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Aliases & Descriptionsfor ZNF136 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions zinc finger protein 1361 2 pHZ-201 2 zinc finger protein 136 (clone pHZ-20)1 OTTHUMP000002098712
Export aliases for ZNF136 gene to outside databases Previous GC identifers: GC19P012405 GC19P012496 GC19P012119 GC19P012134 GC19P012037 GC19P012273
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Summariesfor ZNF136 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 Function : May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused witha heterologous protein containing a KRAB B-domain
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Genomic Viewsfor ZNF136 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF136 gene promoter: GCNF-1 GCNF-2 PPAR-gamma1 PPAR-gamma2 RORalpha1 p300 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF136 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF136
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2-p13.12 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19q13.2 ZNF136 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P011848: view genomic region
(about GC identifiers )
Start:
11,848,917 bp from pter
End:
11,875,108 bp from pter
Size:
26,192 bases
Orientation:
plus strand
1 alternative location : Chr 19+ 12,273,879-12,300,064
RefSeq DNA sequence: NC_000019.9 NT_011295.11
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Proteinsfor ZNF136 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 (See
protein sequence )Recommended Name: Zinc finger protein 136 Size : 540 amino acids; 62784 Da
Subcellular location : Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF136: NX_P52737
REFSEQ proteins: NP_003428.1 ENSEMBL proteins: ENSP00000388759 ENSP00000344162 ENSP00000397176 ENSP00000403707 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
ZNF136 for ontologies About GeneDecksing Antibodies for ZNF136: Assays for ZNF136:
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Protein
Domains/ Familiesfor ZNF136 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF136 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P52737 ProtoNet protein and cluster: P52737
2 Blocks protein families : IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 14 C2H2-type zinc fingersSimilarity : Contains 1 KRAB domain
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Gene Functionfor ZNF136 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 Function : May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused witha heterologous protein containing a KRAB B-domain
Genatlas biochemistry entry for ZNF136 :zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily) 5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):
About this table
ZNF136 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF136 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for ZNF136 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF136 1 Interacting protein for ZNF136 (P52737 1 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
TAS 7649249 GO:0006355 regulation of transcription, DNA-dependent
IEA --
About this table
ZNF136 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF136 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for ZNF136
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Transcriptsfor ZNF136 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for ZNF136 gene: NM_003437.3
Additional cDNA sequence: AK123008.1 AK291242.1 AK299601.1 AY500356.1 BC006421.1 U09367.1
4 DOTS entries : DT.206860 DT.91686143 DT.95366624 DT.102822301
24/43 AceView cDNA sequences (see all 43 ):
BM905782 NM_003437 BQ440904 BU541852 BE677097 W67486 BU542575 CA417915 BQ574220 AW949871 BI259319 BX420069 BM049625 BM049184 BX106718 BF962022 BI035607 BX452164 BM457272 BX956550 AL710695 AY500356 AI538106 U09367
highest scoring ESTs for ZNF136 :U09367 AA384071 AL710695 AW949871 BE936480 BF183055 BM046955 BM049184 BM049625 BM457272 Unigene Cluster for ZNF136:
Zinc finger protein 136 Hs.479874 [show with all ESTs ] Unigene Representative Sequence: AK123008 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136 ExUns: 1a · 1b ^ 2 ^ 3a · 3b SP1 :           SP2 :          
About this scheme ECgene alternative splicing isoforms for ZNF136 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000464860 ENST00000439995 ENST00000343979 (uc002mti.2 uc010xmh.1 )ENST00000418338 ENST00000476676 ENST00000425827
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Expression for ZNF136 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section ZNF136 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching ZNF136 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
38603_at2 , 3
U95-A
1
1.00
1.00
1.00
1.00
U09367
1.00
0.90
0.95
1
206240_s_at2 , 3
U133-A
1
0.91
1.00
--
--
NM_003437
0.60
1.00
0.82
1
206240_s_at2
U133Plus2
1
0.91
1.00
--
--
--
--
--
--
--
About this table
ZNF136 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AATTTCATAG SOURCE GeneReport for Unigene cluster: Hs.479874 Expression variation in blood from EXPOLDB for ZNF136
UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 Tissue specificity : Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney andpancreas
SABiosciences Custom PCR Arrays for ZNF136
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Orthologsfor ZNF136 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for ZNF136 gene from 1 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
fruit fly (Drosophila melanogaster)
CG117623
85A9
--
41(a) (best of 3)
--
About this table Species with no ortholog for ZNF136 ENSEMBL Gene Tree for ZNF136 (if available)
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Paralogsfor ZNF136 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for ZNF136 gene ZNF669 2 ZNF564 2 ZNF490 2 ZNF441 2 ZNF878 2 ZNF14 2 ENSG00000196826 2 ZNF700 2 ZNF69 2 ZNF440 2 ZNF443 2 ZNF44 2 ZNF439 2 ZNF823 2 ZNF491 2 ZNF861P 2 ZNF555 2 ZNF709 2 ZNF625 2 ZNF799 2 ZNF20 2 ZNF101 2 ZNF791 2 ZNF442 2 ZNF57 2 ZNF433 2 ZNF563 2 ZNF627 2 ZNF556 2 ZNF670 2 ZNF763 2 ZNF124 2 ZNF844 2
ZNF136 for paralogs About GeneDecksing
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Genomic Variantsfor ZNF136 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 19 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for ZNF136 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF136: --
QIAGEN SeqTarget long-range PCR primers for resequencing ZNF136
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Disorders & Mutationsfor ZNF136 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF136 for disorders About GeneDecksing
OMIM: 604078 Export disorders and mutations for ZNF136 gene to outside databases
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Medical Newsfor ZNF136 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor ZNF136 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 9 PubMed articles for ZNF136 gene integrated from 7 sources : (articles sorted by number of sources associating them with ZNF136) Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990) 1 , 2 , 3 Tommerup N. and Vissing H. (1995) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249) 1 , 2 Vissing H.... Thiesen H.-J. (1995) An empirical framework for binary interactome mapping . (PubMed id 19060904) 1 Venkatesan K....Vidal M. (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130) 1 Abrink M.... Hellman L. (1995)
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External Searches for ZNF136 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF136 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF136 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF136 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ZNF136 gene: Search GeneIP for patents involving ZNF136 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF136 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for ZNF136
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