Aliases &
Descriptions
for ZYG11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zyg-11 homolog B (C. elegans)1 2 | | FLJ134561 2 | | zyg-11 homolog (C. elegans)1 | | protein zyg-11 homolog B2 | | ZYG112 | | KIAA17303 |
Export aliases for ZYG11B gene to outside databasesPrevious GC identifers: GC01P052904 GC01P052964 GC01P053192 |
Summaries
for ZYG11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC
|
Genomic Views
for ZYG11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZYG11B gene promoter:
IRF-7A c-Myb Pax-2 POU2F1 FOXD1 AhR HNF-1A YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZYG11B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3ZYG11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P051337: view genomic region
(about GC identifiers)
Start:
|
51,337,919 bp from pter |
End:
|
51,408,984 bp from pter |
Size:
|
71,066 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 53,192,131-53,293,014 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for ZYG11B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3 (See
protein sequence)Recommended Name: Protein zyg-11 homolog B Size: 744 amino acids; 83921 Da
Subunit: Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC
Sequence caution: Sequence=BAB21821.1; Type=Erroneous initiation;
Secondary accessions: Q8N2X3 Q9H8L8Alternative splicing: 2 isoforms: Q9C0D3-1 Q9C0D3-2 Explore the universe of human proteins at neXtProt for ZYG11B: NX_Q9C0D3
REFSEQ proteins: NP_078922.1
ENSEMBL proteins: ENSP00000294353 ENSP00000400522
Human Recombinant Proteins
Antibodies for ZYG11B:
Assays for ZYG11B: |
Protein
Domains/
Families
for ZYG11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZYG11B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0D3ProtoNet protein and cluster: Q9C0D3 UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Similarity: Belongs to the zyg-11 familySimilarity: Contains 2 ARM repeatsSimilarity: Contains 3 LRR (leucine-rich) repeats |
Gene Function
for ZYG11B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZYG11B for ontologies About GeneDecksing
|
Pathways & Interactions
for ZYG11B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZYG11B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZYG11B
2 Interacting proteins for ZYG11B (Q9C0D31, 2) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for ZYG11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZYG11B
|
Transcripts
for ZYG11B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZYG11B gene: NM_024646.2 Additional cDNA sequence: AB051517.1 AK023518.1 AK025056.1 AK056645.1 AK095643.1 AK296460.1 BC029832.1 BX647643.1 8 DOTS entries: DT.114040 DT.100748751 DT.100817444 DT.100817447 DT.121431412 DT.97791975 DT.424044 DT.95265734 24/207 AceView cDNA sequences (see all 207): AA628780 BM666475 Z40634 BI492777 AA767175 AI245091 AK056645 AL599990 AA127250 AI242322 BQ029127 BX500188 BM716545 CA435801 AI291586 CB321863 CD674672 AW673221 AI433668 BI039406 Z42566 BI039415 BG059880 T32194
 highest scoring ESTs for ZYG11B:AA625326 AA157529 AA158182 AA677075 AA694279 AA767175 AA772826 AI370456 AI433668 AI935439 Unigene Cluster for ZYG11B: Zyg-11 homolog B (C. elegans) Hs.476280 [show with all ESTs]Unigene Representative Sequence: NM_024646
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11B
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ZYG11B
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294353(uc009vzg.2 uc001cuj.2 uc009vzh.2) ENST00000443756(uc010onj.1)
|
Expression
for ZYG11B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZYG11B expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching ZYG11B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 62195_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.82 |
0.46 |
AA625326 |
1.00 |
1.00 |
1.00 |
1 |
| 91457_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.89 |
1.21 |
AI433668 |
0.80 |
1.00 |
0.91 |
1 |
| 48598_at2, 3
|
U95-B |
1 |
0.81 |
1.00 |
0.93 |
1.35 |
AI735760 |
0.60 |
1.00 |
0.82 |
1 |
| 227918_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
N21008 |
0.80 |
1.00 |
0.91 |
1 |
| 225350_s_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AV701229 |
0.60 |
1.00 |
0.82 |
1 |
| 225338_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
AI767447 |
0.60 |
1.00 |
0.82 |
1 |
| 227918_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225350_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225338_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZYG11B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGTATTTTA
SOURCE GeneReport for Unigene cluster: Hs.476280
SABiosciences Custom PCR Arrays for ZYG11B
|
Orthologs
for ZYG11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZYG11B gene from 5/8 species (see all 8)
About this table Species with no ortholog for ZYG11B
ENSEMBL Gene Tree for ZYG11B (if available) |
Paralogs
for ZYG11B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZYG11B gene
- ZER12 ZYG11A2
ZYG11B for paralogs About GeneDecksing
|
Genomic Variants
for ZYG11B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZYG11B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZYG11B
2 CNVs: 4225 3290
1 Indel: 59929 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZYG11B |
|
Disorders & Mutations
for ZYG11B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for ZYG11B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZYG11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
6 PubMed articles for ZYG11B gene integrated from 7 sources:
(articles sorted by number of sources associating them with ZYG11B)- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZYG11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZYG11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZYG11B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZYG11B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZYG11B gene:
Search GeneIP for patents involving ZYG11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZYG11B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ZYG11B |
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