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Aliases & Descriptionsfor ZNF408 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions zinc finger protein 4081 2 FLJ128271 2 PR domain zinc finger protein 172 3 PRDM173 PFM143
Export aliases for ZNF408 gene to outside databases Previous GC identifers: GC11P047600 GC11P046753 GC11P046686 GC11P046678
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Summariesfor ZNF408 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 Function : May be involved in transcriptional regulation
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Genomic Viewsfor ZNF408 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF408 gene promoter: AP-1 CREB AhR p53 deltaCREB NF-1 PPAR-gamma1 PPAR-gamma2 Egr-1 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF408 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF408
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2 ZNF408 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P046428: view genomic region
(about GC identifiers )
Start:
46,428,356 bp from pter
End:
46,433,505 bp from pter
Size:
5,150 bases
Orientation:
plus strand
1 alternative location : Chr 11+ 46,722,368-46,727,461
RefSeq DNA sequence: NC_000011.9 NT_009237.18
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Proteinsfor ZNF408 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 (See
protein sequence )Recommended Name: Zinc finger protein 408 Size : 720 amino acids; 78439 Da
Subcellular location : Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF408: NX_Q9H9D4 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001171680.1 NP_079017.1 ENSEMBL proteins: ENSP00000309606 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
ZNF408 for ontologies About GeneDecksing Antibodies for ZNF408: Assays for ZNF408:
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Protein
Domains/ Familiesfor ZNF408 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF408 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H9D4 ProtoNet protein and cluster: Q9H9D4
UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 Similarity : Contains 10 C2H2-type zinc fingers
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Gene Functionfor ZNF408 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 Function : May be involved in transcriptional regulation
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
ZNF408 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF408 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for ZNF408 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF408 5/24 Interacting proteins for ZNF408 (Q9H9D4 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 24 )About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006281 DNA repair
-- -- GO:0045449 regulation of transcription
IEA --
About this table
ZNF408 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF408 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for ZNF408
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Transcriptsfor ZNF408 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for ZNF408 gene (2 alternative transcripts): NM_001184751.1 NM_024741.2
Additional cDNA sequence: AF346626.1 AK022889.1 AK302180.1 BC013355.2 BC015708.2 CR603963.1 CR606317.1
5 DOTS entries : DT.308775 DT.120706588 DT.120706600 DT.102841102 DT.99945789
24/121 AceView cDNA sequences (see all 121 ):
CD632274 BM680571 AU279752 BM914264 CR603963 CB130839 AK022889 BQ671338 CF243074 BC015708 BM717376 BQ709038 H63042 BQ674757 BM828902 AU130916 BQ925223 AI816535 BQ059385 BQ707434 BC013355 BI760881 AI242496 BQ670029
highest scoring ESTs for ZNF408 :AA639997 AI968450 AA635466 AA759024 AF346626 AI092401 AI242496 AI357201 AI816535 AI887341 Unigene Cluster for ZNF408:
Zinc finger protein 408 Hs.726461 [show with all ESTs ] Unigene Representative Sequence: NM_024741 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF408 ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 SP1 :       -   -     -     -         SP2 :         -     -     -         SP3 :       -   -     -             SP4 :       -   -                 SP5 :             -            
About this scheme ECgene alternative splicing isoforms for ZNF408 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000311764 (uc001nde.1 uc010rgw.1 )
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Expression for ZNF408 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section ZNF408 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching ZNF408 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
88717_at2 , 3
U95-E
1
1.00
1.00
1.00
1.00
AA639997
0.80
0.80
0.80
1
219224_x_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_024741
0.40
0.67
0.55
1
219224_x_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
ZNF408 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGCCTCGGCG SOURCE GeneReport for Unigene cluster: Hs.726461 SABiosciences Custom PCR Arrays for ZNF408
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Orthologsfor ZNF408 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for ZNF408 gene from 5/6 species (see all 6 )
About this table Species with no ortholog for ZNF408 ENSEMBL Gene Tree for ZNF408 (if available)
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Paralogsfor ZNF408 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for ZNF408 gene ZNF668 2
ZNF408 for paralogs About GeneDecksing
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Genomic Variantsfor ZNF408 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for ZNF408 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF408: --
QIAGEN SeqTarget long-range PCR primers for resequencing ZNF408
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Disorders & Mutationsfor ZNF408 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor ZNF408 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor ZNF408 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/12 PubMed articles for ZNF408 gene, integrated from 7 sources (see all 12 ): (articles sorted by number of sources associating them with ZNF408) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A protein interaction framework for human mRNA degradation. (PubMed id 15231747) 1 , 3 Lehner B. and Sanderson C.M. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142) 1 Ravasi T....Hayashizaki Y. (2010 Mar 5) Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982) 1 Rivadeneira F....Uitterlinden A.G. (2009) An empirical framework for binary interactome mapping . (PubMed id 19060904) 1 Venkatesan K....Vidal M. (2009) A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255) 1 Gao J....Yu Y. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819) 1 Lehner B....Sanderson C.M. (2004)
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External Searches for ZNF408 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF408 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF408 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF408 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ZNF408 gene: Search GeneIP for patents involving ZNF408 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF408 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for ZNF408
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