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ZNF621 Gene

protein-coding GIFtS: 40

GC03P040541

zinc finger protein 621
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 621¹ ²
FLJ45246¹ ²
DKFZp686B11107²
FLJ23786²
MGC126668²
OTTHUMP00000209112²

External Ids:	HGNC: 24787¹	Entrez Gene: 285268²	Ensembl: ENSG00000172888⁷	UniProtKB: Q6ZSS3³

Export aliases for ZNF621 gene to outside databases

Previous GC identifer: GC03P040527

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF621 gene promoter:
         AREB6   C/EBPbeta
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZNF621

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF621

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p21.33

ZNF621 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF621 gene location

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P040541: view genomic region (about GC identifiers)

Start:	40,566,369 bp from pter
End:	40,616,176 bp from pter
Size:	49,808 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.11 NT_022517.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3 (See protein sequence)

Recommended Name: Zinc finger protein 621

Size: 439 amino acids; 49205 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q14DC7 Q8TE91

Alternative splicing: 2 isoforms: Q6ZSS3-1 Q6ZSS3-2

Explore the universe of human proteins at neXtProt for ZNF621: NX_Q6ZSS3

REFSEQ proteins (2 alternative transcripts):

NP_001091884.1 NP_940886.1

ENSEMBL proteins:

ENSP00000386051 ENSP00000340841 ENSP00000413236 ENSP00000408779 ENSP00000312144

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

ZNF621 for ontologies About GeneDecksing

Antibodies for ZNF621:

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	Browse antibodies at Epitomics

Assays for ZNF621:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZNF621
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF621 for domains About GeneDecksing

4 InterPro domains/families:

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZSS3

ProtoNet protein and cluster: Q6ZSS3

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 7 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3

Function: May be involved in transcriptional regulation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF621 Sigma-Aldrich shRNA for ZNF621
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ZNF621 OriGene shRNA RFP (see all 4): ZNF621 OriGene basic RS shRNA (see all 4): ZNF621 OriGene siRNA (see all 3): ZNF621
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF621

miRNA:		Sigma-Aldrich microRNA Mimics for ZNF621 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF621
		1 SABiosciences Assays for microRNA that regulate ZNF621:
		hsa-miR-335

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF621 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF621 OriGene untagged cDNA clones in CMV expression vector (see all 3): ZNF621 OriGene 3'-UTR clone (see all 2): ZNF621 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF621
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZNF621

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZNF621 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZNF621

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF621

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

ZNF621 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF621

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF621 Sigma-Aldrich shRNA for ZNF621
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ZNF621 OriGene shRNA RFP (see all 4): ZNF621 OriGene basic RS shRNA (see all 4): ZNF621 OriGene siRNA (see all 3): ZNF621
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF621

miRNA:		Sigma-Aldrich microRNA Mimics for ZNF621 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF621
		1 SABiosciences Assays for microRNA that regulate ZNF621:
		hsa-miR-335

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF621 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF621 OriGene untagged cDNA clones in CMV expression vector (see all 3): ZNF621 OriGene 3'-UTR Clone (see all 2): ZNF621 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF621

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF621 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF621: PPH08240A

REFSEQ mRNAs for ZNF621 gene (2 alternative transcripts):

NM_001098414.1 NM_198484.3

Additional cDNA sequence:

AK074366.1 BC101619.1 BC113415.1 CR749268.1

5 DOTS entries:

DT.101981767 DT.91865015 DT.120853231 DT.92042620 DT.100019783

24/104 AceView cDNA sequences (see all 104):

AA430479 R40398 NM_198484 BU188973 AA029153 AI094286 N41962 BQ718780

AI672426 AK127181 BQ677703 AI375136 BX457201 BX951154 BX091128 CB853133

AL044008 CR749268 AA719398 AW969594 CF126937 AA641212 BM722416 BX503658

highest scoring ESTs for ZNF621:

AA130158 AI672426 AA417970 AA418147 AA430479 AA457312 AA641212 AA897122 AA897142 AI094286

Unigene Cluster for ZNF621:

Zinc finger protein 621

Hs.19977 [show with all ESTs]

Unigene Representative Sequence: NM_198484

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 (see all 6)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:											-		-						-
SP2:													-						-
SP3:											-		-				-
SP4:																			-
SP5:													-				-		-

About this scheme

ECgene alternative splicing isoforms for ZNF621
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000403205 ENST00000339296(uc003ckm.2 uc003ckn.2 uc003cko.2 uc011aze.1)

ENST00000431278 ENST00000490457 ENST00000462161 ENST00000453351 ENST00000492098

ENST00000310898

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF621 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching ZNF621 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48423_at²^{, 3}	U95-B	1	1.00	1.00	0.91	1.10	AA130158	0.80	1.00	0.91	1
80378_at²^{, 3}	U95-D	1	0.69	1.00	0.75	0.92	AI672426	0.80	1.00	0.91	1
230164_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA417970	0.60	1.00	0.82	1
241499_at²^{, 3}	U133-B	1	0.73	1.00	--	--	AI672426	0.80	1.00	0.91	1
230164_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558620_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
241499_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

ZNF621 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ZNF621 gene electronic northern expression

About these images

CGAP SAGE TAG: CTACAGATAA

SOURCE GeneReport for Unigene cluster: Hs.19977

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF621 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF621: PPH08240A

SABiosciences Custom PCR Arrays for ZNF621

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF621 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	LOC786193¹	--	similar to zinc finger protein 619	84.6(n) 83.14(a)	786193 XM_001253951.1 XP_001253952.1

About this table Species with no ortholog for ZNF621

ENSEMBL Gene Tree for ZNF621 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZNF621 gene

ZNF19² ZNF619² ZNF620²

ZNF621 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs12520^1,2	C,	40580387(-)	`TCCACC/TGAAGT`	2	--	ut3¹		1		WA	2
rs1142464^1,2	C,F,	40581013(+)	`TAGGTA/GCTGGA`	2	--	ut3¹		8		NA NS EA WA	588
rs3924444^1,2	C,F,A,	40576061(+)	`ATGTGC/TCTGAA`	2	--	ut3¹		16		NS EA NA WA	836
rs4264703^1,2	H	40575896(+)	`GAACTT/AGAATT`	2	--	ut3¹		4		NS EA	420
rs4602359^1,2	C,F,	40579357(+)	`tagctA/Gagtta`	2	--	ut3¹		11		NS EA NA WA	762
rs5848568^1,2	--	40575972(+)	`TTTTT-/TTTTTT`	2	--	ut3¹ trp³		0	--	--	--	--
rs6599108^1,2	C,F,A,	40565594(+)	`GAAAAA/GTAAGT`	2	--	ng5¹		8		NA EA WA	356
rs6775029^1,2	C,F,A,	40578815(+)	`tggccA/Gggtgc`	2	--	ut3¹		1		WA	50
rs6807150^1,2	C	40568557(+)	`aggctG/Agagtg`	2	--	int¹		1		WA	2
rs7624102^1,2	C,F,	40579256(+)	`agcagA/Tggttg`	2	--	ut3¹		2		WA	52

About this table

HapMap Linkage Disequilibrium images for ZNF621 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF621: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF621

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

5 PubMed articles for ZNF621 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF621)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285268	HGNC: 24787	AceView: ZNF621	Ensembl:ENSG00000172888	euGenes: HUgn285268
ECgene: ZNF621	H-InvDB: ZNF621

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZNF621 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ZNF621 gene:
Search GeneIP for patents involving ZNF621

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF621
	SeqTarget long-range PCR primers for resequencing ZNF621
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF621
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF621

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ZNF621 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for ZNF621 gene

Summaries
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for ZNF621 gene

Proteins
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Gene Function
for ZNF621 gene

Pathways & Interactions
for ZNF621 gene

Drugs & Compounds
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Expression
for ZNF621 gene

Orthologs
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for ZNF621 gene

Genomic Variants
for ZNF621 gene

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ZNF621 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor ZNF621 gene

Summariesfor ZNF621 gene

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Proteinsfor ZNF621 gene

Protein Domains/Familiesfor ZNF621 gene

Gene Functionfor ZNF621 gene

Pathways & Interactionsfor ZNF621 gene

Drugs & Compoundsfor ZNF621 gene

Transcriptsfor ZNF621 gene

Expression for ZNF621 gene

Orthologsfor ZNF621 gene

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Genomic Variantsfor ZNF621 gene

Disorders & Mutationsfor ZNF621 gene

Medical Newsfor ZNF621 gene

Publicationsfor ZNF621 gene

External Searches for ZNF621 gene

Genome Databases showing ZNF621 gene

Other Databases showing ZNF621 gene

Specialized Databases showing ZNF621 gene

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Productsfor ZNF621 gene

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Aliases &
Descriptions
for ZNF621 gene

Summaries
for ZNF621 gene

Genomic Views
for ZNF621 gene

Proteins
for ZNF621 gene

Protein Domains/
Families
for ZNF621 gene

Gene Function
for ZNF621 gene

Pathways & Interactions
for ZNF621 gene

Drugs & Compounds
for ZNF621 gene

Transcripts
for ZNF621 gene

Expression
for ZNF621 gene

Orthologs
for ZNF621 gene

Paralogs
for ZNF621 gene

Genomic Variants
for ZNF621 gene

Disorders & Mutations
for ZNF621 gene

Medical News
for ZNF621 gene

Publications
for ZNF621 gene

Intellectual Property
for ZNF621 gene

Products
for ZNF621 gene