Aliases &
Descriptions
for ZNF217 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger protein 2171 2 | | ZABC11 2 3 | | OTTHUMP000000313072 |
Export aliases for ZNF217 gene to outside databasesPrevious GC identifers: GC20M051912 GC20M052822 GC20M052869 GC20M051617 GC20M052183 |
Summaries
for ZNF217 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation andantagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'
Gene Wiki entry for ZNF217 |
Genomic Views
for ZNF217 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF217 gene promoter:
p53 CUTL1 C/EBPbeta MEF-2A PPAR-gamma1 PPAR-gamma2 NF-kappaB NF-kappaB2 NF-kappaB1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF217
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13.2ZNF217 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M048929: view genomic region
(about GC identifiers)
Start:
|
48,929,869 bp from pter |
End:
|
48,945,895 bp from pter |
Size:
|
16,027 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr20- 52,183,604-52,226,446 |
RefSeq DNA sequence:- NC_000020.10 NT_011362.10
|
Proteins
for ZNF217 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362 (See
protein sequence)Recommended Name: Zinc finger protein 217 Size: 1048 amino acids; 115272 Da
Subunit: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component ofa BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2,ZNF217, ZMYM3, GSE1 and GTF2I. Interacts wit CTBP1 and CTBP2
Subcellular location: Nucleus (Probable)
PDB structures from  and Proteopedia  :2HU2 (3D)
Secondary accessions: Q14DB8Explore the universe of human proteins at neXtProt for ZNF217: NX_O75362
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006517.1
ENSEMBL proteins: ENSP00000304308 ENSP00000379298 ENSP00000360526 ENSP00000394010 ENSP00000399672
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZNF217 for ontologies About GeneDecksing
Antibodies for ZNF217:
Assays for ZNF217: |
Protein
Domains/
Families
for ZNF217 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF217 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75362ProtoNet protein and cluster: O75362 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Gene Function
for ZNF217 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation andantagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'
Genatlas biochemistry entry for ZNF217:zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed inbreast carcinoma5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
ZNF217 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF217 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZNF217
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF217
1 Interacting protein for ZNF217 (O753622) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
ZNF217 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF217 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ZNF217 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF217
1  Novoseek chemical compound relationship for ZNF217 gene
About this table
|
Transcripts
for ZNF217 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZNF217 gene: NM_006526.2 Additional cDNA sequence: AK290350.1 6 DOTS entries: DT.112015 DT.100751266 DT.120838356 DT.120838360 DT.91917842 DT.91733753 24/93 AceView cDNA sequences (see all 93): BP366185 AA353699 CR598126 BM834501 CD644465 AA513383 AA563911 BC039055 CA449440 BX119280 BG010798 AA460802 AF041259 AA451924 D17016 AW600304 BX350697 BP366481 AW298383 AA460368 NM_006526 BX955300 BM460857 AI244205
 highest scoring ESTs for ZNF217:AF041259 AA069107 AA451924 BF237807 BF803309 BF803316 BF944766 BF963063 BM834501 BX119280 Unigene Clusters for ZNF217: Zinc finger protein 217 Hs.155040 [show with all ESTs], Hs.711564 [show with all ESTs]Unigene Representative Sequences: NM_006526, AK290350
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302342 ENST00000487458 ENST00000395971(uc010gij.1) ENST00000371471(uc002xwq.3)
ENST00000437222 ENST00000431687
|
Expression
for ZNF217 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZNF217 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching ZNF217 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 203739_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_006526 |
0.60 |
1.00 |
0.82 |
1 |
| 203739_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCTTAGTGA
SOURCE GeneReport for Unigene clusters: Hs.155040 Hs.711564
Expression variation in blood from EXPOLDB for ZNF217 SABiosciences Custom PCR Arrays for ZNF217
|
Orthologs
for ZNF217 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZNF217 gene from 5/9 species (see all 9)
About this table Species with no ortholog for ZNF217
ENSEMBL Gene Tree for ZNF217 (if available) |
Paralogs
for ZNF217 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZNF217 gene
- ZNF2192 ZNF5362 ZNF5162
ZNF217 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF217 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZNF217 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF217
1 CNV: 5142 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZNF217 |
|
Disorders & Mutations
for ZNF217 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF217 for disorders About GeneDecksing
OMIM: 602967
3 Novoseek disease relationships for ZNF217 gene
About this table
Export disorders and mutations for ZNF217 gene to outside databases
|
Medical News
for ZNF217 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZNF217 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/30 PubMed articles for ZNF217 gene, integrated from 7 sources (see all 30):
(articles sorted by number of sources associating them with ZNF217)- Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 2, 3 Collins C.... Gray J.W. (1998)
- Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PubMed id 18625718)1, 2 Thillainadesan G....Torchia J. (2008)
- Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. (PubMed id 16940172)1, 2 Quinlan K.G.R.... Crossley M. (2006)
- ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. (PubMed id 16203743)1, 2 Huang G....Collins C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.A....Shiekhattar R. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PubMed id 17130829)1, 7 Cowger J.J....Torchia J. (2007)
- The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PubMed id 19242095)1, 7 Banck M.S....Walsh M.J. (2009)
|
External Searches for ZNF217 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF217 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF217 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF217 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF217 gene:
Search GeneIP for patents involving ZNF217
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF217 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for ZNF217 |
| |  |  |  |  | | | | |
 | | |
|
|
