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YWHAB Gene

protein-coding   GIFtS: 70

GC20P040256
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: YWHAA)
Products    

Aliases &
Descriptions
for YWHAB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
polypeptide1 2
     brain protein 14-3-3, beta isoform2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha
polypeptide1 2
     HS12
Protein 10542 3     14-3-3 protein beta/alpha2
Protein kinase C inhibitor protein 12 3     GW1282
KCIP-12 3     YWHAA2
protein kinase C inhibitor protein-12     14-3-3 alpha2

External Ids:    HGNC: 128491   Entrez Gene: 75292   Ensembl: ENSG000001669137   UniProtKB: P319463   

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P043515


Summaries
for YWHAB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YWHAB:
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by
binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and
mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play
a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same
protein, have been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis

summary for YWHAB:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAB

Genomic Views
for YWHAB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAB gene promoter:
         Hlf   POU2F1   POU3F1   E47   Tal-1beta   AP-1   PPAR-gamma2   PPAR-gamma1   AP-2rep   Nkx6-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for YWHAB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P040256:  view genomic region     (about GC identifiers)

Start:
 40,256,235 bp from pter
End:
 40,278,993 bp from pter
Size:
 22,759 bases
Orientation:
 plus strand

1 alternative location:
Chr20+ 43,514,317-43,537,173     
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  

Proteins
for YWHAB gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)
Recommended Name: 14-3-3 protein beta/alpha  
Size: 246 amino acids; 28082 Da
Subunit: Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic
location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in
phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I
to stage IV
PDB structure from and Proteopedia :
2BQ0 (3D)    2C23 (3D)    
Secondary accessions: A8K9K2
Alternative initiation: 2 isoforms:  P31946-1   P31946-2   

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946 

Post-translational modifications:

  • The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity)1
  • Isoform Short contains a N-acetylmethionine at position 1 (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_003395.1  NP_647539.1  


    ENSEMBL proteins: 
    ENSP00000361930 ENSP00000394558 ENSP00000394729 ENSP00000300161 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for YWHAB
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAB
    OriGene Purified Proteins (see all 2): YWHAB
    OriGene Protein Over-expression Lysate (see all 2): YWHAB
    GenScript Custom Purified and Recombinant Proteins Services for YWHAB 
    Novus Biologicals Protein for YWHAB
    Novus Biologicals Lysates for YWHAB
    Sino Biological Recombinant Protein for YWHAB
    ProSpec Recombinant Protein for YWHAB

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA12963375
    GO:0005813 centrosome IDA18029348
    GO:0005829 cytosol EXP9069260
    About this table

    YWHAB for ontologies           About GeneDecksing



    Antibodies for YWHAB: 
    Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
    Sigma-Aldrich Antibodies for YWHAB
    R&D Systems Antibodies for YWHAB (14-3-3 beta)
    Cell Signaling Technology (CST) Antibodies for YWHAB  (14-3-3 beta/alpha)
    OriGene Antibodies (see all 2): YWHAB
    GenScript Custom Superior Antibodies Services for YWHAB 
    Novus Biologicals Antibodies for YWHAB
    Epitomics antibodies for YWHAB

    Assays for YWHAB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAB 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for YWHAB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YWHAB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P31946

    ProtoNet protein and cluster: P31946

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
    Similarity: Belongs to the 14-3-3 family


    Gene Function
    for YWHAB gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for YWHAB
    Sigma-Aldrich shRNA for YWHAB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): YWHAB
    OriGene shRNA RFP (see all 2): YWHAB
    OriGene basic RS shRNA (see all 2): YWHAB
    OriGene siRNA (see all 2): YWHAB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YWHAB 
    miRNA:Sigma-Aldrich microRNA Mimics for YWHAB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YWHAB 
    8/11 SABiosciences Assays for microRNAs that regulate YWHAB (see all 11):
    hsa-miR-217 hsa-miR-148b hsa-miR-922 hsa-miR-27a hsa-miR-128 hsa-miR-216b hsa-miR-152 hsa-miR-1276

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene 3'-UTR clone (see all 2): YWHAB 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): YWHAB 
    Sino Biological Human cDNA Clone for YWHAB

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for YWHAB 

    Genatlas biochemistry entry for YWHAB:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated
    form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal
    transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714 transcription corepressor activity IEA--
    GO:0005515 protein binding IPI17974916
    GO:0008022 protein C-terminus binding IEA--
    GO:0019899 enzyme binding IPI17255105
    GO:0019904 protein domain specific binding IPI11984006
    About this table

    YWHAB for ontologies           About GeneDecksing


    Pathways & Interactions
    for YWHAB gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    YWHAB for pathways           About GeneDecksing

    5/7 Millipore Pathways for YWHAB (see all 7)
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/9 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  YWHAB (see all 9)
        ERK5 Signaling
    ERK/MAPK Signaling
    IGF-1 Signaling
    PI3K/AKT Signaling
    Protein Kinase A Signaling

    3 Kegg Pathways  (Kegg details for YWHAB):
        hsa04110 Cell cycle
    hsa04114 Oocyte meiosis
    hsa04722 Neurotrophin signaling pathway

        SABiosciences Custom Pathway-Focused PCR Arrays for YWHAB 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for YWHAB
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAB

    5/227 Interacting proteins for YWHAB (ENSP000003619303 P319461, 2) via UniProtKB, MINT, and/or STRING (see all 227)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25BP303051, 2STRING: ENSP00000245960 EBI-359815,EBI-1051746 MINT-19327 MINT-8006726 MINT-51064 MINT-51065 MINT-8007484 MINT-25122
    RAF1P040491, 2STRING: ENSP00000251849 EBI-359815,EBI-365996 MINT-8004910 MINT-8004894 MINT-8009103 MINT-8004954 MINT-8005906
    BRAFP150561, 2STRING: ENSP00000288602 EBI-359815,EBI-365980 MINT-50344
    EPB41L3Q9Y2J21, 2STRING: ENSP00000343158 EBI-359815,EBI-310986 MINT-50963
    FAM82A2Q96TC71, 2EBI-359815,EBI-1056589 MINT-50964 MINT-8008612
    About this table

    5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165 MAPKKK cascade TAS--
    GO:0000186 activation of MAPKK activity TAS--
    GO:0006605 protein targeting IEA--
    GO:0006915 apoptosis TAS--
    GO:0007173 epidermal growth factor receptor signaling pathway TAS--
    About this table

    YWHAB for ontologies           About GeneDecksing



    Drugs & Compounds
    for YWHAB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    YWHAB for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAB available from Tocris Bioscience
    CompoundAction CAS number
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]
    About this table


    1 Novoseek chemical compound relationship for YWHAB gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 28.2 1 16469478 (1)
    About this table



    Transcripts
    for YWHAB gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for YWHAB
    Sigma-Aldrich shRNA for YWHAB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): YWHAB
    OriGene shRNA RFP (see all 2): YWHAB
    OriGene basic RS shRNA (see all 2): YWHAB
    OriGene siRNA (see all 2): YWHAB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YWHAB 
    miRNA: Sigma-Aldrich microRNA Mimics for YWHAB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YWHAB 
    8/11 SABiosciences Assays for microRNAs that regulate YWHAB (see all 11):
    hsa-miR-217 hsa-miR-148b hsa-miR-922 hsa-miR-27a hsa-miR-128 hsa-miR-216b hsa-miR-152 hsa-miR-1276
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): YWHAB
    OriGene 3'-UTR Clone (see all 2): YWHAB 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): YWHAB 
    Primers: OriGene genome-wide validated SYBR primer pairs: YWHAB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for YWHAB: PPH15803A

    REFSEQ mRNAs for YWHAB gene (2 alternative transcripts): 

    NM_003404.3  NM_139323.2  

    Additional cDNA sequence: 

    AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2 
    BC010352.1 CR595602.1 CR603709.1 CR614687.1 X57346.1 

    24/43 DOTS entries (see all 43):

    DT.75122682  DT.92325870  DT.100059833  DT.100883300  DT.100883297  DT.100883284  DT.100883281  DT.87077844 
    DT.92007444  DT.120826031  DT.95256702  DT.95118446  DT.100883292  DT.100059820  DT.100883274  DT.95151426 
    DT.95151410  DT.120826094  DT.91772166  DT.100883277  DT.100883289  DT.95151421  DT.99977735  DT.100883266 

    24/1367 AceView cDNA sequences (see all 1367):

    CA421730 BU540599 AA167429 CD743146 AA459239 BM843443 BM758152 CB119741 
    F05953 H39869 N33792 BM754925 BM830874 BF718694 AW467473 CB140640 
    T33559 BQ679676 AA614855 BQ893661 T48550 BM709010 CA448653 BM915954 

    highest scoring ESTs for YWHAB:

    X57346 AA055810 AA056434 AA070440 AA074917 AA075401 AA075468 AA088416 AA088539 AA100475 

    Unigene Cluster for YWHAB:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
    Hs.643544  [show with all ESTs]
    Unigene Representative Sequence: AB209759


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10)

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:              -     -                             -     -     -     -                                                   
    SP2:              -     -     -                       -     -     -     -                                                   
    SP3:                                                                                                                        
    SP4:                                                  -                                                                     
    SP5:                    -                                                                                                   

    About this scheme

    ECgene alternative splicing isoforms for YWHAB
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479758 ENST00000372839(uc002xmt.2) ENST00000445830 ENST00000428262
    ENST00000353703(uc002xmu.2) ENST00000477896 ENST00000479421

    Expression
    for YWHAB gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    YWHAB expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching YWHAB gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32324_at2, 3 U95-A 1 0.88 1.00 1.00 1.00 X57346 1.00 1.00 1.00 1
    208743_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC001359 0.80 1.00 0.91 1
    217717_s_at2, 3 U133-A 1 1.00 1.00 -- -- BF246499 0.80 1.00 0.91 1
    217718_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014052 0.20 1.00 0.72 1
    208743_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    217717_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    217718_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    YWHAB for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    YWHAB gene expression
    YWHAB gene electronic northern expression
    YWHAB gene sage expression
    About these images

    CGAP SAGE TAG: CAGTTACTTA

    SOURCE GeneReport for Unigene cluster: Hs.643544

    Expression variation in blood from EXPOLDB for YWHAB

    Primers: OriGene genome-wide validated SYBR primer pairs: YWHAB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for YWHAB: PPH15803A
        SABiosciences Custom PCR Arrays for YWHAB 


    Orthologs
    for YWHAB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for YWHAB gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 YWHAB1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 93.72(n)
    100(a)    		 477237  XM_847661.1  XP_852754.1 
    cow
    (Bos taurus)    		 YWHAB1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 92.01(n)
    100(a)    		 286863  NM_174794.2  NP_777219.2 
    rat
    (Rattus norvegicus)    		 Ywhab1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 91.33(n)
    98.37(a)    		 56011  NM_019377.1  NP_062250.1 
    mouse
    (Mus musculus)    		 Ywhab1 , 5 2 (84.59 cM)5
    		 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 90.65(n)1
    98.78(a)1    		 544011  NM_018753.41  NP_061223.21 
     AF0587975  AI0606945  (see all 48)
    chicken
    (Gallus gallus)    		 YWHAB1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 84.7(n)
    97.95(a)    		 419190  NM_001006289.1  NP_001006289.1 
    About this table        Species with no ortholog for YWHAB

    ENSEMBL Gene Tree for YWHAB (if available)

    Paralogs
    for YWHAB gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for YWHAB gene
    YWHAE2  YWHAH2  YWHAQ2  YWHAG2  LOC2841002  SFN2  YWHAZ2  

    YWHAB for paralogs           About GeneDecksing


    Pseudogenes
    2 related pseudogenes



    Genomic Variants
    for YWHAB gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/238 NCBI SNPs in YWHAB are shown (see all 238)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs49311,2
    		C,F,A,43530234(+) GAGCGA/C/G/T 
                TATGA     		8 R ref1 syn18NS NA MN WA 356
    rs68761,2
    		C,F,O,43535101(+) TGATCT/CGTTCA 2 -- ut318Minor allele frequency- C:0.31MN NA NS 696
    rs83561,2
    		C,F,A,43536455(+) CAACAC/TGGTGT 2 -- ut31 ese38Minor allele frequency- T:0.16MN NA EA WA 2074
    rs87871,2
    		--43536259(+) CTCTTC/TTAAGT 2 -- ut31 trp31Minor allele frequency- T:0.00MN 184
    rs134491,2
    		--43536692(-) TGATTC/TTGTGA 2 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs10598331,2
    		--43535548(+) TCATTG/TGGCAT 2 -- ut310--------
    rs22395351,2
    		C,F,A,43516156(+) ACCCTG/ATAATC 2 -- int123Minor allele frequency- A:0.23EA NS NA WA 4436
    rs22537121,2
    		C,F,O,A,H,43523764(+) CAAGGT/CAAATC 2 -- int113Minor allele frequency- C:0.24NA EA WA 718
    rs22678481,2
    		C,F,43524205(+) cctagC/Actcaa 2 -- int13Minor allele frequency- A:0.24NA WA 76
    rs22678491,2
    		C,F,A,43524369(+) ctccaA/Gaagca 2 -- int14Minor allele frequency- G:0.27NA EA WA 212
    About this table

    HapMap Linkage Disequilibrium images for YWHAB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAB: --

    QIAGEN SeqTarget long-range PCR primers for resequencing YWHAB 

    Disorders & Mutations
    for YWHAB gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YWHAB for disorders           About GeneDecksing

    OMIM: 601289

    Genetic Association Database (GAD): YWHAB
    Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

    Export disorders and mutations for YWHAB gene to outside databases

    Medical News
    for YWHAB gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for YWHAB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/146 PubMed articles for YWHAB gene, integrated from 7 sources (see all 146):
    (articles sorted by number of sources associating them with YWHAB)
    1. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    2. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2 Zhao B.... Guan K.L. (2007)
    3. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)1, 2 Liu Y.... Billiard J. (2007)
    4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    5. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
    6. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
    7. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)1, 4 Otsuka J....Harada M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    External Searches for YWHAB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing YWHAB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7529 HGNC: 12849 AceView: YWHAB Ensembl:ENSG00000166913 euGenes: HUgn7529
    ECgene: YWHAB Kegg: 7529 H-InvDB: YWHAB

    Other Databases showing YWHAB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YWHAB gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for YWHAB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for YWHAB gene:
    Search GeneIP for patents involving YWHAB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for YWHAB gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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