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ZNF441 Gene

protein-coding   GIFtS: 36

GC19P011452
zinc finger protein 441
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 4411 2
FLJ386371 2

External Ids:    HGNC: 208751   Entrez Gene: 1260682   Ensembl: ENSG000001970447   UniProtKB: Q8N8Z83   

Export aliases for ZNF441 gene to outside databases

Previous GC identifers: GC19P011723 GC19P011738 GC19P011659 GC19P011878


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF441
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF441

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF441 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

ZNF441 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF441 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P011452:  view genomic region     (about GC identifiers)

Start:
11,452,542 bp from pter
End:
11,469,618 bp from pter
Size:
17,077 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 11,877,815-11,894,893     
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8 (See protein sequence)
Recommended Name: Zinc finger protein 441  
Size: 693 amino acids; 80136 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAC04661.1; Type=Frameshift; Positions=2;
Alternative splicing: 2 isoforms:  Q8N8Z8-1   Q8N8Z8-2   

Explore the universe of human proteins at neXtProt for ZNF441: NX_Q8N8Z8 

REFSEQ proteins: NP_689568.2  

ENSEMBL proteins: 
ENSP00000403738 ENSP00000350576 ENSP00000386658 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

ZNF441 for ontologies           About GeneDecksing



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Assays for ZNF441: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF441 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N8Z8

ProtoNet protein and cluster: Q8N8Z8

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 19 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8
Function: May be involved in transcriptional regulation

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF441
Sigma-Aldrich shRNA for ZNF441
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF441
OriGene shRNA RFP: ZNF441
OriGene basic RS shRNA: ZNF441
OriGene siRNA: ZNF441
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF441 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF441 
Search SABiosciences for Assays for microRNAs that regulate ZNF441

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF441
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF441
OriGene untagged cDNA clones in CMV expression vector: ZNF441
OriGene 3'-UTR clone: ZNF441 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF441 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZNF441 

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding ----
GO:0003677 DNA binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

ZNF441 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF441 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF441

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0045449 regulation of transcription ----
About this table

ZNF441 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF441


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF441
Sigma-Aldrich shRNA for ZNF441
OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF441
OriGene shRNA RFP: ZNF441
OriGene basic RS shRNA: ZNF441
OriGene siRNA: ZNF441
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF441 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF441 
Search SABiosciences for Assays for microRNAs that regulate ZNF441
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF441
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF441
OriGene untagged cDNA clones in CMV expression vector: ZNF441
OriGene 3'-UTR Clone: ZNF441 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF441 
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF441
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF441: PPH17093A

REFSEQ mRNAs for ZNF441 gene: 

NM_152355.2  

Additional cDNA sequence: 

AK092721.1 AK095956.1 BC144217.1 BX649086.1 

1 DOTS entry:

DT.100027156 

24/32 AceView cDNA sequences (see all 32):

BU783332 BX649086 AA836290 AK092721 BU159782 NM_152355 BU783088 BG286420 
AI373552 AK095956 BQ002549 AI861891 AW292547 AI378454 AI678174 AA424356 
BG399973 AA035079 AI797710 BU532083 BU783925 BQ003442 CN478653 BG574594 

highest scoring ESTs for ZNF441:

AK092721 AK095956 BU159782 BU170994 BU532083 BX649086 AW748992 BE170897 BE693374 BG286420 

Unigene Cluster for ZNF441:

Zinc finger protein 441
Hs.675132  [show with all ESTs]
Unigene Representative Sequence: NM_152355


GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000454339(uc010dyj.2 uc002msn.3) ENST00000357901 ENST00000409902
ENST00000462251

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF441 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching ZNF441 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1553192_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
1553193_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZNF441 gene expression
ZNF441 gene electronic northern expression
ZNF441 gene sage expression
About these images

CGAP SAGE TAG: TGTACCTTAT

SOURCE GeneReport for Unigene cluster: Hs.675132
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF441
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF441: PPH17093A
    SABiosciences Custom PCR Arrays for ZNF441 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
ENSEMBL Gene Tree for ZNF441 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF441 gene
ZNF6692  ZNF5642  ZNF4902  ZNF8782  ZNF142  ENSG000001968262  ZNF7002  ZNF692  
ZNF4402  ZNF4432  ZNF442  ZNF4392  ZNF8232  ZNF4912  ZNF861P2  ZNF5552  
ZNF7092  ZNF6252  ZNF7992  ZNF202  ZNF1012  ZNF7912  ZNF4422  ZNF572  
ZNF4332  ZNF5632  ZNF6272  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ZNF1242  
ZNF8442  

ZNF441 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/234 NCBI SNPs in ZNF441 are shown (see all 234)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs2862161,2
C,F,A,11892935(+) TCTTTC/GTCTAG 1 -- ut3120Minor allele frequency- G:0.45NS EA NA WA 1206
rs2862171,2
C,F,O,A,H,11893555(+) GGTTAT/CAGGCA 1 -- ut3114Minor allele frequency- C:0.31MN NS NA WA 700
rs2862181,2
C,F,A,H,11893862(+) ctatgT/Cgacaa 1 -- ut3118Minor allele frequency- C:0.49MN NS EA NA WA 966
rs2862191,2
C,F,A,11894535(+) aacttC/Gacctc 1 -- ut3112Minor allele frequency- G:0.27NS EA NA WA 748
rs2862201,2
C,F,A,H,11894878(+) TATAAG/AATAGT 1 -- ut316Minor allele frequency- A:0.29NA EA WA 218
rs3644801,2
C,H,11883163(-) ggtgaT/Cgagag 1 -- int14Minor allele frequency- C:0.00NA 8
rs3662901,2
F,H11882955(-) tccacG/Tggacg 1 -- int13Minor allele frequency- T:0.46EA NS 246
rs3711341,2
C,F,A,11889347(-) acagcG/Aagcta 1 -- int18Minor allele frequency- A:0.20NA EA WA 222
rs3720581,2
C,A,11877120(+) ctcgcC/Tcactc 1 -- ng516Minor allele frequency- T:0.14NA EA 98
rs3767971,2
C,F,A,H11886649(-) cctggC/Tcaaca 1 -- int17Minor allele frequency- T:0.19NA WA 16
About this table

HapMap Linkage Disequilibrium images for ZNF441 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF441
     1 Indel: 11139

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF441 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF441 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZNF441 (1 document)

Export disorders and mutations for ZNF441 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

6 PubMed articles for ZNF441 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF441)
  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 126068 HGNC: 20875 AceView: ZNF441 Ensembl:ENSG00000197044 euGenes: HUgn126068
ECgene: ZNF441 H-InvDB: ZNF441

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF441 gene:
Search GeneIP for patents involving ZNF441

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF441
 SeqTarget long-range PCR primers for resequencing ZNF441
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF441
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF441
 GenScript Custom Purified and Recombinant Proteins Services for ZNF441 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZNF441
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