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ZNF136 Gene

protein-coding   GIFtS: 45

GC19P011848
zinc finger protein 136
(Previous name: zinc finger protein 136 (clone pHZ-20) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 1361 2
pHZ-201 2
zinc finger protein 136 (clone pHZ-20)1
OTTHUMP000002098712

External Ids:    HGNC: 129201   Entrez Gene: 76952   Ensembl: ENSG000001966467   UniProtKB: P527373   

Export aliases for ZNF136 gene to outside databases

Previous GC identifers: GC19P012405 GC19P012496 GC19P012119 GC19P012134 GC19P012037 GC19P012273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with
a heterologous protein containing a KRAB B-domain


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF136 gene promoter:
         GCNF-1   GCNF-2   PPAR-gamma1   PPAR-gamma2   RORalpha1   p300   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF136

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF136 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2-p13.12   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19q13.2

ZNF136 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF136 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P011848:  view genomic region     (about GC identifiers)

Start:
11,848,917 bp from pter
End:
11,875,108 bp from pter
Size:
26,192 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 12,273,879-12,300,064     
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 (See protein sequence)
Recommended Name: Zinc finger protein 136  
Size: 540 amino acids; 62784 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF136: NX_P52737 

REFSEQ proteins: NP_003428.1  

ENSEMBL proteins: 
ENSP00000388759 ENSP00000344162 ENSP00000397176 ENSP00000403707 


Human Recombinant Proteins 
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Novus Biologicals Lysate for ZNF136
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

ZNF136 for ontologies           About GeneDecksing



Antibodies for ZNF136: 
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GenScript Custom Assay Services for ZNF136 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for ZNF136 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF136 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P52737

ProtoNet protein and cluster: P52737

2 Blocks protein families:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 14 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with
a heterologous protein containing a KRAB B-domain

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF136
Sigma-Aldrich shRNA for ZNF136
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF136
OriGene shRNA RFP: ZNF136
OriGene basic RS shRNA: ZNF136
OriGene siRNA: ZNF136
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF136 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF136 
1 SABiosciences Assays for microRNA that regulate ZNF136:
hsa-miR-188-3p

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF136
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF136
OriGene untagged cDNA clones in CMV expression vector: ZNF136
OriGene 3'-UTR clone: ZNF136 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF136 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZNF136 

Genatlas biochemistry entry for ZNF136:
zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily)

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding ----
GO:0003677 DNA binding IEA--
GO:0003704 specific RNA polymerase II transcription factor activity TAS7649249
GO:0003714 transcription corepressor activity TAS7649249
GO:0005515 protein binding IPI16189514
About this table

ZNF136 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF136 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF136

1 Interacting protein for ZNF136 (P527371) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
MDFIQ997501EBI-749129,EBI-724076
About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS7649249
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table

ZNF136 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF136


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF136
Sigma-Aldrich shRNA for ZNF136
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF136
OriGene shRNA RFP: ZNF136
OriGene basic RS shRNA: ZNF136
OriGene siRNA: ZNF136
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF136 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF136 
1 SABiosciences Assays for microRNA that regulate ZNF136:
hsa-miR-188-3p
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF136
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF136
OriGene untagged cDNA clones in CMV expression vector: ZNF136
OriGene 3'-UTR Clone: ZNF136 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF136 
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF136
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for ZNF136

REFSEQ mRNAs for ZNF136 gene: 

NM_003437.3  

Additional cDNA sequence: 

AK123008.1 AK291242.1 AK299601.1 AY500356.1 BC006421.1 U09367.1 

4 DOTS entries:

DT.206860  DT.91686143  DT.95366624  DT.102822301 

24/43 AceView cDNA sequences (see all 43):

BM905782 NM_003437 BQ440904 BU541852 BE677097 W67486 BU542575 CA417915 
BQ574220 AW949871 BI259319 BX420069 BM049625 BM049184 BX106718 BF962022 
BI035607 BX452164 BM457272 BX956550 AL710695 AY500356 AI538106 U09367 

highest scoring ESTs for ZNF136:

U09367 AA384071 AL710695 AW949871 BE936480 BF183055 BM046955 BM049184 BM049625 BM457272 

Unigene Cluster for ZNF136:

Zinc finger protein 136
Hs.479874  [show with all ESTs]
Unigene Representative Sequence: AK123008


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:                              
SP2:                              

About this scheme

ECgene alternative splicing isoforms for ZNF136
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000464860 ENST00000439995 ENST00000343979(uc002mti.2 uc010xmh.1)
ENST00000418338 ENST00000476676 ENST00000425827

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF136 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching ZNF136 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38603_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U09367 1.00 0.90 0.95 1
206240_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_003437 0.60 1.00 0.82 1
206240_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

ZNF136 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZNF136 gene expression
ZNF136 gene electronic northern expression
ZNF136 gene sage expression
About these images

CGAP SAGE TAG: AATTTCATAG

SOURCE GeneReport for Unigene cluster: Hs.479874

Expression variation in blood from EXPOLDB for ZNF136

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and
pancreas

Primers: OriGene genome-wide validated SYBR primer pairs: ZNF136
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for ZNF136
    SABiosciences Custom PCR Arrays for ZNF136 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF136 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
fruit fly
(Drosophila melanogaster)
CG117623 85A9   -- 41(a)
(best of 3)
  --
About this table        Species with no ortholog for ZNF136

ENSEMBL Gene Tree for ZNF136 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF136 gene
ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF8782  ZNF142  ENSG000001968262  ZNF7002  
ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  ZNF8232  ZNF4912  ZNF861P2  
ZNF5552  ZNF7092  ZNF6252  ZNF7992  ZNF202  ZNF1012  ZNF7912  ZNF4422  
ZNF572  ZNF4332  ZNF5632  ZNF6272  ZNF5562  ZNF6702  ZNF7632  ZNF1242  
ZNF8442  

ZNF136 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/13 NCBI SNPs in ZNF136 are shown (see all 13)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs104259951,2
C,F,12297513(+) TGTATA/GTGGAG 2 Y C ref1 mis1 ese38Minor allele frequency- G:0.01NS EA 840
rs116673401,2
C,F,H,12299400(+) ttaaaG/Ctactt 1 -- ut31 ese35Minor allele frequency- C:0.01NS EA NA 492
rs341510351,2
C,12297493(+) GTGAAA/GCTCTG 2 K ref1 syn11Minor allele frequency- G:0.01NA 74
rs359977831,2
--12297705(+) TGTAA-/GGGAAT 3 K R fra1 ref10--------
rs360261611,2
--12297514(+) TATAT-/GGGAGA 3 Y X fra1 ref10--------
rs455638351,2
--12299902(+) GTCAGC/TAAATA 1 -- ut310--------
rs617298921,2
12298717(+) AAGGAA/GTGTGG 2 E ref1 syn10--------
rs617474381,2
--12298276(+) GGAGAA/GAAACC 2 E ref1 syn10--------
rs762141481,2
--12299057(+) AACCCA/GTATTT 1 -- ut310--------
rs780015661,2
C,12298743(+) CCGTGC/TCAGCT 2 A V ref1 mis11Minor allele frequency- T:0.01EA 88
About this table

HapMap Linkage Disequilibrium images for ZNF136 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ZNF136: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF136 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF136 for disorders           About GeneDecksing

OMIM: 604078


Export disorders and mutations for ZNF136 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

9 PubMed articles for ZNF136 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF136)
  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (1995)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (1995)
  4. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1 Abrink M.... Hellman L. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7695 HGNC: 12920 AceView: ZNF136 Ensembl:ENSG00000196646 euGenes: HUgn7695
ECgene: ZNF136 H-InvDB: ZNF136

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF136 gene:
Search GeneIP for patents involving ZNF136

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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