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ZNF75A Gene

protein-coding GIFtS: 44

GC16P003325

zinc finger protein 75a
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 75a¹ ²
FLJ31529¹ ²
MGC59959²

External Ids:	HGNC: 13146¹	Entrez Gene: 7627²	Ensembl: ENSG00000162086⁷	UniProtKB: Q96N20³

Export aliases for ZNF75A gene to outside databases

Previous GC identifers: GC16U990066 GC16P003389 GC16P003355 GC16P003295

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF75A gene promoter:
         FOXC1   PPAR-gamma2   PPAR-gamma1   RelA   STAT5A   Chx10   RREB-1   GCNF-1   GCNF-2   FOXO3b
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ZNF75A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF75A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.11

ZNF75A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF75A gene location

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003325: view genomic region (about GC identifiers)

Start:	3,325,084 bp from pter
End:	3,338,228 bp from pter
Size:	13,145 bases
Orientation:	plus strand

1 alternative location:

Chr16+ 3,355,486-3,368,574

RefSeq DNA sequence:

NC_000016.9 NT_010393.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20 (See protein sequence)

Recommended Name: Zinc finger protein 75A

Size: 296 amino acids; 34694 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q0VDI8 Q92669

Explore the universe of human proteins at neXtProt for ZNF75A: NX_Q96N20

REFSEQ proteins: NP_694573.1

ENSEMBL proteins:

ENSP00000413315 ENSP00000293995

Human Recombinant Proteins

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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0043231	intracellular membrane-bounded organelle	--	--

About this table

ZNF75A for ontologies About GeneDecksing

Antibodies for ZNF75A:

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Assays for ZNF75A:

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	Uscn ELISAs and CLIAs for ZNF75A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF75A for domains About GeneDecksing

4 InterPro domains/families:

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96N20

ProtoNet protein and cluster: Q96N20

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN75A_HUMAN, Q96N20

Function: May be involved in transcriptional regulation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF75A Sigma-Aldrich shRNA for ZNF75A
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF75A
		Search SABiosciences for Assays for microRNAs that regulate ZNF75A

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF75A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF75A OriGene untagged cDNA clones in CMV expression vector: ZNF75A OriGene 3'-UTR clone: ZNF75A Browse MicroRNA Expression Plasmids
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ZNF75A

Genatlas biochemistry entry for ZNF75A:

zinc finger protein 75,related sequence A

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZNF75A for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZNF75A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF75A

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--

About this table

ZNF75A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF75A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZNF75A Sigma-Aldrich shRNA for ZNF75A
		OriGene 29mer shRNA kits in GFP-retroviral vector: ZNF75A OriGene shRNA RFP: ZNF75A OriGene basic RS shRNA: ZNF75A OriGene siRNA: ZNF75A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF75A

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF75A
		Search SABiosciences for Assays for microRNAs that regulate ZNF75A

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZNF75A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF75A OriGene untagged cDNA clones in CMV expression vector: ZNF75A OriGene 3'-UTR Clone: ZNF75A Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZNF75A

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF75A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF75A: PPH09410A

REFSEQ mRNAs for ZNF75A gene:

NM_153028.2

Additional cDNA sequence:

AK056091.1 AK093979.1 BC039601.1 BC051366.1 BC119652.1 BC119653.1 BC150306.1 CR749782.1

12 DOTS entries:

DT.413448 DT.120672483 DT.100745633 DT.70104846 DT.40113378 DT.204411 DT.100717723 DT.120672458

DT.120672488 DT.92417086 DT.95203949 DT.120672495

24/91 AceView cDNA sequences (see all 91):

AI572250 BU145762 CA413716 AA423932 AI313421 R85696 AK093979 CR749782

BU101946 BC051366 AA829635 AA884695 AI263181 AI648586 AA969310 BE208132

AA279687 AW628313 BX101232 AI745304 AX748391 BM746950 H88041 NM_012368

highest scoring ESTs for ZNF75A:

N74222 AA126829 AA127311 AA278382 AA279687 AA423932 AA631980 AA631981 AA712108 AA776830

Unigene Cluster for ZNF75A:

Zinc finger protein 75a

Hs.513292 [show with all ESTs]

Unigene Representative Sequence: BC150306

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A (see all 9)

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:									-		-		-		-		-		-												-
SP2:									-		-		-		-		-		-								-		-		-
SP3:															-		-		-								-		-		-
SP4:															-		-		-
SP5:															-		-		-

About this scheme

ECgene alternative splicing isoforms for ZNF75A
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421945 ENST00000498240(uc002cuv.3) ENST00000293995(uc002cut.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF75A expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching ZNF75A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45689_at²^{, 3}	U95-B	1	0.94	1.00	0.77	1.16	N74222	1.00	1.00	1.00	1
60183_at²^{, 3}	U95-C	1	0.31	1.00	0.79	0.85	AI804230	0.60	1.00	0.82	1
227670_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N74222	1.00	1.00	1.00	1
239204_at²^{, 3}	U133-B	1	0.36	1.00	--	--	BG054519	0.40	1.00	0.76	1
227670_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239204_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

ZNF75A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ZNF75A gene electronic northern expression

About these images

CGAP SAGE TAG: GTGGAACCCT

SOURCE GeneReport for Unigene cluster: Hs.513292

Primers:		OriGene genome-wide validated SYBR primer pairs: ZNF75A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ZNF75A: PPH09410A

SABiosciences Custom PCR Arrays for ZNF75A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF75A gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZNF75A¹	--	zinc finger protein 75a	99.21(n) 99.66(a)	453861 XM_510768.2 XP_510768.2

About this table Species with no ortholog for ZNF75A

ENSEMBL Gene Tree for ZNF75A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZNF75A gene

ZNF75D²

ZNF75A for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs37840^1,2	C,F,H,	3362953(+)	`GTTCTG/TTTAAT`	1	--	int¹		16		NA PA NS EA WA	748
rs757108^1,2	C,	3362017(+)	`TGTCAT/CGGGCA`	1	--	int¹		9		MN NS EA NA	768
rs1149483^1,2	C,F,A,H,	3356834(+)	`TTTACT/CTTCTG`	1	--	int¹		11		NS EA NA WA	632
rs1149484^1,2	C,F,H,	3355264(+)	`AGACGT/CGGCAG`	1	--	ng5¹		7		NA WA	16
rs1149485^1,2	C	3355035(+)	`ACCTAG/AAAAAC`	1	--	ng5¹		4		MN EA NA	242
rs1714502^1,2	C	3357299(+)	`tattgT/Gaccta`	1	--	int¹		4		NS EA	410
rs2240024^1,2	C,F,	3361884(+)	`ACATAC/TGAGGG`	1	--	ut5¹ ese³		5		NS EA	508
rs2524313^1,2	A	3353902(+)	`AACTCA/GGCTCA`	1	--	ng5¹		1		NA	2
rs2680232^1,2	C,A,H	3353901(+)	`gaactC/CG /G/GAggctc`	1	--	ng5¹		0	--	--	--	--
rs3840980^1,2	--	3362915(-)	`AAAAA-/AGGAGA`	1	--	int¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZNF75A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF75A: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF75A

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF75A for disorders About GeneDecksing

OMIM: 601473

Export disorders and mutations for ZNF75A gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

7 PubMed articles for ZNF75A gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF75A)

The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PubMed id 8661144)^{1, 2, 3} Villa A.... Vezzoni P. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7627	HGNC: 13146	AceView: OR2C1andZNF75A	Ensembl:ENSG00000162086	euGenes: HUgn7627
ECgene: ZNF75A	H-InvDB: ZNF75A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZNF75A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ZNF75A gene:
Search GeneIP for patents involving ZNF75A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF75A
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF75A

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ZNF75A Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for ZNF75A gene

Summaries
for ZNF75A gene

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ZNF75A Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor ZNF75A gene

Summariesfor ZNF75A gene

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Proteinsfor ZNF75A gene

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Gene Functionfor ZNF75A gene

Pathways & Interactionsfor ZNF75A gene

Drugs & Compoundsfor ZNF75A gene

Transcriptsfor ZNF75A gene

Expression for ZNF75A gene

Orthologsfor ZNF75A gene

Paralogsfor ZNF75A gene

Genomic Variantsfor ZNF75A gene

Disorders & Mutationsfor ZNF75A gene

Medical Newsfor ZNF75A gene

Publicationsfor ZNF75A gene

External Searches for ZNF75A gene

Genome Databases showing ZNF75A gene

Other Databases showing ZNF75A gene

Specialized Databases showing ZNF75A gene

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View Random Gene

Aliases &
Descriptions
for ZNF75A gene

Summaries
for ZNF75A gene

Genomic Views
for ZNF75A gene

Proteins
for ZNF75A gene

Protein Domains/
Families
for ZNF75A gene

Gene Function
for ZNF75A gene

Pathways & Interactions
for ZNF75A gene

Drugs & Compounds
for ZNF75A gene

Transcripts
for ZNF75A gene

Expression
for ZNF75A gene

Orthologs
for ZNF75A gene

Paralogs
for ZNF75A gene

Genomic Variants
for ZNF75A gene

Disorders & Mutations
for ZNF75A gene

Medical News
for ZNF75A gene

Publications
for ZNF75A gene

Intellectual Property
for ZNF75A gene

Products
for ZNF75A gene