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ZNF33B Gene

protein-coding   GIFtS: 48

GC10M039611
zinc finger protein 33B
(Previous names: zinc finger protein 33b (KOX 31), zinc finger protein 11B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF11B)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 33B1 2     Zinc finger protein 11B1 3
KOX21 2 3 5     Zinc finger protein KOX22 3
ZNF11B2 3 5     FLJ233272
KOX311 2     MGC1296962
zinc finger protein 33b (KOX 31)1 2     zinc finger protein 11b (KOX 2)2

External Ids:    HGNC: 130971   Entrez Gene: 75822   Ensembl: ENSG000001966937   UniProtKB: Q067323   

Export aliases for ZNF33B gene to outside databases

Previous GC identifers: GC10M042377 GC10U900001 GC10P038188 GC07P006406 GC03P044571 GC10M042405 GC10M043069


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF33B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF33B
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF33B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF33B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.2

ZNF33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF33B gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M039611:  view genomic region     (about GC identifiers)

Start:
39,611,330 bp from pter
End:
39,660,708 bp from pter
Size:
49,379 bases
Orientation:
minus strand

1 alternative location:
Chr10- 43,069,633-43,134,285     
RefSeq DNA sequence:
NC_000010.10  NT_033985.7  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732 (See protein sequence)
Recommended Name: Zinc finger protein 33B  
Size: 778 amino acids; 90683 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
Secondary accessions: Q06731 Q32MA2 Q86XY8 Q8NDW3

Explore the universe of human proteins at neXtProt for ZNF33B: NX_Q06732 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_008886.1  

    ENSEMBL proteins: 
    ENSP00000352444 ENSP00000392313 ENSP00000379177 ENSP00000402467 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus NAS--
    About this table

    ZNF33B for ontologies           About GeneDecksing



    Antibodies for ZNF33B: 
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    Uscn ELISAs and CLIAs for ZNF33B 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF33B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q06732

    ProtoNet protein and cluster: Q06732

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732
    Function: May be involved in transcriptional regulation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    OriGene basic RS shRNA: ZNF33B
    OriGene siRNA: ZNF33B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF33B 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF33B 
    1 SABiosciences Assays for microRNA that regulate ZNF33B:
    hsa-miR-105

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF33B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF33B
    OriGene untagged cDNA clones in CMV expression vector: ZNF33B
    OriGene 3'-UTR clone: ZNF33B 
    Browse MicroRNA Expression Plasmids 
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    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNF33B 

    Genatlas biochemistry entry for ZNF33B:
    zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0003700 sequence-specific DNA binding transcription factor activity NAS--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF33B for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF33B 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF33B

    2 Interacting proteins for ZNF33B (Q067322) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAP1P542572MINT-64056 MINT-3979808
    ZHX1Q9UKY12MINT-3979791
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    About this table

    ZNF33B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF33B


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF33B
    OriGene shRNA RFP: ZNF33B
    OriGene basic RS shRNA: ZNF33B
    OriGene siRNA: ZNF33B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF33B 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF33B 
    1 SABiosciences Assays for microRNA that regulate ZNF33B:
    hsa-miR-105
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF33B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF33B
    OriGene untagged cDNA clones in CMV expression vector: ZNF33B
    OriGene 3'-UTR Clone: ZNF33B 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ZNF33B 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF33B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF33B: PPH20290A

    REFSEQ mRNAs for ZNF33B gene: 

    NM_006955.1  

    Additional cDNA sequence: 

    AF027147.1 AF222749.1 AJ491697.1 AK025638.1 AK096683.1 AK304306.1 AK309564.1 AK310073.1 
    BC035770.1 BC036398.1 BC042873.1 BC048313.2 BC065181.1 BC107726.1 BC109232.2 BC160932.1 
    CR619942.1 X52333.1 X68684.1 

    9 DOTS entries:

    DT.97812540  DT.100028161  DT.100790224  DT.98083450  DT.121245221  DT.100790219  DT.100790220  DT.121245189 
    DT.450526 

    highest scoring ESTs for ZNF33B:

    X68688 AJ491697 AK096683 AL539493 BC036398 BC048313 BC065181 BC107726 BC109232 BE464339 

    Unigene Cluster for ZNF33B:

    Zinc finger protein 33B
    Hs.499453  [show with all ESTs]
    Unigene Representative Sequence: BC036398


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B (see all 9)

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                          -                       -     -                           
    SP2:                          -                       -     -                           
    SP3:                          -                                                         
    SP4:                          -                       -     -                           
    SP5:                          -                 -     -     -                           

    About this scheme

    ECgene alternative splicing isoforms for ZNF33B
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462075(uc001jad.2) ENST00000486187(uc009xmg.1 uc001jae.1)
    ENST00000465206 ENST00000359467(uc001jaf.1 uc001jag.1) ENST00000476796
    ENST00000493285 ENST00000486614 ENST00000416780 ENST00000395836 ENST00000432900


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF33B expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching ZNF33B gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32429_f_at2, 3 U95-A 2 0.83 0.90 0.43 0.64 X68688 0.20 1.00 0.72 1
    71834_at2, 3 U95-D 2 0.62 0.91 0.71 1.04 AA936524 0.20 0.33 0.27 1
    85986_at2 U95-E 2 0.50 0.59 0.14 1.33 -- -- -- -- --
    215022_x_at2 U133-A 2 0.91 0.85 -- -- -- -- -- -- --
    215022_x_at2 U133Plus2 2 0.91 0.85 -- -- -- -- -- -- --
    1562743_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    ZNF33B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNF33B gene expression
    ZNF33B gene electronic northern expression
    ZNF33B gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.499453
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF33B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF33B: PPH20290A
        SABiosciences Custom PCR Arrays for ZNF33B 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNF33B gene from 2 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ZNF33B1   -- zinc finger protein 33B 99.18(n)
    98.84(a)
    744117  XM_001148551.1  XP_001148551.1 
    cow
    (Bos taurus)
    ZNF33B1   -- zinc finger protein 33B 88.24(n)
    84.86(a)
    520684  XM_001252724.1  XP_001252725.1 
    About this table        Species with no ortholog for ZNF33B

    ENSEMBL Gene Tree for ZNF33B (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF33B gene
    ZNF3342  MIR42732  ZNF5102  ENSG000002157562  ZNF33A2  ZNF5672  ZNF487P2  ZNF37A2  
    ZNF3822  

    ZNF33B for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/560 NCBI SNPs in ZNF33B are shown (see all 560)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1583671,2
    C,F,A,43096289(+) ttgtaT/Caaagt 1 -- int12Minor allele frequency- C:0.02MN EA 272
    rs1583681,2
    A43097070(-) gtggcA/Cggcac 1 -- int10--------
    rs1583691,2
    C,A43097402(+) actccG/Atcacc 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1583701,2
    A,43097761(-) aaaaaA/Caacaa 1 -- int1 trp30--------
    rs1583711,2
    A,43097840(-) tgacaG/Agttca 1 -- int11Minor allele frequency- A:0.00MN 184
    rs1583721,2
    A43098863(-) ggtctA/Gtggtt 1 -- int10--------
    rs1583731,2
    C,F,A,H,43099542(-) cagttG/Cctgtt 1 -- int111Minor allele frequency- C:0.21NS EA NA 846
    rs1583741,2
    43100337(-) agctgG/Tagtgc 1 -- int10--------
    rs1583751,2
    --43101733(+) catgaC/Tgaaac 1 -- int10--------
    rs1583761,2
    C,F,A,H,43116859(+) acacaT/Cacaca 1 -- int17Minor allele frequency- C:0.36NS EA NA 494
    About this table

    HapMap Linkage Disequilibrium images for ZNF33B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ZNF33B
         4 CNVs: 9147 3797 2862 2152

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF33B 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF33B for disorders           About GeneDecksing

    OMIM: 194522

    Human Genome Epidemiology (HuGE) Navigator: ZNF33B (1 document)

    Export disorders and mutations for ZNF33B gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/11 PubMed articles for ZNF33B gene, integrated from 7 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF33B)
    1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PubMed id 8464732)1, 2, 7 Tunnacliffe A.... Ponder B.A. (1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PubMed id 12566394)1, 2 Guy J....Jackson M.S. (2003)
    5. Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
    6. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7582 HGNC: 13097 Ensembl:ENSG00000196693 euGenes: HUgn7582 ECgene: ZNF33B
    H-InvDB: ZNF33B

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNF33B gene:
    Search GeneIP for patents involving ZNF33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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