Aliases &
Descriptions
for XPO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| exportin 1 (CRM1 homolog, yeast)1 2 | | DKFZp686B18232 | | CRM11 2 3 5 | | OTTHUMP000002014942 | | exportin 1 (CRM1, yeast, homolog)1 2 | | exportin-12 | | emb1 2 | | OTTHUMP000002014962 | | Chromosome region maintenance 1 protein homolog2 3 | | exp12 | | Exportin-1 (required for chromosome region maintenance)2 | | Exp13 | | CRM1, yeast, homolog2 | | |
Export aliases for XPO1 gene to outside databasesPrevious GC identifers: GC02M061833 GC02M061662 GC02M061679 GC02M061616 GC02M061704 |
Summaries
for XPO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XPO1:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport.Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of severalcellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulatesNFAT and AP-1. (provided by RefSeq)
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES)and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and tothe GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) ismediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassemblingof the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of thecargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetricdistribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1,HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interactswith, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization
Gene Wiki entry for XPO1 |
Genomic Views
for XPO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XPO1 gene promoter:
p53 C/EBPbeta NF-kappaB1 NF-kappaB STAT1 c-Myc Max AhR Arnt Max1
Other transcription factors
Search SABiosciences Chromatin IP Primers for XPO1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for XPO1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p16 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p15XPO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M061445: view genomic region
(about GC identifiers)
Start:
|
61,445,666 bp from pter |
End:
|
61,506,245 bp from pter |
Size:
|
60,580 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 61,704,984-61,765,761 |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for XPO1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980 (See
protein sequence)Recommended Name: Exportin-1 Size: 1071 amino acids; 123386 Da
Subunit: Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity).Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric exportcomplex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomalsubunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Alsofound in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interactspresumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in thenucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm
Miscellaneous: Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor
PDB structure from  and Proteopedia  :1W9C (3D)
3GB8 (3D)
Secondary accessions: A6NL14 A8K1K5 Q63HP8 Q68CP3 Q99433Explore the universe of human proteins at neXtProt for XPO1: NX_O14980
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003391.1
ENSEMBL proteins: ENSP00000384863 ENSP00000413853 ENSP00000406819 ENSP00000388927 ENSP00000407170 ENSP00000393484 ENSP00000385559 ENSP00000408190 ENSP00000390843 ENSP00000399583 ENSP00000394951 ENSP00000385942 ENSP00000406428 ENSP00000412478
Human Recombinant Proteins
5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10): About this table
XPO1 for ontologies About GeneDecksing
Antibodies for XPO1:
Assays for XPO1: |
Protein
Domains/
Families
for XPO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XPO1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14980ProtoNet protein and cluster: O14980 2 Blocks protein families: IPB001494 Importin-beta IPB013598 Exportin 1-like
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Similarity: Belongs to the exportin familySimilarity: Contains 10 HEAT repeatsSimilarity: Contains 1 importin N-terminal domain |
Gene Function
for XPO1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES)and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and tothe GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) ismediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassemblingof the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of thecargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetricdistribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1,HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interactswith, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization
Genatlas biochemistry entry for XPO1:exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear porecomplex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybeinvolved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
XPO1 for ontologies About GeneDecksing
|
Pathways & Interactions
for XPO1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
XPO1 for pathways About GeneDecksing
2  Millipore Pathways for XPO1
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for XPO1
1  Kegg Pathway (Kegg details for XPO1):
SABiosciences Pathway-Focused PCR Array including XPO1: PAHS-051A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for XPO1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XPO1
5/17 Interacting proteins for XPO1 (O149801, 2) via UniProtKB, MINT, and/or STRING (see all 17)About this table
5/15 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 15): About this table
XPO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for XPO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
XPO1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for XPO1 |
 Browse Tocris compounds for XPO1
10/12  Novoseek chemical compound relationships for XPO1 gene (see all 12)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leptomycin b |
96.9 |
81 |
9683540 (9), 12519765 (2), 11704659 (2), 10639332 (2) (see all 46) |
| leptomycin |
91.3 |
2 |
9323133 (1), 11733048 (1) |
| tetramethylammonium hydroxide |
50.8 |
5 |
12724356 (4), 17347149 (1) |
| gtp |
43.4 |
5 |
10330396 (1), 9765402 (1), 14688242 (1), 19339972 (1) (see all 5) |
| threonine |
24.9 |
1 |
11162834 (1) |
| serine |
23.3 |
2 |
11162834 (1), 11060306 (1) |
| leucine |
21.2 |
8 |
10339570 (2), 11704659 (2), 18316374 (1), 9837918 (1) |
| alanine |
17.9 |
4 |
11704659 (1), 16513647 (1), 15128734 (1) |
| calcitriol |
14.9 |
3 |
16707848 (2), 16847355 (1) |
| glucose |
0 |
3 |
15128734 (2) |
About this table
|
Transcripts
for XPO1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for XPO1 gene: NM_003400.3 Additional cDNA sequence: AK094339.1 AK098297.1 AK124769.1 AK289920.1 AK299039.1 AK312426.1 AK316481.1 AL833550.1 BC032847.2 BX647758.1 CR609163.1 CR749840.1 D89729.1 Y08614.2 24/33 DOTS entries (see all 33): DT.451914 DT.101970151 DT.65286138 DT.100805049 DT.100029629 DT.304652 DT.70103690 DT.121012048 DT.121011983 DT.100670922 DT.100701374 DT.100844887 DT.418354 DT.91687310 DT.121012023 DT.121012055 DT.86851469 DT.91713166 DT.92473443 DT.95277044 DT.91673128 DT.92040061 DT.97791962 DT.100670913 24/534 AceView cDNA sequences (see all 534): AU143284 AW500740 AI633038 AL710257 BM456804 BE888208 AI795929 BM905123 BP348555 AI420942 BP350720 AU130160 AU130770 BM980272 CB140651 BX493637 AU118302 BG697239 AK094339 BM788658 AI805585 CA430937 CA441097 BM549274
 highest scoring ESTs for XPO1:Y08614 AA282076 AI660118 AI761130 AI865913 AL710174 AL710185 AL710257 AL833550 BC032847 Unigene Cluster for XPO1: Exportin 1 (CRM1 homolog, yeast) Hs.370770 [show with all ESTs]Unigene Representative Sequence: AL833550
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 (see all 11)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for XPO1
18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000401558(uc002sbg.2 uc010fcl.2 uc010ypn.1 uc002sbj.2)
ENST00000481073(uc002sbh.2) ENST00000461407 ENST00000451765 ENST00000460037
ENST00000449444 ENST00000468259 ENST00000494468 ENST00000476585 ENST00000437159
ENST00000428210(uc002sbk.2) ENST00000420673 ENST00000475744 ENST00000406957
ENST00000422552 ENST00000436018 ENST00000495003 ENST00000455184
|
Expression
for XPO1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| XPO1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching XPO1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37729_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
Y08614 |
1.00 |
1.00 |
1.00 |
1 |
| 208775_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
D89729 |
0.60 |
1.00 |
0.82 |
1 |
| 208775_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
XPO1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCATATCAT
SOURCE GeneReport for Unigene cluster: Hs.370770
Expression variation in blood from EXPOLDB for XPO1 UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus,prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney
SABiosciences Expression via Pathway-Focused PCR Array including XPO1: PAHS-051A
|
Orthologs
for XPO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPO1 gene from 5/24 species (see all 24)
About this table Species with no ortholog for XPO1
ENSEMBL Gene Tree for XPO1 (if available) |
Paralogs
for XPO1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for XPO1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for XPO1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for XPO1
2 CNVs: 97869 0019
2 Indels: 33336 33684 | | QIAGEN SeqTarget long-range PCR primers for resequencing XPO1 |
|
Disorders & Mutations
for XPO1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XPO1 for disorders About GeneDecksing
OMIM: 602559
9 Novoseek disease relationships for XPO1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia t-cell |
55.1 |
16 |
9658105 (2), 9765402 (2), 14612415 (2), 16504563 (2) (see all 7) |
| immunodeficiency |
46.2 |
5 |
9765402 (2), 19776134 (1), 10875611 (1), 10400785 (1) |
| familial adenomatous polyposis |
18.5 |
5 |
18262809 (2), 16378739 (1), 16314428 (1) |
| myeloid leukemia |
11.9 |
1 |
9702053 (1) |
| shock |
0 |
2 |
11565755 (1) |
| tumors |
0 |
7 |
18306389 (4), 19082467 (1), 19574837 (1) |
| influenza |
0 |
1 |
11118210 (1) |
| hepatitis b |
0 |
2 |
12861014 (1), 10875611 (1) |
| cancer |
0 |
14 |
19117056 (3), 20003838 (1), 18306389 (1) |
About this table
Export disorders and mutations for XPO1 gene to outside databases
|
Medical News
for XPO1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for XPO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/270 PubMed articles for XPO1 gene, integrated from 7 sources (see all 270):
(articles sorted by number of sources associating them with XPO1)- Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PubMed id 9368044)1, 2, 3, 7 Kudo N....Horinouchi S. (1997)
- Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PubMed id 12724356)1, 2, 7 Thomas F. and Kutay U. (2003)
- RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PubMed id 11571268)1, 2, 7 Englmeier L....Kutay U. (2001)
- CRM1 is an export receptor for leucine-rich nuclear export signals. (PubMed id 9323133)1, 2, 7 Fornerod M.... Mattaj I.W. (1997)
- A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PubMed id 14612415)1, 2, 7 Hakata Y.... Shida H. (2003)
- Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PubMed id 15632073)1, 2, 7 Daelemans D.... Pavlakis G.N. (2005)
- Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PubMed id 11932251)1, 2, 7 Nemergut M.E.... Macara I.G. (2002)
- Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. (PubMed id 11119609)1, 2, 7 Elton D.... Digard P. (2001)
- CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 2, 7 Paraskeva E.... Goerlich D. (1999)
- The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PubMed id 9837918)1, 2, 7 Askjaer P.... Kjems J. (1998)
|
External Searches for XPO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XPO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XPO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XPO1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for XPO1 gene:
Search GeneIP for patents involving XPO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XPO1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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| |  | Search Tocris compounds for XPO1 |
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 | | | ELISAs and CLIAs for XPO1 |
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