miR-30d hsa-miR-320c hsa-miR-30a hsa-miR-532-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: XPO1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: XPO1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): XPO1
    OriGene 3'-UTR clone: XPO1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: XPO1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for XPO1 

    Genatlas biochemistry entry for XPO1:
    exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore
    complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe
    involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0005488 binding ----
    GO:0005515 protein binding IPI11545741
    GO:0008565 protein transporter activity IEA--
    About this table

    XPO1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    XPO1 for pathways           About GeneDecksing

    2 Millipore Pathways for XPO1
        Cell cycle ESR1 regulation of G1/S transition
    Immune response MIF-JAB1 signaling

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  XPO1
        LPS/IL-1 Mediated Inhibition of RXR Function
    Mechanisms of Viral Exit from Host Cells
    Role of NFAT in Regulation of the Immune Response
    RAN Signaling

    1 Kegg Pathway  (Kegg details for XPO1):
        hsa03013 RNA transport

        SABiosciences Pathway-Focused PCR Array including XPO1: PAHS-051A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for XPO1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XPO1

    5/17 Interacting proteins for XPO1 (O149801, 2) via UniProtKB, MINT, and/or STRING (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352321EBI-355867,EBI-354213
    RCC1P187541EBI-355867,EBI-992720
    BIRC5O153922MINT-4055407 MINT-4509587
    HNRNPA1P096512MINT-7234858 MINT-7234902
    NCBP1Q091612MINT-7234858 MINT-7234902
    About this table

    5/15 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 15):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087 M phase of mitotic cell cycle TAS--
    GO:0000236 mitotic prometaphase TAS--
    GO:0000278 mitotic cell cycle TAS--
    GO:0006611 protein export from nucleus ----
    GO:0006886 intracellular protein transport IEA--
    About this table

    XPO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    XPO1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Enzo Life Sciences drugs & compounds for XPO1

    Browse Tocris compounds for XPO1
    10/12 Novoseek chemical compound relationships for XPO1 gene (see all 12)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 96.9 81 9683540 (9), 12519765 (2), 11704659 (2), 10639332 (2) (see all 46)
    leptomycin 91.3 2 9323133 (1), 11733048 (1)
    tetramethylammonium hydroxide 50.8 5 12724356 (4), 17347149 (1)
    gtp 43.4 5 10330396 (1), 9765402 (1), 14688242 (1), 19339972 (1) (see all 5)
    threonine 24.9 1 11162834 (1)
    serine 23.3 2 11162834 (1), 11060306 (1)
    leucine 21.2 8 10339570 (2), 11704659 (2), 18316374 (1), 9837918 (1)
    alanine 17.9 4 11704659 (1), 16513647 (1), 15128734 (1)
    calcitriol 14.9 3 16707848 (2), 16847355 (1)
    glucose 0 3 15128734 (2)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for XPO1
    Sigma-Aldrich shRNA for XPO1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): XPO1
    OriGene shRNA RFP (see all 2): XPO1
    OriGene basic RS shRNA (see all 2): XPO1
    OriGene siRNA: XPO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of XPO1 
    miRNA: Sigma-Aldrich microRNA Mimics for XPO1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of XPO1 
    8/17 SABiosciences Assays for microRNAs that regulate XPO1 (see all 17):
    hsa-miR-142-3p hsa-miR-30c hsa-miR-320a hsa-miR-513a-5p hsa-miR-30d hsa-miR-320c hsa-miR-30a hsa-miR-532-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: XPO1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: XPO1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): XPO1
    OriGene 3'-UTR Clone: XPO1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: XPO1 
    Primers: OriGene genome-wide validated SYBR primer pairs: XPO1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for XPO1: PPH06883A

    REFSEQ mRNAs for XPO1 gene: 

    NM_003400.3  

    Additional cDNA sequence: 

    AK094339.1 AK098297.1 AK124769.1 AK289920.1 AK299039.1 AK312426.1 AK316481.1 AL833550.1 
    BC032847.2 BX647758.1 CR609163.1 CR749840.1 D89729.1 Y08614.2 

    24/33 DOTS entries (see all 33):

    DT.451914  DT.101970151  DT.65286138  DT.100805049  DT.100029629  DT.304652  DT.70103690  DT.121012048 
    DT.121011983  DT.100670922  DT.100701374  DT.100844887  DT.418354  DT.91687310  DT.121012023  DT.121012055 
    DT.86851469  DT.91713166  DT.92473443  DT.95277044  DT.91673128  DT.92040061  DT.97791962  DT.100670913 

    24/534 AceView cDNA sequences (see all 534):

    AU143284 AW500740 AI633038 AL710257 BM456804 BE888208 AI795929 BM905123 
    BP348555 AI420942 BP350720 AU130160 AU130770 BM980272 CB140651 BX493637 
    AU118302 BG697239 AK094339 BM788658 AI805585 CA430937 CA441097 BM549274 

    highest scoring ESTs for XPO1:

    Y08614 AA282076 AI660118 AI761130 AI865913 AL710174 AL710185 AL710257 AL833550 BC032847 

    Unigene Cluster for XPO1:

    Exportin 1 (CRM1 homolog, yeast)
    Hs.370770  [show with all ESTs]
    Unigene Representative Sequence: AL833550


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 (see all 11)

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
    SP1:              -     -                       -     -                                                                       -           -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                    -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
    SP1:                                            -     -                                 
    SP2:                                            -     -                                 
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:              -                                                                     

    About this scheme

    ECgene alternative splicing isoforms for XPO1
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000401558(uc002sbg.2 uc010fcl.2 uc010ypn.1 uc002sbj.2)
    ENST00000481073(uc002sbh.2) ENST00000461407 ENST00000451765 ENST00000460037
    ENST00000449444 ENST00000468259 ENST00000494468 ENST00000476585 ENST00000437159
    ENST00000428210(uc002sbk.2) ENST00000420673 ENST00000475744 ENST00000406957
    ENST00000422552 ENST00000436018 ENST00000495003 ENST00000455184

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    XPO1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching XPO1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37729_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Y08614 1.00 1.00 1.00 1
    208775_at2, 3 U133-A 1 1.00 1.00 -- -- D89729 0.60 1.00 0.82 1
    208775_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    XPO1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    XPO1 gene expression
    XPO1 gene electronic northern expression
    XPO1 gene sage expression
    About these images

    CGAP SAGE TAG: TGCATATCAT

    SOURCE GeneReport for Unigene cluster: Hs.370770

    Expression variation in blood from EXPOLDB for XPO1

    UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus,
    prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: XPO1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for XPO1: PPH06883A
        SABiosciences Expression via Pathway-Focused PCR Array including XPO1: PAHS-051A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for XPO1 gene from 5/24 species (see all 24)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XPO11   -- exportin 1 (CRM1 homolog, yeast) 94.37(n)
    98.88(a)
    474609  XM_531839.2  XP_531839.2 
    chimpanzee
    (Pan troglodytes)
    XPO11   -- exportin 1 (CRM1 homolog, yeast) 99.75(n)
    99.91(a)
    459534  XM_001160843.1  XP_001160843.1 
    cow
    (Bos taurus)
    XPO11   -- exportin 1 (CRM1 homolog, yeast) 93.65(n)
    98.88(a)
    510568  XM_587722.3  XP_587722.3 
    rat
    (Rattus norvegicus)
    Xpo11   -- exportin 1, CRM1 homolog (yeast) 89.57(n)
    97.85(a)
    85252  NM_053490.1  NP_445942.1 
    mouse
    (Mus musculus)
    Xpo11 , 5 11 (14.28 cM)5
    exportin 1, CRM1 homolog (yeast)1, 5 91.53(n)1
    98.04(a)1
    1035731  NM_134014.31  NP_598775.21 
     AA4204175  AA5491615  (see all 27)
    About this table        Species with no ortholog for XPO1

    ENSEMBL Gene Tree for XPO1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/557 NCBI SNPs in XPO1 are shown (see all 557)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs140131,2
    C61705287(-) TTTCCT/CCAATG 1 -- ut311Minor allele frequency- C:0.00MN 184
    rs7664471,2
    C,F,O,A,61735569(-) TGTTAA/GACACA 1 -- int116Minor allele frequency- G:0.43NA EA MN NS WA 1232
    rs7664481,2
    C,F,O,61735446(-) CTACGG/AGTGTG 1 -- int118Minor allele frequency- A:0.49NA EA NS WA 1084
    rs9957101,2
    --61764646(+) gcccgC/Gcccgc 1 -- int10--------
    rs10505671,2
    C,F,61705663(-) AATTCG/AATTTG 1 -- ut3113Minor allele frequency- A:0.13MN NS EA NA 1192
    rs10506081,2
    --61705105(-) AGAACA/CCTACT 1 -- ut31 ese30--------
    rs14465321,2
    C,F,O,H,61761169(+) TTACAA/GAAAAC 1 -- int114Minor allele frequency- G:0.02MN NA NS EA WA 848
    rs15623071,2
    --61766697(+) GTGCCA/CCCAAG 1 -- ng51 tfbs30--------
    rs18025451,2
    --61713034(-) ATGTCC/TCAGCT 2 P S ref1 mis10--------
    rs18025461,2
    --61705487(-) AGTTAG/TCACCT 1 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for XPO1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for XPO1
         2 CNVs: 97869 0019
         2 Indels: 33336 33684

    QIAGEN SeqTarget long-range PCR primers for resequencing XPO1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    XPO1 for disorders           About GeneDecksing

    OMIM: 602559

    9 Novoseek disease relationships for XPO1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.1 16 9658105 (2), 9765402 (2), 14612415 (2), 16504563 (2) (see all 7)
    immunodeficiency 46.2 5 9765402 (2), 19776134 (1), 10875611 (1), 10400785 (1)
    familial adenomatous polyposis 18.5 5 18262809 (2), 16378739 (1), 16314428 (1)
    myeloid leukemia 11.9 1 9702053 (1)
    shock 0 2 11565755 (1)
    tumors 0 7 18306389 (4), 19082467 (1), 19574837 (1)
    influenza 0 1 11118210 (1)
    hepatitis b 0 2 12861014 (1), 10875611 (1)
    cancer 0 14 19117056 (3), 20003838 (1), 18306389 (1)
    About this table


    Export disorders and mutations for XPO1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/270 PubMed articles for XPO1 gene, integrated from 7 sources (see all 270):
    (articles sorted by number of sources associating them with XPO1)
    1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PubMed id 9368044)1, 2, 3, 7 Kudo N....Horinouchi S. (1997)
    2. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PubMed id 12724356)1, 2, 7 Thomas F. and Kutay U. (2003)
    3. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PubMed id 11571268)1, 2, 7 Englmeier L....Kutay U. (2001)
    4. CRM1 is an export receptor for leucine-rich nuclear export signals. (PubMed id 9323133)1, 2, 7 Fornerod M.... Mattaj I.W. (1997)
    5. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PubMed id 14612415)1, 2, 7 Hakata Y.... Shida H. (2003)
    6. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PubMed id 15632073)1, 2, 7 Daelemans D.... Pavlakis G.N. (2005)
    7. Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PubMed id 11932251)1, 2, 7 Nemergut M.E.... Macara I.G. (2002)
    8. Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. (PubMed id 11119609)1, 2, 7 Elton D.... Digard P. (2001)
    9. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 2, 7 Paraskeva E.... Goerlich D. (1999)
    10. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PubMed id 9837918)1, 2, 7 Askjaer P.... Kjems J. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7514 HGNC: 12825 AceView: XPO1 Ensembl:ENSG00000082898 euGenes: HUgn7514
    ECgene: XPO1 Kegg: 7514 H-InvDB: XPO1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for XPO1 gene:
    Search GeneIP for patents involving XPO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in XPO1 promoter
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     ELISAs and CLIAs for XPO1
           

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