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ZFAND5 Gene

protein-coding GIFtS: 51

GC09M044789

zinc finger, AN1-type domain 5
(Previous names: zinc finger protein 216, zinc finger, A20 domain containing 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ZNF216, ZA20D2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger, AN1-type domain 5¹ ²		Zinc finger A20 domain-containing protein 2² ³
Zinc finger protein 216¹ ² ³		ZA20D2² ³
ZNF216² ³ ⁵		OTTHUMP00000021471²
ZFAND5A¹ ²		AN1-type zinc finger protein 5²
zinc finger, A20 domain containing 2¹ ²

External Ids:	HGNC: 13008¹	Entrez Gene: 7763²	Ensembl: ENSG00000107372⁷	UniProtKB: O76080³

Export aliases for ZFAND5 gene to outside databases

Previous GC identifers: GC09M074159 GC09M074966

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080

Function: Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also

tumor necrosis (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression

sensitizes cells to TNF-induced apoptosis. Could be involved in regulating NF-kappa-B activation and apoptosis. Is a

potent inhibitory factor for osteoclast differentiation. Involved in protein degradation via the ubiquitin-proteasome

system and plays a critical role in muscle atrophy. May act by anchoring ubiquitinylated proteins to the proteasome,

playing a critical role in protein degradation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZFAND5 gene promoter:
         NF-kappaB   NF-kappaB1   ATF   MEF-2A   RSRFC4   Cdc5   NF-E2   RORalpha2   NF-E2 p45   Arnt
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZFAND5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFAND5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13-q21 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q13-q21

ZFAND5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND5 gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M044789: view genomic region (about GC identifiers)

Start:	44,789,852 bp from pter
End:	44,803,687 bp from pter
Size:	13,836 bases
Orientation:	minus strand

1 alternative location:

Chr9- 74,966,341-74,980,163

RefSeq DNA sequence:

NC_000009.11 NT_008470.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080 (See protein sequence)

Recommended Name: AN1-type zinc finger protein 5

Size: 213 amino acids; 23132 Da

Subunit: homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via

AN1-type domain)

Secondary accessions: A8K484

Explore the universe of human proteins at neXtProt for ZFAND5: NX_O76080

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001095890.1 NP_001095891.1 NP_005998.1

ENSEMBL proteins:

ENSP00000237937 ENSP00000366155 ENSP00000350586 ENSP00000411752 ENSP00000401275 ENSP00000366159

ENSP00000366161

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ZFAND5
	GenScript Custom Purified and Recombinant Proteins Services for ZFAND5
	Novus Biologicals Proteins for ZFAND5
	Novus Biologicals Lysate for ZFAND5
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

About this table

ZFAND5 for ontologies About GeneDecksing

Antibodies for ZFAND5:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZFAND5
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ZFAND5
	Browse antibodies at Epitomics

Assays for ZFAND5:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZFAND5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZFAND5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZFAND5 for domains About GeneDecksing

2 InterPro domains/families:

IPR000058 Znf_AN1

IPR002653 Znf_A20

Graphical View of Domain Structure for InterPro Entry O76080

ProtoNet protein and cluster: O76080

2 Blocks protein families:

IPB000058 Zn-finger

IPB002653 Zn-finger

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080

Domain: The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The

zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity)

Similarity: Contains 1 A20-type zinc finger

Similarity: Contains 1 AN1-type zinc finger

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080

Function: Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also

tumor necrosis (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression

sensitizes cells to TNF-induced apoptosis. Could be involved in regulating NF-kappa-B activation and apoptosis. Is a

potent inhibitory factor for osteoclast differentiation. Involved in protein degradation via the ubiquitin-proteasome

system and plays a critical role in muscle atrophy. May act by anchoring ubiquitinylated proteins to the proteasome,

playing a critical role in protein degradation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZFAND5 Sigma-Aldrich shRNA for ZFAND5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ZFAND5 OriGene shRNA RFP (see all 4): ZFAND5 OriGene basic RS shRNA (see all 4): ZFAND5 OriGene siRNA (see all 3): ZFAND5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFAND5

miRNA:		Sigma-Aldrich microRNA Mimics for ZFAND5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFAND5
		8/35 SABiosciences Assays for microRNAs that regulate ZFAND5 (see all 35):
		hsa-miR-578 hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-556-3p hsa-miR-561 hsa-miR-499-3p hsa-miR-548e

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene untagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene 3'-UTR clone (see all 3): ZFAND5 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZFAND5
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZFAND5

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZFAND5 for ontologies About GeneDecksing

Animal Models: 10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zfand5):

adipose tissue	cardiovascular system	cellular	craniofacial	growth/size
homeostasis/metabolism	lethality-prenatal/perinatal	muscle	respiratory system	skeleton

ZFAND5 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZFAND5

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZFAND5

4 Interacting proteins for ZFAND5 (ENSP00000366155³ O76080²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMD6	Q15008²	MINT-1959040
RAD23B	P54727²	MINT-1977998
FOXO4	ENSP00000363377³	STRING: ENSP00000363377
--	P62988²	MINT-1958898 MINT-1958929 MINT-1958963

About this table

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001944	vasculature development	IEA	--
GO:0003016	respiratory system process	IEA	--
GO:0008150	biological_process	ND	--
GO:0010761	fibroblast migration	IEA	--

About this table

ZFAND5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZFAND5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZFAND5 Sigma-Aldrich shRNA for ZFAND5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ZFAND5 OriGene shRNA RFP (see all 4): ZFAND5 OriGene basic RS shRNA (see all 4): ZFAND5 OriGene siRNA (see all 3): ZFAND5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFAND5

miRNA:		Sigma-Aldrich microRNA Mimics for ZFAND5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFAND5
		8/35 SABiosciences Assays for microRNAs that regulate ZFAND5 (see all 35):
		hsa-miR-578 hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-556-3p hsa-miR-561 hsa-miR-499-3p hsa-miR-548e

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene untagged cDNA clones in CMV expression vector (see all 3): ZFAND5 OriGene 3'-UTR Clone (see all 3): ZFAND5 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZFAND5

Primers:		OriGene genome-wide validated SYBR primer pairs: ZFAND5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZFAND5: PPH19215A

REFSEQ mRNAs for ZFAND5 gene (3 alternative transcripts):

NM_001102420.1 NM_001102421.1 NM_006007.2

Additional cDNA sequence:

AF062346.1 AF062347.1 AK025782.1 AK290849.1 AK307376.1 BC011018.1 BC027707.2 BC073131.1

BX648551.1 BX649046.1 CR612072.1 CR619628.1 CR624137.1 CR624990.1 X75687.1

24/43 DOTS entries (see all 43):

DT.449625 DT.99986394 DT.92007842 DT.95078895 DT.100846038 DT.210220 DT.121193093 DT.99944019

DT.121193065 DT.121193046 DT.215241 DT.121193016 DT.121193129 DT.100846050 DT.101971278 DT.97786306

DT.75119387 DT.121193186 DT.100745043 DT.100846043 DT.100846048 DT.95078891 DT.95078899 DT.95085345

24/737 AceView cDNA sequences (see all 737):

N26016 BE005734 BG057321 CB155401 BM994178 BU619236 AW631275 AK025782

CA748687 AI382512 BP375697 AI421363 BM673681 CB129880 AA974076 AA370253

F01856 BM822686 CA425621 AU133608 CR624990 N67994 T30904 T34827

highest scoring ESTs for ZFAND5:

AF062346 AI825842 AA082696 AA243648 AA314971 AI026003 AI034259 AI094600 AI244054 AI246278

Unigene Cluster for ZFAND5:

Zinc finger, AN1-type domain 5

Hs.406096 [show with all ESTs]

Unigene Representative Sequence: NM_001102420

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND5

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c
SP1:					-
SP2:
SP3:			-		-

About this scheme

ECgene alternative splicing isoforms for ZFAND5
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000237937(uc004aix.2 uc004aiw.2 uc004aiy.2) ENST00000376956

ENST00000343431 ENST00000437241 ENST00000488164 ENST00000456474(uc010mox.1 uc004aiv.2 uc010moy.1)

ENST00000376960 ENST00000487330 ENST00000471197 ENST00000376962

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZFAND5 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching ZFAND5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50763_at²^{, 3}	U95-B	1	1.00	1.00	0.89	0.83	AA779863	0.20	1.00	0.72	1
41542_at²^{, 3}	U95-A	2	1.00	0.97	0.89	1.14	AF062346	1.00	1.00	1.00	1
71025_at²^{, 3}	U95-E	1	0.31	1.00	0.87	1.03	AI825842	1.00	1.00	1.00	1
217741_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW471220	0.60	1.00	0.82	1
210275_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF062347	0.60	1.00	0.82	1
217741_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210275_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

ZFAND5 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ZFAND5 gene electronic northern expression

About these images

CGAP SAGE TAG: TACAGAGGGA

SOURCE GeneReport for Unigene cluster: Hs.406096

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080

Tissue specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain,

fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly

expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung

and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level)

Primers:		OriGene genome-wide validated SYBR primer pairs: ZFAND5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZFAND5: PPH19215A

SABiosciences Custom PCR Arrays for ZFAND5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZFAND5 gene from 5/12 species (see all 12)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZFAND5¹	--	zinc finger, AN1-type domain 5	97.34(n) 100(a)	476324 XM_533526.2 XP_533526.1
chimpanzee (Pan troglodytes)	ZFAND5¹	--	zinc finger, AN1-type domain 5	99.84(n) 100(a)	464527 XM_520073.2 XP_520073.2
cow (Bos taurus)	ZFAND5¹	--	zinc finger, AN1-type domain 5	97.34(n) 98.59(a)	404110 XM_876095.2 XP_881188.1
rat (Rattus norvegicus)	Zfand5¹	--	zinc finger, AN1-type domain 5	95.62(n) 98.12(a)	293960 XM_215251.4 XP_215251.3
mouse (Mus musculus)	Zfand5^{1 , 5}	19 (14.32 cM)⁵	zinc finger, AN1-type domain 5^{1, 5}	96.56(n)¹ 98.59(a)¹	22682¹ NM_009551.3¹ NP_033577.1¹ AA124553⁵ AA415485⁵ (see all 33)

About this table Species with no ortholog for ZFAND5

ENSEMBL Gene Tree for ZFAND5 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZFAND5 gene

ANUBL1² ZFAND6²

ZFAND5 for paralogs About GeneDecksing

Pseudogenes

1 related pseudogene

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs969^1,2	C,F,O,A,H,	74969864(+)	`AGTGGT/CGCTGG`	3	--	ut3¹		14		MN NA NS EA WA	1106
rs3398^1,2	C,F,O,A,H,	74969076(+)	`GAATTA/GTCATA`	3	--	ut3¹		20		MN EA NA NS WA	1450
rs6715^1,2	C,	74969582(-)	`GCACTA/CCTTCT`	3	--	ut3¹ ese³		1		MN	184
rs909170^1,2	--	74978134(-)	`TATTTG/TTTTCT`	3	--	int¹		0	--	--	--	--
rs909171^1,2	H	74978119(-)	`TACAAG/CGGGAA`	3	--	int¹		4		NS EA	418
rs909172^1,2	C,F,O,A,H,	74977980(-)	`CTATGC/TTTTCA`	3	--	int¹		25		NA EA NS WA	3100
rs909173^1,2	H	74977513(-)	`TTGTTA/GTCTCT`	3	--	int¹		8		NA EA MN NS	768
rs909174^1,2	C,F,O,A,	74977457(-)	`ACAAAT/GATTTT`	3	--	int¹		11		MN NS EA NA WA	818
rs1043033^1,2	--	74969578(-)	`TACTTC/TTGATT`	3	--	ut3¹ ese³		1		MN	184
rs1043071^1,2	--	74969494(-)	`TAGTTC/TTGAGT`	3	--	ut3¹ ese³		1		MN	184

About this table

HapMap Linkage Disequilibrium images for ZFAND5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFAND5: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZFAND5

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZFAND5 for disorders About GeneDecksing

OMIM: 604761

Human Genome Epidemiology (HuGE) Navigator: ZFAND5 (2 documents)

Export disorders and mutations for ZFAND5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/13 PubMed articles for ZFAND5 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with ZFAND5)

Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. (PubMed id 9758550)^{1, 2, 3} Scott D.A....Sheffield V.C. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. (PubMed id 14754897)^{1, 2} Huang J....Shu H.-B. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy. (PubMed id 16424905)¹ Hishiya A....Watanabe K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7763	HGNC: 13008	AceView: ZA20D2	Ensembl:ENSG00000107372	euGenes: HUgn7763
ECgene: ZFAND5	H-InvDB: ZFAND5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZFAND5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ZFAND5 gene:
Search GeneIP for patents involving ZFAND5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFAND5
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Search for Antibodies & Assays

	Regulatory tfbs in ZFAND5 promoter
	Search Chromatin IP Primers for ZFAND5
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	SABiosciences Custom PCR Arrays for ZFAND5

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ELISAs and CLIAs for ZFAND5

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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