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YIPF1 Gene

protein-coding   GIFtS: 45

GC01M052433
Yip1 domain family, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
Yip1 domain family, member 11 2
DJ167A19.11 2
FinGER11 2
YIP1 family member 12 3
OTTHUMP000000100472
protein YIPF12

External Ids:    HGNC: 252311   Entrez Gene: 544322   Ensembl: ENSG000000587997   UniProtKB: Q9Y5483   

Export aliases for YIPF1 gene to outside databases

Previous GC identifers: GC01M054030 GC01M054317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for YIPF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YIPF1 gene promoter:
         Sp1   c-Myb   GCNF-1   GCNF-2   ZID   RORalpha1   RORalpha2   FOXF2   GATA-3   AREB6   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for YIPF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for YIPF1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32.1   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p33-p32.1

YIPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YIPF1 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052433:  view genomic region     (about GC identifiers)

Start:
52,433,095 bp from pter
End:
52,471,166 bp from pter
Size:
38,072 bases
Orientation:
minus strand

1 alternative location:
Chr1- 54,317,392-54,355,507     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: YIPF1_HUMAN, Q9Y548 (See protein sequence)
Recommended Name: Protein YIPF1  
Size: 306 amino acids; 34277 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH09674.1; Type=Erroneous initiation;
Secondary accessions: B2RCM7 Q9NWJ1
Alternative splicing: 2 isoforms:  Q9Y548-1   Q9Y548-2   

Explore the universe of human proteins at neXtProt for YIPF1: NX_Q9Y548 

REFSEQ proteins: NP_061855.1  

ENSEMBL proteins: 
ENSP00000360452 ENSP00000072644 ENSP00000416507 


Human Recombinant Proteins 
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OriGene Protein Over-expression Lysate: YIPF1
GenScript Custom Purified and Recombinant Proteins Services for YIPF1 
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Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
GO:0030133 transport vesicle IDA11256614
About this table

YIPF1 for ontologies           About GeneDecksing



Antibodies for YIPF1: 
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Assays for YIPF1: 
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GenScript Custom Assay Services for YIPF1 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for YIPF1 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YIPF1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR006977 Yip1

Graphical View of Domain Structure for InterPro Entry Q9Y548

ProtoNet protein and cluster: Q9Y548

UniProtKB/Swiss-Prot: YIPF1_HUMAN, Q9Y548
Similarity: Belongs to the YIP1 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for YIPF1
Sigma-Aldrich shRNA for YIPF1
OriGene 29mer shRNA kits in GFP-retroviral vector: YIPF1
OriGene shRNA RFP: YIPF1
OriGene basic RS shRNA: YIPF1
OriGene siRNA: YIPF1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YIPF1 
miRNA:Sigma-Aldrich microRNA Mimics for YIPF1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YIPF1 
1 SABiosciences Assays for microRNA that regulate YIPF1:
hsa-miR-202

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: YIPF1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: YIPF1
OriGene untagged cDNA clones in CMV expression vector: YIPF1
OriGene 3'-UTR clone: YIPF1 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: YIPF1 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for YIPF1 

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003723 RNA binding ----
GO:0004540 ribonuclease activity ----
About this table

YIPF1 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for YIPF1 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIPF1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for YIPF1


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for YIPF1
Sigma-Aldrich shRNA for YIPF1
OriGene 29mer shRNA kits in GFP-retroviral vector: YIPF1
OriGene shRNA RFP: YIPF1
OriGene basic RS shRNA: YIPF1
OriGene siRNA: YIPF1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YIPF1 
miRNA: Sigma-Aldrich microRNA Mimics for YIPF1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YIPF1 
1 SABiosciences Assays for microRNA that regulate YIPF1:
hsa-miR-202
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: YIPF1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: YIPF1
OriGene untagged cDNA clones in CMV expression vector: YIPF1
OriGene 3'-UTR Clone: YIPF1 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: YIPF1 
Primers: OriGene genome-wide validated SYBR primer pairs: YIPF1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for YIPF1: PPH07816A

REFSEQ mRNAs for YIPF1 gene: 

NM_018982.4  

Additional cDNA sequence: 

AK000823.1 AK300240.1 AK315183.1 AL713668.1 BC009674.1 BC064590.1 CR595743.1 CR601785.1 
CR602343.1 CR612966.1 CR615001.1 CR621847.1 CR623623.1 CR624867.1 

13 DOTS entries:

DT.92437172  DT.100782964  DT.100782957  DT.100782959  DT.92437173  DT.100782961  DT.121370361  DT.92437176 
DT.95126675  DT.95126680  DT.95263009  DT.92437174  DT.99970827 

24/190 AceView cDNA sequences (see all 190):

AL558899 BM760914 CR624867 CR623623 BM752394 BM760117 CR621847 BM760141 
CR602343 BM756401 BG742307 BM474869 BI916236 CR601785 CR615001 CR612966 
CB159366 BG387679 BG339043 BM661997 BQ020516 AI271452 BQ941063 BG745504 

highest scoring ESTs for YIPF1:

AA354863 AK000823 AL549408 AL551031 AL713668 BC064590 BE789873 BF686451 BF971376 BG338987 

Unigene Cluster for YIPF1:

Yip1 domain family, member 1
Hs.11923  [show with all ESTs]
Unigene Representative Sequence: BC064590


GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF1 (see all 9)

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b
SP1:                          -                 -     -                                                           -               
SP2:              -     -     -                 -     -                                                           -               
SP3:              -           -                 -     -                                                                           
SP4:              -     -                       -     -                                                                           
SP5:              -           -                                                                                                   

About this scheme

ECgene alternative splicing isoforms for YIPF1
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371399 ENST00000480151 ENST00000072644(uc001cvu.2 uc001cvv.2)
ENST00000469457 ENST00000465897 ENST00000412288 ENST00000464950(uc001cvw.2 uc001cvx.2 uc001cvy.2)
ENST00000472983

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

YIPF1 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching YIPF1 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
41640_at2, 3 U95-A 1 0.69 1.00 1.00 1.00 AL031427 0.20 0.33 0.27 1
214733_s_at2, 3 U133-A 1 0.64 1.00 -- -- AL031427 0.20 0.33 0.27 1
214733_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table

YIPF1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
YIPF1 gene expression
YIPF1 gene electronic northern expression
YIPF1 gene sage expression
About these images

CGAP SAGE TAG: CTTCACTGTG

SOURCE GeneReport for Unigene cluster: Hs.11923
Primers: OriGene genome-wide validated SYBR primer pairs: YIPF1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for YIPF1: PPH07816A
    SABiosciences Custom PCR Arrays for YIPF1 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YIPF1 gene from 5/16 species (see all 16)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
YIPF11   -- Yip1 domain family, member 1 92.21(n)
93.42(a)
489581  XM_546701.2  XP_546701.2 
chimpanzee
(Pan troglodytes)
YIPF11   -- Yip1 domain family, member 1 99.78(n)
99.67(a)
738392  XM_001148917.1  XP_001148917.1 
cow
(Bos taurus)
YIPF11   -- Yip1 domain family, member 1 90.96(n)
92.81(a)
511748  XM_875653.2  XP_880746.1 
rat
(Rattus norvegicus)
Yipf11   -- Yip1 domain family, member 1 84.2(n)
88.56(a)
298312  NM_199383.1  NP_955415.1 
mouse
(Mus musculus)
Yipf11 , 5 4 (50.18 cM)5
Yip1 domain family, member 11, 5 83.77(n)1
87.58(a)1
2305841  NM_145550.21  NP_663525.11 
 AA5474955  AI4131605  (see all 14)
About this table        Species with no ortholog for YIPF1

ENSEMBL Gene Tree for YIPF1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for YIPF1 gene
YIPF22  

YIPF1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/395 NCBI SNPs in YIPF1 are shown (see all 395)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs146671,2
C54317854(+) GTGCCA/GCTCCA 1 -- ut315Minor allele frequency- G:0.01MN NS EA 604
rs9264561,2
C,F,A,H,54354165(+) attcaG/AtgaGG 1 -- int113Minor allele frequency- A:0.23EA NS NA WA 498
rs10184021,2
C,F,O,A,H,54349366(+) GGTTAA/TTTTTT 1 -- int120Minor allele frequency- T:0.26NS EA NA WA 820
rs11279221,2
C,A,H,54317697(-) ATGCCA/C/GGGGAA 1 -- ut31 ese311NS EA NA WA 362
rs11279291,2
--54317594(-) AAATTC/TTGATG 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
rs11279311,2
C,F,54317485(-) TTAACC/TGGGAG 1 -- ut3118Minor allele frequency- T:0.06MN NS EA NA 1602
rs11810941,2
C,F,O,A,54320383(+) tctccT/Gttgtt 1 -- int113Minor allele frequency- G:0.49MN NS EA NA WA 822
rs11810951,2
54322550(+) aattgC/Tctccc 1 -- int10--------
rs11810961,2
C,O,A,H,54326301(+) CCTGGA/CACAGT 1 -- int19Minor allele frequency- C:0.43EA NA WA 398
rs11810971,2
C,F,A,H,54326490(+) AAAAGA/TCAGAA 1 -- int117Minor allele frequency- T:0.45NS EA NA WA 766
About this table

HapMap Linkage Disequilibrium images for YIPF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for YIPF1
     2 CNVs: 63759 84246
     4 Indels: 84248 84247 84249 74485

QIAGEN SeqTarget long-range PCR primers for resequencing YIPF1 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/11 PubMed articles for YIPF1 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with YIPF1)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  6. High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. (PubMed id 15466293)1 Starkuviene V....Pepperkok R. (2004)
  7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
  8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
  9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
  10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54432 HGNC: 25231 AceView: DJ167A19.1 Ensembl:ENSG00000058799 euGenes: HUgn54432
ECgene: YIPF1 H-InvDB: YIPF1

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for YIPF1 gene:
Search GeneIP for patents involving YIPF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YIPF1
 SeqTarget long-range PCR primers for resequencing YIPF1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for YIPF1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YIPF1
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 ELISAs and CLIAs for YIPF1
       

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