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ZFP2 Gene

protein-coding   GIFtS: 42

GC05P173049
zinc finger protein 2 homolog (mouse)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 2 homolog (mouse)1 2     zinc finger protein 2 homolog2
ZNF7511 2 3     zfp-22
FLJ216281 2     Zfp-23
Zinc finger protein 7512 3     

External Ids:    HGNC: 261381   Entrez Gene: 801082   Ensembl: ENSG000001989397   UniProtKB: Q6ZN573   

Export aliases for ZFP2 gene to outside databases

Previous GC identifers: GC05P178256 GC05P178257 GC05P178322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57
Function: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance (By
similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP2 gene promoter:
         Cart-1   SRY   C/EBPalpha   MEF-2A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZFP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFP2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

ZFP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP2 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P173049:  view genomic region     (about GC identifiers)

Start:
173,049,444 bp from pter
End:
173,086,824 bp from pter
Size:
37,381 bases
Orientation:
plus strand

1 alternative location:
Chr5+ 178,322,895-178,360,213     
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57 (See protein sequence)
Recommended Name: Zinc finger protein 2 homolog  
Size: 461 amino acids; 52740 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB15104.1; Type=Erroneous initiation;
Secondary accessions: A5PLN5 B7ZM23 Q9H6Z6

Explore the universe of human proteins at neXtProt for ZFP2: NX_Q6ZN57 

REFSEQ proteins: NP_085116.2  

ENSEMBL proteins: 
ENSP00000354453 ENSP00000429095 ENSP00000431074 ENSP00000430980 ENSP00000430531 


Human Recombinant Proteins 
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Novus Biologicals Lysate for ZFP2
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

ZFP2 for ontologies           About GeneDecksing



Antibodies for ZFP2: 
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Assays for ZFP2: 
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ZFP2 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZFP2 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZN57

ProtoNet protein and cluster: Q6ZN57

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 13 C2H2-type zinc fingers


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57
Function: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance (By
similarity)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich esiRNA and siRNA for ZFP2
Sigma-Aldrich shRNA for ZFP2
OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP2
OriGene shRNA RFP: ZFP2
OriGene basic RS shRNA: ZFP2
OriGene siRNA: ZFP2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP2 
miRNA:Sigma-Aldrich microRNA Mimics for ZFP2
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP2 
3 SABiosciences Assays for microRNAs that regulate ZFP2:
hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-664

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZFP2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP2
OriGene untagged cDNA clones in CMV expression vector: ZFP2
OriGene 3'-UTR clone: ZFP2 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: ZFP2 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZFP2 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

ZFP2 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZFP2 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP2

1 Interacting protein for ZFP2 (Q6ZN572) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PTPN12Q052092MINT-61773
About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0045449 regulation of transcription IEA--
About this table

ZFP2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZFP2


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZFP2
Sigma-Aldrich shRNA for ZFP2
OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP2
OriGene shRNA RFP: ZFP2
OriGene basic RS shRNA: ZFP2
OriGene siRNA: ZFP2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP2 
miRNA: Sigma-Aldrich microRNA Mimics for ZFP2
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP2 
3 SABiosciences Assays for microRNAs that regulate ZFP2:
hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-664
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZFP2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP2
OriGene untagged cDNA clones in CMV expression vector: ZFP2
OriGene 3'-UTR Clone: ZFP2 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: ZFP2 
Primers: OriGene genome-wide validated SYBR primer pairs: ZFP2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZFP2: PPH16088A

REFSEQ mRNAs for ZFP2 gene: 

NM_030613.2  

Additional cDNA sequence: 

AK025281.1 AK131367.1 BC132779.1 BC132781.1 BC142989.1 BC144213.1 BC144216.1 

3 DOTS entries:

DT.75198419  DT.411647  DT.120864386 

7 AceView cDNA sequences:

AK131367 NM_030613 BP376633 AK025281 AI908348 AI908349 BQ343739 

highest scoring ESTs for ZFP2:

R07943 AI908348 AK025281 BQ343739 AK131367 AI908349 BP376633 NM_030613 BC132779 BC132781 

Unigene Cluster for ZFP2:

Zinc finger protein 2 homolog (mouse)
Hs.654533  [show with all ESTs]
Unigene Representative Sequence: BC142989


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000361362(uc003mjn.1 uc010jky.2 uc010jkx.1) ENST00000520660
ENST00000520805 ENST00000520301 ENST00000523286

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZFP2 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching ZFP2 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
207757_at2, 3 U133-A 1 0.91 1.00 -- -- NM_030613 0.40 0.67 0.55 1
207757_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZFP2 gene expression
ZFP2 gene electronic northern expression
ZFP2 gene sage expression
About these images

CGAP SAGE TAG: CTGAAGATAA

SOURCE GeneReport for Unigene cluster: Hs.654533
Primers: OriGene genome-wide validated SYBR primer pairs: ZFP2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZFP2: PPH16088A
    SABiosciences Custom PCR Arrays for ZFP2 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZFP2 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
Zfp21 , 5 11 (30.94 cM)5
zinc finger protein 21, 5 84.53(n)1
85.84(a)1
226781  NM_001044699.11  NP_001038164.11 
 AB0103725  AF4835205  (see all 16)
chicken
(Gallus gallus)
LOC4307311   -- hypothetical LOC430731 57.5(n)
50.29(a)
430731  XM_428283.2  XP_428283.2 
worm
(Caenorhabditis elegans)
Y55F3AM.141   -- hypothetical protein 47.28(n)
40.31(a)
190310  NM_067632.1  NP_500033.1 
About this table        Species with no ortholog for ZFP2

ENSEMBL Gene Tree for ZFP2 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZFP2 gene
ZNF712  ZNF162  ZNF5012  ZNF6232  ZNF232  ZNF8522  ZFP32  ZNF1672  
ZNF5022  ZNF2522  ZNF6602  ZNF352  

ZFP2 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/572 NCBI SNPs in ZFP2 are shown (see all 572)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs7325311,2
C,F,O,178337215(-) TTCCAG/TGCTGC 1 -- int111Minor allele frequency- T:0.20NA MN NS EA 730
rs9537401,2
C,F,A,H,178329728(-) ATGAGG/AAGAGA 1 -- int1108Minor allele frequency- A:0.46NS MN EA PA EU CA WA NA 6986
rs9537411,2
C,F,O,A,H,178329846(-) TCCTGA/GGTAAA 1 -- int1110Minor allele frequency- N:0.00EA NA NS PA EU CA WA 7052
rs9610301,2
C,F,O,A,178359136(+) AGTCAA/GTGTGG 2 Q ref1 syn121Minor allele frequency- G:0.28MN EA NA NS WA 3004
rs11377251,2
--178322236(+) aaggcA/Gggagg 1 -- ng510--------
rs11377261,2
C178322279(+) gggcaA/Gcagag 1 -- ng510--------
rs14969481,2
C,F,A,H,178337506(+) GGCCTG/ACACCC 1 -- int113Minor allele frequency- A:0.15MN NS EA NA 1098
rs14969491,2
C,F,O,H,178337776(+) TCCAAA/CCCTCC 1 -- int118Minor allele frequency- C:0.39MN NS EA NA 1332
rs14969501,2
C,F,O,A,H,178338079(+) CTTGGA/TTAAAA 1 -- int111Minor allele frequency- T:0.40NS EA NA WA 638
rs15661051,2
C,F,A,178342035(-) GAACAC/TTCAGa 1 -- int115Minor allele frequency- T:0.22NS EA NA WA 1000
About this table

HapMap Linkage Disequilibrium images for ZFP2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZFP2
     4 CNVs: 81152 64393 93389 59252

QIAGEN SeqTarget long-range PCR primers for resequencing ZFP2 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for ZFP2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZFP2)
  1. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
  2. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80108 HGNC: 26138 AceView: FLJ21628 Ensembl:ENSG00000198939 euGenes: HUgn80108
ECgene: ZFP2 H-InvDB: ZFP2

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZFP2 gene:
Search GeneIP for patents involving ZFP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP2
 SeqTarget long-range PCR primers for resequencing ZFP2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFP2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP2
 GenScript Custom Purified and Recombinant Proteins Services for ZFP2 GenScript cDNA clones with any tag delivered in your preferred vector for ZFP2
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