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ZNF19 Gene

protein-coding   GIFtS: 47

GC16M057276
zinc finger protein 19
(Previous name: zinc finger protein 19 (KOX 12) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 191 2
KOX121 2 3 5
zinc finger protein 19 (KOX 12)1 2
MGC510211 2
Zinc finger protein KOX122 3

External Ids:    HGNC: 129811   Entrez Gene: 75672   Ensembl: ENSG000001574297   UniProtKB: P170233   

Export aliases for ZNF19 gene to outside databases

Previous GC identifers: GC16U990061 GC16M072231 GC16M071217 GC16M071284 GC16M070065 GC16M071507


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF19:
The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription
factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16.
(provided by RefSeq)

UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF19 gene promoter:
         NRSF form 1   NRSF form 2   HNF-1A   AML1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22

ZNF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF19 gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M057276:  view genomic region     (about GC identifiers)

Start:
57,276,019 bp from pter
End:
57,291,299 bp from pter
Size:
15,281 bases
Orientation:
minus strand

1 alternative location:
Chr16- 71,507,486-71,523,241     
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023 (See protein sequence)
Recommended Name: Zinc finger protein 19  
Size: 458 amino acids; 52449 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAA36814.1; Type=Erroneous initiation;
Secondary accessions: A8K895 Q86Y66 Q8NDE2 Q96M79 Q96NE5
Alternative splicing: 2 isoforms:  P17023-1   P17023-2   

Explore the universe of human proteins at neXtProt for ZNF19: NX_P17023 

REFSEQ proteins: NP_008892.2  

ENSEMBL proteins: 
ENSP00000288177 ENSP00000384271 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus NAS7557990
About this table

ZNF19 for ontologies           About GeneDecksing



Antibodies for ZNF19: 
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Uscn ELISAs and CLIAs for ZNF19 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF19 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P17023

ProtoNet protein and cluster: P17023

2 Blocks protein families:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 10 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023
Function: May be involved in transcriptional regulation

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZNF19
Sigma-Aldrich shRNA for ZNF19
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF19
OriGene shRNA RFP (see all 2): ZNF19
OriGene basic RS shRNA (see all 2): ZNF19
OriGene siRNA: ZNF19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF19 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF19 
2 SABiosciences Assays for microRNAs that regulate ZNF19:
hsa-miR-580 hsa-miR-597

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF19
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF19
OriGene untagged cDNA clones in CMV expression vector: ZNF19
OriGene 3'-UTR clone: ZNF19 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF19 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZNF19 

Genatlas biochemistry entry for ZNF19:
zinc finger protein 19 (KOX12) (C2H2 type,Kruppel-like)

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding ----
GO:0003677 DNA binding IEA--
GO:0003700 sequence-specific DNA binding transcription factor activity NAS7557990
GO:0008270 zinc ion binding IEA--
GO:0030528 transcription regulator activity ----
About this table

ZNF19 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF19 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF19

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent NAS7557990
GO:0045449 regulation of transcription ----
About this table

ZNF19 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF19


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZNF19
Sigma-Aldrich shRNA for ZNF19
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF19
OriGene shRNA RFP (see all 2): ZNF19
OriGene basic RS shRNA (see all 2): ZNF19
OriGene siRNA: ZNF19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF19 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF19 
2 SABiosciences Assays for microRNAs that regulate ZNF19:
hsa-miR-580 hsa-miR-597
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF19
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF19
OriGene untagged cDNA clones in CMV expression vector: ZNF19
OriGene 3'-UTR Clone: ZNF19 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF19 
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF19
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF19: PPH23366A

REFSEQ mRNAs for ZNF19 gene: 

NM_006961.3  

Additional cDNA sequence: 

AK055567.1 AK057330.1 AK292260.1 AK311003.1 AL834237.1 BC047091.1 X52343.1 

10 DOTS entries:

DT.95272837  DT.99948028  DT.309678  DT.100756801  DT.120663172  DT.120663131  DT.120663181  DT.40113788 
DT.95190248  DT.95272841 

24/132 AceView cDNA sequences (see all 132):

BT007400 AL833815 AI937864 BQ000009 CK429424 AA026601 BX537507 CF890829 
AA805092 BM465669 AW160828 BM310653 X52347 BC007256 N47634 BX098236 
AK091039 CD623493 AF507946 CB265954 BM022007 BU684801 NM_145911 BM021862 

highest scoring ESTs for ZNF19:

AI567345 DB037765 DB053318 DB079697 DB079826 DB094852 DB100078 NM_152907 AI655693 AK057330 

Unigene Cluster for ZNF19:

Zinc finger protein 19
Hs.660076  [show with all ESTs]
Unigene Representative Sequence: NM_006961


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF19 (see all 6)

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1:                          -     -                             -                                       
SP2:                                -                 -     -     -                                       
SP3:                                                                                                      
SP4:                          -                                                                           
SP5:                                -                             -                                       

About this scheme

ECgene alternative splicing isoforms for ZNF19
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000288177(uc002fak.1 uc010cgc.1 uc002fal.1 uc002fam.1)
ENST00000408023

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF19 expression in normal and diseased human tissues

1  / 2  / 3

8 probe-sets matching ZNF19 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
57108_at2, 3 U95-C 1 0.69 1.00 0.51 1.29 AI655693 0.60 0.62 0.61 1
53695_at2, 3 U95-B 1 0.69 1.00 0.76 0.80 AW003084 0.60 0.62 0.61 1
234953_x_at2 U133-B 30 1.00 0.65 -- -- -- -- -- -- --
228958_at2, 3 U133-B 1 0.82 1.00 -- -- AW003084 0.60 0.62 0.61 1
240836_at2, 3 U133-B 1 0.46 1.00 -- -- AI655693 0.60 0.62 0.61 1
234953_x_at2 U133Plus2 30 1.00 0.65 -- -- -- -- -- -- --
228958_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
240836_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
About this table

ZNF19 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZNF19 gene expression
ZNF19 gene electronic northern expression
ZNF19 gene sage expression
About these images

CGAP SAGE TAG: CCTGAAGCTA

SOURCE GeneReport for Unigene cluster: Hs.660076
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF19
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF19: PPH23366A
    SABiosciences Custom PCR Arrays for ZNF19 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF19 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZNF191   -- zinc finger protein 19 87.87(n)
82.81(a)
489721  XM_546841.2  XP_546841.2 
chimpanzee
(Pan troglodytes)
ZNF191   -- zinc finger protein 19 99.34(n)
98.69(a)
468018  XM_523410.2  XP_523410.2 
cow
(Bos taurus)
ZNF191   -- zinc finger protein 19 85(n)
81.48(a)
532079  XM_610589.3  XP_610589.3 
About this table        Species with no ortholog for ZNF19

ENSEMBL Gene Tree for ZNF19 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF19 gene
ZNF6212  ZNF6192  ZNF6202  

ZNF19 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/130 NCBI SNPs in ZNF19 are shown (see all 130)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs22884861,2
C,F,A,H,71513034(-) GTTCTG/TTCACA 1 -- int128Minor allele frequency- N:0.00EA NA NS WA 3166
rs22884871,2
C,F,71509588(+) AAGTAG/AGGGTG 2 /L ref1 syn1 ese311Minor allele frequency- A:0.30EA NA NS WA 2258
rs22884881,2
C,F,71509634(+) TCATAG/CGGTTT 2 /P ref1 syn1 ese32Minor allele frequency- C:0.27EA NA 1538
rs22884891,2
C,F,O,A,71509685(+) CTACTC/GGTGAA 2 T syn1 ref123Minor allele frequency- N:0.00EA NS NA WA 2436
rs38137431,2
C,F,A,H,71523051(+) CCACAA/GTTGTA 1 -- int117Minor allele frequency- G:0.44EA NS NA WA 2080
rs42758571,2
C71522028(+) gaggcA/Caaggt 1 -- int13Minor allele frequency- C:0.33NA WA 6
rs46194131,2
C,F,H,71523527(+) CCTGGA/TTGCTT 1 -- ng5114Minor allele frequency- T:0.00NS EA NA WA 850
rs47888051,2
C,F,H,71514638(+) CTAGAA/Gcagtg 1 -- int113Minor allele frequency- G:0.13NS EA NA WA 596
rs71871651,2
C,F,A,71524543(+) CATGAT/CCCAGG 1 -- ng5118Minor allele frequency- C:0.49NS EA NA WA 1200
rs71873541,2
C,F,A,H,71524632(+) TATCCC/TGAGTT 1 -- ng5112Minor allele frequency- T:0.43NS EA NA WA 592
About this table

HapMap Linkage Disequilibrium images for ZNF19 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ZNF19: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF19 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF19 for disorders           About GeneDecksing

OMIM: 194525


Export disorders and mutations for ZNF19 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/12 PubMed articles for ZNF19 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with ZNF19)
  1. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 2, 3 Bray P.L.... Dawid I.B. (1991)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P....Ward D.C. (1992)
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7567 HGNC: 12981 AceView: ZNF19andZNF23 Ensembl:ENSG00000157429 euGenes: HUgn7567
ECgene: ZNF19 H-InvDB: ZNF19

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF19 gene:
Search GeneIP for patents involving ZNF19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF19
 SeqTarget long-range PCR primers for resequencing ZNF19
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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