Aliases &
Descriptions
for ZNRF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc and ring finger 11 2 | | nin2831 | | NIN2832 3 5 | | nerve injury gene 2832 | | FLJ148461 2 | | E3 ubiquitin-protein ligase ZNRF12 | | DKFZp434E2291 2 | | MGC154302 | | Zinc/RING finger protein 12 3 | | zinc and ring finger protein 12 | | Nerve injury-induced gene 283 protein2 3 | | EC 6.3.2.-3 |
Export aliases for ZNRF1 gene to outside databasesPrevious GC identifers: GC16P074812 GC00U917013 GC16P073590 GC16P075033 |
Summaries
for ZNRF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNRF1:
In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressedin ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zincfinger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may beinvolved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar insequence to that encoded by the rat gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenanceof neuronal transmission and plasticity via its ubiquitin-protein ligase activity
Gene Wiki entry for ZNRF1 |
Genomic Views
for ZNRF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNRF1 gene promoter:
NF-kappaB2 NF-kappaB NF-kappaB1 RelA c-Rel MZF-1 AP-2gamma AP-2alphaA RFX1 POU3F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNRF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNRF1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.3ZNRF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P060784: view genomic region
(about GC identifiers)
Start:
|
60,784,212 bp from pter |
End:
|
60,895,817 bp from pter |
Size:
|
111,606 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 75,033,250-75,144,611 |
RefSeq DNA sequence:- NC_000016.9 NT_010498.15
|
Proteins
for ZNRF1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase ZNRF1 Size: 227 amino acids; 23783 Da
Subcellular location: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretoryvesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Associated with synaptic vesiclemembranes in neurons
Secondary accessions: Q9H083Alternative splicing: 2 isoforms: Q8ND25-1 Q8ND25-2 Explore the universe of human proteins at neXtProt for ZNRF1: NX_Q8ND25
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_115644.1
ENSEMBL proteins: ENSP00000323362 ENSP00000335091
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
ZNRF1 for ontologies About GeneDecksing
Antibodies for ZNRF1:
Assays for ZNRF1: |
Protein
Domains/
Families
for ZNRF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNRF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8ND25ProtoNet protein and cluster: Q8ND25 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)Similarity: Contains 1 RING-type zinc finger |
Gene Function
for ZNRF1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenanceof neuronal transmission and plasticity via its ubiquitin-protein ligase activityEnzyme Number (IUBMB): EC 6.3.2.-
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZNRF1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNRF1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for ZNRF1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF1
5/7 Interacting proteins for ZNRF1 (Q8ND251) via UniProtKB, MINT, and/or STRING (see all 7) About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006281 | DNA repair |
-- | -- |
About this table
ZNRF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNRF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZNRF1
|
Transcripts
for ZNRF1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZNRF1 gene: NM_032268.4 Additional cDNA sequence: AK027752.1 AK128349.1 AK294434.1 AL136903.1 AL834440.1 BC007235.1 CR594702.1 CR598108.1 CR602026.1 CR604234.1 CR611561.1 CR615201.1 CR623763.1 8 DOTS entries: DT.311875 DT.100792987 DT.100760151 DT.100029009 DT.100775890 DT.95279682 DT.100645627 DT.121625620 24/234 AceView cDNA sequences (see all 234): BE671247 AL834440 AL390144 AI031696 BM791765 CR623763 BE549617 BQ102430 BU621498 Z39895 CR611561 BX427398 AA354443 AI758253 AW673271 BX104196 CR615201 BQ086362 CR598108 BE219234 AA361151 BF432625 AI243881 BM128095
 highest scoring ESTs for ZNRF1:AI680721 AI765981 AA290987 AA324040 AA345924 AA406216 AA428186 AA428675 AA534847 AA559175 Unigene Cluster for ZNRF1: Zinc and ring finger 1 Hs.427284 [show with all ESTs]Unigene Representative Sequence: NM_032268
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | - | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ZNRF1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000320619(uc010cgr.1) ENST00000335325(uc010vmz.1 uc002fdk.2 uc002fdl.1)
|
Expression
for ZNRF1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZNRF1 expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching ZNRF1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 52988_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.95 |
1.02 |
AI765981 |
1.00 |
1.00 |
1.00 |
1 |
| 57579_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.95 |
1.18 |
AI680721 |
1.00 |
1.00 |
1.00 |
1 |
| 46582_at2, 3
|
U95-B |
1 |
0.75 |
1.00 |
0.84 |
0.81 |
AA632424 |
0.80 |
1.00 |
0.91 |
1 |
| 223383_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL136903 |
0.80 |
1.00 |
0.91 |
1 |
| 223382_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL136903 |
0.80 |
1.00 |
0.91 |
1 |
| 225959_s_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
BF432625 |
0.80 |
1.00 |
0.91 |
1 |
| 225962_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
AI199541 |
0.80 |
1.00 |
0.91 |
1 |
| 225960_at*2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
AI144394 |
0.60 |
1.00 |
0.82 |
1 |
| 223383_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223382_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225959_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225962_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225960_at*2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZNRF1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTTCTCCCTT
SOURCE GeneReport for Unigene cluster: Hs.427284
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25Tissue specificity: Expressed primarily in the nervous system, with expression higher in developing brain relative toadult. Expressed at low levels in testis and thymus
SABiosciences Custom PCR Arrays for ZNRF1
|
Orthologs
for ZNRF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZNRF1 gene from 5 species
About this table Species with no ortholog for ZNRF1
ENSEMBL Gene Tree for ZNRF1 (if available) |
Paralogs
for ZNRF1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZNRF1 gene
- ZNRF22
ZNRF1 for paralogs About GeneDecksing
|
Genomic Variants
for ZNRF1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZNRF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNRF1
1 CNV: 5838
1 Indel: 41588 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZNRF1 |
|
Disorders & Mutations
for ZNRF1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNRF1 for disorders About GeneDecksing
OMIM: 612060
Human Genome Epidemiology (HuGE) Navigator: ZNRF1 (1 document)
Export disorders and mutations for ZNRF1 gene to outside databases
|
Medical News
for ZNRF1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZNRF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for ZNRF1 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with ZNRF1)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PubMed id 14561866)1, 2 Araki T. and Milbrandt J. (2003)
- Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. (PubMed id 11427537)1, 2 Araki T.... Milbrandt J. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- ZNRF1 interacts with tubulin and regulates cell morph ogenesis. (PubMed id 19737534)1 Yoshida K....Hatakeyama S. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for ZNRF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNRF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNRF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNRF1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNRF1 gene:
Search GeneIP for patents involving ZNRF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNRF1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for ZNRF1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ZNRF1 |
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