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ZNF836 Gene

protein-coding   GIFtS: 37

GC19M048989
zinc finger protein 836
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 8361 2
FLJ162871 2

External Ids:    HGNC: 343331   Entrez Gene: 1629622   Ensembl: ENSG000001962677   UniProtKB: Q6ZNA13   

Export aliases for ZNF836 gene to outside databases

Previous GC identifers: GC19M057352 GC19M052659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN836_HUMAN, Q6ZNA1
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF836
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF836

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF836 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

ZNF836 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF836 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048989:  view genomic region     (about GC identifiers)

Start:
48,988,552 bp from pter
End:
49,005,322 bp from pter
Size:
16,771 bases
Orientation:
minus strand

1 alternative location:
Chr19- 52,658,125-52,674,896     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN836_HUMAN, Q6ZNA1 (See protein sequence)
Recommended Name: Zinc finger protein 836  
Size: 936 amino acids; 107717 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF836: NX_Q6ZNA1 

REFSEQ proteins: NP_001096127.1  

ENSEMBL proteins: 
ENSP00000325038 ENSP00000408965 ENSP00000379720 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
About this table

ZNF836 for ontologies           About GeneDecksing



Antibodies for ZNF836: 
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Assays for ZNF836: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF836 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZNA1

ProtoNet protein and cluster: Q6ZNA1

2 Blocks protein families:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZN836_HUMAN, Q6ZNA1
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 25 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZN836_HUMAN, Q6ZNA1
Function: May be involved in transcriptional regulation

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF836
Sigma-Aldrich shRNA for ZNF836
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ZNF836
OriGene shRNA RFP (see all 3): ZNF836
OriGene basic RS shRNA (see all 3): ZNF836
OriGene siRNA (see all 3): ZNF836
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF836 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF836 
Search SABiosciences for Assays for microRNAs that regulate ZNF836

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF836
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF836
OriGene untagged cDNA clones in CMV expression vector: ZNF836
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF836 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZNF836 

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding ----
GO:0003677 DNA binding IEA--
GO:0003700 sequence-specific DNA binding transcription factor activity ----
GO:0008270 zinc ion binding IEA--
GO:0030528 transcription regulator activity ----
About this table

ZNF836 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF836 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF836

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0045449 regulation of transcription ----
About this table

ZNF836 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF836


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF836
Sigma-Aldrich shRNA for ZNF836
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ZNF836
OriGene shRNA RFP (see all 3): ZNF836
OriGene basic RS shRNA (see all 3): ZNF836
OriGene siRNA (see all 3): ZNF836
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF836 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF836 
Search SABiosciences for Assays for microRNAs that regulate ZNF836
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZNF836
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF836
OriGene untagged cDNA clones in CMV expression vector: ZNF836
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF836 
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF836
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF836: PPH22713A

REFSEQ mRNAs for ZNF836 gene: 

NM_001102657.1  

Additional cDNA sequence: 

AK131308.1 BC011784.2 BC049172.1 

4 DOTS entries:

DT.97792340  DT.95153483  DT.424978  DT.40129780 

24/31 AceView cDNA sequences (see all 31):

BC049172 BQ924523 BC011784 BE880918 AI279289 BE791720 BE543323 BM785374 
CB267899 AA564470 BQ017126 AK131308 BQ948973 BX282298 BG503293 N94749 
AL599886 BI117191 W76168 W38920 AA319593 BF437664 AA054324 T94241 

Unigene Cluster for ZNF836:

Zinc finger protein 836
Hs.631584  [show with all ESTs]
Unigene Representative Sequence: NM_001102657


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF836 (see all 6)

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1:              -     -                                         -                           
SP2:              -     -                                   -     -                           
SP3:              -     -                                                                     
SP4:                    -                                   -     -                           
SP5:              -     -           -     -                 -     -                           

About this scheme

ECgene alternative splicing isoforms for ZNF836
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000322146(uc010ydi.1 uc010ydj.1) ENST00000457013 ENST00000396443


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF836 expression in normal and diseased human tissues

1  / 2

2 probe-sets matching ZNF836 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1569076_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
1569077_x_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZNF836 gene expression
ZNF836 gene electronic northern expression
ZNF836 gene sage expression
About these images

CGAP SAGE TAG: ATCTCCGCTC

SOURCE GeneReport for Unigene cluster: Hs.631584
Primers: OriGene genome-wide validated SYBR primer pairs: ZNF836
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZNF836: PPH22713A
    SABiosciences Custom PCR Arrays for ZNF836 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZNF836 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZNF8361   -- zinc finger protein 836 58.8(n)
50.67(a)
486429  XM_543555.2  XP_543555.2 
chimpanzee
(Pan troglodytes)
ZNF8361   -- zinc finger protein 836 99.29(n)
98.82(a)
456261  XM_001174455.1  XP_001174455.1 
cow
(Bos taurus)
LOC5269391   -- hypothetical LOC526939 72.92(n)
62.5(a)
526939  XM_605322.3  XP_605322.3 
About this table        Species with no ortholog for ZNF836

ENSEMBL Gene Tree for ZNF836 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF836 gene
ZNF780B2  ZNF912  ZNF4202  ZNF1892  ZNF1072  ZNF7292  ZNF992  ZNF5462  
ZNF7212  ZNF585B2  ZNF6242  ZNF5942  ZFP622  ZNF8412  ZNF2082  

ZNF836 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/191 NCBI SNPs in ZNF836 are shown (see all 191)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs9192681,2
C,F,A,H,52671898(-) AGATAT/AGTATA 1 -- int18Minor allele frequency- A:0.33NS EA NA WA 370
rs9192701,2
C,F,A,H,52668553(-) ATCTTC/TACCAC 1 -- int123Minor allele frequency- N:0.00MN NS EA NA WA 1468
rs9192711,2
C,F,A,H,52668414(-) GTGATT/CATAAA 1 -- int117Minor allele frequency- C:0.28NS EA NA WA 784
rs9192721,2
C,F,A,H,52668369(-) CTTACA/GTTTTC 1 -- int111Minor allele frequency- G:0.47NS EA NA WA 524
rs13662451,2
C,F,O,A,H,52660279(-) TATATG/ATGTAA 2 /I /M mis1 ref1 ese333Minor allele frequency- A:0.49NA EA NS WA 3542
rs18085341,2
--52672604(-) CTGCCA/GGCCTC 1 -- int10--------
rs18212781,2
C,F,O,A,52659991(+) AGGTTA/GTAACT 2 Y syn1 ref113Minor allele frequency- G:0.49NA NS EA WA 778
rs20138991,2
C,F,A,H,52668697(-) TGAAGC/TGTACA 1 -- int126Minor allele frequency- N:0.00NS EA NA WA 3146
rs30343181,2
--52671795(-) ggcat-/CATgatct 1 -- int10--------
rs32145521,2
C52674191(-) TCGAT-/TCCCCC 1 -- int1 trp30--------
About this table

HapMap Linkage Disequilibrium images for ZNF836 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF836
     1 CNV: 9805

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF836 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

3 PubMed articles for ZNF836 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZNF836)
  1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 162962 HGNC: 34333 AceView: FLJ16287 Ensembl:ENSG00000196267 euGenes: HUgn162962
ECgene: ZNF836 H-InvDB: ZNF836

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF836 gene:
Search GeneIP for patents involving ZNF836

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF836
 SeqTarget long-range PCR primers for resequencing ZNF836
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF836
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF836
 GenScript Custom Purified and Recombinant Proteins Services for ZNF836 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZNF836
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