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YJEFN3 Gene

protein-coding GIFtS: 29

GC19P019201

YjeF N-terminal domain containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
YjeF N-terminal domain containing 3¹ ²		MGC138490²
hYjeF_N3-19p13.11¹ ²		apolipoprotein A1 binding protein²
FLJ44968¹ ²		OTTHUMP00000221709²
hYjeF_N3² ³		yjeF N-terminal domain-containing protein 3²
OTTHUMP00000221708²		YjeF_N3³
yjeF_N3²

External Ids:	HGNC: 24785¹	Entrez Gene: 374887²	Ensembl: ENSG00000250067⁷	UniProtKB: A6XGL0³

Export aliases for YJEFN3 gene to outside databases

Previous GC identifers: GC19P019501 GC19P019627

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0

Function: May play a role in spermiogenesis and oogenesis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for YJEFN3
Other transcription factors

Search SABiosciences Chromatin IP Primers for YJEFN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11

YJEFN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YJEFN3 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P019201: view genomic region (about GC identifiers)

Start:	19,201,895 bp from pter
End:	19,210,613 bp from pter
Size:	8,719 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 19,639,707-19,648,393

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0 (See protein sequence)

Recommended Name: YjeF N-terminal domain-containing protein 3

Size: 299 amino acids; 32585 Da

Sequence caution: Sequence=BC020948; Type=Frameshift; Positions=200;

Secondary accessions: A6XGK9 Q4G1C0

Alternative splicing: 2 isoforms: A6XGL0-1 A6XGL0-2

Explore the universe of human proteins at neXtProt for YJEFN3: NX_A6XGL0

REFSEQ proteins (2 alternative transcripts):

NP_001177257.1 NP_940939.2

ENSEMBL proteins:

ENSP00000423979 ENSP00000334752 ENSP00000426964 ENSP00000398520 ENSP00000380364

Human Recombinant Proteins

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Assays for YJEFN3:

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	Uscn ELISAs and CLIAs for YJEFN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YJEFN3 for domains About GeneDecksing

1 InterPro domain/family:

IPR004443 YjeF_N

Graphical View of Domain Structure for InterPro Entry A6XGL0

ProtoNet protein and cluster: A6XGL0

UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0

Similarity: Contains 1 YjeF N-terminal domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0

Function: May play a role in spermiogenesis and oogenesis

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
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Gene
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Cell
Lines:

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(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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SABiosciences Custom Pathway-Focused PCR Arrays for YJEFN3

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for YJEFN3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for YJEFN3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for YJEFN3 Sigma-Aldrich shRNA for YJEFN3
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YJEFN3
		Search SABiosciences for Assays for microRNAs that regulate YJEFN3

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: YJEFN3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: YJEFN3 OriGene untagged cDNA clones in CMV expression vector (see all 2): YJEFN3 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for YJEFN3

Primers:		OriGene genome-wide validated SYBR primer pairs: YJEFN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for YJEFN3: PPH15749A

REFSEQ mRNAs for YJEFN3 gene (2 alternative transcripts):

NM_001190328.1 NM_198537.3

24/469 AceView cDNA sequences (see all 469):

CD678943 BM921707 BE378562 BM668365 BQ929017 F27361 BM695773 BM850820

AI056888 BU164243 BU956921 BQ026764 CB128799 AK129579 AI357370 AW006149

BM699888 BM693008 CB155813 AI311010 F33589 CD671540 BM661998 BM797483

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000510139 ENST00000458210(uc010xqx.1 uc002nmu.1) ENST00000334631

ENST00000514277 ENST00000436027(uc010ecf.1) ENST00000397179(uc002nmt.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

YJEFN3 expression in normal and diseased human tissues

¹ / ²

3 probe-sets matching YJEFN3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76402_at²	U95-E	1	0.69	1.00	1.00	1.00	--	--	--	--	--
229961_x_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
229961_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

YJEFN3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

YJEFN3 gene electronic northern expression

About these images

CGAP SAGE TAG: --

UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0

Tissue specificity: Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressed

in brain and mammary gland

Primers:		OriGene genome-wide validated SYBR primer pairs: YJEFN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for YJEFN3: PPH15749A

SABiosciences Custom PCR Arrays for YJEFN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YJEFN3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YJEFN3¹	--	YjeF N-terminal domain containing 3	90.63(n) 95.18(a)	484805 XM_541921.2 XP_541921.2
chimpanzee (Pan troglodytes)	YJEFN3¹	--	YjeF N-terminal domain containing 3	99.44(n) 99.67(a)	455877 XM_001142440.1 XP_001142440.1
rat (Rattus norvegicus)	Yjefn3¹	--	YjeF N-terminal domain containing 3	81.74(n) 83.91(a)	498608 XM_573886.2 XP_573886.2
mouse (Mus musculus)	Yjefn3^{1 , 5}	8 (34.02 cM)⁵	YjeF N-terminal domain containing 3^{1, 5}	81.01(n)¹ 83.12(a)¹	234365¹ XM_978251.1¹ XP_983345.1¹ BC028663⁵
zebrafish (Danio rerio)	si:ch211-212d10.3¹	--	si:ch211-212d10.3	62.41(n) 63.44(a)	557840 NM_001044843.1 NP_001038308.1

About this table Species with no ortholog for YJEFN3

ENSEMBL Gene Tree for YJEFN3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YJEFN3 gene

APOA1BP² NDUFA13²

YJEFN3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2304098^1,2	C,F,H,	19646272(-)	`TTGCCA/GCCCAG`	2	--	int¹		13		EA NS NA WA	2132
rs4808205^1,2	C,F,	19645493(+)	`GGGGCT/GGAGGT`	2	--	int¹		3		NA WA	124
rs4808206^1,2	C,F,	19645645(+)	`GAGACC/AGGGCC`	2	--	int¹		11		NS EA NA WA	964
rs4808967^1,2	C,F,A,	19640524(+)	`GTGTTT/CTAGGA`	2	--	int¹		19		NS EA NA WA	1244
rs4808968^1,2	C,F,	19644402(+)	`ACTTAC/TCCTAc`	2	--	int¹		6		NS EA NA WA	538
rs8100927^1,2	C,A,H,	19643636(+)	`GTTCAC/GCCCTC`	2	--	int¹		4		NA WA	126
rs8101219^1,2	C,A,H,	19643715(+)	`CTGGTA/GCAGGC`	2	--	int¹		1		NA	2
rs10422819^1,2	C,F,A,H,	19643028(+)	`TGTTCC/AGTGGC`	2	--	int¹		10		NS EA NA WA	582
rs10426732^1,2	C,F,	19640054(+)	`AGCTGC/TGTTGC`	2	--	int¹		2		NS WA	170
rs10570879^1,2	--	19642538(+)	`ttttt-/TTTT ttttt`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for YJEFN3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YJEFN3: --

QIAGEN SeqTarget long-range PCR primers for resequencing YJEFN3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

6 PubMed articles for YJEFN3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with YJEFN3)

ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PubMed id 17533573)^{1, 2, 3} Rudolph C.... Schmitz G. (2007)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 374887	HGNC: 24785	AceView: GRIM19andFLJ44968	Ensembl:ENSG00000250067	euGenes: HUgn374887
ECgene: YJEFN3	H-InvDB: YJEFN3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for YJEFN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for YJEFN3 gene:
Search GeneIP for patents involving YJEFN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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YJEFN3 Gene

protein-coding GIFtS: 29

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YJEFN3 Gene

protein-coding GIFtS: 29

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Gene Function
for YJEFN3 gene

Pathways & Interactions
for YJEFN3 gene

Drugs & Compounds
for YJEFN3 gene

Transcripts
for YJEFN3 gene

Expression
for YJEFN3 gene

Orthologs
for YJEFN3 gene

Paralogs
for YJEFN3 gene

Genomic Variants
for YJEFN3 gene

Disorders & Mutations
for YJEFN3 gene

Medical News
for YJEFN3 gene

Publications
for YJEFN3 gene

Intellectual Property
for YJEFN3 gene

Products
for YJEFN3 gene