Aliases &
Descriptions
for ZBTB38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger and BTB domain containing 381 2 | | OTTHUMP000002176562 | | FLJ350361 2 | | OTTHUMP000002176552 | | CIBZ1 2 | | OTTHUMP000002176592 | | ZNF9211 2 | | OTTHUMP000002176002 | | OTTHUMP000002176572 | | zinc finger and BTB domain-containing protein 382 | | FLJ311312 | | OTTHUMP000002176022 | | FLJ223322 | | OTTHUMP000002176582 | | OTTHUMP000002176602 | | OTTHUMP000002176032 | | OTTHUMP000002176012 | | OTTHUMP000002176542 |
Export aliases for ZBTB38 gene to outside databasesPrevious GC identifers: GC03P142628 GC03P142525 GC03P141043 |
Summaries
for ZBTB38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZBTB38:
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encodedprotein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein hasbeen associated with apoptosis in some cell types. (provided by RefSeq)
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of latepostmitotic neurons (By similarity)
|
Genomic Views
for ZBTB38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB38 gene promoter:
ATF ATF-2 Tal-1beta ITF-2 Tal-1 E47 c-Jun CUTL1 POU3F2 ISGF-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB38
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23ZBTB38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P138418: view genomic region
(about GC identifiers)
Start:
|
138,418,028 bp from pter |
End:
|
138,543,648 bp from pter |
Size:
|
125,621 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr3+ 141,043,055-141,168,634 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for ZBTB38 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 38 Size: 1195 amino acids; 134257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC03868.1; Type=Frameshift; Positions=147;Explore the universe of human proteins at neXtProt for ZBTB38: NX_Q8NAP3
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001073881.2
ENSEMBL proteins: ENSP00000422347 ENSP00000421037 ENSP00000422757 ENSP00000426288 ENSP00000372635 ENSP00000426931 ENSP00000422894 ENSP00000422051 ENSP00000425705 ENSP00000426387 ENSP00000406955 ENSP00000424254 ENSP00000422081
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZBTB38 for ontologies About GeneDecksing
Antibodies for ZBTB38:
Assays for ZBTB38: |
Protein
Domains/
Families
for ZBTB38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB38 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8NAP3ProtoNet protein and cluster: Q8NAP3 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 10 C2H2-type zinc fingers |
Gene Function
for ZBTB38 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Function: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of latepostmitotic neurons (By similarity)
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZBTB38 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB38 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZBTB38
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB38
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
ISS | -- |
About this table
ZBTB38 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZBTB38
|
Transcripts
for ZBTB38 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZBTB38 gene: NM_001080412.2 Additional cDNA sequence: AK025985.1 AK055693.1 AK092355.1 AK094201.1 AK302568.1 AK307452.1 AK311479.1 AK311501.1 AL833148.1 BC008901.2 BC015444.1 BC022936.1 BC051734.1 BC072415.1 BC107745.1 CR596380.1 12 DOTS entries: DT.455936 DT.100726896 DT.120898500 DT.100009025 DT.100811255 DT.120898448 DT.95253719 DT.120898403 DT.120898470 DT.102843102 DT.120898435 DT.95096094 24/244 AceView cDNA sequences (see all 244): AI131123 AA465113 F05113 AI383204 BX107719 BU178920 CD678417 AK055693 AA258171 BM682234 F03089 CA310084 BM785229 CR596380 AI741178 BP352907 CA866923 BP351991 CA866664 BC072415 BP378214 Z40228 Z38164 AA745689
 highest scoring ESTs for ZBTB38:AI376649 AI928164 W90534 AI741178 AA176404 AA178877 AA196420 AA258171 AA281121 AA302675 Unigene Cluster for ZBTB38: Zinc finger and BTB domain containing 38 Hs.518301 [show with all ESTs]Unigene Representative Sequence: NM_001080412
GeneLoc Exon Structure
18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000504673 ENST00000512327 ENST00000507722 ENST00000513619 ENST00000513570
ENST00000513258 ENST00000321464 ENST00000506623 ENST00000509842 ENST00000509813
ENST00000503809 ENST00000510338 ENST00000507657 ENST00000514251(uc003etw.2 uc010hun.2 uc010huo.2 uc003ety.2 uc010hup.2)
ENST00000505929 ENST00000513249 ENST00000512276 ENST00000441582
|
Expression
for ZBTB38 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZBTB38 expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching ZBTB38 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 56959_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.91 |
0.94 |
AI376649 |
1.00 |
1.00 |
1.00 |
1 |
| 50266_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.84 |
1.59 |
AI741178 |
1.00 |
0.90 |
0.95 |
1 |
| 53604_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.54 |
0.95 |
AI928164 |
1.00 |
1.00 |
1.00 |
1 |
| 67599_at2, 3
|
U95-E |
1 |
0.75 |
1.00 |
0.38 |
0.56 |
W90534 |
1.00 |
1.00 |
1.00 |
1 |
| 225512_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI005245 |
0.80 |
0.88 |
0.84 |
1 |
| 219221_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_024724 |
0.20 |
1.00 |
0.72 |
1 |
| 230754_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AI928164 |
1.00 |
1.00 |
1.00 |
1 |
| 236557_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AW085625 |
0.80 |
1.00 |
0.91 |
1 |
| 225512_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 219221_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230754_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1558733_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 236557_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZBTB38 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACCAACTAGA
SOURCE GeneReport for Unigene cluster: Hs.518301
SABiosciences Custom PCR Arrays for ZBTB38
|
Orthologs
for ZBTB38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBTB38 gene from 5/7 species (see all 7)
About this table Species with no ortholog for ZBTB38
ENSEMBL Gene Tree for ZBTB38 (if available) |
Paralogs
for ZBTB38 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZBTB38 gene
- ZNF2952 ZBTB332 ZBTB42
ZBTB38 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB38 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
UniProtKB/Swiss-Prot: ZBT38_HUMAN, Q8NAP3Polymorphism: Genetic variations in ZBTB38 influences stature as a quantitative trait type 10 (STQTL10) [MIM:612221].Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a modeltrait for studying genetic influence on quantitative traits
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZBTB38 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBTB38
1 Indel: 59093 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZBTB38 |
|
Disorders & Mutations
for ZBTB38 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB38 for disorders About GeneDecksing
OMIM: 612218
Human Genome Epidemiology (HuGE) Navigator: ZBTB38 (7 documents)
Export disorders and mutations for ZBTB38 gene to outside databases
|
Medical News
for ZBTB38 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZBTB38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/22 PubMed articles for ZBTB38 gene, integrated from 7 sources (see all 22):
(articles sorted by number of sources associating them with ZBTB38)- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
- A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1 Okada Y....Kamatani N. (2010)
- Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010 Oct 21)
- Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1 Kim J.J....Lee J.K. (2010)
- Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PubMed id 20846217)1 Lee J.J....Hirschhorn J. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for ZBTB38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB38 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZBTB38 gene:
Search GeneIP for patents involving ZBTB38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB38 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ZBTB38 |
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