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ZNF385D Gene

protein-coding   GIFtS: 40

GC03M021412
zinc finger protein 385D
(Previous name: zinc finger protein 659 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF659)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 385D1 2
Zinc finger protein 6591 2 3
FLJ224191 2
ZNF6592 3

External Ids:    HGNC: 261911   Entrez Gene: 797502   Ensembl: ENSG000001517897   UniProtKB: Q9H6B13   

Export aliases for ZNF385D gene to outside databases

Previous GC identifer: GC03M021439


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF385D
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF385D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF385D 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

ZNF385D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385D gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M021412:  view genomic region     (about GC identifiers)

Start:
21,412,304 bp from pter
End:
22,414,812 bp from pter
Size:
1,002,509 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1 (See protein sequence)
Recommended Name: Zinc finger protein 385D  
Size: 395 amino acids; 42296 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF385D: NX_Q9H6B1 

REFSEQ proteins: NP_078973.1  

ENSEMBL proteins: 
ENSP00000281523 ENSP00000388232 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: ZNF385D
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

ZNF385D for ontologies           About GeneDecksing



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Assays for ZNF385D: 
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GenScript Custom Assay Services for ZNF385D 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF385D for domains           About GeneDecksing

4 InterPro domains/families:
 IPR003604 Znf_U1
 IPR015880 Znf_C2H2-like
 IPR007087 Znf_C2H2
 IPR022755 Znf_C2H2_jaz

Graphical View of Domain Structure for InterPro Entry Q9H6B1

ProtoNet protein and cluster: Q9H6B1

1 Blocks protein family: IPB003604 Zn-finger

UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1
Similarity: Contains 3 matrin-type zinc fingers


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZNF385D
Sigma-Aldrich shRNA for ZNF385D
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF385D
OriGene shRNA RFP: ZNF385D
OriGene basic RS shRNA: ZNF385D
OriGene siRNA: ZNF385D
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF385D 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF385D 
Search SABiosciences for Assays for microRNAs that regulate ZNF385D

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF385D
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF385D
OriGene untagged cDNA clones in CMV expression vector: ZNF385D
OriGene 3'-UTR clone: ZNF385D 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF385D 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZNF385D 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

ZNF385D for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF385D 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF385D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF385D


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZNF385D
Sigma-Aldrich shRNA for ZNF385D
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF385D
OriGene shRNA RFP: ZNF385D
OriGene basic RS shRNA: ZNF385D
OriGene siRNA: ZNF385D
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF385D 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF385D 
Search SABiosciences for Assays for microRNAs that regulate ZNF385D
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF385D
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF385D
OriGene untagged cDNA clones in CMV expression vector: ZNF385D
OriGene 3'-UTR Clone: ZNF385D 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF385D 
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF385D
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF385D: PPH10772A

REFSEQ mRNAs for ZNF385D gene: 

NM_024697.2  

Additional cDNA sequence: 

AK026072.1 AK310298.1 BC007212.1 

4 DOTS entries:

DT.109805  DT.109806  DT.120861497  DT.91791481 

24/41 AceView cDNA sequences (see all 41):

F10799 AW161285 BE272789 Z42617 F02126 BM955844 AA188641 AW157713 
BQ429087 BQ014047 NM_024697 AI929820 BC007212 BQ722558 CA422185 BX952022 
AA416755 AK026072 F13195 BG192742 BQ709208 AA416849 BG187933 AA451868 

Unigene Cluster for ZNF385D:

Zinc finger protein 385D
Hs.21026  [show with all ESTs]
Unigene Representative Sequence: NM_024697


GeneLoc Exon Structure

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000467140 ENST00000474607 ENST00000466511 ENST00000478967 ENST00000495739
ENST00000469927 ENST00000281523(uc003cce.2) ENST00000494108 ENST00000494118(uc010hfb.1)
ENST00000446749 ENST00000497570

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF385D expression in normal and diseased human tissues

1  / 2

7 probe-sets matching ZNF385D gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
58389_at2 U95-C 1 0.38 1.00 0.67 0.64 -- -- -- -- --
52873_at2 U95-C 1 0.38 1.00 0.55 0.42 -- -- -- -- --
56681_at2 U95-C 1 0.31 1.00 0.89 1.36 -- -- -- -- --
220117_at2 U133-A 1 0.82 1.00 -- -- -- -- -- -- --
230773_at2 U133-B 1 0.73 1.00 -- -- -- -- -- -- --
220117_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
230773_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table

ZNF385D for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZNF385D gene expression
ZNF385D gene electronic northern expression
ZNF385D gene sage expression
About these images

CGAP SAGE TAG: TTAGAAGCCC

SOURCE GeneReport for Unigene cluster: Hs.21026
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF385D
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF385D: PPH10772A
    SABiosciences Custom PCR Arrays for ZNF385D 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF385D gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZNF385D1   -- zinc finger protein 385D 90.21(n)
94.59(a)
477051  XM_857978.1  XP_863071.1 
rat
(Rattus norvegicus)
LOC3056911   -- similar to hypothetical protein FLJ22419 87.53(n)
90.59(a)
305691  NM_001013992.1  NP_001014014.1 
chicken
(Gallus gallus)
ZNF6591   -- zinc finger protein 659 88.92(n)
95.4(a)
420651  XM_418750.2  XP_418750.2 
About this table        Species with no ortholog for ZNF385D

ENSEMBL Gene Tree for ZNF385D (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF385D gene
ZNF385C2  ZNF385A2  ZNF385B2  

ZNF385D for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/4089 NCBI SNPs in ZNF385D are shown (see all 4089)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs1492671,2
C,F,A,21580991(+) CATGAC/TTTCTA 1 -- int19Minor allele frequency- T:0.21NS NA EA WA 432
rs1512761,2
C,F,O,A,21577797(-) TAATAC/TTTTTT 1 -- int116Minor allele frequency- T:0.25NS EA NA WA 1268
rs1512771,2
C,F,A,21508823(+) AGATAC/TGGGGC 1 -- int114Minor allele frequency- T:0.27NS EA NA WA 1056
rs1512781,2
C,F,O,H,21506540(+) GTCATC/TTTTAC 1 -- int118Minor allele frequency- T:0.15NS EA NA WA 1048
rs1512791,2
C,F,21504722(-) TGCTAC/TTGAAT 1 -- int13Minor allele frequency- T:0.50NA 6
rs1512801,2
C,F,O,H,21530728(-) GGGCTC/TCCTGG 1 -- int114Minor allele frequency- T:0.21MN NS EA NA WA 824
rs1512811,2
C,F,O,H,21529805(-) TCAATA/TTAAAA 1 -- int113Minor allele frequency- T:0.07NA EA NS WA 562
rs1512821,2
C,F,A,21529582(-) TTCAAC/TCAGGA 1 -- int115Minor allele frequency- T:0.31NS EA NA WA 1064
rs1611961,2
C,F,A,H,21578096(+) atataC/Tgaagc 1 -- int198Minor allele frequency- T:0.01NS EA PA EU CA WA NA 5710
rs1611971,2
C,O,A,H,21520266(-) AGATAC/GTCATA 1 -- int18Minor allele frequency- G:0.23NA WA 134
About this table

HapMap Linkage Disequilibrium images for ZNF385D (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ZNF385D
     6 CNVs: 6165 8418 91225 63415 4332 62038
     1 Indel: 63414

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF385D 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF385D for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZNF385D (1 document)

Export disorders and mutations for ZNF385D gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

8 PubMed articles for ZNF385D gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF385D)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  5. Common genetic variation and susceptibility to partia l epilepsies: a genome-wide association study. (PubMed id 20522523)1 KasperaviciAte D....Sisodiya S.M. (2010)
  6. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1 Ferreira M.A....Craddock N. (2008)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79750 HGNC: 26191 AceView: FLJ22419 Ensembl:ENSG00000151789 euGenes: HUgn79750
ECgene: ZNF385D H-InvDB: ZNF385D

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF385D gene:
Search GeneIP for patents involving ZNF385D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF385D
 SeqTarget long-range PCR primers for resequencing ZNF385D
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF385D
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF385D
 GenScript Custom Purified and Recombinant Proteins Services for ZNF385D GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZNF385D
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