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ZNF828 Gene

protein-coding   GIFtS: 44

GC13P095342
zinc finger protein 828
(Previous name: chromosome 13 open reading frame 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C13orf8)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 8281 2
KIAA18022 3
C13orf82 3
chromosome 13 open reading frame 81
FLJ904132
CAMP2

External Ids:    HGNC: 203111   Entrez Gene: 2834892   Ensembl: ENSG000001988247   UniProtKB: Q96JM33   

Export aliases for ZNF828 gene to outside databases

Previous GC identifers: GC13P114099 GC13P115079


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for ZNF828 (C13orf8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF828
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF828

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF828 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ZNF828 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF828 gene location

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P095342:  view genomic region     (about GC identifiers)

Start:
95,342,333 bp from pter
End:
95,355,170 bp from pter
Size:
12,838 bases
Orientation:
plus strand

1 alternative location:
Chr13+ 115,079,988-115,092,796     
RefSeq DNA sequence:
NC_000013.10  NT_024498.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN828_HUMAN, Q96JM3 (See protein sequence)
Recommended Name: Zinc finger protein 828  
Size: 812 amino acids; 89099 Da
Sequence caution: Sequence=BAB47431.1; Type=Erroneous initiation; Sequence=BAC11273.1; Type=Erroneous initiation;
Secondary accessions: B3KU06 Q6P181 Q8NC88 Q9BST0

Explore the universe of human proteins at neXtProt for ZNF828: NX_Q96JM3 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001157616.1  NP_001157617.1  NP_115812.1  


    ENSEMBL proteins: 
    ENSP00000354730 


    Human Recombinant Proteins 
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    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777 condensed chromosome kinetochore IDA--
    GO:0000793 condensed chromosome IDA--
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IDA--
    GO:0005819 spindle IDA--
    About this table

    ZNF828 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF828 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF828 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96JM3

    ProtoNet protein and cluster: Q96JM3

    UniProtKB/Swiss-Prot: ZN828_HUMAN, Q96JM3
    Similarity: Contains 1 C2H2-type zinc finger


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF828 
    2 SABiosciences Assays for microRNAs that regulate ZNF828:
    hsa-miR-182 hsa-miR-7

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene 3'-UTR clone (see all 3): ZNF828 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF828 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNF828 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0005515 protein binding IPI--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF828 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF828 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF828

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031134 sister chromatid biorientation IMP--
    GO:0034501 protein localization to kinetochore IMP--
    GO:0035372 protein localization to microtubule IMP--
    GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation IMP--
    About this table

    ZNF828 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF828


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZNF828
    Sigma-Aldrich shRNA for ZNF828
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): ZNF828
    OriGene shRNA RFP (see all 5): ZNF828
    OriGene basic RS shRNA (see all 5): ZNF828
    OriGene siRNA (see all 4): ZNF828
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF828 
    miRNA: Sigma-Aldrich microRNA Mimics for ZNF828
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF828 
    2 SABiosciences Assays for microRNAs that regulate ZNF828:
    hsa-miR-182 hsa-miR-7
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ZNF828
    OriGene 3'-UTR Clone (see all 3): ZNF828 
    Browse OriGene MicroRNA Expression Plasmids 
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    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF828
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF828: PPH07523A

    REFSEQ mRNAs for ZNF828 gene (3 alternative transcripts): 

    NM_001164144.1  NM_001164145.1  NM_032436.2  

    Additional cDNA sequence: 

    AB058705.1 AK074894.1 AK096346.1 BC004820.1 BC019576.1 BC065237.1 

    3 DOTS entries:

    DT.117256  DT.100700238  DT.102824764 

    24/144 AceView cDNA sequences (see all 144):

    NM_032436 AI276616 AA947217 BU623010 AI094008 AI279795 AI524282 AI272787 
    BC065237 AB058705 BC004820 BU183977 AW072859 AI147639 AA830479 AI991432 
    AA830342 AA768835 AI805803 AA767338 BU686031 AI078066 AA258957 BM802649 

    Unigene Cluster for ZNF828:

    Zinc finger protein 828
    Hs.7542  [show with all ESTs]
    Unigene Representative Sequence: NM_032436


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF828

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
    SP1:                    -                                       
    SP2:                                                            
    SP3:                                                            
    SP4:                                -                           

    About this scheme

    ECgene alternative splicing isoforms for ZNF828
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463003 ENST00000478022 ENST00000361283(uc010ahb.2 uc001vuv.2 uc010tko.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF828 expression in normal and diseased human tissues

    1  / 2

    3 probe-sets matching ZNF828 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    46269_at2 U95-B 1 1.00 1.00 1.00 1.00 -- -- -- -- --
    226194_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --
    226194_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    ZNF828 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNF828 gene expression
    ZNF828 gene electronic northern expression
    ZNF828 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.7542
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF828
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF828: PPH07523A
        SABiosciences Custom PCR Arrays for ZNF828 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNF828 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ZNF8281   -- zinc finger protein 828 99.79(n)
    99.63(a)
    467339  XM_522736.2  XP_522736.2 
    rat
    (Rattus norvegicus)
    Zfp8281   -- zinc finger protein 828 80.56(n)
    78.6(a)
    306647  XM_225063.4  XP_225063.3 
    mouse
    (Mus musculus)
    Zfp8281 , 5 8 (6.40 cM)5
    zinc finger protein 8281, 5 79.57(n)1
    77.07(a)1
    1019941  NM_181854.11  NP_862902.11 
     AA6738155  AI1160015  (see all 22)
    chicken
    (Gallus gallus)
    ZNF8281   -- zinc finger protein 828 64.24(n)
    58.11(a)
    418733  XM_416932.2  XP_416932.2 
    African clawed frog
    (Xenopus laevis)
    BJ066571.12   --   -- 77.6(n)  BJ066571.1 
    About this table        Species with no ortholog for ZNF828

    ENSEMBL Gene Tree for ZNF828 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF828 gene
    ENSG000002045332  

    ZNF828 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/161 NCBI SNPs in ZNF828 are shown (see all 161)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 13 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs21494311,2
    --115078250(+) aaaaaA/Ggaaaa 2 -- ng51 tfbs3 trp30--------
    rs24029501,2
    A115078246(+) aaaaaA/Gaaaag 2 -- ng51 trp30--------
    rs37645221,2
    C,F115091019(-) GAATAG/CAGCAG 6 /L /V ref1 mis19Minor allele frequency- C:0.01EA NS 2332
    rs38131311,2
    C,F,A,H,115090019(+) TTCCCG/AGAAAC 6 /P syn1 ref1 ese313Minor allele frequency- A:0.18NS EA NA WA 992
    rs38131321,2
    C,115090136(+) CGGACT/CACCTC 6 /T syn1 ref1 ese31Minor allele frequency- C:0.01NA 78
    rs38131331,2
    C,F,A,H,115090193(+) AAGCCG/ATTCCC 6 /P syn1 ref111Minor allele frequency- A:0.11NS EA NA 840
    rs39934241,2
    --115083917(+) cctcaA/Ggctcc 2 -- int10--------
    rs44775601,2
    --115079992(+) GATCCC/GGGCTC 2 -- ut51 ese30--------
    rs61452571,2
    --115087093(+) CAGTT-/GGGCT 
     GTTCATT
    ATTGC
    2 -- int10--------
    rs73385471,2
    C,F,115081108(+) aaaaaG/Aacata 2 -- int15Minor allele frequency- A:0.02NS EA WA 468
    About this table

    HapMap Linkage Disequilibrium images for ZNF828 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZNF828
         2 CNVs: 49180 71827

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF828 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/21 PubMed articles for ZNF828 gene, integrated from 7 sources (see all 21):
    (articles sorted by number of sources associating them with ZNF828)
    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    7. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    8. CAMP (C13orf8, ZNF828) is a novel regulator of kineto chore-microtubule attachment. (PubMed id 21063390)1 Itoh G....Tanaka K. (2010 Nov 9)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283489 HGNC: 20311 AceView: C13orf8 Ensembl:ENSG00000198824 euGenes: HUgn283489
    ECgene: ZNF828 H-InvDB: ZNF828

    (According to HUGE)
    About This Section
    HUGE: KIAA1802

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNF828 gene:
    Search GeneIP for patents involving ZNF828

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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