Aliases &
Descriptions
for YAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| Yes-associated protein 11 2 | | YAP22 | | YAP651 2 3 | | yes-associated protein beta2 | | Yes-associated protein 1, 65kDa1 2 | | yorkie homolog2 | | 65 kDa Yes-associated protein2 3 | | yes-associated protein 22 | | YAP2 | | YKI2 | | yes-associated protein delta2 | | |
Export aliases for YAP1 gene to outside databasesPrevious GC identifers: GC11P104175 GC11P103338 GC11P102015 GC11P101519 GC11P101486 |
Summaries
for YAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YAP1:
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogeneproduct. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules inyeast, nematode, and mammals, and may be involved in protein-protein interaction. (provided by RefSeq)
UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the criticaldownstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 incomplex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death,and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cellgrowth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3)
Gene Wiki entry for YAP1 |
Genomic Views
for YAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YAP1 gene promoter:
AP-1 TFIID TBP Chx10 c-Jun c-Fos HSF1 (long) MZF-1 IRF-1 Bach1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YAP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q13YAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P097907: view genomic region
(about GC identifiers)
Start:
|
97,907,865 bp from pter |
End:
|
98,030,476 bp from pter |
Size:
|
122,612 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 101,981,210-102,104,154 |
RefSeq DNA sequence:- NC_000011.9 NT_033899.8
|
Proteins
for YAP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 (See
protein sequence)Recommended Name: Yorkie homolog Size: 504 amino acids; 54462 Da
Subunit: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, toneural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB.Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform 3 interact (viaWW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4
Subcellular location: Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellularlocalization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At lowdensity, predominantly nuclear and is translocated to the cytoplasm at high density
PDB structures from  and Proteopedia  :1JMQ (3D)
1K5R (3D)
1K9Q (3D)
1K9R (3D)
3KYS (3D)
Secondary accessions: Q7Z574 Q8IUY9Alternative splicing: 3 isoforms: P46937-1 P46937-2 P46937-3 (Additional isoforms lacking the transactivation domain exist)Explore the universe of human proteins at neXtProt for YAP1: NX_P46937
Post-translational modifications:
Phosphorylated by LATS1 and LATS2. Phosphorylation inhibits its nuclear localization and activity and enhancesinteraction with YWHAB1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001123617.1 NP_001181973.1 NP_001181974.1 NP_006097.2
ENSEMBL proteins: ENSP00000331023 ENSP00000282441
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
YAP1 for ontologies About GeneDecksing
Antibodies for YAP1:
Assays for YAP1: |
Protein
Domains/
Families
for YAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YAP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P46937ProtoNet protein and cluster: P46937 1 Blocks protein family: IPB002349 WW domain signature
UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937Similarity: Belongs to the YORKIE familySimilarity: Contains 2 WW domains |
Gene Function
for YAP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the criticaldownstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 incomplex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death,and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cellgrowth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3)
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
YAP1 for ontologies About GeneDecksing
Animal Models: 13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Yap1):
YAP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for YAP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
YAP1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for YAP1
1 
Cell Signaling Technology (CST) Pathway for YAP1
SABiosciences Custom Pathway-Focused PCR Arrays for YAP1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for YAP1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YAP1
5/17 Interacting proteins for YAP1 (P469371, 2 ENSP000002824413) via UniProtKB, MINT, and/or STRING (see all 17)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
YAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for YAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
YAP1 for compounds About GeneDecksing
 Browse Tocris compounds for YAP1
3  Novoseek chemical compound relationships for YAP1 gene
About this table
|
Transcripts
for YAP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for YAP1 gene (4 alternative transcripts): NM_001130145.2 NM_001195044.1 NM_001195045.1 NM_006106.4 Additional cDNA sequence: AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 BC026212.2 BC038235.1 CR618214.1 15 DOTS entries: DT.100824242 DT.446373 DT.91673001 DT.91745842 DT.100043384 DT.101979534 DT.120701800 DT.100824244 DT.307255 DT.120701753 DT.120701732 DT.212517 DT.92436111 DT.100710900 DT.120701734 24/292 AceView cDNA sequences (see all 292): AW612907 AA973159 CA426862 AI831200 AI598122 AI128142 BE504889 AW081855 AA781002 AL036707 AI474170 AA460703 AA181566 BI223791 AI184829 BU073244 AA992459 AA430596 BI261054 BU682055 AA948114 AI561312 AI346143 AI911652
 highest scoring ESTs for YAP1:AL048399 AA029669 AA091179 AA181566 AA182461 AA186831 AA313079 AA345313 AA346756 AA430595 Unigene Cluster for YAP1: Yes-associated protein 1 Hs.503692 [show with all ESTs]Unigene Representative Sequence: NM_001130145
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for YAP1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000345877(uc001pgs.2 uc001pgv.2) ENST00000282441(uc001pgt.2 uc001pgu.2 uc010ruo.1 uc001pgw.2 uc010rup.1)
|
Expression
for YAP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| YAP1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching YAP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37979_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.97 |
0.61 |
X80507 |
0.20 |
1.00 |
0.72 |
1 |
| 46314_at2, 3
|
U95-B |
1 |
0.75 |
1.00 |
0.95 |
1.40 |
AL048399 |
1.00 |
1.00 |
1.00 |
1 |
| 213342_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AI745185 |
0.80 |
1.00 |
0.91 |
1 |
| 224895_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
AA557632 |
0.80 |
1.00 |
0.91 |
1 |
| 224894_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
BF247906 |
0.80 |
1.00 |
0.91 |
1 |
| 213342_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 224895_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 224894_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
YAP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTCATATGTT
SOURCE GeneReport for Unigene cluster: Hs.503692
Expression variation in blood from EXPOLDB for YAP1 UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937Tissue specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivationdomain found in striatal neurons of patients with Huntington disease (at protein level)
SABiosciences Custom PCR Arrays for YAP1
|
Orthologs
for YAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YAP1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for YAP1
ENSEMBL Gene Tree for YAP1 (if available) |
Paralogs
for YAP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for YAP1 gene
- WWTR12
YAP1 for paralogs About GeneDecksing
|
Genomic Variants
for YAP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for YAP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for YAP1
1 CNV: 101319 | | QIAGEN SeqTarget long-range PCR primers for resequencing YAP1 |
|
Disorders & Mutations
for YAP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YAP1 for disorders About GeneDecksing
OMIM: 606608
2 Novoseek disease relationships for YAP1 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: YAP1 (1 document)
Export disorders and mutations for YAP1 gene to outside databases
|
Medical News
for YAP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for YAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/99 PubMed articles for YAP1 gene, integrated from 7 sources (see all 99):
(articles sorted by number of sources associating them with YAP1)- Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PubMed id 7782338)1, 2, 3, 7 Sudol M.... Lehman D. (1995)
- WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PubMed id 12807903)1, 2, 7 Komuro A.... Sudol M. (2003)
- Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2, 7 Zhao B.... Guan K.L. (2007)
- Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y....Yang X. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. (PubMed id 11743730)1, 2 Pires J.R.... Oschkinat H. (2001)
- Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (1997)
- Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. (PubMed id 16596258)1, 7 Guo J....Friess H. (2006)
|
External Searches for YAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YAP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for YAP1 gene:
Search GeneIP for patents involving YAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YAP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for YAP1 (YAP) |
| | | | Search Tocris compounds for YAP1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for YAP1 |
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