Aliases &
Descriptions
for ZFR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger RNA binding protein1 2 | | ZFR11 2 | | M-phase phosphoprotein homolog2 3 | | hZFR2 3 | | zinc finger RNA-binding protein2 | | FLJ413122 |
Export aliases for ZFR gene to outside databasesPrevious GC identifers: GC05M032141 GC05M032800 GC05M032354 GC05M032399 |
Summaries
for ZFR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmicshuttling of STAU2. Binds to DNA and RNA (By similarity)
|
Genomic Views
for ZFR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFR gene promoter:
YY1 p300 AhR Arnt POU2F1 HNF-4alpha2 COUP-TF1 Pax-5 ER-alpha ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFR  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.3 Ensembl cytogenetic band: 5p13.3 HGNC cytogenetic band: 5p15.2ZFR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M032390: view genomic region
(about GC identifiers)
Start:
|
32,321,365 bp from pter |
End:
|
32,444,867 bp from pter |
Size:
|
123,503 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.9 NT_006576.16
|
Proteins
for ZFR gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1 (See
protein sequence)Recommended Name: Zinc finger RNA-binding protein Size: 1074 amino acids; 117012 Da
Subunit: Found in a cytoplasmic RNP complex with STAU2. Interacts with STAU2. Does not interact with STAU1 (Bysimilarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasmic granule (By similarity).Chromosome (By similarity). Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendriticcompartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity)
Sequence caution: Sequence=AAD40385.1; Type=Erroneous initiation; Sequence=AAH30540.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI07418.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15147.1; Type=Erroneous initiation;Sequence=CAC40818.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC40818.1;Type=Frameshift; Positions=1057;
Secondary accessions: B2RNR5 Q05C08 Q3B7X5 Q6P5A3 Q86UA0 Q9H6V4 Q9NTI1 Q9Y687Explore the universe of human proteins at neXtProt for ZFR: NX_Q96KR1
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057191.2
ENSEMBL proteins: ENSP00000422300 ENSP00000393243 ENSP00000371560 ENSP00000265069
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZFR for ontologies About GeneDecksing
Antibodies for ZFR:
Assays for ZFR: |
Protein
Domains/
Families
for ZFR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFR for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96KR1ProtoNet protein and cluster: Q96KR1 1 Blocks protein family: IPB003604 Zn-finger
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1Similarity: Contains 1 DZF domain |
Gene Function
for ZFR gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmicshuttling of STAU2. Binds to DNA and RNA (By similarity)
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZFR for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zfr):
ZFR for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZFR gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZFR
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFR
1 Interacting protein for ZFR (Q96KR12) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
About this table
ZFR for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ZFR for compounds About GeneDecksing
 Browse Tocris compounds for ZFR
1  Novoseek chemical compound relationship for ZFR gene
About this table
|
Transcripts
for ZFR gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZFR gene: NM_016107.3 Additional cDNA sequence: AF100742.1 AJ314790.1 AK025481.1 AK055938.1 AK123306.1 AK292214.1 AK295297.1 AK307808.1 AK309638.1 AL137258.1 BC017879.1 BC030540.1 BC038973.1 BC051893.1 BC062986.1 BC107417.1 BC137084.1 BC137085.1 U00951.1 U00960.1 9 DOTS entries: DT.447844 DT.91759257 DT.40111860 DT.95123261 DT.101966650 DT.120816384 DT.120816377 DT.112477 DT.121366606 24/308 AceView cDNA sequences (see all 308): AW963207 AI435114 BP873250 AW245266 BM769158 AK025481 AA450197 AI554259 BM699032 BQ694032 NM_016107 BX955036 BX472923 AI355964 AI459130 AA322086 BQ219704 AI198040 BF431469 BX115375 AI239441 AA506082 BX503021 AA928638
 highest scoring ESTs for ZFR:AI459274 AU117155 BC030540 BF105996 BF576282 BG023720 BG026250 BG542107 BG622066 BM801813 Unigene Cluster for ZFR: Zinc finger RNA binding protein Hs.435231 [show with all ESTs]Unigene Representative Sequence: NM_016107
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFR (see all 8)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | |
About this scheme
ECgene alternative splicing isoforms for ZFR
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507465 ENST00000502988 ENST00000416900 ENST00000382126 ENST00000510369
ENST00000514356 ENST00000265069(uc010ium.1 uc011cny.1 uc003jhr.1)
ENST00000505204 ENST00000505366(uc010iun.1)
|
Expression
for ZFR gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZFR expression in normal and diseased human tissues
1 / 2 / 3 11 probe-sets matching ZFR gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33148_at2, 3
|
U133-A |
1 |
0.94 |
1.00 |
0.91 |
0.32 |
AI459274 |
0.80 |
1.00 |
0.91 |
1 |
| 40610_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
0.74 |
1.21 |
AI743507 |
0.60 |
1.00 |
0.82 |
1 |
| 48848_at2, 3
|
U95-B |
1 |
0.69 |
1.00 |
0.87 |
1.49 |
AW009457 |
0.60 |
1.00 |
0.82 |
1 |
| 213286_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
BF445199 |
0.60 |
1.00 |
0.82 |
1 |
| 201856_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 33148_at2, 3
|
U133-A |
1 |
0.94 |
1.00 |
-- |
-- |
AI459274 |
0.80 |
1.00 |
0.91 |
1 |
| 201857_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_016107 |
0.60 |
1.00 |
0.82 |
1 |
| 213286_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201856_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 33148_at2
|
U133Plus2 |
1 |
0.94 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201857_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZFR for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACATTCTTGT
SOURCE GeneReport for Unigene cluster: Hs.435231
Expression variation in blood from EXPOLDB for ZFR UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1Tissue specificity: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney
SABiosciences Custom PCR Arrays for ZFR
|
Orthologs
for ZFR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZFR gene from 5/10 species (see all 10)
About this table Species with no ortholog for ZFR
ENSEMBL Gene Tree for ZFR (if available) |
Paralogs
for ZFR gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZFR gene
- ZFR22 ILF22 STRBP2 ILF32
ZFR for paralogs About GeneDecksing
|
Genomic Variants
for ZFR gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZFR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZFR
1 CNV: 3552 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZFR |
|
Disorders & Mutations
for ZFR gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for ZFR gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZFR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/35 PubMed articles for ZFR gene, integrated from 7 sources (see all 35):
(articles sorted by number of sources associating them with ZFR)- Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. (PubMed id 11574164)1, 2, 3 Kleines M.... Schaade L. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
|
External Searches for ZFR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFR gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZFR gene:
Search GeneIP for patents involving ZFR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFR gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for ZFR |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ZFR |
| |
|
|
