Aliases &
Descriptions
for ZNF446 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger protein 4461 2 | | ZKSCAN201 2 3 | | FLJ206261 2 | | Zinc finger protein with KRAB and SCAN domains 202 3 | | ZSCAN302 |
Export aliases for ZNF446 gene to outside databasesPrevious GC identifers: GC00U911635 GC19P063680 GC19P059044 GC19P059050 |
Summaries
for ZNF446 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF446 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF446 gene promoter:
AP-1 STAT3 STAT1alpha STAT1beta STAT1 C/EBPalpha LCR-F1 MIF-1 c-Jun c-Fos
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF446
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF446  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF446 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055296: view genomic region
(about GC identifiers)
Start:
|
55,296,743 bp from pter |
End:
|
55,301,545 bp from pter |
Size:
|
4,803 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 58,987,795-58,992,591 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for ZNF446 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9 (See
protein sequence)Recommended Name: Zinc finger protein 446 Size: 450 amino acids; 48957 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF446: NX_Q9NWS9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060378.1
ENSEMBL proteins: ENSP00000336565 ENSP00000375576
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZNF446 for ontologies About GeneDecksing
Antibodies for ZNF446:
Assays for ZNF446: |
Protein
Domains/
Families
for ZNF446 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF446 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NWS9ProtoNet protein and cluster: Q9NWS9 2 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Gene Function
for ZNF446 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Function: May be involved in transcriptional regulation
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZNF446 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF446 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZNF446
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF446
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
About this table
ZNF446 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF446 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZNF446
|
Transcripts
for ZNF446 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZNF446 gene: NM_017908.2 Additional cDNA sequence: AK000633.1 AK026153.1 AK055359.1 AK310384.1 AL122108.1 AL833955.1 AY279351.1 AY280800.1 BC017206.2 8 DOTS entries: DT.95155673 DT.100779523 DT.97839687 DT.91980096 DT.100779525 DT.102840965 DT.121457189 DT.75172544 24/60 AceView cDNA sequences (see all 60): BQ441187 AW249600 BF724990 BP375489 AW070519 BU527229 CA422428 BE743568 BG819435 BF194745 AL122108 CB131805 BU151642 AY280800 BG748470 BI160944 BC017206 AA335574 AI436448 BG478804 AW902283 AK000633 BM549905 BX353954
 highest scoring ESTs for ZNF446:AI436448 AA335574 AI286331 AI459502 AK000633 AK026153 AL122108 AL833955 AW070519 AW198009 Unigene Cluster for ZNF446: Zinc finger protein 446 Hs.710284 [show with all ESTs]Unigene Representative Sequence: AK055359
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ZNF446
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335841 ENST00000391694(uc002qsz.2 uc002qta.2 uc010eur.2)
|
Expression
for ZNF446 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZNF446 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching ZNF446 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 84153_at2, 3
|
U95-E |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AI436448 |
1.00 |
1.00 |
1.00 |
1 |
| 219900_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_017908 |
0.60 |
1.00 |
0.82 |
1 |
| 219900_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1554160_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZNF446 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCCTGGGCTG
SOURCE GeneReport for Unigene cluster: Hs.710284
SABiosciences Custom PCR Arrays for ZNF446
|
Orthologs
for ZNF446 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZNF446 gene from 3 species
About this table Species with no ortholog for ZNF446
ENSEMBL Gene Tree for ZNF446 (if available) |
Paralogs
for ZNF446 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZNF446 gene
- ZNF4962 ZNF2022 ZNF4982 ZNF6412 ZNF182
ZNF446 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF446 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZNF446 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF446
4 CNVs: 50240 50238 50239 5119 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZNF446 |
|
Disorders & Mutations
for ZNF446 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for ZNF446 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZNF446 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for ZNF446 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF446)- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PubMed id 15936718)1, 7 Liu F....Liu M. (2005)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. (PubMed id 18433299)7 Xiao P....Deng H.W. (2008)
|
External Searches for ZNF446 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF446 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF446 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF446 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF446 gene:
Search GeneIP for patents involving ZNF446
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF446 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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