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YBEY Gene

protein-coding GIFtS: 34

GC21P047707

ybeY metallopeptidase (putative)
(Previous name: chromosome 21 open reading frame 57 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C21orf57)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
ybeY metallopeptidase (putative)¹ ²		FLJ46907²
chromosome 21 open reading frame 57¹		putative metalloprotease C21orf57²
OTTHUMP00000115779²		EC 3.4.24.-³
C21orf57²

External Ids:	HGNC: 1299¹	Entrez Gene: 54059²	Ensembl: ENSG00000182362⁷	UniProtKB: P58557³

Export aliases for YBEY gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CU057_HUMAN, P58557

Function: May have metalloprotease activity (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for YBEY
Other transcription factors

Search SABiosciences Chromatin IP Primers for YBEY

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for YBEY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3

YBEY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YBEY gene location

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21P047707: view genomic region (about GC identifiers)

Start:	47,706,251 bp from pter
End:	47,717,665 bp from pter
Size:	11,415 bases
Orientation:	plus strand

1 alternative location:

Chr21+ 33,089,429-33,101,028

RefSeq DNA sequence:

NC_000021.8 NT_011515.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: CU057_HUMAN, P58557 (See protein sequence)

Recommended Name: Putative metalloprotease C21orf57

Size: 167 amino acids; 19298 Da

Cofactor: Binds 1 zinc ion (By similarity)

Sequence caution: Sequence=AAK74138.1; Type=Erroneous initiation; Sequence=AAK74139.1; Type=Erroneous initiation;

Sequence=AAK74140.1; Type=Erroneous initiation; Sequence=AAK74141.1; Type=Erroneous initiation;

Secondary accessions: B7WPA9 B7WPF7

Alternative splicing: 4 isoforms: P58557-1 P58557-2 P58557-3 P58557-4

Explore the universe of human proteins at neXtProt for YBEY: NX_P58557

REFSEQ proteins (2 alternative transcripts):

NP_001006114.1 NP_478061.1

ENSEMBL proteins:

ENSP00000389546 ENSP00000397263 ENSP00000329614 ENSP00000380806 ENSP00000380813 ENSP00000380805

ENSP00000407028 ENSP00000380808 ENSP00000340675

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

About this table

YBEY for ontologies About GeneDecksing

Antibodies for YBEY:

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Assays for YBEY:

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	GenScript Custom Assay Services for YBEY
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YBEY for domains About GeneDecksing

3 InterPro domains/families:

IPR020549 UPF0054_CS

IPR002036 UPF0054_metalloprotease_prd

IPR023091 MetalPrtase_cat_dom_prd

Graphical View of Domain Structure for InterPro Entry P58557

ProtoNet protein and cluster: P58557

1 Blocks protein family: IPB002036 Protein of unknown function UPF0054

UniProtKB/Swiss-Prot: CU057_HUMAN, P58557

Similarity: Belongs to the UPF0054 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CU057_HUMAN, P58557

Function: May have metalloprotease activity (Potential)

Enzyme Number (IUBMB): EC 3.4.24.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for YBEY Sigma-Aldrich shRNA for YBEY
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): YBEY OriGene shRNA RFP (see all 3): YBEY OriGene basic RS shRNA (see all 3): YBEY OriGene siRNA (see all 2): YBEY
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YBEY
		Search SABiosciences for Assays for microRNAs that regulate YBEY

Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene untagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene 3'-UTR clone (see all 2): YBEY Browse MicroRNA Expression Plasmids
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for YBEY

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008233	peptidase activity	IEA	--
GO:0008237	metallopeptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

YBEY for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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SABiosciences Custom Pathway-Focused PCR Arrays for YBEY

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for YBEY

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for YBEY

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for YBEY Sigma-Aldrich shRNA for YBEY
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): YBEY OriGene shRNA RFP (see all 3): YBEY OriGene basic RS shRNA (see all 3): YBEY OriGene siRNA (see all 2): YBEY
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YBEY

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YBEY
		Search SABiosciences for Assays for microRNAs that regulate YBEY

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene untagged cDNA clones in CMV expression vector (see all 2): YBEY OriGene 3'-UTR Clone (see all 2): YBEY Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for YBEY

Primers:		OriGene genome-wide validated SYBR primer pairs: YBEY Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for YBEY

REFSEQ mRNAs for YBEY gene (2 alternative transcripts):

NM_001006114.1 NM_058181.1

Additional cDNA sequence:

AK128875.1 AK294975.1 AY040873.1 AY040874.1 AY040875.1 AY040876.1 BC022828.1 BC068100.1

BC119770.1 BC122865.1 BC131553.1 DQ786290.1

10 DOTS entries:

DT.442093 DT.100750019 DT.121134432 DT.97823524 DT.100750018 DT.92417452 DT.91879059 DT.87046385

DT.412085 DT.99975493

Unigene Cluster for YBEY:

Chromosome 21 open reading frame 57

Hs.474066 [show with all ESTs]

Unigene Representative Sequence: AK294975

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for YBEY (see all 9)

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6	^	7
SP1:					-		-								-		-		-
SP2:					-		-				-				-		-		-
SP3:															-		-		-
SP4:					-		-								-		-
SP5:					-		-				-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for YBEY
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000431786 ENST00000492864(uc002zit.1 uc002ziu.1) ENST00000423005

ENST00000329319(uc002ziv.2) ENST00000397692 ENST00000397701(uc002ziw.2 uc002zix.2 uc010gqh.2)

ENST00000397691 ENST00000468924 ENST00000453984 ENST00000397694 ENST00000339195(uc002ziy.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

YBEY expression in normal and diseased human tissues

Data from GNF BioGPS
About these images

YBEY gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.474066

Primers:		OriGene genome-wide validated SYBR primer pairs: YBEY Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for YBEY

SABiosciences Custom PCR Arrays for YBEY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YBEY gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC606842¹	--	similar to UPF0054 protein C21orf57 homolog	73.17(n) 67.68(a)	606842 XM_843149.1 XP_848242.1
chimpanzee (Pan troglodytes)	LOC742420¹	--	similar to C21orf57 isoform A protein	99.45(n) 99.18(a)	742420 XM_001145583.1 XP_001145583.1
rat (Rattus norvegicus)	RGD1308722¹	--	similar to RIKEN cDNA A130042E20; open reading frame more	83.74(n) 79.88(a)	361822 XM_342116.3 XP_342117.2
mouse (Mus musculus)	Ybey⁵ A130042E20Rik¹	10 (38.85 cM)⁵	ybeY metallopeptidase⁵ RIKEN cDNA A130042E20 gene¹	82.32(n)¹ 77.44(a)¹	216119¹ NM_172550.4¹ NP_766138.3¹ AC007937⁵ AI464450⁵ (see all 10)
zebrafish (Danio rerio)	wufb30h03²	--	Transcribed sequence with weak similarity to protein more	72.8(n)	BG985784.1

About this table Species with no ortholog for YBEY

ENSEMBL Gene Tree for YBEY (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs8651^1,2	C,F,A,H,	47717616(-)	`TTATTT/CGTGTG`	1	--	ut3¹ ese³		14		MN NA EA WA	770
rs696327^1,2	--	47712700(+)	`agttaA/Gactct`	1	--	int¹		0	--	--	--	--
rs697804^1,2	C,H	47712534(+)	`AGTGGA/GGACAG`	2	--	int¹ ng3¹		3		NA	6
rs697805^1,2	C,H	47712536(+)	`TGGGGT/ACAGCC`	2	--	ng3¹ int¹		3		NA	6
rs697806^1,2	C,H	47712470(+)	`GCCACA/GCaagt`	2	--	int¹ ng3¹		3		NA	6
rs708377^1,2	--	47713728(+)	`GCCACA/GCAAGT`	1	--	int¹		1		NA	4
rs1061050^1,2	C,F	47712738(+)	`GACCCG/ATGCCC`	1	--	int¹		2		NA	6
rs1061068^1,2	--	47713486(+)	`cccggA/Gactca`	1	--	int¹		0	--	--	--	--
rs1061069^1,2	--	47713488(+)	`CGGGAC/GTCAGT`	1	--	int¹		0	--	--	--	--
rs1061070^1,2	--	47713490(+)	`GGACTC/GAGTGG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for YBEY (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YBEY: --

QIAGEN SeqTarget long-range PCR primers for resequencing YBEY

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

5 PubMed articles for YBEY gene integrated from 7 sources:
(articles sorted by number of sources associating them with YBEY)

From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)^{1, 2} Reymond A....Antonarakis S.E. (2001)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H....Kim N.S. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54059	HGNC: 1299	Ensembl:ENSG00000182362	euGenes: HUgn54059	ECgene: YBEY
H-InvDB: YBEY

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for YBEY gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for YBEY gene:
Search GeneIP for patents involving YBEY

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YBEY
	SeqTarget long-range PCR primers for resequencing YBEY
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for YBEY
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YBEY Gene

protein-coding GIFtS: 34

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YBEY Gene

protein-coding GIFtS: 34

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Protein Domains/
Families
for YBEY gene

Gene Function
for YBEY gene

Pathways & Interactions
for YBEY gene

Drugs & Compounds
for YBEY gene

Transcripts
for YBEY gene

Expression
for YBEY gene

Orthologs
for YBEY gene

Paralogs
for YBEY gene

Genomic Variants
for YBEY gene

Disorders & Mutations
for YBEY gene

Medical News
for YBEY gene

Publications
for YBEY gene

Intellectual Property
for YBEY gene

Products
for YBEY gene