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ZNF572 Gene

protein-coding GIFtS: 37

GC08P121308

zinc finger protein 572
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 572¹ ²
FLJ38002¹ ²

External Ids:	HGNC: 26758¹	Entrez Gene: 137209²	Ensembl: ENSG00000180938⁷	UniProtKB: Q7Z3I7³

Export aliases for ZNF572 gene to outside databases

Previous GC identifers: GC08P125943 GC08P126054

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN572_HUMAN, Q7Z3I7

Function: May be involved in transcriptional regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF572 gene promoter:
         POU3F1   MEF-2A   GATA-1   HOXA9B   Meis-1   Hlf   AREB6   SREBP-1b   SREBP-1c   SREBP-1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZNF572

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC chromosome: 8

ZNF572 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF572 gene location

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P121308: view genomic region (about GC identifiers)

Start:	121,308,987 bp from pter
End:	121,315,079 bp from pter
Size:	6,093 bases
Orientation:	plus strand

1 alternative location:

Chr8+ 125,985,540-125,991,631

RefSeq DNA sequence:

NC_000008.10 NT_008046.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN572_HUMAN, Q7Z3I7 (See protein sequence)

Recommended Name: Zinc finger protein 572

Size: 529 amino acids; 61238 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A1L4F1 Q8N1Q0

Explore the universe of human proteins at neXtProt for ZNF572: NX_Q7Z3I7

REFSEQ proteins: NP_689625.2

ENSEMBL proteins:

ENSP00000319305

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	11256614

About this table

ZNF572 for ontologies About GeneDecksing

Antibodies for ZNF572:

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Assays for ZNF572:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF572 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q7Z3I7

ProtoNet protein and cluster: Q7Z3I7

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN572_HUMAN, Q7Z3I7

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN572_HUMAN, Q7Z3I7

Function: May be involved in transcriptional regulation (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF572 Sigma-Aldrich shRNA for ZNF572
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miRNA:		Sigma-Aldrich microRNA Mimics for ZNF572 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF572
		2 SABiosciences Assays for microRNAs that regulate ZNF572:
		hsa-miR-127-5p hsa-miR-24

Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF572 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF572 OriGene untagged cDNA clones in CMV expression vector: ZNF572 OriGene 3'-UTR clone: ZNF572 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF572
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Cell
Lines:

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3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZNF572 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZNF572

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF572

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045449	regulation of transcription	IEA	--

About this table

ZNF572 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF572

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF572 Sigma-Aldrich shRNA for ZNF572
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF572 OriGene shRNA RFP: ZNF572 OriGene basic RS shRNA: ZNF572 OriGene siRNA: ZNF572
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF572

miRNA:		Sigma-Aldrich microRNA Mimics for ZNF572 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF572
		2 SABiosciences Assays for microRNAs that regulate ZNF572:
		hsa-miR-127-5p hsa-miR-24

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF572 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF572 OriGene untagged cDNA clones in CMV expression vector: ZNF572 OriGene 3'-UTR Clone: ZNF572 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF572

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF572 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF572: PPH13630A

REFSEQ mRNAs for ZNF572 gene:

NM_152412.2

Additional cDNA sequence:

AK095321.1 BC130515.1 BC130517.1 BX537876.1

1 DOTS entry:

DT.75171814

7 AceView cDNA sequences:

AK095321 NM_152412 AI148077 BX537876 BE797682 AI582428 AW881659

highest scoring ESTs for ZNF572:

AI148077 AK095321 BX537876 AI582428 AW881659 AW881660 BE797682 NM_152412 W27300 BC130515

Unigene Cluster for ZNF572:

Zinc finger protein 572

Hs.175350 [show with all ESTs]

Unigene Representative Sequence: BX537876

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000319286(uc003yrr.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF572 expression in normal and diseased human tissues

¹ / ²

1 probe-set matching ZNF572 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1553229_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

ZNF572 gene electronic northern expression

About these images

CGAP SAGE TAG: ATTGTGGTGC

SOURCE GeneReport for Unigene cluster: Hs.175350

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF572 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF572: PPH13630A

SABiosciences Custom PCR Arrays for ZNF572

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF572 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZNF572¹	--	zinc finger protein 572	86.92(n) 83.62(a)	482038 XM_539159.2 XP_539159.2
chimpanzee (Pan troglodytes)	ZNF572¹	--	zinc finger protein 572	99.18(n) 98.48(a)	472857 XM_528229.2 XP_528229.2
cow (Bos taurus)	ZNF572¹	--	zinc finger protein 572	85.74(n) 80.61(a)	768004 NM_001077064.1 NP_001070532.1
mouse (Mus musculus)	Zfp572⁵	15	zinc finger protein 572	--	AK015560
rainbow trout (Oncorhynchus mykiss)	BX878670.1²	--	--	76.88(n)	BX878670.1

About this table Species with no ortholog for ZNF572

ENSEMBL Gene Tree for ZNF572 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZNF572 gene

ZNF768² ZNF436² ZNF263² ZSCAN2² ZNF774² ZNF358² ZNF629²

ZNF572 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1955102^1,2	C,F,	125991283(-)	`AGCATC/TATTCC`	1	--	ut3¹ ese³		10	NS EA NA WA	898
rs7825375^1,2	C,F,	125990008(+)	`CCGACG/ATTGGG`	2	/I /V	mis¹ ref¹ ese³		10	NS EA WA	976
rs7829785^1,2	C,F,A,	125990858(+)	`CAAAAA/GGAATT`	1	--	ut3¹		9	NS EA NA WA	680
rs7830564^1,2	C,	125991171(+)	`AAGGAG/ATACTG`	1	--	ut3¹ ese³		4	NS EA	420
rs7830621^1,2	H	125991375(+)	`GGACTC/TCTGAG`	1	--	ut3¹ ese³		4	NS EA	420
rs10104558^1,2	C,F,	125989460(+)	`AATAAA/CACATC`	2	K T	ref¹ mis¹ ese³		9	NS EA NA	910
rs10105106^1,2	C,F,	125989649(+)	`GTTAGG/AAGAGA`	2	/E /G	mis¹ ref¹ trp³		10	NS EA NA WA	960
rs10107774^1,2	C,F,A,	125989852(+)	`GTGAAA/TGCTTC`	2	S C	ref¹ mis¹ ese³		10	NS EA NA WA	960
rs12682497^1,2	C,F,A,H	125991820(+)	`cctccT/Cgggtt`	1	--	ng3¹		4	NA WA	8
rs13265502^1,2	H	125986756(+)	`AAGATA/CCAATA`	1	--	int¹		4	NS EA	418

About this table

HapMap Linkage Disequilibrium images for ZNF572 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF572: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF572

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/11 PubMed articles for ZNF572 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with ZNF572)

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 137209	HGNC: 26758	AceView: ZNF572	Ensembl:ENSG00000180938	euGenes: HUgn137209
ECgene: ZNF572	H-InvDB: ZNF572

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZNF572 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ZNF572 gene:
Search GeneIP for patents involving ZNF572

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF572
	SeqTarget long-range PCR primers for resequencing ZNF572
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF572

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ZNF572 Gene

protein-coding GIFtS: 37

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ZNF572 Gene

protein-coding GIFtS: 37

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for ZNF572 gene

Disorders & Mutations
for ZNF572 gene

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for ZNF572 gene

Publications
for ZNF572 gene

Intellectual Property
for ZNF572 gene

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for ZNF572 gene