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ZFYVE16 Gene

protein-coding   GIFtS: 52

GC05P074911
zinc finger, FYVE domain containing 16
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for ZFYVE16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
zinc finger, FYVE domain containing 161 2     DKFZp686E131622
KIAA03051 2 3     zinc finger FYVE domain-containing protein 162
Endosome-associated FYVE domain protein2 3     endosome-associated FYVE-domain protein2
OTTHUMP000002222272     ENDOFIN2
OTTHUMP000002222262     Endofin3

External Ids:    HGNC: 207561   Entrez Gene: 97652   Ensembl: ENSG000000393197   UniProtKB: Q7Z3T83   

Export aliases for ZFYVE16 gene to outside databases

Previous GC identifers: GC05P079942 GC05P079742 GC05P079787 GC05P079739


Summaries
for ZFYVE16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZFYVE16:
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is
characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of
the molecule (Seet et al., 2004 (PubMed 14613930)).(supplied by OMIM)

UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
Function: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome
aggregation. Required to target TOM1 to endosomes

Gene Wiki entry for ZFYVE16

Genomic Views
for ZFYVE16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE16 gene promoter:
         AP-1   POU2F1   PPAR-gamma1   PPAR-gamma2   Sp1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPbeta   E4BP4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZFYVE16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZFYVE16 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5p15.2-q14.3

ZFYVE16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE16 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P074911:  view genomic region     (about GC identifiers)

Start:
 74,911,945 bp from pter
End:
 74,983,612 bp from pter
Size:
 71,668 bases
Orientation:
 plus strand

1 alternative location:
Chr5+ 79,703,832-79,775,498     
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  

Proteins
for ZFYVE16 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 16  
Size: 1539 amino acids; 168903 Da
Subunit: Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2
Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early
endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P)
Sequence caution: Sequence=BAA20764.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O15023 Q5H9U2 Q7LAU7 Q86T69 Q8N5L3 Q8NEK3
Alternative splicing: 2 isoforms:  Q7Z3T8-1   Q7Z3T8-3   

Explore the universe of human proteins at neXtProt for ZFYVE16: NX_Q7Z3T8 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001098721.1  NP_055548.3  


    ENSEMBL proteins: 
    ENSP00000426536 ENSP00000426500 ENSP00000421785 ENSP00000337159 ENSP00000400229 ENSP00000423663 
    ENSP00000426848 ENSP00000422356 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ZFYVE16 
    Novus Biologicals Proteins for ZFYVE16
    Novus Biologicals Lysate for ZFYVE16
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005769 early endosome IDA11546807
    GO:0016020 membrane IEA--
    GO:0031901 early endosome membrane TAS--
    About this table

    ZFYVE16 for ontologies           About GeneDecksing



    Antibodies for ZFYVE16: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZFYVE16
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ZFYVE16 
    Novus Biologicals Antibodies for ZFYVE16
    Browse antibodies at Epitomics

    Assays for ZFYVE16: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFYVE16 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for ZFYVE16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFYVE16 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000306 Znf_FYVE
     IPR017165 Znf_FYVE_SARA/endofin
     IPR013083 Znf_RING/FYVE/PHD
     IPR017455 Znf_FYVE-rel
     IPR022557 DUF3480

    Graphical View of Domain Structure for InterPro Entry Q7Z3T8

    ProtoNet protein and cluster: Q7Z3T8

    1 Blocks protein family: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
    Domain: The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates
    the association with PI3P
    Similarity: Contains 1 FYVE-type zinc finger


    Gene Function
    for ZFYVE16 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
    Function: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome
    aggregation. Required to target TOM1 to endosomes

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZFYVE16
    Sigma-Aldrich shRNA for ZFYVE16
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZFYVE16
    OriGene shRNA RFP (see all 2): ZFYVE16
    OriGene basic RS shRNA (see all 2): ZFYVE16
    OriGene siRNA (see all 2): ZFYVE16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFYVE16 
    miRNA:Sigma-Aldrich microRNA Mimics for ZFYVE16
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFYVE16 
    8/19 SABiosciences Assays for microRNAs that regulate ZFYVE16 (see all 19):
    hsa-miR-137 hsa-miR-106a hsa-miR-578 hsa-miR-944 hsa-miR-340 hsa-miR-221 hsa-miR-519a hsa-miR-511

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZFYVE16
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZFYVE16
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFYVE16
    OriGene 3'-UTR clone (see all 2): ZFYVE16 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZFYVE16 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ZFYVE16 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI14613930
    GO:0005545 phosphatidylinositol binding IDA11546807
    GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA11433298
    GO:0008270 zinc ion binding IEA--
    GO:0008565 protein transporter activity IMP11546807
    About this table

    ZFYVE16 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZFYVE16 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ZFYVE16 for pathways           About GeneDecksing

    2 Kegg Pathways  (Kegg details for ZFYVE16):
        hsa04144 Endocytosis
    hsa04350 TGF-beta signaling pathway

        SABiosciences Custom Pathway-Focused PCR Arrays for ZFYVE16 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFYVE16

    5/26 Interacting proteins for ZFYVE16 (ENSP000003371593 Q7Z3T81, 2) via UniProtKB, MINT, and/or STRING (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362STRING: ENSP00000326031 MINT-62205
    EEA1Q150751EBI-298055,EBI-298113
    TOM1O607841EBI-298055,EBI-74634
    RNF11Q9Y3C52MINT-60843
    BMP2ENSP000003681043STRING: ENSP00000368104
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006622 protein targeting to lysosome IMP11546807
    GO:0007165 signal transduction NAS11546807
    GO:0016050 vesicle organization NAS11546807
    GO:0016197 endosome transport IMP11546807
    GO:0030100 regulation of endocytosis TAS11546807
    About this table

    ZFYVE16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFYVE16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ZFYVE16 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFYVE16
    1 Novoseek chemical compound relationship for ZFYVE16 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 49.5 3 19887107 (1)
    About this table



    Transcripts
    for ZFYVE16 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZFYVE16
    Sigma-Aldrich shRNA for ZFYVE16
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZFYVE16
    OriGene shRNA RFP (see all 2): ZFYVE16
    OriGene basic RS shRNA (see all 2): ZFYVE16
    OriGene siRNA (see all 2): ZFYVE16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZFYVE16 
    miRNA: Sigma-Aldrich microRNA Mimics for ZFYVE16
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZFYVE16 
    8/19 SABiosciences Assays for microRNAs that regulate ZFYVE16 (see all 19):
    hsa-miR-137 hsa-miR-106a hsa-miR-578 hsa-miR-944 hsa-miR-340 hsa-miR-221 hsa-miR-519a hsa-miR-511
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZFYVE16
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZFYVE16
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZFYVE16
    OriGene 3'-UTR Clone (see all 2): ZFYVE16 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZFYVE16 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZFYVE16
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZFYVE16: PPH20763A

    REFSEQ mRNAs for ZFYVE16 gene (2 alternative transcripts): 

    NM_001105251.1  NM_014733.3  

    Additional cDNA sequence: 

    AB002303.1 AF434817.1 AK090896.1 AK127003.1 AL833087.2 BC030808.1 BX537424.1 CR933621.1 

    13 DOTS entries:

    DT.75161116  DT.101983544  DT.75135092  DT.416510  DT.101983543  DT.75100255  DT.92429515  DT.100025221 
    DT.120873316  DT.425603  DT.95259779  DT.120873281  DT.40215515 

    24/160 AceView cDNA sequences (see all 160):

    AA815426 AV717110 AI243668 BQ884268 AA349901 AA235268 AA828247 BM052837 
    N21588 BM976393 AL705583 AI493297 AA864794 AA443383 BX106860 AF434817 
    AA349613 BM052610 CB216048 N23475 C01346 AA349902 CA393193 AA349612 

    highest scoring ESTs for ZFYVE16:

    AB002303 AA028938 AA028939 AA349612 AA349901 AA360667 AA443383 AA447356 AA483588 AA632051 

    Unigene Cluster for ZFYVE16:

    Zinc finger, FYVE domain containing 16
    Hs.482660  [show with all ESTs]
    Unigene Representative Sequence: NM_001105251


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE16 (see all 8)

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                -           -                                   -     -                                               -                     
    SP2:                          -     -           -                                   -     -                                               -                     
    SP3:                                                                                                        -                             -                     
    SP4:                          -     -           -                                   -     -                                                                     
    SP5:                          -     -                                                                                                                           

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          

    About this scheme

    ECgene alternative splicing isoforms for ZFYVE16
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511829 ENST00000509558 ENST00000510995(uc010jak.1) ENST00000513789
    ENST00000512442 ENST00000507548 ENST00000338008 ENST00000425484(uc003kgr.3 uc003kgq.3 uc003kgs.3 uc003kgt.3)
    ENST00000512907(uc003kgu.3) ENST00000512558(uc003kgp.2) ENST00000511050
    ENST00000510158 ENST00000505560 ENST00000509562

    Expression
    for ZFYVE16 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZFYVE16 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching ZFYVE16 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37914_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB002303 1.00 1.00 1.00 1
    203651_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014733 0.60 1.00 0.82 1
    203651_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555011_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    1554638_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    ZFYVE16 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZFYVE16 gene expression
    ZFYVE16 gene electronic northern expression
    ZFYVE16 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.482660

    Expression variation in blood from EXPOLDB for ZFYVE16

    UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
    Tissue specificity: Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in
    heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes

    Primers: OriGene genome-wide validated SYBR primer pairs: ZFYVE16
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZFYVE16: PPH20763A
        SABiosciences Custom PCR Arrays for ZFYVE16 


    Orthologs
    for ZFYVE16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZFYVE16 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZFYVE161   -- zinc finger, FYVE domain containing 16 89.68(n)
    85.28(a)    		 479167  XM_536310.2  XP_536310.2 
    chimpanzee
    (Pan troglodytes)    		 ZFYVE161   -- zinc finger, FYVE domain containing 16 99.26(n)
    98.44(a)    		 461775  XM_001135982.1  XP_001135982.1 
    cow
    (Bos taurus)    		 ZFYVE161   -- zinc finger, FYVE domain containing 16 89.4(n)
    84.43(a)    		 536671  XM_866874.2  XP_871967.2 
    rat
    (Rattus norvegicus)    		 Zfyve161   -- zinc finger, FYVE domain containing 16 80.28(n)
    73.17(a)    		 499508  XM_574833.2  XP_574833.2 
    mouse
    (Mus musculus)    		 Zfyve161 , 5 13 (47.72 cM)5
    		 zinc finger, FYVE domain containing 161, 5 81.46(n)1
    74.19(a)1    		 2184411  NM_173392.21  NP_775568.11 
     AI0356325  AK0450905  (see all 11)
    About this table        Species with no ortholog for ZFYVE16

    ENSEMBL Gene Tree for ZFYVE16 (if available)

    Paralogs
    for ZFYVE16 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZFYVE16 gene
    ZFYVE92  ENSG000002350482  

    ZFYVE16 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFYVE16 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/608 NCBI SNPs in ZFYVE16 are shown (see all 608)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs104331,2
    		C,F,A,H,79774906(-) TGAATG/ATAGAG 1 -- ut3113Minor allele frequency- A:0.12MN NA EA WA 546
    rs1660621,2
    		C,F,O,A,H,79773028(-) AAAAAC/AAAAAA 1 -- int1 trp38Minor allele frequency- A:0.11NA EA 286
    rs1689381,2
    		C,H79719852(+) ctccaT/Cctccc 1 -- int15Minor allele frequency- C:0.10NA WA 10
    rs1689391,2
    		C,F,O,A,H,79735858(+) TGAGTG/ATTAAC 1 -- int113Minor allele frequency- A:0.21NS EA NA WA 766
    rs1735991,2
    		C,F,79760522(-) tttacT/Aagagt 1 -- int111Minor allele frequency- A:0.10NS EA NA WA 632
    rs1740751,2
    		C,F,O,79740313(+) TTTTCA/GTAACC 1 -- int111Minor allele frequency- G:0.09NS EA NA WA 1224
    rs1851001,2
    		C,F,O,A,79751819(+) AGTGCG/CTTTTG 1 -- int124Minor allele frequency- C:0.21EA NA MN NS WA 1434
    rs1874791,2
    		C,F,O,A,79774171(-) TACACC/TGGTGT 1 -- ut31 ese314Minor allele frequency- T:0.10MN EA NA NS WA 2386
    rs1923131,2
    		C,F,A,79721720(-) TAGGCA/CATGGC 1 -- int113Minor allele frequency- C:0.21NS EA NA WA 690
    rs1945391,2
    		C,F,O,A,H,79737669(+) GATCAA/GTTTGG 1 -- int120Minor allele frequency- N:0.00NS EA NA WA 1100
    About this table

    HapMap Linkage Disequilibrium images for ZFYVE16 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZFYVE16: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ZFYVE16 

    Disorders & Mutations
    for ZFYVE16 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFYVE16 for disorders           About GeneDecksing

    OMIM: 608880


    Export disorders and mutations for ZFYVE16 gene to outside databases

    Medical News
    for ZFYVE16 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for ZFYVE16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/27 PubMed articles for ZFYVE16 gene, integrated from 7 sources (see all 27):
    (articles sorted by number of sources associating them with ZFYVE16)
    1. Endofin, an endosomal FYVE domain protein. (PubMed id 11546807)1, 2, 3, 7 Seet L.-F. and Hong W. (2001)
    2. Endofin recruits TOM1 to endosomes. (PubMed id 14613930)1, 2, 7 Seet L.-F.... Hong W. (2004)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    7. EGF-induced tyrosine phosphorylation of Endofin is de pendent on PI3K activity and proper localization to endosomes. (PubMed id 19887107)1, 7 Toy W....Lim Y.P. (2010)
    8. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling. (PubMed id 17272273)1, 7 Chen Y.G....Lu Z. (2007)
    9. Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells. (PubMed id 17570516)1, 7 Chen Y....Lim Y.P. (2007)
    10. Endofin acts as a Smad anchor for receptor activation in BMP signaling. (PubMed id 17356069)1, 7 Shi W....Cao X. (2007)

    External Searches for ZFYVE16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    Genome Databases showing ZFYVE16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9765 HGNC: 20756 AceView: ZFYVE16 Ensembl:ENSG00000039319 euGenes: HUgn9765
    ECgene: ZFYVE16 Kegg: 9765 H-InvDB: ZFYVE16

    Other Databases showing ZFYVE16 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0305

    Specialized Databases showing ZFYVE16 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for ZFYVE16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for ZFYVE16 gene:
    Search GeneIP for patents involving ZFYVE16

    GeneCards and IP:
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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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