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ZNF215 Gene

protein-coding   GIFtS: 45

GC11P006606
zinc finger protein 215
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 2151 2     BAZ22 3
ZKSCAN111 2 3     BAZ-22 3
Zinc finger protein with KRAB and SCAN domains 112 3     BAZ 22
BWSCR2-associated zinc finger protein 22 3     

External Ids:    HGNC: 130071   Entrez Gene: 77622   Ensembl: ENSG000001490547   UniProtKB: Q9UL583   

Export aliases for ZNF215 gene to outside databases

Previous GC identifers: GC11P007690 GC11P007408 GC11P006906 GC11P006911 GC11P006904


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN215_HUMAN, Q9UL58
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF215 gene promoter:
         LCR-F1   GATA-1   AP-2rep   C/EBPalpha   CHOP-10   GR-alpha   GR-beta   Bach1   NF-AT3   NF-AT1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF215

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF215 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ZNF215 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF215 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006606:  view genomic region     (about GC identifiers)

Start:
6,606,247 bp from pter
End:
6,637,874 bp from pter
Size:
31,628 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 6,947,654-7,005,469     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN215_HUMAN, Q9UL58 (See protein sequence)
Recommended Name: Zinc finger protein 215  
Size: 517 amino acids; 60034 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF215: NX_Q9UL58 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_037382.2  

    ENSEMBL proteins: 
    ENSP00000299468 ENSP00000393202 ENSP00000278319 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus NAS--
    About this table

    ZNF215 for ontologies           About GeneDecksing



    Antibodies for ZNF215: 
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    Browse antibodies at Epitomics

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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZNF215 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF215 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9UL58

    ProtoNet protein and cluster: Q9UL58

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN


    UniProtKB/Swiss-Prot: ZN215_HUMAN, Q9UL58
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZN215_HUMAN, Q9UL58
    Function: May be involved in transcriptional regulation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZNF215
    Sigma-Aldrich shRNA for ZNF215
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    OriGene shRNA RFP: ZNF215
    OriGene basic RS shRNA: ZNF215
    OriGene siRNA: ZNF215
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF215 
    miRNA:Sigma-Aldrich microRNA Mimics for ZNF215
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF215 
    2 SABiosciences Assays for microRNAs that regulate ZNF215:
    hsa-miR-199a-5p hsa-miR-578

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF215
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF215
    OriGene untagged cDNA clones in CMV expression vector: ZNF215
    Browse 3'-UTR reporter clones for miRNA target validation 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNF215 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0003700 sequence-specific DNA binding transcription factor activity NAS10762538
    GO:0008270 zinc ion binding NAS--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF215 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF215 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF215

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    GO:0016032 viral reproduction IEA--
    About this table

    ZNF215 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF215


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZNF215
    Sigma-Aldrich shRNA for ZNF215
    OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF215
    OriGene shRNA RFP: ZNF215
    OriGene basic RS shRNA: ZNF215
    OriGene siRNA: ZNF215
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF215 
    miRNA: Sigma-Aldrich microRNA Mimics for ZNF215
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF215 
    2 SABiosciences Assays for microRNAs that regulate ZNF215:
    hsa-miR-199a-5p hsa-miR-578
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF215
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF215
    OriGene untagged cDNA clones in CMV expression vector: ZNF215
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF215 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF215
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF215: PPH13223A

    REFSEQ mRNAs for ZNF215 gene: 

    NM_013250.2  

    Additional cDNA sequence: 

    AF056618.1 AK298365.1 AK302639.1 BC014538.1 

    2 DOTS entries:

    DT.100647711  DT.75176959 

    24/30 AceView cDNA sequences (see all 30):

    AA721335 AI424805 AA911733 AA829377 AI810619 BU622513 AI684939 AF056618 
    AA724860 CN483744 BX117423 AI962824 AA639668 AA481227 NM_013250 AI636885 
    AA481148 AI633862 CB130717 BC014538 AW295091 AW873531 AW511358 BM798335 

    highest scoring ESTs for ZNF215:

    AA481227 AA527514 AA721335 AA724860 AA829377 AA911733 AF056618 AI424805 AI636885 AW295091 

    Unigene Cluster for ZNF215:

    Zinc finger protein 215
    Hs.523457  [show with all ESTs]
    Unigene Representative Sequence: NM_013250


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299468(uc001mez.1) ENST00000414517(uc010raw.1 uc010rax.1)
    ENST00000278319(uc001mey.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF215 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching ZNF215 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    84172_s_at2, 3 U95-D 1 0.75 1.00 -0.17 0.25 AI424805 0.80 1.00 0.91 1
    84176_r_at2, 3 U95-D 1 0.75 1.00 0.57 0.44 AI636885 0.80 1.00 0.91 1
    55892_at2, 3 U95-C 1 0.56 1.00 1.00 1.00 AA527514 0.80 1.00 0.91 1
    84174_r_at2, 3 U95-D 1 0.44 1.00 -0.20 0.56 AI424805 0.80 1.00 0.91 1
    220214_at2, 3 U133-A 1 0.73 1.00 -- -- NM_013250 0.60 1.00 0.82 1
    220214_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    ZNF215 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNF215 gene expression
    ZNF215 gene electronic northern expression
    ZNF215 gene sage expression
    About these images

    CGAP SAGE TAG: GCCCTGTACT

    SOURCE GeneReport for Unigene cluster: Hs.523457
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF215
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF215: PPH13223A
        SABiosciences Custom PCR Arrays for ZNF215 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNF215 gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZNF2151   -- zinc finger protein 215 84.53(n)
    72.43(a)
    485362  XM_542480.2  XP_542480.2 
    chimpanzee
    (Pan troglodytes)
    ZNF2151   -- zinc finger protein 215 99.23(n)
    98.26(a)
    451003  XM_508266.2  XP_508266.2 
    cow
    (Bos taurus)
    ZNF2151   -- zinc finger protein 215 80.77(n)
    70.71(a)
    529157  NM_001076882.1  NP_001070350.1 
    About this table        Species with no ortholog for ZNF215

    ENSEMBL Gene Tree for ZNF215 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF215 gene
    ZSCAN182  ZNF2742  ZNF4832  ZSCAN12  

    ZNF215 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/337 NCBI SNPs in ZNF215 are shown (see all 337)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9577471,2
    C,F,A,6966814(-) AGGAAT/CGTCTC 1 -- int14Minor allele frequency- C:0.16NA EA WA 212
    rs9577481,2
    C,F,A,H,6966708(-) gggtaT/Cggaat 1 -- int114Minor allele frequency- C:0.28NS EA NA WA 646
    rs10047541,2
    C,A,6946248(+) aaaaaT/Caaatt 1 -- ng512Minor allele frequency- C:0.24NA 74
    rs11365281,2
    --6978881(+) tatccA/Cttagt 1 -- ut310--------
    rs13528611,2
    C,F,H,6960477(+) TGAAGT/CAACCT 1 -- int111Minor allele frequency- C:0.02NS EA NA WA 432
    rs13528621,2
    C,F,H,6960686(+) TTACAA/GCATCA 1 -- int115Minor allele frequency- G:0.02EA NA MN NS WA 684
    rs13885271,2
    C,F,O,6948441(+) TTTTCC/TCAGTC 1 -- int113Minor allele frequency- T:0.14EA NA MN NS 878
    rs13885331,2
    C,F,A,H,6966772(-) tcattC/Aaaaac 1 -- int114Minor allele frequency- A:0.11NS EA NA WA 648
    rs13885341,2
    C,F,A,H,6966499(-) tagGGG/ACAAAT 1 -- int115Minor allele frequency- A:0.18MN NS EA NA WA 824
    rs14661011,2
    C,A,6946254(+) aaattA/Taaaaa 1 -- ng513Minor allele frequency- T:0.00NA 6
    About this table

    HapMap Linkage Disequilibrium images for ZNF215 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF215
         1 CNV: 101121

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF215 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF215 for disorders           About GeneDecksing

    OMIM: 605016


    Export disorders and mutations for ZNF215 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    4 PubMed articles for ZNF215 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ZNF215)
    1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PubMed id 10762538)1, 2 Alders M.... Mannens M. (2000)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. (PubMed id 7959730)1 Redeker E....van den Bogaard R. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7762 HGNC: 13007 AceView: ZNF215 Ensembl:ENSG00000149054 euGenes: HUgn7762
    ECgene: ZNF215 H-InvDB: ZNF215

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ZNF215 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNF215 gene:
    Search GeneIP for patents involving ZNF215

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in ZNF215 promoter
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     ELISAs and CLIAs for ZNF215
           

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    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    ZNF215 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4