Aliases &
Descriptions
for ZXDA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger, X-linked, duplicated A1 2 | | ZNF8961 2 | | zinc finger X-linked protein ZXDA2 | | zinc finger protein 8962 |
Export aliases for ZXDA gene to outside databasesPrevious GC identifers: GC0XM054714 GC0XM055912 GC0XM056539 GC0XM056902 GC0XM056900 GC0XM057817 GC0XM057949 |
Summaries
for ZXDA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZXDA:
This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predictedproteins contain 10 tandem zinc finger motifs. (provided by RefSeq)
UniProtKB/Swiss-Prot: ZXDA_HUMAN, P98168Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes
|
Genomic Views
for ZXDA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZXDA gene promoter:
C/EBPalpha NF-E2 NF-E2 p45 E4BP4 AREB6 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Cdc5 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZXDA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZXDA  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.1 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.21ZXDA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM054990: view genomic region
(about GC identifiers)
Start:
|
54,990,999 bp from pter |
End:
|
54,996,202 bp from pter |
Size:
|
5,204 bases |
Orientation:
|
minus strand |
1 alternative location:
| ChrX- 57,934,198-57,937,067 |
RefSeq DNA sequence:- NC_000023.10 NT_011630.14
|
Proteins
for ZXDA gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZXDA_HUMAN, P98168 (See
protein sequence)Recommended Name: Zinc finger X-linked protein ZXDA Size: 799 amino acids; 84771 Da
Subunit: Self-associates. Interacts with ZXDC and CIITA
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC37521.1; Type=Frameshift; Positions=753;
Secondary accessions: Q9UJP7Explore the universe of human proteins at neXtProt for ZXDA: NX_P98168
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009087.1
ENSEMBL proteins: ENSP00000351530
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZXDA for ontologies About GeneDecksing
Antibodies for ZXDA:
Assays for ZXDA: |
Protein
Domains/
Families
for ZXDA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZXDA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P98168ProtoNet protein and cluster: P98168 UniProtKB/Swiss-Prot: ZXDA_HUMAN, P98168Similarity: Belongs to the ZXD familySimilarity: Contains 10 C2H2-type zinc fingers |
Gene Function
for ZXDA gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZXDA_HUMAN, P98168Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes
Genatlas biochemistry entry for ZXDA:zinc finger protein (C2H2 type),X linked,duplicated A5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
ZXDA for ontologies About GeneDecksing
|
Pathways & Interactions
for ZXDA gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZXDA
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZXDA
2 Interacting proteins for ZXDA (P981681) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045941 | positive regulation of transcription |
IMP | 17493635 |
About this table
ZXDA for ontologies About GeneDecksing
|
Drugs & Compounds
for ZXDA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZXDA
|
Transcripts
for ZXDA gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZXDA gene: NM_007156.4 Additional cDNA sequence: AK122815.1 AK292686.1 BC059356.1 L14787.1 2 DOTS entries: DT.101981193 DT.75158643 4 AceView cDNA sequences: L14787 AK122815 NM_007156 BC059356
 highest scoring ESTs for ZXDA:AK122815 AL046615 AL707266 BC059356 BX476975 CB988499 CF594011 L14787 BE173794 CD109443 Unigene Cluster for ZXDA: Zinc finger, X-linked, duplicated A Hs.550094 [show with all ESTs]Unigene Representative Sequence: NM_007156
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000358697(uc004dve.2)
|
Expression
for ZXDA gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZXDA expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching ZXDA gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36373_at2, 3
|
U95-A |
2 |
1.00 |
0.59 |
0.78 |
0.90 |
AL034396 |
0.20 |
0.50 |
0.38 |
1 |
| 68089_r_at2, 3
|
U95-E |
1 |
0.31 |
1.00 |
0.20 |
1.11 |
AI620206 |
0.20 |
1.00 |
0.72 |
1 |
| 216014_s_at2, 3
|
U133-A |
2 |
1.00 |
0.64 |
-- |
-- |
AL034396 |
0.20 |
0.50 |
0.38 |
1 |
| 215263_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
BF509566 |
0.60 |
1.00 |
0.82 |
1 |
| 243521_at2
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 216014_s_at2
|
U133Plus2 |
2 |
1.00 |
0.64 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215263_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 243521_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZXDA for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGGCTAACTT
SOURCE GeneReport for Unigene cluster: Hs.550094
Expression variation in blood from EXPOLDB for ZXDA UniProtKB/Swiss-Prot: ZXDA_HUMAN, P98168Tissue specificity: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta
SABiosciences Custom PCR Arrays for ZXDA
|
Orthologs
for ZXDA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZXDA gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
ZXDA1 |
-- |
zinc finger, X-linked, duplicated A |
99.25(n)
98.62(a) |
473635 XM_529007.2 XP_529007.2 |
About this table Species with no ortholog for ZXDA
ENSEMBL Gene Tree for ZXDA (if available) |
Paralogs
for ZXDA gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZXDA gene
- GTF3A2 ZXDC2 ZXDB2
ZXDA for paralogs About GeneDecksing
|
Genomic Variants
for ZXDA gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZXDA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZXDA
2 CNVs: 96717 83545
4 Indels: 96718 96719 83546 96720 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZXDA |
|
Disorders & Mutations
for ZXDA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZXDA for disorders About GeneDecksing
OMIM: 300235
Locus Specific Mutation Databases (LSDB): ZXDA
Export disorders and mutations for ZXDA gene to outside databases
|
Medical News
for ZXDA gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZXDA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for ZXDA gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with ZXDA)- Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. (PubMed id 8268913)1, 2, 3 Greig G.M.... Willard H.F. (1993)
- The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PubMed id 17493635)1, 2, 7 Al-Kandari W.... Fontes J.D. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PubMed id 19777325)1 Aleksandrova A....Fontes J.D. (2010)
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
- Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)
- Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. (PubMed id 17696781)1 Jambunathan S. and Fontes J.D. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for ZXDA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZXDA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZXDA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZXDA gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZXDA gene:
Search GeneIP for patents involving ZXDA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZXDA gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for ZXDA |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ZXDA |
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