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ZC3H10 Gene

protein-coding   GIFtS: 44

GC12P053553
zinc finger CCCH-type containing 10
(Previous name: zinc finger CCCH-type domain containing 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZC3HDC10)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger CCCH-type containing 101 2
zinc finger CCCH-type domain containing 101 2
FLJ144511 2
ZC3HDC102 3
zinc finger CCCH domain-containing protein 102

External Ids:    HGNC: 258931   Entrez Gene: 848722   Ensembl: ENSG000001354827   UniProtKB: Q96K803   

Export aliases for ZC3H10 gene to outside databases

Previous GC identifers: GC12P054799 GC12P056512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZC3H10 gene promoter:
         RFX1   ATF-2   FOXC1   GR-alpha   ISGF-3   C/EBPalpha   CHOP-10   Max1   c-Myc   c-Jun   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZC3H10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZC3H10 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

ZC3H10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZC3H10 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053553:  view genomic region     (about GC identifiers)

Start:
53,551,163 bp from pter
End:
53,555,411 bp from pter
Size:
4,249 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 56,512,030-56,516,278     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80 (See protein sequence)
Recommended Name: Zinc finger CCCH domain-containing protein 10  
Size: 434 amino acids; 46052 Da

Explore the universe of human proteins at neXtProt for ZC3H10: NX_Q96K80 

REFSEQ proteins: NP_116175.1  

ENSEMBL proteins: 
ENSP00000257940 


Human Recombinant Proteins 
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OriGene Purified Protein: ZC3H10
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Antibodies for ZC3H10: 
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GenScript Custom Superior Antibodies Services for ZC3H10 
Novus Biologicals Antibodies for ZC3H10
Browse antibodies at Epitomics

Assays for ZC3H10: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ZC3H10 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZC3H10 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR000571 Znf_CCCH

Graphical View of Domain Structure for InterPro Entry Q96K80

ProtoNet protein and cluster: Q96K80

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: ZC3HA_HUMAN, Q96K80
Similarity: Contains 3 C3H1-type zinc fingers


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZC3H10
Sigma-Aldrich shRNA for ZC3H10
OriGene 29mer shRNA kits in GFP-retroviral vector: ZC3H10
OriGene shRNA RFP: ZC3H10
OriGene basic RS shRNA: ZC3H10
OriGene siRNA: ZC3H10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10 
miRNA:Sigma-Aldrich microRNA Mimics for ZC3H10
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10 
6 SABiosciences Assays for microRNAs that regulate ZC3H10:
hsa-miR-1246 hsa-miR-9 hsa-miR-362-3p hsa-miR-1324 hsa-miR-1825 hsa-miR-329

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZC3H10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZC3H10
OriGene untagged cDNA clones in CMV expression vector: ZC3H10
OriGene 3'-UTR clone: ZC3H10 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: ZC3H10 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZC3H10 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

ZC3H10 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZC3H10 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZC3H10

3 Interacting proteins for ZC3H10 (Q96K802) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542532MINT-2877674 MINT-2877693 MINT-2877655
RBPMSQ930622MINT-66274
ZC3H10Q96K802MINT-67043
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZC3H10


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZC3H10
Sigma-Aldrich shRNA for ZC3H10
OriGene 29mer shRNA kits in GFP-retroviral vector: ZC3H10
OriGene shRNA RFP: ZC3H10
OriGene basic RS shRNA: ZC3H10
OriGene siRNA: ZC3H10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10 
miRNA: Sigma-Aldrich microRNA Mimics for ZC3H10
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10 
6 SABiosciences Assays for microRNAs that regulate ZC3H10:
hsa-miR-1246 hsa-miR-9 hsa-miR-362-3p hsa-miR-1324 hsa-miR-1825 hsa-miR-329
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZC3H10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZC3H10
OriGene untagged cDNA clones in CMV expression vector: ZC3H10
OriGene 3'-UTR Clone: ZC3H10 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: ZC3H10 
Primers: OriGene genome-wide validated SYBR primer pairs: ZC3H10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZC3H10: PPH24211A

REFSEQ mRNAs for ZC3H10 gene: 

NM_032786.1  

Additional cDNA sequence: 

AK027357.1 BC018708.1 CR613256.1 

8 DOTS entries:

DT.110044  DT.121169603  DT.100833901  DT.121169464  DT.91688146  DT.100778958  DT.121169589  DT.95102735 

24/77 AceView cDNA sequences (see all 77):

BU621020 AW172460 AI392828 CR613256 BC018708 BE218067 AI939459 CA455322 
NM_032786 AK027357 AI758611 BQ448544 CB148206 AI095114 AW272428 AI969773 
BU689451 BX331659 BX280083 BQ000497 AU279921 AI217892 BQ073665 AA904967 

highest scoring ESTs for ZC3H10:

AI969773 AA035449 AA035476 AA190841 AA653919 AA654323 AI091077 AI192987 AI392828 AI758611 

Unigene Cluster for ZC3H10:

Zinc finger CCCH-type containing 10
Hs.632706  [show with all ESTs]
Unigene Representative Sequence: BC018708


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZC3H10

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1:              -     -           -               
SP2:                                -               
SP3:              -     -                           
SP4:                                -               

About this scheme

ECgene alternative splicing isoforms for ZC3H10
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000257940(uc001sjp.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZC3H10 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching ZC3H10 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
227430_at2, 3 U133-B 1 0.64 1.00 -- -- AI969773 1.00 1.00 1.00 1
227430_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZC3H10 gene expression
ZC3H10 gene electronic northern expression
ZC3H10 gene sage expression
About these images

CGAP SAGE TAG: CCACACTGAT

SOURCE GeneReport for Unigene cluster: Hs.632706
Primers: OriGene genome-wide validated SYBR primer pairs: ZC3H10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZC3H10: PPH24211A
    SABiosciences Custom PCR Arrays for ZC3H10 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZC3H10 gene from 5/8 species (see all 8)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZC3H101   -- zinc finger CCCH-type containing 10 94.16(n)
97.24(a)
481106  XM_538227.2  XP_538227.1 
chimpanzee
(Pan troglodytes)
ZC3H101   -- zinc finger CCCH-type containing 10 99.62(n)
99.77(a)
451982  XM_509133.2  XP_509133.2 
cow
(Bos taurus)
ZC3H101   -- zinc finger CCCH-type containing 10 93.7(n)
97.47(a)
507466  XM_584071.3  XP_584071.2 
rat
(Rattus norvegicus)
Zc3h101   -- zinc finger CCCH type containing 10 89.63(n)
96.54(a)
685928  XM_001065797.1  XP_001065797.1 
mouse
(Mus musculus)
Zc3h101 , 5 10 (77.01 cM)5
zinc finger CCCH type containing 101, 5 88.71(n)1
97.24(a)1
1032841  NM_134003.11  NP_598764.11 
 AA3881655  AI1156235  (see all 11)
About this table        Species with no ortholog for ZC3H10

ENSEMBL Gene Tree for ZC3H10 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/29 NCBI SNPs in ZC3H10 are shown (see all 29)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs10485391,2
C56515762(+) GAACTA/GGGACA 1 -- ut313Minor allele frequency- G:0.00MN EA NS 362
rs38029961,2
C,F56512258(+) GACCCC/TGCATC 1 -- int13Minor allele frequency- T:0.01EA NS 298
rs111717451,2
C,F,A,56512671(+) AACCCC/ATCCTC 1 -- int1 trp38Minor allele frequency- A:0.26NS NA EA WA 452
rs111717461,2
C,F,A,56516156(+) GGGAAA/GGCTGG 1 -- ut317Minor allele frequency- G:0.04NS EA NA WA 622
rs122981361,2
C,F,56516770(+) TGAAGC/GCTTCA 1 -- ng312Minor allele frequency- G:0.04NA WA 122
rs360993651,2
--56513450(+) CTCTT-/GGGGAA 1 -- int10--------
rs572805851,2
C,F,56516569(+) GGGCTC/GCTAGG 1 -- ng311Minor allele frequency- G:0.03EA 88
rs580631981,2
--56516529(+) TCTGT-/CTGT  
        
ATGTG
1 -- ng310--------
rs617322941,2
--56514660(+) TGGCTA/GTAAGA 2 Y C ref1 mis10--------
rs740945391,2
C,F,56514940(+) GACAGG/AGGCTT 2 /R syn1 ref11Minor allele frequency- A:0.08WA 50
About this table

HapMap Linkage Disequilibrium images for ZC3H10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ZC3H10: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZC3H10 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZC3H10 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZC3H10 (1 document)

Export disorders and mutations for ZC3H10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

8 PubMed articles for ZC3H10 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZC3H10)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
  5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
  6. Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. (PubMed id 18814840)1 Guardiola-Serrano F....Altschmied J. (2008)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84872 HGNC: 25893 AceView: FLJ14451 Ensembl:ENSG00000135482 euGenes: HUgn84872
ECgene: ZC3H10 H-InvDB: ZC3H10

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZC3H10 gene:
Search GeneIP for patents involving ZC3H10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Predesigned and custom siRNAs for ZC3H10 Antibodies for ZC3H10
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZC3H10
 SeqTarget long-range PCR primers for resequencing ZC3H10
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZC3H10
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZC3H10
 GenScript Custom Purified and Recombinant Proteins Services for ZC3H10 GenScript cDNA clones with any tag delivered in your preferred vector for ZC3H10
 GenScript Custom Assay Services for ZC3H10 GenScript Custom Superior Antibodies Services for ZC3H10
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 Regulatory tfbs in ZC3H10 promoter
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