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ZFP36 Gene

protein-coding GIFtS: 58

GC19P036344

zinc finger protein 36, C3H type, homolog (mouse)
(Previous names: zinc finger protein, C3H type, 36 homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 36, C3H type, homolog (mouse)¹ ²		zinc finger protein, C3H type, 36 homolog (mouse)¹
TTP¹ ² ³ ⁵		tristetraprolin²
TIS11¹ ² ³		GOS24²
G0S24¹ ² ³		tristetraproline²
RNF162A¹ ² ³		zfp-36²
NUP475¹ ²		zinc finger protein, C3H type, 36 homolog²
Zinc finger protein 36 homolog² ³		TIS11A³
Growth factor-inducible nuclear protein NUP475² ³		Protein TIS11A³
G0/G1 switch regulatory protein 24² ³		Zfp-36³

External Ids:	HGNC: 12862¹	Entrez Gene: 7538²	Ensembl: ENSG00000128016⁷	UniProtKB: P26651³

Export aliases for ZFP36 gene to outside databases

Previous GC identifers: GC19P040538 GC19P040288 GC19P044573 GC19P044589 GC19P039897

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651

Function: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth

factors. Has been experimentally shown to be able to bind zinc

Gene Wiki entry for ZFP36

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZFP36 gene promoter:
         NF-kappaB1   AP-1   AhR   c-Fos   c-Jun   NF-kappaB   NF-E2   NF-E2 p45   SRF   CUTL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZFP36

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFP36

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1

ZFP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P036344: view genomic region (about GC identifiers)

Start:	36,344,174 bp from pter
End:	36,346,732 bp from pter
Size:	2,559 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 39,897,453-39,900,013

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651 (See protein sequence)

Recommended Name: Tristetraprolin

Size: 326 amino acids; 34003 Da

Subcellular location: Nucleus

Secondary accessions: B2RA54

Explore the universe of human proteins at neXtProt for ZFP36: NX_P26651

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003398.1

ENSEMBL proteins:

ENSP00000248673

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ZFP36
	GenScript Custom Purified and Recombinant Proteins Services for ZFP36
	Novus Biologicals Protein for ZFP36
	Novus Biologicals Lysate for ZFP36
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10330172
GO:0005737	cytoplasm	IDA	10330172
GO:0005829	cytosol	IDA	10751406

About this table

ZFP36 for ontologies About GeneDecksing

Antibodies for ZFP36:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZFP36
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): ZFP36
	GenScript Custom Superior Antibodies Services for ZFP36
	Novus Biologicals Antibody for ZFP36
	Browse antibodies at Epitomics

Assays for ZFP36:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZFP36
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZFP36

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZFP36 for domains About GeneDecksing

1 InterPro domain/family:

IPR000571 Znf_CCCH

Graphical View of Domain Structure for InterPro Entry P26651

ProtoNet protein and cluster: P26651

1 Blocks protein family: IPB000571 Zn-finger

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651

Similarity: Contains 2 C3H1-type zinc fingers

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651

Function: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth

factors. Has been experimentally shown to be able to bind zinc

Induction: By stimulation with various mitogens

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZFP36 Sigma-Aldrich shRNA for ZFP36
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP36 OriGene shRNA RFP: ZFP36 OriGene basic RS shRNA: ZFP36 OriGene siRNA: ZFP36
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP36

miRNA:		Sigma-Aldrich microRNA Mimics for ZFP36 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP36
		4 SABiosciences Assays for microRNAs that regulate ZFP36:
		hsa-miR-569 hsa-miR-656 hsa-miR-551a hsa-miR-551b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZFP36 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP36 OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFP36 OriGene 3'-UTR clone: ZFP36 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZFP36
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZFP36

Genatlas biochemistry entry for ZFP36:

zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003727	single-stranded RNA binding	TAS	9703499
GO:0003729	mRNA binding	IDA	11782475
GO:0005515	protein binding	IPI	15231747

About this table

ZFP36 for ontologies About GeneDecksing

Animal Models: 11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zfp36):

adipose tissue	cardiovascular system	growth/size	hematopoietic system	immune system
life span-post-weaning/aging	liver/biliary system	renal/urinary system	skeleton	skin/coat/nails
vision/eye

ZFP36 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZFP36

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZFP36

5 Interacting proteins for ZFP36 (P26651^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCP1A	Q9NPI6¹	EBI-374248,EBI-374238
EDC3	Q96F86¹	EBI-374248,EBI-997311
EXOSC8	Q96B26¹	EBI-374248,EBI-371922
UPF2	Q9HAU5¹	EBI-374248,EBI-372073
CCDC85B	Q15834²	MINT-67159

About this table

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	--	--
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	--	--
GO:0006402	mRNA catabolic process	IDA	10751406
GO:0007243	intracellular protein kinase cascade	IEA	--
GO:0043488	regulation of mRNA stability	IEA	--

About this table

ZFP36 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

ZFP36 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZFP36
10/13 Novoseek chemical compound relationships for ZFP36 gene (see all 13)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	66.1	87	20052970 (5), 17105199 (3), 15117938 (3), 10072766 (2) (see all 32)
actinomycin d	37	5	19925787 (2), 16982682 (1), 18523301 (1)
adenine	36	4	19435930 (1), 17599736 (1), 1627834 (1)
cycloheximide	29.2	3	16982682 (1), 9539105 (1), 17369404 (1)
infliximab	27	2	17599736 (2)
butyrate	24.9	6	10367403 (3), 12198173 (1), 16982678 (1)
adenylate	22.2	9	12748283 (3), 17855506 (1), 17964608 (1), 15117938 (1) (see all 5)
mifepristone	19.3	1	16982682 (1)
arsenite	18.6	2	15944294 (1), 16982678 (1)
12-o-tetradecanoylphorbol 13-acetate	13.1	3	1996120 (2), 7615073 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZFP36 Sigma-Aldrich shRNA for ZFP36
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP36 OriGene shRNA RFP: ZFP36 OriGene basic RS shRNA: ZFP36 OriGene siRNA: ZFP36
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP36

miRNA:		Sigma-Aldrich microRNA Mimics for ZFP36 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP36
		4 SABiosciences Assays for microRNAs that regulate ZFP36:
		hsa-miR-569 hsa-miR-656 hsa-miR-551a hsa-miR-551b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZFP36 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP36 OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFP36 OriGene 3'-UTR Clone: ZFP36 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZFP36

Primers:		OriGene genome-wide validated SYBR primer pairs: ZFP36 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZFP36: PPH17294A

REFSEQ mRNAs for ZFP36 gene:

NM_003407.2

Additional cDNA sequence:

AK314042.1 BC009693.1 CR592848.1 CR597101.1 CR597168.1 CR597638.1 CR598791.1 CR603935.1

CR604025.1 CR604446.1 CR604736.1 CR604863.1 CR608862.1 CR609570.1 CR612171.1 CR615025.1

CR615152.1 CR617754.1 CR617965.1 CR618285.1 CR618597.1 CR619778.1 CR620077.1 CR620571.1

CR623140.1 CR623493.1 CR626033.1 CR626058.1 M63625.1 M92843.1

24/33 DOTS entries (see all 33):

DT.95370479 DT.121415663 DT.100846146 DT.100692470 DT.452147 DT.92451941 DT.100684836 DT.100846168

DT.100846149 DT.40255181 DT.100846153 DT.100760728 DT.121415753 DT.121415642 DT.40261034 DT.121415831

DT.121415870 DT.95205743 DT.95221092 DT.99943256 DT.100838912 DT.100846157 DT.100846160 DT.121608692

24/595 AceView cDNA sequences (see all 595):

BU150664 BG413402 CD515325 BX366149 AL048497 BU150391 CR598791 AL551985

BX415525 BQ889345 CR623140 CR612171 AV661270 CN484323 CR604863 NM_003407

BI793300 AI720564 BF725153 BX365199 AA404735 AI769497 AL551830 CR620571

highest scoring ESTs for ZFP36:

M92843 AA043478 AA054267 AA284940 AA287938 AA288002 AA299254 AA394212 AA397613 AA401461

Unigene Cluster for ZFP36:

Zinc finger protein 36, C3H type, homolog (mouse)

Hs.534052 [show with all ESTs]

Unigene Representative Sequence: CR597101

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36

ExUns:	1a	·	1b	·	1c	^	2a	·	2b
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for ZFP36
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000248673(uc002olh.1 uc010egn.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZFP36 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching ZFP36 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40448_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.00	M92843	1.00	1.00	1.00	1
201531_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_003407	0.60	1.00	0.82	1
201531_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

ZFP36 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ZFP36 gene electronic northern expression

About these images

CGAP SAGE TAG: ATGGTGGGGG

SOURCE GeneReport for Unigene cluster: Hs.534052

Expression variation in blood from EXPOLDB for ZFP36

Primers:		OriGene genome-wide validated SYBR primer pairs: ZFP36 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZFP36: PPH17294A

SABiosciences Custom PCR Arrays for ZFP36

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZFP36 gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZFP36¹	--	zinc finger protein 36, C3H type, homolog (mouse)	99.58(n) 99.69(a)	736203 XM_001136016.1 XP_001136016.1
cow (Bos taurus)	ZFP36¹	--	zinc finger protein 36, C3H type, homolog (mouse)	86.27(n) 87.31(a)	282127 NM_174493.1 NP_776918.1
rat (Rattus norvegicus)	Zfp36¹	--	zinc finger protein 36	85.68(n) 86.52(a)	79426 NM_133290.2 NP_579824.1
mouse (Mus musculus)	Zfp36^{1 , 5}	7 (16.72 cM)⁵	zinc finger protein 36^{1, 5}	84.7(n)¹ 86.16(a)¹	22695¹ NM_011756.4¹ NP_035886.1¹ AK154825⁵ AK158286⁵ (see all 12)
zebrafish (Danio rerio)	zgc:114130¹	--	zgc:114130	51.98(n) 47.89(a)	570332 NM_001030247.1 NP_001025418.1

About this table Species with no ortholog for ZFP36

ENSEMBL Gene Tree for ZFP36 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZFP36 gene

ZFP36L1² ZFP36L2²

ZFP36 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs14860^1,2	--	39899924(+)	`TTTTTG/TTAATA`	1	--	ut3¹		1		MN	184
rs251864^1,2	C,F,A,	39897293(+)	`CGGTCA/GCGGCT`	1	--	ng5¹ tfbs³		6		EA MN NS NA	1824
rs565545^1,2	C,A,H	39895580(+)	`ctgggC/Tgaaag`	1	--	ng5¹		2		NA WA	4
rs1803662^1,2	--	39899681(+)	`GCCTTA/CACTGC`	1	--	ut3¹		0	--	--	--	--
rs2229272^1,2	C,F	39898521(+)	`GCCTGC/TCTGGC`	2	P S	ref¹ mis¹ ese³		2		MN NA	136
rs3746083^1,2	C,F,	39898667(+)	`TCGCGA/C/G/T TACAA`	4	R	syn¹ ref¹ ese³		12		EA NS NA WA	2456
rs4446003^1,2	--	39899365(+)	`ATCAGC/GTGGAT`	1	--	ut3¹ ese³		0	--	--	--	--
rs4458127^1,2	--	39899366(+)	`TCAGCG/TGGATC`	1	--	ut3¹ ese³		0	--	--	--	--
rs12975691^1,2	--	39897242(+)	`GCAGGC/GGTCCC`	1	--	ng5¹		0	--	--	--	--
rs17878633^1,2	C,F,	39898467(+)	`CGGGAC/TCCTGG`	2	P S	ref¹ mis¹ ese³		2		NS NA	234

About this table

HapMap Linkage Disequilibrium images for ZFP36 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFP36: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZFP36

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZFP36 for disorders About GeneDecksing

OMIM: 190700

10 Novoseek disease relationships for ZFP36 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	56.7	46	12646273 (2), 11782475 (2), 17599736 (2), 20093488 (2) (see all 26)
tumors	43.2	62	17855506 (3), 12646273 (2), 12789264 (2), 19491267 (2) (see all 33)
arthritis	20	5	16262601 (1), 19215754 (1)
rheumatoid arthritis	18	13	15170914 (2), 15309217 (2), 18536977 (2), 16820934 (1) (see all 7)
inflammation	15.9	14	18682699 (1), 18481987 (1), 16514065 (1), 19106809 (1) (see all 7)
autoimmunity	8.2	3	16262601 (1), 12754205 (1)
hyperplasia	5.84	5	16262601 (1), 19215754 (1)
cervical cancer	0	3	20157568 (2), 20157555 (1)
osteoarthritis	0	3	15170914 (1), 16820934 (1)
cancer	0	7	19491267 (1), 19962963 (1), 17517366 (1), 20335167 (1) (see all 5)

About this table

Human Gene Mutation Database (HGMD): ZFP36
Human Genome Epidemiology (HuGE) Navigator: ZFP36 (1 document)
Tumor Gene Database (TGDB): ZFP36

Export disorders and mutations for ZFP36 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/163 PubMed articles for ZFP36 gene, integrated from 7 sources (see all 163):
(articles sorted by number of sources associating them with ZFP36)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. (PubMed id 2062660)^{1, 2} Taylor G.A.... Blackshear P.J. (1991)
A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. (PubMed id 1699942)^{1, 3} DuBois R.N....Nathans D. (1990)
Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. (PubMed id 15504035)^{1, 7} Cao H. (2004)
Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (PubMed id 15170914)^{1, 7} Tsutsumi A....Sumida T. (2004)
The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. (PubMed id 15187101)^{1, 7} Brooks S.A....Rigby W.F. (2004)
Regulation and localization of endogenous human tristetraprolin. (PubMed id 12823857)^{1, 7} Fairhurst A.M....Wallace P.K. (2003)
The mRNA decay factor tristetraprolin (TTP) induces s enescence in human papillomavirus-transformed cervical cancer cells by targetin g E6-AP ubiquitin ligase. (PubMed id 20157568)^{1, 7} Sanduja S....Dixon D.A. (2009)
Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. (PubMed id 12646273)^{1, 7} Cao H....Blackshear P.J. (2003)
Transcriptional regulation of tristetraprolin by transforming growth factor-beta in human T cells. (PubMed id 12754205)^{1, 7} Ogawa K....Chen Y. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7538	HGNC: 12862	AceView: ZFP36	Ensembl:ENSG00000128016	euGenes: HUgn7538
ECgene: ZFP36	H-InvDB: ZFP36

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/zfp36/

Intellectual Property for ZFP36 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ZFP36 gene:
Search GeneIP for patents involving ZFP36

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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ZFP36 Gene

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ZFP36 Gene

protein-coding GIFtS: 58

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