Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



ZNRF1 Gene

protein-coding   GIFtS: 49

GC16P060784
zinc and ring finger 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc and ring finger 11 2     nin2831
NIN2832 3 5     nerve injury gene 2832
FLJ148461 2     E3 ubiquitin-protein ligase ZNRF12
DKFZp434E2291 2     MGC154302
Zinc/RING finger protein 12 3     zinc and ring finger protein 12
Nerve injury-induced gene 283 protein2 3     EC 6.3.2.-3

External Ids:    HGNC: 184521   Entrez Gene: 849372   Ensembl: ENSG000001861877   UniProtKB: Q8ND253   

Export aliases for ZNRF1 gene to outside databases

Previous GC identifers: GC16P074812 GC00U917013 GC16P073590 GC16P075033


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNRF1:
In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed
in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc
finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be
involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in
sequence to that encoded by the rat gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
thioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenance
of neuronal transmission and plasticity via its ubiquitin-protein ligase activity

Gene Wiki entry for ZNRF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNRF1 gene promoter:
         NF-kappaB2   NF-kappaB   NF-kappaB1   RelA   c-Rel   MZF-1   AP-2gamma   AP-2alphaA   RFX1   POU3F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNRF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNRF1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

ZNRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRF1 gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P060784:  view genomic region     (about GC identifiers)

Start:
60,784,212 bp from pter
End:
60,895,817 bp from pter
Size:
111,606 bases
Orientation:
plus strand

1 alternative location:
Chr16+ 75,033,250-75,144,611     
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZNRF1  
Size: 227 amino acids; 23783 Da
Subcellular location: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory
vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Associated with synaptic vesicle
membranes in neurons
Secondary accessions: Q9H083
Alternative splicing: 2 isoforms:  Q8ND25-1   Q8ND25-2   

Explore the universe of human proteins at neXtProt for ZNRF1: NX_Q8ND25 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_115644.1  

    ENSEMBL proteins: 
    ENSP00000323362 ENSP00000335091 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ZNRF1 
    Novus Biologicals Proteins for ZNRF1
    Novus Biologicals Lysate for ZNRF1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764 lysosome IEA--
    GO:0005768 endosome IDA11256614
    GO:0016020 membrane IEA--
    GO:0030054 cell junction IEA--
    GO:0030672 synaptic vesicle membrane IEA--
    About this table

    ZNRF1 for ontologies           About GeneDecksing



    Antibodies for ZNRF1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZNRF1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ZNRF1 
    Novus Biologicals Antibodies for ZNRF1
    Browse antibodies at Epitomics

    Assays for ZNRF1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNRF1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZNRF1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNRF1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q8ND25

    ProtoNet protein and cluster: Q8ND25

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
    thioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenance
    of neuronal transmission and plasticity via its ubiquitin-protein ligase activity
    Enzyme Number (IUBMB): EC 6.3.2.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ZNRF1
    Sigma-Aldrich shRNA Panels and shRNA for ZNRF1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ZNRF1
    OriGene shRNA RFP (see all 3): ZNRF1
    OriGene basic RS shRNA (see all 3): ZNRF1
    OriGene siRNA: ZNRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNRF1 
    miRNA:Sigma-Aldrich microRNA Mimics for ZNRF1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNRF1 
    8/19 SABiosciences Assays for microRNAs that regulate ZNRF1 (see all 19):
    hsa-miR-30c hsa-miR-146b-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-410 hsa-miR-508-3p hsa-miR-30a hsa-miR-298

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNRF1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNRF1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZNRF1
    OriGene 3'-UTR clone: ZNRF1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNRF1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNRF1 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0005515 protein binding IPI19690564
    GO:0008270 zinc ion binding IEA--
    GO:0016874 ligase activity IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNRF1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Pathway: Protein modification; protein ubiquitination

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNRF1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF1

    5/7 Interacting proteins for ZNRF1 (Q8ND251) via UniProtKB, MINT, and/or STRING (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC34P494271EBI-2129250,EBI-975634
    UBE2D1P516681EBI-2129250,EBI-743540
    UBE2D2P628371EBI-2129250,EBI-347677
    UBE2D3P610771EBI-2129250,EBI-348268
    UBE2D4Q9Y2X81EBI-2129250,EBI-745527
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281 DNA repair ----
    About this table

    ZNRF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNRF1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ZNRF1
    Sigma-Aldrich shRNA Panels and shRNA for ZNRF1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ZNRF1
    OriGene shRNA RFP (see all 3): ZNRF1
    OriGene basic RS shRNA (see all 3): ZNRF1
    OriGene siRNA: ZNRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNRF1 
    miRNA: Sigma-Aldrich microRNA Mimics for ZNRF1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNRF1 
    8/19 SABiosciences Assays for microRNAs that regulate ZNRF1 (see all 19):
    hsa-miR-30c hsa-miR-146b-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-410 hsa-miR-508-3p hsa-miR-30a hsa-miR-298
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNRF1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNRF1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZNRF1
    OriGene 3'-UTR Clone: ZNRF1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNRF1 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNRF1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNRF1: PPH16879A

    REFSEQ mRNAs for ZNRF1 gene: 

    NM_032268.4  

    Additional cDNA sequence: 

    AK027752.1 AK128349.1 AK294434.1 AL136903.1 AL834440.1 BC007235.1 CR594702.1 CR598108.1 
    CR602026.1 CR604234.1 CR611561.1 CR615201.1 CR623763.1 

    8 DOTS entries:

    DT.311875  DT.100792987  DT.100760151  DT.100029009  DT.100775890  DT.95279682  DT.100645627  DT.121625620 

    24/234 AceView cDNA sequences (see all 234):

    BE671247 AL834440 AL390144 AI031696 BM791765 CR623763 BE549617 BQ102430 
    BU621498 Z39895 CR611561 BX427398 AA354443 AI758253 AW673271 BX104196 
    CR615201 BQ086362 CR598108 BE219234 AA361151 BF432625 AI243881 BM128095 

    highest scoring ESTs for ZNRF1:

    AI680721 AI765981 AA290987 AA324040 AA345924 AA406216 AA428186 AA428675 AA534847 AA559175 

    Unigene Cluster for ZNRF1:

    Zinc and ring finger 1
    Hs.427284  [show with all ESTs]
    Unigene Representative Sequence: NM_032268


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF1

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -                                             
    SP2:              -     -           -                                 
    SP3:              -     -           -                       -         
    SP4:                                -                                 
    SP5:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for ZNRF1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320619(uc010cgr.1) ENST00000335325(uc010vmz.1 uc002fdk.2 uc002fdl.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNRF1 expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching ZNRF1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    52988_at2, 3 U95-B 1 0.94 1.00 0.95 1.02 AI765981 1.00 1.00 1.00 1
    57579_at2, 3 U95-B 1 0.88 1.00 0.95 1.18 AI680721 1.00 1.00 1.00 1
    46582_at2, 3 U95-B 1 0.75 1.00 0.84 0.81 AA632424 0.80 1.00 0.91 1
    223383_at2, 3 U133-B 1 1.00 1.00 -- -- AL136903 0.80 1.00 0.91 1
    223382_s_at2, 3 U133-B 1 1.00 1.00 -- -- AL136903 0.80 1.00 0.91 1
    225959_s_at2, 3 U133-B 1 0.82 1.00 -- -- BF432625 0.80 1.00 0.91 1
    225962_at2, 3 U133-B 1 0.64 1.00 -- -- AI199541 0.80 1.00 0.91 1
    225960_at*2, 3 U133-B 1 0.36 1.00 -- -- AI144394 0.60 1.00 0.82 1
    223383_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    223382_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    225959_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    225962_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    225960_at*2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    ZNRF1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNRF1 gene expression
    ZNRF1 gene electronic northern expression
    ZNRF1 gene sage expression
    About these images

    CGAP SAGE TAG: GTTCTCCCTT

    SOURCE GeneReport for Unigene cluster: Hs.427284

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Tissue specificity: Expressed primarily in the nervous system, with expression higher in developing brain relative to
    adult. Expressed at low levels in testis and thymus

    Primers: OriGene genome-wide validated SYBR primer pairs: ZNRF1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNRF1: PPH16879A
        SABiosciences Custom PCR Arrays for ZNRF1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNRF1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    ZNRF11   -- zinc and ring finger 1 95.3(n)
    97.36(a)
    509076  XM_585964.3  XP_585964.3 
    mouse
    (Mus musculus)
    Znrf11 , 5 8 (57.98 cM)5
    zinc and ring finger 11, 5 95.01(n)1
    99.12(a)1
    1707371  NM_133206.21  NP_573469.11 
     AA6901635  AA7639505  (see all 18)
    zebrafish
    (Danio rerio)
    zgc778962   -- hypothetical protein MGC77896 79.69(n) 393844  BC063239.1 
    African clawed frog
    (Xenopus laevis)
    BC047964.12   --   -- 81.76(n)  BC047964.1 
    tropical clawed frog
    (Silurana tropicalis)
    1377175342   --   -- 81.94(n)  137717534 
    About this table        Species with no ortholog for ZNRF1

    ENSEMBL Gene Tree for ZNRF1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNRF1 gene
    ZNRF22  

    ZNRF1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1053 NCBI SNPs in ZNRF1 are shown (see all 1053)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs31351,2
    C,F,75045187(+) ATATTG/ATTCTA 1 -- int19Minor allele frequency- A:0.26NS EA NA WA 622
    rs158191,2
    C,F,75144265(-) GAACCG/TGCTCG 1 -- ut31 ese314Minor allele frequency- N:0.01MN EA NA NS 1084
    rs8788911,2
    C,F,O,A,H,75115703(-) CCTCTC/TCCTCT 1 -- int1 trp316Minor allele frequency- T:0.29MN NS EA NA WA 876
    rs9487941,2
    C,F,H,75037364(+) actctA/Gactct 1 -- int112Minor allele frequency- G:0.07NS EA NA WA 482
    rs9899251,2
    C,F,75141060(-) GGGGAT/CGTGTG 1 -- int111Minor allele frequency- C:0.08NA EA MN NS WA 908
    rs10435031,2
    C,F,O,A,75144297(+) AGCACG/ACTTTG 1 -- ut31 ese329Minor allele frequency- A:0.24MN NS EA NA WA 2084
    rs10435091,2
    C,F,H,75144408(+) GATAGA/TTGCTG 1 -- ut31 ese3107Minor allele frequency- T:0.09NS MN EA PA EU CA WA NA 7166
    rs11355331,2
    C,A,H,75084190(+) aggtcA/Gaggcg 1 -- int16Minor allele frequency- G:0.12NA WA 82
    rs13206961,2
    C,H,75102194(-) gcttcG/Aacctc 1 -- int18Minor allele frequency- A:0.03NA WA 86
    rs19430651,2
    C,A75085572(+) caccaC/Tgccca 1 -- int11Minor allele frequency- T:0.50NA 2
    About this table

    HapMap Linkage Disequilibrium images for ZNRF1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZNRF1
         1 CNV: 5838
         1 Indel: 41588

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNRF1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNRF1 for disorders           About GeneDecksing

    OMIM: 612060

    Human Genome Epidemiology (HuGE) Navigator: ZNRF1 (1 document)

    Export disorders and mutations for ZNRF1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/15 PubMed articles for ZNRF1 gene, integrated from 7 sources (see all 15):
    (articles sorted by number of sources associating them with ZNRF1)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PubMed id 14561866)1, 2 Araki T. and Milbrandt J. (2003)
    3. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. (PubMed id 11427537)1, 2 Araki T.... Milbrandt J. (2001)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    7. ZNRF1 interacts with tubulin and regulates cell morph ogenesis. (PubMed id 19737534)1 Yoshida K....Hatakeyama S. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    10. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84937 HGNC: 18452 AceView: ZNRF1 Ensembl:ENSG00000186187 euGenes: HUgn84937
    ECgene: ZNRF1 H-InvDB: ZNRF1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNRF1 gene:
    Search GeneIP for patents involving ZNRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for ZNRF1 Antibodies for ZNRF1
     Super-pooled esiRNAs for ZNRF1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZNRF1 microRNA Mimics for ZNRF1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNRF1
     SeqTarget long-range PCR primers for resequencing ZNRF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNRF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNRF1
     GenScript Custom Purified and Recombinant Proteins Services for ZNRF1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZNRF1
     GenScript Custom Assay Services for ZNRF1 GenScript Custom Superior Antibodies Services for ZNRF1
     GenScript Custom overexpressing Cell Line Services for ZNRF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZNRF1 promoter
     Search Chromatin IP Primers for ZNRF1
     RT2 qPCR Primer Assay for ZNRF1
     Search GNC Networks for ZNRF1
     Assays for microRNAs that regulate ZNRF1
     SABiosciences Custom PCR Arrays for ZNRF1
     Search Tocris compounds for ZNRF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for ZNRF1
     Proteins for ZNRF1
     Lysates for ZNRF1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for ZNRF1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    ZNRF1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4