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ZSCAN1 Gene

protein-coding   GIFtS: 38

GC19P054858
zinc finger and SCAN domain containing 1
(Previous name: zinc finger with SCAN domain 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger and SCAN domain containing 11 2     MGC1044722
FLJ337791 2     MZF-12
ZNF9151 2     zinc finger and SCAN domain-containing protein 12
zinc finger with SCAN domain 11 2     

External Ids:    HGNC: 237121   Entrez Gene: 2843122   Ensembl: ENSG000001524677   UniProtKB: Q8NBB43   

Export aliases for ZSCAN1 gene to outside databases

Previous GC identifers: GC19P063238 GC19P063239 GC19P058547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSCA1_HUMAN, Q8NBB4
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN1 gene promoter:
         AP-1   c-Jun   c-Fos   YY1   C/EBPalpha   GATA-2   GATA-1   E47   Tal-1beta   ZID   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZSCAN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZSCAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN1 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054858:  view genomic region     (about GC identifiers)

Start:
54,858,421 bp from pter
End:
54,877,116 bp from pter
Size:
18,696 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 58,545,400-58,565,999     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZSCA1_HUMAN, Q8NBB4 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 1  
Size: 408 amino acids; 45286 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q3B798 Q6WLH8 Q86WS8
Alternative splicing: 2 isoforms:  Q8NBB4-1   Q8NBB4-2   

Explore the universe of human proteins at neXtProt for ZSCAN1: NX_Q8NBB4 

REFSEQ proteins: NP_872378.3  

ENSEMBL proteins: 
ENSP00000282326 ENSP00000375581 


Human Recombinant Proteins 
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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
GO:0005730 nucleolus ----
About this table

ZSCAN1 for ontologies           About GeneDecksing



Antibodies for ZSCAN1: 
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Browse antibodies at Epitomics

Assays for ZSCAN1: 
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Browse ELISAs at Sigma-Aldrich
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ZSCAN1 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for ZSCAN1 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZSCAN1 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR008916 Retrov_capsid_C
 IPR003309 Tscrpt_reg_SCAN
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8NBB4

ProtoNet protein and cluster: Q8NBB4

1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: ZSCA1_HUMAN, Q8NBB4
Similarity: Contains 3 C2H2-type zinc fingers
Similarity: Contains 1 SCAN box domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZSCA1_HUMAN, Q8NBB4
Function: May be involved in transcriptional regulation

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich esiRNA and siRNA for ZSCAN1
Sigma-Aldrich shRNA for ZSCAN1
OriGene 29mer shRNA kits in GFP-retroviral vector: ZSCAN1
OriGene shRNA RFP: ZSCAN1
OriGene basic RS shRNA: ZSCAN1
OriGene siRNA: ZSCAN1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZSCAN1 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZSCAN1 
Search SABiosciences for Assays for microRNAs that regulate ZSCAN1

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZSCAN1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZSCAN1
OriGene untagged cDNA clones in CMV expression vector: ZSCAN1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZSCAN1 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ZSCAN1 

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

ZSCAN1 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for ZSCAN1 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN1

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0016032 viral reproduction IEA--
About this table

ZSCAN1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZSCAN1


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for ZSCAN1
Sigma-Aldrich shRNA for ZSCAN1
OriGene 29mer shRNA kits in GFP-retroviral vector: ZSCAN1
OriGene shRNA RFP: ZSCAN1
OriGene basic RS shRNA: ZSCAN1
OriGene siRNA: ZSCAN1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZSCAN1 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZSCAN1 
Search SABiosciences for Assays for microRNAs that regulate ZSCAN1
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: ZSCAN1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZSCAN1
OriGene untagged cDNA clones in CMV expression vector: ZSCAN1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ZSCAN1 
Primers: OriGene genome-wide validated SYBR primer pairs: ZSCAN1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZSCAN1: PPH20578A

REFSEQ mRNAs for ZSCAN1 gene: 

NM_182572.3  

Additional cDNA sequence: 

AK091098.1 AY280370.1 BC048099.1 BC107729.1 

5 DOTS entries:

DT.99938228  DT.99977654  DT.95257078  DT.40189036  DT.95289960 

14 AceView cDNA sequences:

AY280370 BI461169 BM692204 BM689967 BU728750 AK091098 AI564769 NM_182572 
BC048099 AX746779 AI627414 W58330 W58016 BG715512 

highest scoring ESTs for ZSCAN1:

AK091098 BC048099 BG715512 NM_182572 AI564769 AI627414 AX746779 AY280370 BI461169 BM689967 

Unigene Cluster for ZSCAN1:

Zinc finger and SCAN domain containing 1
Hs.643437  [show with all ESTs]
Unigene Representative Sequence: NM_182572


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000282326(uc002qrc.1) ENST00000391700(uc002qra.1 uc002qrb.1)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZSCAN1 expression in normal and diseased human tissues

1  / 2  / 3

1 probe-set matching ZSCAN1 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1562651_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
ZSCAN1 gene expression
ZSCAN1 gene electronic northern expression
ZSCAN1 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.643437
Primers: OriGene genome-wide validated SYBR primer pairs: ZSCAN1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ZSCAN1: PPH20578A
    SABiosciences Custom PCR Arrays for ZSCAN1 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZSCAN1 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
ZSCAN11   -- zinc finger and SCAN domain containing 1 100(n)
100(a)
469048  XM_524433.2  XP_524433.2 
About this table        Species with no ortholog for ZSCAN1

ENSEMBL Gene Tree for ZSCAN1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ZSCAN1 gene
ZSCAN182  ZNF2742  ZNF2152  ZNF4832  

ZSCAN1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/224 NCBI SNPs in ZSCAN1 are shown (see all 224)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs1598701,2
C,A,H,58549366(+) CACCTG/CGCGCT 2 /L ref1 syn17Minor allele frequency- C:0.17NA WA 86
rs1598711,2
C,F,A,H,58550281(+) CCCCAC/GCAGGG 1 -- int113Minor allele frequency- G:0.35NS EA NA WA 640
rs1598721,2
C,F,A,H,58547449(+) ACACTA/CACGCA 1 -- int117Minor allele frequency- C:0.34MN NS EA NA WA 1194
rs1598731,2
C,F,A,H,58547516(+) TCCCCA/GTGGTC 1 -- int19Minor allele frequency- G:0.24MN NA EA WA 356
rs1598741,2
C,A,H,58548431(+) CCTGGC/TCTCCA 1 -- int16Minor allele frequency- T:0.05MN NA 194
rs1697761,2
C,F,A,H,58550436(+) CGTAGG/ACCAAC 1 -- int113Minor allele frequency- A:0.38MN NS EA WA NA 746
rs1841281,2
C,F,A,H,58548760(+) TAAGTG/AAGGGG 1 -- int1 trp312Minor allele frequency- A:0.30MN NS EA NA WA 814
rs1933901,2
C,F,A,H,58548658(+) CTTCAT/CTGGGC 1 -- int114Minor allele frequency- C:0.28NS EA NA WA 636
rs2928271,2
C,F,A,H58544472(+) CTCCCA/GAGTAG 1 -- ng516Minor allele frequency- G:0.29NA WA 14
rs2928281,2
C,F,H,58545133(+) TGGAAC/TGCCGT 1 -- ng51 tfbs36Minor allele frequency- T:0.05MN NA WA 242
About this table

HapMap Linkage Disequilibrium images for ZSCAN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZSCAN1
     1 CNV: 5118

QIAGEN SeqTarget long-range PCR primers for resequencing ZSCAN1 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

7 PubMed articles for ZSCAN1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZSCAN1)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
  5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 284312 HGNC: 23712 AceView: ZSCAN1 Ensembl:ENSG00000152467 euGenes: HUgn284312
ECgene: ZSCAN1 H-InvDB: ZSCAN1

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ZSCAN1 gene:
Search GeneIP for patents involving ZSCAN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZSCAN1
 SeqTarget long-range PCR primers for resequencing ZSCAN1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZSCAN1
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 Regulatory tfbs in ZSCAN1 promoter
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 ELISAs and CLIAs for ZSCAN1
       

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