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ZC3H10 Gene

protein-coding GIFtS: 44

GC12P053553

zinc finger CCCH-type containing 10
(Previous name: zinc finger CCCH-type domain containing 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC10)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger CCCH-type containing 10¹ ²
zinc finger CCCH-type domain containing 10¹ ²
FLJ14451¹ ²
ZC3HDC10² ³
zinc finger CCCH domain-containing protein 10²

External Ids:	HGNC: 25893¹	Entrez Gene: 84872²	Ensembl: ENSG00000135482⁷	UniProtKB: Q96K80³

Export aliases for ZC3H10 gene to outside databases

Previous GC identifers: GC12P054799 GC12P056512

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZC3H10 gene promoter:
         RFX1   ATF-2   FOXC1   GR-alpha   ISGF-3   C/EBPalpha   CHOP-10   Max1   c-Myc   c-Jun
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZC3H10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZC3H10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2

ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H10 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P053553: view genomic region (about GC identifiers)

Start:	53,551,163 bp from pter
End:	53,555,411 bp from pter
Size:	4,249 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 56,512,030-56,516,278

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80 (See protein sequence)

Recommended Name: Zinc finger CCCH domain-containing protein 10

Size: 434 amino acids; 46052 Da

Explore the universe of human proteins at neXtProt for ZC3H10: NX_Q96K80

REFSEQ proteins: NP_116175.1

ENSEMBL proteins:

ENSP00000257940

Human Recombinant Proteins

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Assays for ZC3H10:

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	GenScript Custom Assay Services for ZC3H10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZC3H10 for domains About GeneDecksing

1 InterPro domain/family:

IPR000571 Znf_CCCH

Graphical View of Domain Structure for InterPro Entry Q96K80

ProtoNet protein and cluster: Q96K80

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80

Similarity: Contains 3 C3H1-type zinc fingers

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZC3H10 Sigma-Aldrich shRNA for ZC3H10
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZC3H10 OriGene shRNA RFP: ZC3H10 OriGene basic RS shRNA: ZC3H10 OriGene siRNA: ZC3H10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10

miRNA:		Sigma-Aldrich microRNA Mimics for ZC3H10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10
		6 SABiosciences Assays for microRNAs that regulate ZC3H10:
		hsa-miR-1246 hsa-miR-9 hsa-miR-362-3p hsa-miR-1324 hsa-miR-1825 hsa-miR-329

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZC3H10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZC3H10 OriGene untagged cDNA clones in CMV expression vector: ZC3H10 OriGene 3'-UTR clone: ZC3H10 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ZC3H10
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZC3H10

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZC3H10 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZC3H10

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZC3H10

3 Interacting proteins for ZC3H10 (Q96K80²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²	MINT-2877674 MINT-2877693 MINT-2877655
RBPMS	Q93062²	MINT-66274
ZC3H10	Q96K80²	MINT-67043

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZC3H10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZC3H10 Sigma-Aldrich shRNA for ZC3H10
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZC3H10 OriGene shRNA RFP: ZC3H10 OriGene basic RS shRNA: ZC3H10 OriGene siRNA: ZC3H10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10

miRNA:		Sigma-Aldrich microRNA Mimics for ZC3H10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10
		6 SABiosciences Assays for microRNAs that regulate ZC3H10:
		hsa-miR-1246 hsa-miR-9 hsa-miR-362-3p hsa-miR-1324 hsa-miR-1825 hsa-miR-329

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZC3H10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZC3H10 OriGene untagged cDNA clones in CMV expression vector: ZC3H10 OriGene 3'-UTR Clone: ZC3H10 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ZC3H10

Primers:		OriGene genome-wide validated SYBR primer pairs: ZC3H10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZC3H10: PPH24211A

REFSEQ mRNAs for ZC3H10 gene:

NM_032786.1

Additional cDNA sequence:

AK027357.1 BC018708.1 CR613256.1

8 DOTS entries:

DT.110044 DT.121169603 DT.100833901 DT.121169464 DT.91688146 DT.100778958 DT.121169589 DT.95102735

24/77 AceView cDNA sequences (see all 77):

BU621020 AW172460 AI392828 CR613256 BC018708 BE218067 AI939459 CA455322

NM_032786 AK027357 AI758611 BQ448544 CB148206 AI095114 AW272428 AI969773

BU689451 BX331659 BX280083 BQ000497 AU279921 AI217892 BQ073665 AA904967

highest scoring ESTs for ZC3H10:

AI969773 AA035449 AA035476 AA190841 AA653919 AA654323 AI091077 AI192987 AI392828 AI758611

Unigene Cluster for ZC3H10:

Zinc finger CCCH-type containing 10

Hs.632706 [show with all ESTs]

Unigene Representative Sequence: BC018708

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b
SP1:					-		-				-
SP2:											-
SP3:					-		-
SP4:											-

About this scheme

ECgene alternative splicing isoforms for ZC3H10
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000257940(uc001sjp.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZC3H10 expression in normal and diseased human tissues

¹ / ² / ³

2 probe-sets matching ZC3H10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
227430_at²^{, 3}	U133-B	1	0.64	1.00	--	--	AI969773	1.00	1.00	1.00	1
227430_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

ZC3H10 gene electronic northern expression

About these images

CGAP SAGE TAG: CCACACTGAT

SOURCE GeneReport for Unigene cluster: Hs.632706

Primers:		OriGene genome-wide validated SYBR primer pairs: ZC3H10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZC3H10: PPH24211A

SABiosciences Custom PCR Arrays for ZC3H10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H10 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZC3H10¹	--	zinc finger CCCH-type containing 10	94.16(n) 97.24(a)	481106 XM_538227.2 XP_538227.1
chimpanzee (Pan troglodytes)	ZC3H10¹	--	zinc finger CCCH-type containing 10	99.62(n) 99.77(a)	451982 XM_509133.2 XP_509133.2
cow (Bos taurus)	ZC3H10¹	--	zinc finger CCCH-type containing 10	93.7(n) 97.47(a)	507466 XM_584071.3 XP_584071.2
rat (Rattus norvegicus)	Zc3h10¹	--	zinc finger CCCH type containing 10	89.63(n) 96.54(a)	685928 XM_001065797.1 XP_001065797.1
mouse (Mus musculus)	Zc3h10^{1 , 5}	10 (77.01 cM)⁵	zinc finger CCCH type containing 10^{1, 5}	88.71(n)¹ 97.24(a)¹	103284¹ NM_134003.1¹ NP_598764.1¹ AA388165⁵ AI115623⁵ (see all 11)

About this table Species with no ortholog for ZC3H10

ENSEMBL Gene Tree for ZC3H10 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1048539^1,2	C	56515762(+)	`GAACTA/GGGACA`	1	--	ut3¹		3		MN EA NS	362
rs3802996^1,2	C,F	56512258(+)	`GACCCC/TGCATC`	1	--	int¹		3		EA NS	298
rs11171745^1,2	C,F,A,	56512671(+)	`AACCCC/ATCCTC`	1	--	int¹ trp³		8		NS NA EA WA	452
rs11171746^1,2	C,F,A,	56516156(+)	`GGGAAA/GGCTGG`	1	--	ut3¹		7		NS EA NA WA	622
rs12298136^1,2	C,F,	56516770(+)	`TGAAGC/GCTTCA`	1	--	ng3¹		2		NA WA	122
rs36099365^1,2	--	56513450(+)	`CTCTT-/GGGGAA`	1	--	int¹		0	--	--	--	--
rs57280585^1,2	C,F,	56516569(+)	`GGGCTC/GCTAGG`	1	--	ng3¹		1		EA	88
rs58063198^1,2	--	56516529(+)	`TCTGT-/CTGT ATGTG`	1	--	ng3¹		0	--	--	--	--
rs61732294^1,2	--	56514660(+)	`TGGCTA/GTAAGA`	2	Y C	ref¹ mis¹		0	--	--	--	--
rs74094539^1,2	C,F,	56514940(+)	`GACAGG/AGGCTT`	2	/R	syn¹ ref¹		1		WA	50

About this table

HapMap Linkage Disequilibrium images for ZC3H10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZC3H10: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZC3H10

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZC3H10 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZC3H10 (1 document)

Export disorders and mutations for ZC3H10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

8 PubMed articles for ZC3H10 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZC3H10)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. (PubMed id 18814840)¹ Guardiola-Serrano F....Altschmied J. (2008)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84872	HGNC: 25893	AceView: FLJ14451	Ensembl:ENSG00000135482	euGenes: HUgn84872
ECgene: ZC3H10	H-InvDB: ZC3H10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZC3H10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ZC3H10 gene:
Search GeneIP for patents involving ZC3H10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10
	SeqTarget long-range PCR primers for resequencing ZC3H10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZC3H10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10

	GenScript Custom Purified and Recombinant Proteins Services for ZC3H10		GenScript cDNA clones with any tag delivered in your preferred vector for ZC3H10
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ZC3H10 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for ZC3H10 gene

Summaries
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for ZC3H10 gene

Proteins
for ZC3H10 gene

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Gene Function
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Pathways & Interactions
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Drugs & Compounds
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Expression
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Disorders & Mutations
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ZC3H10 Gene

protein-coding GIFtS: 44

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Aliases &
Descriptions
for ZC3H10 gene

Summaries
for ZC3H10 gene

Genomic Views
for ZC3H10 gene

Proteins
for ZC3H10 gene

Protein Domains/
Families
for ZC3H10 gene

Gene Function
for ZC3H10 gene

Pathways & Interactions
for ZC3H10 gene

Drugs & Compounds
for ZC3H10 gene

Transcripts
for ZC3H10 gene

Expression
for ZC3H10 gene

Orthologs
for ZC3H10 gene

Paralogs
for ZC3H10 gene

Genomic Variants
for ZC3H10 gene

Disorders & Mutations
for ZC3H10 gene

Medical News
for ZC3H10 gene

Publications
for ZC3H10 gene

Intellectual Property
for ZC3H10 gene

Products
for ZC3H10 gene