Aliases &
Descriptions
for ZZEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger, ZZ-type with EF-hand domain 11 2 | | zinc finger ZZ-type and EF-hand domain-containing protein 12 | | KIAA03991 2 3 | | FLJ237892 | | FLJ108211 2 | | MGC1669292 | | zinc finger, ZZ-type with EF hand domain 11 2 | | FLJ455742 | | ZZZ41 2 | | |
Export aliases for ZZEF1 gene to outside databasesPrevious GC identifer: GC17M004115 |
Summaries
for ZZEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZZEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZZEF1 gene promoter:
ATF-2 CREB deltaCREB Pax-2 ATF PPAR-gamma2 PPAR-gamma1 c-Jun STAT1beta STAT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZZEF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZZEF1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3ZZEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003854: view genomic region
(about GC identifiers)
Start:
|
3,797,502 bp from pter |
End:
|
4,046,314 bp from pter |
Size:
|
248,813 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
|
Proteins
for ZZEF1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149 (See
protein sequence)Recommended Name: Zinc finger ZZ-type and EF-hand domain-containing protein 1 Size: 2961 amino acids; 331075 Da
Sequence caution: Sequence=BAA23695.4; Type=Erroneous initiation; Sequence=BAA91834.1; Type=Erroneous initiation;
Secondary accessions: A7MBM5 Q6NXG0 Q6ZRA1 Q6ZSF4 Q9NVB9Alternative splicing: 3 isoforms: O43149-1 O43149-2 O43149-3 Explore the universe of human proteins at neXtProt for ZZEF1: NX_O43149
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055928.3
ENSEMBL proteins: ENSP00000371051 ENSP00000396775 ENSP00000406368 ENSP00000416574
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005680 | anaphase-promoting complex |
IEA | -- |
About this table
ZZEF1 for ontologies About GeneDecksing
Antibodies for ZZEF1:
Assays for ZZEF1: |
Protein
Domains/
Families
for ZZEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZZEF1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O43149ProtoNet protein and cluster: O43149 1 Blocks protein family: IPB000433 Zn-finger
UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149Similarity: Contains 1 DOC domainSimilarity: Contains 1 EF-hand domainSimilarity: Contains 2 ZZ-type zinc fingers |
Gene Function
for ZZEF1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZZEF1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZZEF1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZZEF1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZZEF1
1 Interacting protein for ZZEF1 (O431492) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030071 | regulation of mitotic metaphase/anaphase transition |
IEA | -- |
About this table
ZZEF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZZEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZZEF1
|
Transcripts
for ZZEF1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZZEF1 gene: NM_015113.3 Additional cDNA sequence: AB007859.4 AK001683.1 AK122719.1 AK124719.1 AK127482.1 AK128386.1 AL831960.1 BC035319.1 BC047285.1 BC067099.1 BC151836.1 U33270.1 12 DOTS entries: DT.75146263 DT.216417 DT.92012537 DT.101979432 DT.100717107 DT.95326300 DT.100773638 DT.92015246 DT.100773636 DT.120998535 DT.120998565 DT.91689250 24/262 AceView cDNA sequences (see all 262): AW298133 AL597153 BC047285 BU754318 BU616635 AW339152 BF109295 AA970385 CN479962 CA396909 T08478 AI537136 CF619273 CA946290 AB007859 AA806452 CA944775 AI167137 BF055468 BE551094 BF732623 CB055268 BX094971 CB046746
 highest scoring ESTs for ZZEF1:AB007859 AI670141 AI906034 AK001683 AK122719 AK124719 AK127482 AL135638 AL831960 AU132996 Unigene Cluster for ZZEF1: Zinc finger, ZZ-type with EF-hand domain 1 Hs.277624 [show with all ESTs]Unigene Representative Sequence: NM_015113
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 (see all 15)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | · | 32c | ^ | 33 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ZZEF1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381638(uc002fxe.2 uc002fxj.1) ENST00000427773(uc002fxh.2 uc002fxi.2)
ENST00000418156(uc002fxk.1) ENST00000414864(uc002fxg.1)
|
Expression
for ZZEF1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZZEF1 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching ZZEF1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38626_at2, 3
|
U95-A |
1 |
0.69 |
1.00 |
1.00 |
1.00 |
AB007859 |
1.00 |
1.00 |
1.00 |
1 |
| 207189_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_015113 |
0.60 |
1.00 |
0.82 |
1 |
| 212601_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AB007859 |
1.00 |
1.00 |
1.00 |
1 |
| 207190_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_015113 |
0.60 |
1.00 |
0.82 |
1 |
| 207189_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212601_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 207190_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZZEF1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.277624
Expression variation in blood from EXPOLDB for ZZEF1 UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149Tissue specificity: Expressed at low levels in cerebellum
SABiosciences Custom PCR Arrays for ZZEF1
|
Orthologs
for ZZEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZZEF1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for ZZEF1
ENSEMBL Gene Tree for ZZEF1 (if available) |
Paralogs
for ZZEF1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for ZZEF1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZZEF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZZEF1
2 CNVs: 72776 8834
2 Indels: 25847 67115 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZZEF1 |
|
Disorders & Mutations
for ZZEF1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZZEF1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZZEF1 (1 document)
Export disorders and mutations for ZZEF1 gene to outside databases
|
Medical News
for ZZEF1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZZEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for ZZEF1 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with ZZEF1)- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. (PubMed id 17053785)2 Wang Y.... Chen Z. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for ZZEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZZEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZZEF1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZZEF1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZZEF1 gene:
Search GeneIP for patents involving ZZEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZZEF1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ZZEF1 |
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