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ZSCAN30 Gene

protein-coding GIFtS: 33

GC18M029690

zinc finger and SCAN domain containing 30
(Previous names: zinc finger protein 397 opposite strand, ZNF397 opposite strand )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF397OS)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
zinc finger and SCAN domain containing 30¹ ²		ZNF-WYM² ³
Zinc finger protein 397 opposite strand¹ ² ³		ZNF397OS² ³
ZNF917¹ ²		zinc finger and SCAN domain-containing protein 30²
ZNF397 opposite strand¹ ²		FLJ46864²
Zinc finger protein 397OS² ³		FLJ16245²

External Ids:	HGNC: 33517¹	Entrez Gene: 100101467²	Ensembl: ENSG00000186814⁷	UniProtKB: Q86W11³

Export aliases for ZSCAN30 gene to outside databases

Previous GC identifer: GC18M032833

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZSCAN30
Other transcription factors

Search SABiosciences Chromatin IP Primers for ZSCAN30

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZSCAN30

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18q12.2

ZSCAN30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN30 gene location

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M029690: view genomic region (about GC identifiers)

Start:	29,690,031 bp from pter
End:	29,729,813 bp from pter
Size:	39,783 bases
Orientation:	minus strand

1 alternative location:

Chr18- 32,832,819-32,870,172

RefSeq DNA sequence:

NC_000018.9 NT_010966.14

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11 (See protein sequence)

Recommended Name: Zinc finger and SCAN domain-containing protein 30

Size: 494 amino acids; 56364 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B4E0N0 Q6ZNB3 Q96PN3

Alternative splicing: 3 isoforms: Q86W11-1 Q86W11-2 Q86W11-3

Explore the universe of human proteins at neXtProt for ZSCAN30: NX_Q86W11

REFSEQ proteins (2 alternative transcripts):

NP_001106205.1 NP_001159484.1

ENSEMBL proteins:

ENSP00000329738 ENSP00000392371 ENSP00000354188 ENSP00000372569

Human Recombinant Proteins

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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--

About this table

ZSCAN30 for ontologies About GeneDecksing

Antibodies for ZSCAN30:

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Assays for ZSCAN30:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZSCAN30 for domains About GeneDecksing

5 InterPro domains/families:

IPR008916 Retrov_capsid_C

IPR003309 Tscrpt_reg_SCAN

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q86W11

ProtoNet protein and cluster: Q86W11

1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 7 C2H2-type zinc fingers

Similarity: Contains 1 SCAN box domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11

Function: May be involved in transcriptional regulation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZSCAN30 Sigma-Aldrich shRNA for ZSCAN30
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZSCAN30 OriGene shRNA RFP (see all 2): ZSCAN30 OriGene basic RS shRNA (see all 2): ZSCAN30 OriGene siRNA (see all 2): ZSCAN30
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZSCAN30
		Search SABiosciences for Assays for microRNAs that regulate ZSCAN30

Gene
Editing:

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		OriGene GFP tagged cDNA clones in CMV expression vector: ZSCAN30 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZSCAN30 OriGene untagged cDNA clones in CMV expression vector: ZSCAN30 OriGene 3'-UTR clone (see all 2): ZSCAN30 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZSCAN30
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Cell
Lines:

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4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

ZSCAN30 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ZSCAN30

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZSCAN30

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016032	viral reproduction	IEA	--

About this table

ZSCAN30 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZSCAN30

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ZSCAN30 Sigma-Aldrich shRNA for ZSCAN30
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZSCAN30 OriGene shRNA RFP (see all 2): ZSCAN30 OriGene basic RS shRNA (see all 2): ZSCAN30 OriGene siRNA (see all 2): ZSCAN30
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZSCAN30

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZSCAN30
		Search SABiosciences for Assays for microRNAs that regulate ZSCAN30

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ZSCAN30 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZSCAN30 OriGene untagged cDNA clones in CMV expression vector: ZSCAN30 OriGene 3'-UTR Clone (see all 2): ZSCAN30 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ZSCAN30

Primers:		OriGene genome-wide validated SYBR primer pairs: ZSCAN30 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for ZSCAN30

REFSEQ mRNAs for ZSCAN30 gene (2 alternative transcripts):

NM_001112734.2 NM_001166012.1

Additional cDNA sequence:

AF303374.1 AK001503.1 AK057386.1 AK057518.1 AK128697.1 AK131291.1 AK303447.1 AL832180.1

AY234408.1

9 DOTS entries:

DT.95090370 DT.95110056 DT.40299345 DT.438211 DT.75191728 DT.95352035 DT.121090861 DT.91776167

DT.97820354

Unigene Cluster for ZSCAN30:

Zinc finger and SCAN domain containing 30

Hs.720483 [show with all ESTs]

Unigene Representative Sequence: AK128697

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN30

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b
SP1:							-		-
SP2:							-
SP3:									-

About this scheme

ECgene alternative splicing isoforms for ZSCAN30
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000333206(uc002kyl.2 uc002kym.2 uc010xce.1 uc002kyn.1)

ENST00000420878 ENST00000360932 ENST00000383091

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ZSCAN30 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

ZSCAN30 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.720483

Primers:		OriGene genome-wide validated SYBR primer pairs: ZSCAN30 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for ZSCAN30

SABiosciences Custom PCR Arrays for ZSCAN30

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZSCAN30 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZNF397OS¹	--	zinc finger protein 397 opposite strand	84.93(n) 80.04(a)	490486 XM_547608.1 XP_547608.1
chimpanzee (Pan troglodytes)	ZNF397OS¹	--	zinc finger protein 397 opposite strand	99.66(n) 99.19(a)	455372 XM_529948.2 XP_529948.2
cow (Bos taurus)	ZNF397OS¹	--	zinc finger protein 397 opposite strand	83.2(n) 77.24(a)	539119 XM_584961.3 XP_584961.2
mouse (Mus musculus)	Zscan30⁵	18 (12.47 cM)	zinc finger and SCAN domain containing 30	--	BC117069

About this table Species with no ortholog for ZSCAN30

ENSEMBL Gene Tree for ZSCAN30 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZSCAN30 gene

ZNF174² ZKSCAN4² ZNF449² ZNF396² SCAND1² ZNF394² ZKSCAN3² ZNF444²

ZSCAN30 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1047293^1,2	C,	32842775(+)	`TGGCAG/CGAAAG`	2	--	int¹		2		MN NA	256
rs1865377^1,2	C,F,O,A,H,	32855151(+)	`TTCTTT/ATCTAT`	2	--	int¹		16		MN NS EA NA WA	1022
rs2164105^1,2	H	32864204(+)	`agtgcA/Ctgctg`	2	--	int¹		4		NS EA	374
rs2278464^1,2	C,F,O,A,H,	32870015(+)	`TAACTA/GATTAA`	2	--	int¹		102		NS EA NA PA EU CA WA	6272
rs2278465^1,2	C,F,A,	32870210(+)	`GCCCTT/CCGTCA`	2	--	ng5¹		11		NS EA NA WA	518
rs2422268^1,2	C,H	32840767(+)	`tgtacG/Attgtc`	2	--	int¹		7		NA WA	16
rs3084116^1,2	C	32858064(+)	`tatat-/TAtgtta`	2	--	int¹		0	--	--	--	--
rs3084119^1,2	C	32865257(+)	`AACCA-/AACAATT`	2	--	int¹		1		NA	2
rs3810022^1,2	C,F,A,H,	32861362(+)	`GAAAGT/CAACAT`	2	--	int¹		17		NA NS EA WA	936
rs4520905^1,2	C,F,	32861921(+)	`ACCACC/TGAAGA`	2	--	int¹		6		NS EA NA	476

About this table

HapMap Linkage Disequilibrium images for ZSCAN30 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZSCAN30: --

QIAGEN SeqTarget long-range PCR primers for resequencing ZSCAN30

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

4 PubMed articles for ZSCAN30 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZSCAN30)

Identification and characterization of two novel human SCAN domain- containing zinc finger genes ZNF396 and ZNF397. (PubMed id 12801647)^{1, 2, 3} Wu Y.... Zhao S. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 100101467	HGNC: 33517	Ensembl:ENSG00000186814	euGenes: HUgn100101467	ECgene: ZSCAN30
H-InvDB: ZSCAN30

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ZSCAN30 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ZSCAN30 gene:
Search GeneIP for patents involving ZSCAN30

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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ZSCAN30 Gene

protein-coding GIFtS: 33

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ZSCAN30 Gene

protein-coding GIFtS: 33

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for ZSCAN30 gene

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for ZSCAN30 gene

Drugs & Compounds
for ZSCAN30 gene

Transcripts
for ZSCAN30 gene

Expression
for ZSCAN30 gene

Orthologs
for ZSCAN30 gene

Paralogs
for ZSCAN30 gene

Genomic Variants
for ZSCAN30 gene

Disorders & Mutations
for ZSCAN30 gene

Medical News
for ZSCAN30 gene

Publications
for ZSCAN30 gene

Intellectual Property
for ZSCAN30 gene

Products
for ZSCAN30 gene