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ZFP36 Gene

protein-coding   GIFtS: 58

GC19P036344
zinc finger protein 36, C3H type, homolog (mouse)
(Previous names: zinc finger protein, C3H type, 36 homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 36, C3H type, homolog (mouse)1 2     zinc finger protein, C3H type, 36 homolog (mouse)1
TTP1 2 3 5     tristetraprolin2
TIS111 2 3     GOS242
G0S241 2 3     tristetraproline2
RNF162A1 2 3     zfp-362
NUP4751 2     zinc finger protein, C3H type, 36 homolog2
Zinc finger protein 36 homolog2 3     TIS11A3
Growth factor-inducible nuclear protein NUP4752 3     Protein TIS11A3
G0/G1 switch regulatory protein 242 3     Zfp-363

External Ids:    HGNC: 128621   Entrez Gene: 75382   Ensembl: ENSG000001280167   UniProtKB: P266513   

Export aliases for ZFP36 gene to outside databases

Previous GC identifers: GC19P040538 GC19P040288 GC19P044573 GC19P044589 GC19P039897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
Function: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth
factors. Has been experimentally shown to be able to bind zinc

Gene Wiki entry for ZFP36

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP36 gene promoter:
         NF-kappaB1   AP-1   AhR   c-Fos   c-Jun   NF-kappaB   NF-E2   NF-E2 p45   SRF   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZFP36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFP36 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

ZFP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036344:  view genomic region     (about GC identifiers)

Start:
36,344,174 bp from pter
End:
36,346,732 bp from pter
Size:
2,559 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 39,897,453-39,900,013     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651 (See protein sequence)
Recommended Name: Tristetraprolin  
Size: 326 amino acids; 34003 Da
Subcellular location: Nucleus
Secondary accessions: B2RA54

Explore the universe of human proteins at neXtProt for ZFP36: NX_P26651 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003398.1  

    ENSEMBL proteins: 
    ENSP00000248673 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ZFP36
    GenScript Custom Purified and Recombinant Proteins Services for ZFP36 
    Novus Biologicals Protein for ZFP36
    Novus Biologicals Lysate for ZFP36
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA10330172
    GO:0005737 cytoplasm IDA10330172
    GO:0005829 cytosol IDA10751406
    About this table

    ZFP36 for ontologies           About GeneDecksing



    Antibodies for ZFP36: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZFP36
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): ZFP36
    GenScript Custom Superior Antibodies Services for ZFP36 
    Novus Biologicals Antibody for ZFP36
    Browse antibodies at Epitomics

    Assays for ZFP36: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFP36 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZFP36 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZFP36 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry P26651

    ProtoNet protein and cluster: P26651

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Similarity: Contains 2 C3H1-type zinc fingers


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Function: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth
    factors. Has been experimentally shown to be able to bind zinc
    Induction: By stimulation with various mitogens

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZFP36
    Sigma-Aldrich shRNA for ZFP36
    OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP36
    OriGene shRNA RFP: ZFP36
    OriGene basic RS shRNA: ZFP36
    OriGene siRNA: ZFP36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP36 
    miRNA:Sigma-Aldrich microRNA Mimics for ZFP36
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP36 
    4 SABiosciences Assays for microRNAs that regulate ZFP36:
    hsa-miR-569 hsa-miR-656 hsa-miR-551a hsa-miR-551b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZFP36
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP36
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFP36
    OriGene 3'-UTR clone: ZFP36 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZFP36 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZFP36 

    Genatlas biochemistry entry for ZFP36:
    zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0003727 single-stranded RNA binding TAS9703499
    GO:0003729 mRNA binding IDA11782475
    GO:0005515 protein binding IPI15231747
    About this table

    ZFP36 for ontologies           About GeneDecksing

    Animal Models: 11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfp36):

    adipose tissuecardiovascular systemgrowth/sizehematopoietic systemimmune system
    life span-post-weaning/agingliver/biliary systemrenal/urinary systemskeletonskin/coat/nails
    vision/eye

    ZFP36 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZFP36 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP36

    5 Interacting proteins for ZFP36 (P266511, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP1AQ9NPI61EBI-374248,EBI-374238
    EDC3Q96F861EBI-374248,EBI-997311
    EXOSC8Q96B261EBI-374248,EBI-371922
    UPF2Q9HAU51EBI-374248,EBI-372073
    CCDC85BQ158342MINT-67159
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ----
    GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening ----
    GO:0006402 mRNA catabolic process IDA10751406
    GO:0007243 intracellular protein kinase cascade IEA--
    GO:0043488 regulation of mRNA stability IEA--
    About this table

    ZFP36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ZFP36 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP36
    10/13 Novoseek chemical compound relationships for ZFP36 gene (see all 13)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.1 87 20052970 (5), 17105199 (3), 15117938 (3), 10072766 (2) (see all 32)
    actinomycin d 37 5 19925787 (2), 16982682 (1), 18523301 (1)
    adenine 36 4 19435930 (1), 17599736 (1), 1627834 (1)
    cycloheximide 29.2 3 16982682 (1), 9539105 (1), 17369404 (1)
    infliximab 27 2 17599736 (2)
    butyrate 24.9 6 10367403 (3), 12198173 (1), 16982678 (1)
    adenylate 22.2 9 12748283 (3), 17855506 (1), 17964608 (1), 15117938 (1) (see all 5)
    mifepristone 19.3 1 16982682 (1)
    arsenite 18.6 2 15944294 (1), 16982678 (1)
    12-o-tetradecanoylphorbol 13-acetate 13.1 3 1996120 (2), 7615073 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZFP36
    Sigma-Aldrich shRNA for ZFP36
    OriGene 29mer shRNA kits in GFP-retroviral vector: ZFP36
    OriGene shRNA RFP: ZFP36
    OriGene basic RS shRNA: ZFP36
    OriGene siRNA: ZFP36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFP36 
    miRNA: Sigma-Aldrich microRNA Mimics for ZFP36
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFP36 
    4 SABiosciences Assays for microRNAs that regulate ZFP36:
    hsa-miR-569 hsa-miR-656 hsa-miR-551a hsa-miR-551b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZFP36
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZFP36
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFP36
    OriGene 3'-UTR Clone: ZFP36 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZFP36 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZFP36
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZFP36: PPH17294A

    REFSEQ mRNAs for ZFP36 gene: 

    NM_003407.2  

    Additional cDNA sequence: 

    AK314042.1 BC009693.1 CR592848.1 CR597101.1 CR597168.1 CR597638.1 CR598791.1 CR603935.1 
    CR604025.1 CR604446.1 CR604736.1 CR604863.1 CR608862.1 CR609570.1 CR612171.1 CR615025.1 
    CR615152.1 CR617754.1 CR617965.1 CR618285.1 CR618597.1 CR619778.1 CR620077.1 CR620571.1 
    CR623140.1 CR623493.1 CR626033.1 CR626058.1 M63625.1 M92843.1 

    24/33 DOTS entries (see all 33):

    DT.95370479  DT.121415663  DT.100846146  DT.100692470  DT.452147  DT.92451941  DT.100684836  DT.100846168 
    DT.100846149  DT.40255181  DT.100846153  DT.100760728  DT.121415753  DT.121415642  DT.40261034  DT.121415831 
    DT.121415870  DT.95205743  DT.95221092  DT.99943256  DT.100838912  DT.100846157  DT.100846160  DT.121608692 

    24/595 AceView cDNA sequences (see all 595):

    BU150664 BG413402 CD515325 BX366149 AL048497 BU150391 CR598791 AL551985 
    BX415525 BQ889345 CR623140 CR612171 AV661270 CN484323 CR604863 NM_003407 
    BI793300 AI720564 BF725153 BX365199 AA404735 AI769497 AL551830 CR620571 

    highest scoring ESTs for ZFP36:

    M92843 AA043478 AA054267 AA284940 AA287938 AA288002 AA299254 AA394212 AA397613 AA401461 

    Unigene Cluster for ZFP36:

    Zinc finger protein 36, C3H type, homolog (mouse)
    Hs.534052  [show with all ESTs]
    Unigene Representative Sequence: CR597101


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              

    About this scheme

    ECgene alternative splicing isoforms for ZFP36
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248673(uc002olh.1 uc010egn.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZFP36 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching ZFP36 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40448_at2, 3 U95-A 1 0.81 1.00 1.00 1.00 M92843 1.00 1.00 1.00 1
    201531_at2, 3 U133-A 1 0.91 1.00 -- -- NM_003407 0.60 1.00 0.82 1
    201531_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    ZFP36 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZFP36 gene expression
    ZFP36 gene electronic northern expression
    ZFP36 gene sage expression
    About these images

    CGAP SAGE TAG: ATGGTGGGGG

    SOURCE GeneReport for Unigene cluster: Hs.534052

    Expression variation in blood from EXPOLDB for ZFP36

    Primers: OriGene genome-wide validated SYBR primer pairs: ZFP36
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZFP36: PPH17294A
        SABiosciences Custom PCR Arrays for ZFP36 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZFP36 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ZFP361   -- zinc finger protein 36, C3H type, homolog (mouse) 99.58(n)
    99.69(a)
    736203  XM_001136016.1  XP_001136016.1 
    cow
    (Bos taurus)
    ZFP361   -- zinc finger protein 36, C3H type, homolog (mouse) 86.27(n)
    87.31(a)
    282127  NM_174493.1  NP_776918.1 
    rat
    (Rattus norvegicus)
    Zfp361   -- zinc finger protein 36 85.68(n)
    86.52(a)
    79426  NM_133290.2  NP_579824.1 
    mouse
    (Mus musculus)
    Zfp361 , 5 7 (16.72 cM)5
    zinc finger protein 361, 5 84.7(n)1
    86.16(a)1
    226951  NM_011756.41  NP_035886.11 
     AK1548255  AK1582865  (see all 12)
    zebrafish
    (Danio rerio)
    zgc:1141301   -- zgc:114130 51.98(n)
    47.89(a)
    570332  NM_001030247.1  NP_001025418.1 
    About this table        Species with no ortholog for ZFP36

    ENSEMBL Gene Tree for ZFP36 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZFP36 gene
    ZFP36L12  ZFP36L22  

    ZFP36 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/49 NCBI SNPs in ZFP36 are shown (see all 49)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs148601,2
    --39899924(+) TTTTTG/TTAATA 1 -- ut311Minor allele frequency- T:0.00MN 184
    rs2518641,2
    C,F,A,39897293(+) CGGTCA/GCGGCT 1 -- ng51 tfbs36Minor allele frequency- G:0.30EA MN NS NA 1824
    rs5655451,2
    C,A,H39895580(+) ctgggC/Tgaaag 1 -- ng512Minor allele frequency- T:0.00NA WA 4
    rs18036621,2
    --39899681(+) GCCTTA/CACTGC 1 -- ut310--------
    rs22292721,2
    C,F39898521(+) GCCTGC/TCTGGC 2 P S ref1 mis1 ese32Minor allele frequency- T:0.01MN NA 136
    rs37460831,2
    C,F,39898667(+) TCGCGA/C/G/
            
    TACAA
    4 R syn1 ref1 ese312EA NS NA WA 2456
    rs44460031,2
    --39899365(+) ATCAGC/GTGGAT 1 -- ut31 ese30--------
    rs44581271,2
    --39899366(+) TCAGCG/TGGATC 1 -- ut31 ese30--------
    rs129756911,2
    --39897242(+) GCAGGC/GGTCCC 1 -- ng510--------
    rs178786331,2
    C,F,39898467(+) CGGGAC/TCCTGG 2 P S ref1 mis1 ese32Minor allele frequency- T:0.01NS NA 234
    About this table

    HapMap Linkage Disequilibrium images for ZFP36 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZFP36: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ZFP36 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFP36 for disorders           About GeneDecksing

    OMIM: 190700

    10 Novoseek disease relationships for ZFP36 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 46 12646273 (2), 11782475 (2), 17599736 (2), 20093488 (2) (see all 26)
    tumors 43.2 62 17855506 (3), 12646273 (2), 12789264 (2), 19491267 (2) (see all 33)
    arthritis 20 5 16262601 (1), 19215754 (1)
    rheumatoid arthritis 18 13 15170914 (2), 15309217 (2), 18536977 (2), 16820934 (1) (see all 7)
    inflammation 15.9 14 18682699 (1), 18481987 (1), 16514065 (1), 19106809 (1) (see all 7)
    autoimmunity 8.2 3 16262601 (1), 12754205 (1)
    hyperplasia 5.84 5 16262601 (1), 19215754 (1)
    cervical cancer 0 3 20157568 (2), 20157555 (1)
    osteoarthritis 0 3 15170914 (1), 16820934 (1)
    cancer 0 7 19491267 (1), 19962963 (1), 17517366 (1), 20335167 (1) (see all 5)
    About this table

    Human Gene Mutation Database (HGMD): ZFP36
    Human Genome Epidemiology (HuGE) Navigator: ZFP36 (1 document)
    Tumor Gene Database (TGDB): ZFP36

    Export disorders and mutations for ZFP36 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/163 PubMed articles for ZFP36 gene, integrated from 7 sources (see all 163):
    (articles sorted by number of sources associating them with ZFP36)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. (PubMed id 2062660)1, 2 Taylor G.A.... Blackshear P.J. (1991)
    3. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. (PubMed id 1699942)1, 3 DuBois R.N....Nathans D. (1990)
    4. Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. (PubMed id 15504035)1, 7 Cao H. (2004)
    5. Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (PubMed id 15170914)1, 7 Tsutsumi A....Sumida T. (2004)
    6. The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. (PubMed id 15187101)1, 7 Brooks S.A....Rigby W.F. (2004)
    7. Regulation and localization of endogenous human tristetraprolin. (PubMed id 12823857)1, 7 Fairhurst A.M....Wallace P.K. (2003)
    8. The mRNA decay factor tristetraprolin (TTP) induces s enescence in human papillomavirus-transformed cervical cancer cells by targetin g E6-AP ubiquitin ligase. (PubMed id 20157568)1, 7 Sanduja S....Dixon D.A. (2009)
    9. Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. (PubMed id 12646273)1, 7 Cao H....Blackshear P.J. (2003)
    10. Transcriptional regulation of tristetraprolin by transforming growth factor-beta in human T cells. (PubMed id 12754205)1, 7 Ogawa K....Chen Y. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7538 HGNC: 12862 AceView: ZFP36 Ensembl:ENSG00000128016 euGenes: HUgn7538
    ECgene: ZFP36 H-InvDB: ZFP36

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    NIEHS-SNPshttp://egp.gs.washington.edu/data/zfp36/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for ZFP36 gene:
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