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ZNF888 Gene

protein-coding   GIFtS: 26

GC19M053410
zinc finger protein 888
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for ZNF888 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
zinc finger protein 8881 2

External Ids:    HGNC: 386951   Entrez Gene: 3885592   Ensembl: ENSG000002137937   UniProtKB: A8MVZ34   

Export aliases for ZNF888 gene to outside databases


Summaries
for ZNF888 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ZNF888 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF888
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF888

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF888 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF888 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053410:  view genomic region     (about GC identifiers)

Start:
 53,408,210 bp from pter
End:
 53,421,126 bp from pter
Size:
 12,917 bases
Orientation:
 minus strand

1 alternative location:
Chr19- 49,736,094-49,749,025     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

Proteins
for ZNF888 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/TrEMBL: A8MVZ3 (See protein sequence)
Recommended Name: Uncharacterized protein  
Size: 47 amino acids; 5574 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as
preliminary data

Explore the universe of human proteins at neXtProt for ZNF888: NX_A8MVZ3 



ENSEMBL proteins: 
ENSP00000401894 


Human Recombinant Proteins 
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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular ----
About this table

ZNF888 for ontologies           About GeneDecksing



Antibodies for ZNF888: 
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Assays for ZNF888: 
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Protein Domains/
Families
for ZNF888 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
ZNF888 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR001909 Krueppel-associated_box

Graphical View of Domain Structure for InterPro Entry A8MVZ3

ProtoNet protein and cluster: A8MVZ3


Gene Function
for ZNF888 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for ZNF888
Browse shRNA at Sigma-Aldrich
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF888 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF888 
Search SABiosciences for Assays for microRNAs that regulate ZNF888

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Browse OriGene untagged/tagged cDNA clones in CMV expression vector
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for ZNF888 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003676 nucleic acid binding ----
About this table

ZNF888 for ontologies           About GeneDecksing


Pathways & Interactions
for ZNF888 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZNF888 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF888

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent ----
About this table

ZNF888 for ontologies           About GeneDecksing



Drugs & Compounds
for ZNF888 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF888


Transcripts
for ZNF888 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for ZNF888
Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF888 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF888 
Search SABiosciences for Assays for microRNAs that regulate ZNF888
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZNF888 
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for ZNF888

Additional cDNA sequence: XM_496322.5 

2 DOTS entries:

DT.92416069  DT.70104669 

1 AceView cDNA sequence:

BG341005 

Unigene Cluster for ZNF888:

Zinc finger protein 888
Hs.677986  [show with all ESTs]
Unigene Representative Sequence: XM_496322


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000454258

Expression
for ZNF888 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZNF888 expression in normal and diseased human tissues

Data from GNF BioGPS
    About these images

ZNF888 gene expression
ZNF888 gene electronic northern expression
ZNF888 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.677986
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for ZNF888
    SABiosciences Custom PCR Arrays for ZNF888 


Orthologs
for ZNF888 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for ZNF888 gene from 1 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
mouse
(Mus musculus)		 Gm131545 4 (78.51 cM) predicted gene 13154   -- CF896923 
About this table        Species with no ortholog for ZNF888

ENSEMBL Gene Tree for ZNF888 (if available)

Paralogs
for ZNF888 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZNF888 gene
ZNF6162  ZNF5342  ZNF1602  ZNF4682  ZNF6652  ZNF8802  ZNF7662  ZNF8602  
ZNF5252  ZNF3202  ZNF4152  ZNF6002  ZNF3212  ZNF5282  ZNF282  ZNF6112  
ZNF6772  ZNF8082  ZNF3472  ENSG000002138012  ZNF832  ZNF8452  ZNF6102  ZNF8162  
ZNF7012  ZNF7652  ZNF4802  ZNF8132  

ZNF888 for paralogs           About GeneDecksing



Genomic Variants
for ZNF888 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/18 NCBI SNPs in ZNF888 are shown (see all 18)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs28701281,2
C,F,A,53410373(+) TTACAA/GTATGC 2 T I mis1 ref114Minor allele frequency- G:0.44NS EA NA WA 982
rs48030211,2
--53418471(+) CTATAA/GTTCTC 2 N syn1 ref10--------
rs65097021,2
C,F,A,53410828(+) AAGTCT/CTTGCC 2 /K ref1 syn13Minor allele frequency- C:0.21NA WA 76
rs72556681,2
C,A53411166(+) CTGATC/ATTTAA 2 /D /Y mis1 ref12Minor allele frequency- A:0.50WA NA 4
rs72560371,2
C,F,A,53411347(+) CTTGCC/AAGTCT 2 /L ref1 syn14Minor allele frequency- A:0.26NA EA WA 164
rs72562601,2
C,F,A,53411368(+) CCTGTG/ATGGAT 2 /H ref1 syn13Minor allele frequency- A:0.25NA EA WA 162
rs133456391,2
A53418555(+) GCCACA/GTCCCT 2 D syn1 ref10--------
rs343367081,2
--53410806(+) TGCAAA/GGTATC 2 L F ref1 mis10--------
rs558090291,2
C,53409976(+) GAATTC/TTGAAC 2 Q ref1 syn12Minor allele frequency- T:0.50NA WA 4
rs617419541,2
C53409766(+) GGTTTA/CTCTCC 2 E D ref1 mis10--------
About this table

HapMap Linkage Disequilibrium images for ZNF888 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ZNF888: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZNF888 

Disorders & Mutations
for ZNF888 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for ZNF888 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for ZNF888 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section
  --

External Searches for ZNF888 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing ZNF888 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388559 HGNC: 38695 AceView: LOC388559.1 Ensembl:ENSG00000213793 euGenes: HUgn388559
ECgene: ZNF888 H-InvDB: ZNF888

Other Databases showing ZNF888 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing ZNF888 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for ZNF888 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZNF888 gene:
Search GeneIP for patents involving ZNF888

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for ZNF888 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services

 Predesigned and custom siRNAs for ZNF888 Browse antibodies at Sigma-Aldrich
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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