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YWHAE Gene

protein-coding   GIFtS: 71

GC17M001148
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
polypeptide1 2
     protein kinase C inhibitor protein-12
FLJ454651 2     FLJ535592
14-3-3E2 3     tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide2
MDS2 5     mitochondrial import stimulation factor L subunit2
MDCR2 5     14-3-3 protein epsilon2
KCIP-12     14-3-3 epsilon2

External Ids:    HGNC: 128511   Entrez Gene: 75312   Ensembl: ENSG000001089537   UniProtKB: P622583   

Export aliases for YWHAE gene to outside databases

Previous GC identifers: GC17P001321 GC17P001492 GC17M001198 GC17M001454 GC17M001194 GC17M001247


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAE:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this
protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins,
suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and
regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two
transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. (provided by
RefSeq)

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner

summary for YWHAE:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAE gene promoter:
         C/EBPalpha   HSF1 (long)   C/EBPbeta   p53   c-Myc   Max1   Max   SREBP-1c   SREBP-1a   SREBP-1b   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for YWHAE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for YWHAE 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

YWHAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAE gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001148:  view genomic region     (about GC identifiers)

Start:
1,148,526 bp from pter
End:
1,204,512 bp from pter
Size:
55,987 bases
Orientation:
minus strand

1 alternative location:
Chr17- 1,247,566-1,303,505     
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258 (See protein sequence)
Recommended Name: 14-3-3 protein epsilon  
Size: 255 amino acids; 29174 Da
Subunit: Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, RGNEF and TIAM2 (By similarity). Interacts with
HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly
interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10
Subcellular location: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
PDB structures from and Proteopedia :
2BR9 (3D)    
Secondary accessions: B3KY71 P29360 P42655 Q53XZ5 Q63631 Q7M4R4

Explore the universe of human proteins at neXtProt for YWHAE: NX_P62258 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006752.1  

    ENSEMBL proteins: 
    ENSP00000264335 ENSP00000406058 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for YWHAE
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAE
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for YWHAE 
    Novus Biologicals Proteins for YWHAE
    Sino Biological Recombinant Protein for YWHAE
    ProSpec Recombinant Protein for YWHAE

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005739 mitochondrion IEA--
    GO:0005829 cytosol EXP12852856
    GO:0042470 melanosome IEA--
    About this table

    YWHAE for ontologies           About GeneDecksing



    Antibodies for YWHAE: 
    Millipore Mono- and Polyclonal Antibodies for the study of YWHAE
    Sigma-Aldrich Antibodies for YWHAE
    R&D Systems Antibodies for YWHAE (14-3-3 epsilon)
    Cell Signaling Technology (CST) Antibodies for YWHAE  (14-3-3 epsilon)
    OriGene Antibodies (see all 2): YWHAE
    GenScript Custom Superior Antibodies Services for YWHAE 
    Novus Biologicals Antibodies for YWHAE
    Epitomics antibodies for YWHAE

    Assays for YWHAE: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAE 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YWHAE for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P62258

    ProtoNet protein and cluster: P62258

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258
    Similarity: Belongs to the 14-3-3 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for YWHAE
    Sigma-Aldrich shRNA for YWHAE
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): YWHAE
    OriGene shRNA RFP (see all 2): YWHAE
    OriGene basic RS shRNA (see all 2): YWHAE
    OriGene siRNA (see all 2): YWHAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YWHAE 
    miRNA:Sigma-Aldrich microRNA Mimics for YWHAE
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YWHAE 
    4 SABiosciences Assays for microRNAs that regulate YWHAE:
    hsa-miR-548g hsa-miR-634 hsa-miR-876-3p hsa-miR-548b-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: YWHAE
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: YWHAE
    OriGene untagged cDNA clones in CMV expression vector (see all 2): YWHAE
    OriGene 3'-UTR clone: YWHAE 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for YWHAE 
    Sino Biological Human cDNA Clone for YWHAE

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for YWHAE 

    Genatlas biochemistry entry for YWHAE:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 epsilon protein,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16868027
    GO:0019899 enzyme binding IPI10788521
    GO:0019904 protein domain specific binding IEA--
    GO:0042826 histone deacetylase binding IPI10869435
    GO:0050815 phosphoserine binding IPI10869435
    About this table

    YWHAE for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhae):

    lethality-prenatal/perinatalnervous system

    YWHAE for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    YWHAE for pathways           About GeneDecksing

    5 Millipore Pathways for YWHAE
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-RI signaling
    Apoptosis and survival BAD phosphorylation

    5/10 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  YWHAE (see all 10)
        Neuroprotective Role of THOP1 in Alzheimer's Disease
    IGF-1 Signaling
    VEGF Signaling
    Protein Kinase A Signaling
    Cell Cycle: G2/M DNA Damage Checkpoint Regulation

    3 Kegg Pathways  (Kegg details for YWHAE):
        hsa04110 Cell cycle
    hsa04114 Oocyte meiosis
    hsa04722 Neurotrophin signaling pathway

        SABiosciences Pathway-Focused PCR Array including YWHAE: PAHS-096A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for YWHAE
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAE

    5/764 Interacting proteins for YWHAE (ENSP000002643353 P622581, 2) via UniProtKB, MINT, and/or STRING (see all 764)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25BP303051, 2STRING: ENSP00000245960 EBI-356498,EBI-1051746 MINT-51066 MINT-25123 MINT-8004866 MINT-51067
    CDC25AP303041, 2STRING: ENSP00000303706 EBI-356498,EBI-747671 MINT-19304 MINT-19397 MINT-19303
    CDKN1BP465271STRING: ENSP00000228872 EBI-356498,EBI-519280
    IRS1P355682STRING: ENSP00000304895 MINT-8005150 MINT-16661 MINT-16662 MINT-8005105 MINT-8005168 MINT-8005175
    IGF1RP080692STRING: ENSP00000268035 MINT-18626 MINT-18625 MINT-18624 MINT-8005112
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086 G2/M transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    GO:0001764 neuron migration IEA--
    GO:0006605 protein targeting IEA--
    GO:0006915 apoptosis EXP11278287
    About this table

    YWHAE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAE available from Tocris Bioscience
    CompoundAction CAS number
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]
    About this table




    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for YWHAE
    Sigma-Aldrich shRNA for YWHAE
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): YWHAE
    OriGene shRNA RFP (see all 2): YWHAE
    OriGene basic RS shRNA (see all 2): YWHAE
    OriGene siRNA (see all 2): YWHAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of YWHAE 
    miRNA: Sigma-Aldrich microRNA Mimics for YWHAE
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of YWHAE 
    4 SABiosciences Assays for microRNAs that regulate YWHAE:
    hsa-miR-548g hsa-miR-634 hsa-miR-876-3p hsa-miR-548b-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: YWHAE
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: YWHAE
    OriGene untagged cDNA clones in CMV expression vector (see all 2): YWHAE
    OriGene 3'-UTR Clone: YWHAE 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for YWHAE 
    Primers: OriGene genome-wide validated SYBR primer pairs: YWHAE
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for YWHAE: PPH10170A

    REFSEQ mRNAs for YWHAE gene: 

    NM_006761.4  

    Additional cDNA sequence: 

    AK128785.1 AK295260.1 AK295997.1 AK296050.1 AK296555.1 AK316185.1 AK316201.1 AY883089.1 
    BC000179.2 BC001440.2 BT007161.1 CR589991.1 CR593257.1 CR594680.1 CR595118.1 CR599291.1 
    CR600610.1 CR605234.1 CR608365.1 CR609747.1 CR609773.1 CR609824.1 CR610427.1 CR610584.1 
    CR611764.1 CR612456.1 CR615586.1 CR617332.1 CR619511.1 CR620149.1 CR622415.1 CR622589.1 
    CR623549.1 CR624231.1 U20972.1 U28936.1 U43399.1 U43430.1 U54778.1 

    24/55 DOTS entries (see all 55):

    DT.95260129  DT.97862705  DT.100893739  DT.100800719  DT.100893703  DT.99950231  DT.97861309  DT.97862704 
    DT.100893702  DT.95190057  DT.95260196  DT.95260250  DT.95260150  DT.100893733  DT.100893742  DT.99978845 
    DT.454468  DT.120963813  DT.100893735  DT.100893724  DT.120963642  DT.92369109  DT.95260146  DT.40248808 

    24/1840 AceView cDNA sequences (see all 1840):

    AU117492 BP336365 BM982706 BU675123 N28863 BM974353 BP365801 BU682882 
    BM762925 BU517076 BM843902 CA442345 AA128912 AU280622 BM753140 AA404741 
    AW778947 BP373025 AI571505 BU173200 CB306219 BU173310 BU685781 BM973250 

    highest scoring ESTs for YWHAE:

    U54778 BM753140 CB112914 CB117752 CB118066 BE698832 BQ368139 AA083002 AA093671 AA160983 

    Unigene Cluster for YWHAE:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
    Hs.513851  [show with all ESTs]
    Unigene Representative Sequence: NM_006761


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAE (see all 6)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                          -           -                                   -                           
    SP2:                          -     -     -           -                       -                           
    SP3:                                      -                                                               
    SP4:                                                                                                      
    SP5:                          -           -     -     -     -     -     -     -                           

    About this scheme

    ECgene alternative splicing isoforms for YWHAE
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264335(uc002fsk.2 uc002fsj.2 uc010vqh.1 uc010vqi.1)
    ENST00000466227 ENST00000496706 ENST00000469398 ENST00000486241 ENST00000489287
    ENST00000498643 ENST00000414131

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    YWHAE expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching YWHAE gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1011_s_at2, 3 U95-A 2 1.00 0.88 1.00 1.00 U54778 1.00 0.80 0.91 1
    210317_s_at2, 3 U133-A 2 1.00 0.91 -- -- U28936 0.80 0.75 0.78 1
    210996_s_at2, 3 U133-A 2 1.00 0.86 -- -- U43430 0.80 0.75 0.78 1
    210317_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    210996_s_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
    About this table

    YWHAE for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    YWHAE gene expression
    YWHAE gene electronic northern expression
    YWHAE gene sage expression
    About these images

    CGAP SAGE TAG: GAATTAACAT

    SOURCE GeneReport for Unigene cluster: Hs.513851

    Expression variation in blood from EXPOLDB for YWHAE

    Primers: OriGene genome-wide validated SYBR primer pairs: YWHAE
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for YWHAE: PPH10170A
        SABiosciences Expression via Pathway-Focused PCR Array including YWHAE: PAHS-096A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for YWHAE gene from 5/24 species (see all 24)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YWHAE1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 97.52(n)
    100(a)
    480645  XM_849265.1  XP_854358.1 
    chimpanzee
    (Pan troglodytes)
    YWHAE1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 99.87(n)
    100(a)
    454409  XM_001153770.1  XP_001153770.1 
    cow
    (Bos taurus)
    YWHAE1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 97.78(n)
    100(a)
    282125  NM_174491.3  NP_776916.1 
    rat
    (Rattus norvegicus)
    Ywhae1   -- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 92.68(n)
    98.82(a)
    29753  NM_031603.1  NP_113791.1 
    mouse
    (Mus musculus)
    Ywhae1 , 5 11 (45.92 cM)5
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.33(n)1
    99.61(a)1
    226271  NM_009536.31  NP_033562.21 
     AF4834785  AF4834795  (see all 40)
    About this table        Species with no ortholog for YWHAE

    ENSEMBL Gene Tree for YWHAE (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for YWHAE gene
    YWHAH2  YWHAB2  YWHAQ2  YWHAG2  LOC2841002  SFN2  YWHAZ2  

    YWHAE for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/649 NCBI SNPs in YWHAE are shown (see all 649)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs72661,2
    C,F,O,1248466(-) TTACTG/ATGTCG 1 -- ut31 ese39Minor allele frequency- A:0.04MN NS EA NA 740
    rs93931,2
    C,F,A,1248392(-) ACTTAT/CAGGTG 1 -- ut31 ese312Minor allele frequency- C:0.24EA MN NS NA WA 2490
    rs152191,2
    C,F1247962(-) GTAACT/GTGAAG 1 -- ut311Minor allele frequency- G:0.00MN 184
    rs1733291,2
    --1277368(+) gcactC/Ttggga 1 -- int10--------
    rs1814441,2
    --1248541(+) AATCCA/CCAGAA 1 -- ut31 ese34Minor allele frequency- C:0.02EA NA MN 234
    rs1916521,2
    --1248465(+) ACGACA/CCAGTA 1 -- ut31 ese34Minor allele frequency- C:0.01EA NA MN 155
    rs18046351,2
    --1247943(-) TACTAA/CTGGAT 1 -- ut31 ese30--------
    rs18046361,2
    --1248182(-) ATGTTA/GCTGAA 1 -- ut310--------
    rs18046371,2
    --1248273(-) TTGGGG/TGTTAG 1 -- ut310--------
    rs18049221,2
    --1247940(-) TACTGA/GATATC 1 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for YWHAE (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAE: --

    QIAGEN SeqTarget long-range PCR primers for resequencing YWHAE 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YWHAE for disorders           About GeneDecksing

    OMIM: 605066

    Human Gene Mutation Database (HGMD): YWHAE
    Genetic Association Database (GAD): YWHAE
    Human Genome Epidemiology (HuGE) Navigator: YWHAE (1 document)

    Export disorders and mutations for YWHAE gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/137 PubMed articles for YWHAE gene, integrated from 7 sources (see all 137):
    (articles sorted by number of sources associating them with YWHAE)
    1. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    3. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. (PubMed id 16376338)1, 2 Gu Y.-M.... Lee K.-Y. (2006)
    4. Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. (PubMed id 15838597)1, 4 Yanagi M....Maeda K. (2005)
    5. Phosphorylation of grb10 regulates its interaction with 14-3-3. (PubMed id 15722337)1, 2 Urschel S....Duyster J. (2005)
    6. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7531 HGNC: 12851 AceView: YWHAE Ensembl:ENSG00000108953 euGenes: HUgn7531
    ECgene: YWHAE Kegg: 7531 H-InvDB: YWHAE

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for YWHAE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for YWHAE gene:
    Search GeneIP for patents involving YWHAE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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     Regulatory tfbs in YWHAE promoter
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