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ZNF439 Gene

protein-coding GIFtS: 40

GC19P011552

zinc finger protein 439
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 439¹ ²
DKFZp571K0837¹ ²
OTTHUMP00000210064²

External Ids:	HGNC: 20873¹	Entrez Gene: 90594²	Ensembl: ENSG00000171291⁷	UniProtKB: Q8NDP4³

Export aliases for ZNF439 gene to outside databases

Previous GC identifers: GC19P011804 GC19P011837 GC19P011960

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN439_HUMAN, Q8NDP4

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF439
Other transcription factors

Search SABiosciences Chromatin IP Primers for ZNF439

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF439

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.13

ZNF439 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF439 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P011552: view genomic region (about GC identifiers)

Start:	11,551,438 bp from pter
End:	11,554,900 bp from pter
Size:	3,463 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 11,959,576-11,980,306

RefSeq DNA sequence:

NC_000019.9 NT_011295.11

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN439_HUMAN, Q8NDP4 (See protein sequence)

Recommended Name: Zinc finger protein 439

Size: 499 amino acids; 58395 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAB55187.1; Type=Erroneous initiation;

Secondary accessions: Q8IYZ7 Q96SU1

Explore the universe of human proteins at neXtProt for ZNF439: NX_Q8NDP4

REFSEQ proteins: NP_689475.1

ENSEMBL proteins:

ENSP00000395632 ENSP00000305077 ENSP00000388234

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

ZNF439 for ontologies About GeneDecksing

Antibodies for ZNF439:

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Assays for ZNF439:

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	GenScript Custom Assay Services for ZNF439
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF439 for domains About GeneDecksing

4 InterPro domains/families:

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8NDP4

ProtoNet protein and cluster: Q8NDP4

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN439_HUMAN, Q8NDP4

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 11 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN439_HUMAN, Q8NDP4

Function: May be involved in transcriptional regulation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for ZNF439 Sigma-Aldrich shRNA for ZNF439
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF439 OriGene shRNA RFP: ZNF439 OriGene basic RS shRNA: ZNF439 OriGene siRNA: ZNF439
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF439

miRNA:		Sigma-Aldrich microRNA Mimics for ZNF439 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF439
		2 SABiosciences Assays for microRNAs that regulate ZNF439:
		hsa-miR-188-3p hsa-miR-199a-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF439 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF439 OriGene untagged cDNA clones in CMV expression vector: ZNF439 OriGene 3'-UTR clone: ZNF439 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF439
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZNF439

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZNF439 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZNF439

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF439

2 Interacting proteins for ZNF439 (Q8NDP4²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KRTAP4-12	Q9BQ66²	MINT-67088
MDFI	Q99750²	MINT-67229

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

ZNF439 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF439

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for ZNF439 Sigma-Aldrich shRNA for ZNF439
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF439 OriGene shRNA RFP: ZNF439 OriGene basic RS shRNA: ZNF439 OriGene siRNA: ZNF439
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF439

miRNA:		Sigma-Aldrich microRNA Mimics for ZNF439 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF439
		2 SABiosciences Assays for microRNAs that regulate ZNF439:
		hsa-miR-188-3p hsa-miR-199a-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF439 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF439 OriGene untagged cDNA clones in CMV expression vector: ZNF439 OriGene 3'-UTR Clone: ZNF439 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF439

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF439 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF439: PPH18482A

REFSEQ mRNAs for ZNF439 gene:

NM_152262.2

Additional cDNA sequence:

AF024693.1 AK027542.1 AK094739.1 AL833935.1 BC032857.1

13 DOTS entries:

DT.100022039 DT.99933309 DT.404909 DT.92414483 DT.97808567 DT.100813705 DT.92028181 DT.95328684

DT.100721204 DT.100751095 DT.101975455 DT.432463 DT.99959058

24/37 AceView cDNA sequences (see all 37):

BU902145 NM_152262 BQ424701 AK027542 AL833935 BF436917 N57019 BX090322

BQ061210 BQ888384 BP335152 N29327 BQ012928 BE219111 AW088552 AV745540

AW088537 AV745689 BC032857 AA133978 CA336048 AW206752 BI462675 BQ010994

highest scoring ESTs for ZNF439:

N29327 AA133978 AK027542 AL833935 AW088537 AW088552 BC032857 BF436917 BF844888 BQ011606

Unigene Cluster for ZNF439:

Zinc finger protein 439

Hs.528731 [show with all ESTs]

Unigene Representative Sequence: AL833935

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455282(uc002msr.2) ENST00000304030(uc002mss.2) ENST00000442091

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF439 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching ZNF439 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43746_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	N29327	1.00	1.00	1.00	1
236562_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N29327	1.00	1.00	1.00	1
236562_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

ZNF439 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ZNF439 gene electronic northern expression

About these images

CGAP SAGE TAG: TATTAGATCA

SOURCE GeneReport for Unigene cluster: Hs.528731

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF439 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF439: PPH18482A

SABiosciences Custom PCR Arrays for ZNF439

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF439 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZNF439¹	--	zinc finger protein 439	97.44(n) 94.62(a)	746850 XM_001168596.1 XP_001168596.1
baker's yeast (Saccharomyces cerevisiae)	MIG2(YGL209W)⁴	7(95862-97010)	Protein containing zinc fingers, involved in repression, more	--	852663 NP_011306.1

About this table Species with no ortholog for ZNF439

ENSEMBL Gene Tree for ZNF439 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZNF439 gene

ZNF669² ZNF564² ZNF490² ZNF441² ZNF878² ZNF14² ENSG00000196826² ZNF700²

ZNF69² ZNF440² ZNF443² ZNF44² ZNF823² ZNF491² ZNF861P² ZNF555²

ZNF709² ZNF625² ZNF799² ZNF20² ZNF101² ZNF791² ZNF442² ZNF57²

ZNF433² ZNF563² ZNF627² ZNF136² ZNF556² ZNF670² ZNF763² ZNF124²

ZNF844²

ZNF439 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs279213^1,2	--	11976650(+)	`ccagcC/Gtgacc`	1	--	ng5¹		0	--	--	--	--
rs279214^1,2	C,A,H,	11977811(+)	`tgataC/Tcactg`	1	--	int¹		0	--	--	--	--
rs279215^1,2	C,F,O,A,	11980332(+)	`TTGGAT/CATTGT`	1	--	ng3¹		10		NS EA NA	716
rs774579^1,2	--	11975347(+)	`cctcaA/Ggtgaa`	1	--	ng5¹ tfbs³		0	--	--	--	--
rs10403439^1,2	C,F,	11980165(+)	`AGATCG/AGCTAG`	1	--	ut3¹		5		NS EA WA	470
rs10405375^1,2	C,A,	11979919(+)	`GCTTAA/GTTGCT`	1	--	ut3¹		2		NS WA	170
rs10410051^1,2	C,	11980724(+)	`gcctcA/Ggcctc`	1	--	ng3¹		0	--	--	--	--
rs10410052^1,2	--	11980725(+)	`cctcgC/Gcctct`	1	--	ng3¹		0	--	--	--	--
rs10417222^1,2	C,	11978130(+)	`GTCACA/GGAAGA`	2	T	ref¹ syn¹ ese³ trp³		0	--	--	--	--
rs10417930^1,2	--	11980709(+)	`ccttgC/Tgatcc`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZNF439 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF439: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF439

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

5 PubMed articles for ZNF439 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF439)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90594	HGNC: 20873	AceView: ZNF439	Ensembl:ENSG00000171291	euGenes: HUgn90594
ECgene: ZNF439	H-InvDB: ZNF439

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZNF439 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ZNF439 gene:
Search GeneIP for patents involving ZNF439

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF439
	SeqTarget long-range PCR primers for resequencing ZNF439
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF439
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF439

	GenScript Custom Purified and Recombinant Proteins Services for ZNF439		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZNF439
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ZNF439 Gene

protein-coding GIFtS: 40

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ZNF439 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor ZNF439 gene

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