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TP53 Gene

protein-coding   GIFtS: 81

GC17M007465
tumor protein p53
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tumor protein p531 2     cellular tumor antigen p532
LFS11 2 5     transformation-related protein 532
P532 3 5     FLJ929432
Phosphoprotein p532 3     p53 tumor suppressor2
Antigen NY-CO-132 3     OTTHUMP000002213402
p531     Tumor suppressor p533
TRP532     

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   UniProtKB: P046373   

Export aliases for TP53 gene to outside databases

Previous GC identifers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512 GC17M007565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP53:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce
cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level
in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to
transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and
oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes
that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in
a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor
suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as
germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative
promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can
regulate p53 transcriptional activity. (provided by RefSeq)

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes
is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and
FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over

summary for TP53:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state
alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression.

Gene Wiki entry for TP53 (P53)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP53 gene promoter:
         C/EBPbeta   AhR   p53   MIF-1   Sp1   RFX1   E2F-5   E2F-4   E2F-2   E2F-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TP53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP53 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007465:  view genomic region     (about GC identifiers)

Start:
7,465,169 bp from pter
End:
7,484,278 bp from pter
Size:
19,110 bases
Orientation:
minus strand

1 alternative location:
Chr17- 7,565,257-7,590,856     
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds
DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and
recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to
ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation
requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via
C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect.
Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and P53DINP1. Interacts with WWOX. May interact
with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit
histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, BANP, CDKN2AIP and E4F1.
Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58'
inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1.
Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts (phosphorylated at Ser-15
by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell
proliferation. Interacts with PPP2R2A. Interacts with DAXX
Subcellular location: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Interaction with BANP promotes nuclear
localization
PDB structures from and Proteopedia :
1A1U (3D)    1AIE (3D)    1C26 (3D)    1DT7 (3D)    1GZH (3D)    1H26 (3D)    1HS5 (3D)    1JSP (3D)    
1KZY (3D)    1MA3 (3D)    1OLG (3D)    1OLH (3D)    1PES (3D)    1PET (3D)    1SAE (3D)    1SAF (3D)    
1SAH (3D)    1SAJ (3D)    1SAK (3D)    1SAL (3D)    1TSR (3D)    1TUP (3D)    1UOL (3D)    1XQH (3D)    
1YC5 (3D)    1YCQ (3D)    1YCR (3D)    1YCS (3D)    2AC0 (3D)    2ADY (3D)    2AHI (3D)    2ATA (3D)    
2B3G (3D)    2BIM (3D)    2BIN (3D)    2BIO (3D)    2BIP (3D)    2BIQ (3D)    2F1X (3D)    2FEJ (3D)    
2FOJ (3D)    2FOO (3D)    2GS0 (3D)    2H1L (3D)    2H2D (3D)    2H2F (3D)    2H4F (3D)    2H4H (3D)    
2H4J (3D)    2H59 (3D)    2J0Z (3D)    2J10 (3D)    2J11 (3D)    2J1W (3D)    2J1X (3D)    2J1Y (3D)    
2J1Z (3D)    2J20 (3D)    2J21 (3D)    2K8F (3D)    2OCJ (3D)    2PCX (3D)    2QVQ (3D)    2QXA (3D)    
2QXB (3D)    2QXC (3D)    2VUK (3D)    2WGX (3D)    2X0U (3D)    2X0V (3D)    2X0W (3D)    2Z5S (3D)    
2Z5T (3D)    3D05 (3D)    3D06 (3D)    3D07 (3D)    3D08 (3D)    3D09 (3D)    3D0A (3D)    3DAB (3D)    
3DAC (3D)    3IGK (3D)    3IGL (3D)    3KMD (3D)    3KZ8 (3D)    3LW1 (3D)    3SAK (3D)    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q86UG1
Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61
Alternative splicing: 2 isoforms:  P04637-1   P04637-2   

Explore the universe of human proteins at neXtProt for TP53: NX_P04637 

Post-translational modifications:

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
  • impairs its ability to induce proapoptotic program and modulate cell senescence1
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
  • Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1,
    which may prevent the interaction with MDM2. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated
    degradation. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for
    acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated upon DNA
    damage, probably by ATM or ATR. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by
    interaction with BANP1
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC
  • form of PP2A1
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line1
  • Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in
  • cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted
    to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation.
    Deubiquitinated by USP10, leading to its stabilization. Ubiquitination by TOPORS induces degradation. Deubiquitination
    by USP7, leading to stabilize it1
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated
  • at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity.
    Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-3701
  • Sumoylated by SUMO11
  • Demethylation of di-methylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated
  • transcriptional activation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (7 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  


    ENSEMBL proteins: 
    ENSP00000379735 ENSP00000391478 ENSP00000352610 ENSP00000424104 ENSP00000394195 ENSP00000410739 
    ENSP00000423862 ENSP00000426252 ENSP00000269305 ENSP00000398846 ENSP00000391127 ENSP00000425104 
    ENSP00000402130 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant TP53 Protein
    Sigma-Aldrich Proteins for TP53
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for TP53
    OriGene Purified Protein: TP53
    OriGene Protein Over-expression Lysate: TP53
    GenScript Custom Purified and Recombinant Proteins Services for TP53 
    Novus Biologicals Proteins for TP53
    Novus Biologicals Lysates for TP53
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TP53

    5/16 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785 chromatin ISS--
    GO:0005626 insoluble fraction IDA12915590
    GO:0005634 nucleus ISS--
    GO:0005654 nucleoplasm TAS--
    GO:0005657 replication fork ISS--
    About this table

    TP53 for ontologies           About GeneDecksing



    Antibodies for TP53: 
    Millipore Mono- and Polyclonal Antibodies for the study of TP53
    Sigma-Aldrich Antibody Arrays and Antibodies for TP53
    R&D Systems Antibodies for TP53 (p53)
    Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    OriGene Antibodies (see all 16): TP53
    GenScript Custom Superior Antibodies Services for TP53 
    Novus Biologicals Antibodies for TP53
    Epitomics antibodies for TP53

    Assays for TP53: 
    Millipore Kits and Assays for the Analysis of TP53
    Sigma-Aldrich ELISAs for TP53
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for TP53 (p53)
    GenScript Custom Assay Services for TP53 
    Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    Enzo Life Sciences assays for TP53
    Uscn ELISAs and CLIAs for TP53 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TP53 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011615 p53_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR013872 p53_transactivation_domain
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein family: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain
    Similarity: Belongs to the p53 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes
    is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and
    FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of TP53 Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TP53
    Sigma-Aldrich shRNA Panels and shRNA for TP53
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): TP53
    OriGene shRNA RFP (see all 7): TP53
    OriGene basic RS shRNA (see all 7): TP53
    OriGene siRNA (see all 7): TP53
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TP53 
    miRNA:Sigma-Aldrich microRNA Mimics for TP53
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TP53 
    8/12 SABiosciences Assays for microRNAs that regulate TP53 (see all 12):
    hsa-miR-98 hsa-miR-1294 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for TP53 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TP53
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): TP53
    OriGene untagged cDNA clones in CMV expression vector (see all 7): TP53
    OriGene 3'-UTR clone (see all 7): TP53 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TP53 
    Sino Biological Human cDNA Clone for TP53

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TP53 

    Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome dependent
    degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target gene,putative
    teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision repair,activated by ATM
    in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in cancers such as pancreas and
    endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell carcinoma),in hepatocellular
    carcinoma with poor prognosis

    5/28 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 28):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000739 DNA strand annealing activity IDA8183576
    GO:0002020 protease binding IPI11923872
    GO:0002039 p53 binding ISS--
    GO:0003677 DNA binding IMP2144364
    GO:0003682 chromatin binding ISS--
    About this table

    TP53 for ontologies           About GeneDecksing

    Animal Models: 15/30 MGI mutant phenotypes (inferred from 54 alleles(MGI details for Trp53) (see all 30):

    adipose tissuebehavior/neurologicalcardiovascular systemcellularcraniofacial
    digestive/alimentaryembryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/ear
    hematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatal

    TP53 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TP53 for pathways           About GeneDecksing

    5/16 Millipore Pathways for TP53 (see all 16)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Proteolysis Putative SUMO-1 pathway
    Immune response MIF in innate immunity response
    DNA damage DNA-damage-induced responses
    DNA damage Role of SUMO in p53 regulation

    5/39 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TP53 (see all 39)
        Cell Cycle: G1/S Checkpoint Regulation
    Role of BRCA1 in DNA Damage Response
    Huntington's Disease Signaling
    Hereditary Breast Cancer Signaling
    Basal Cell Carcinoma Signaling

    5 Cell Signaling Technology (CST) Pathways for TP53
        Cell Cycle Control: G2/M DNA Damage Checkpoint
    Mitochondrial Control of Apoptosis
    Akt/PKB Signaling
    SAPK/JNK Signaling Cascades
    Cell Cycle Control: G1/S Checkpoint

    5/22 Kegg Pathways  (Kegg details for TP53) (see all 22):
        hsa04010 MAPK signaling pathway
    hsa04110 Cell cycle
    hsa04115 p53 signaling pathway
    hsa04210 Apoptosis
    hsa04310 Wnt signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including TP53 (see all 23): PAHS-003A PAHS-004A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TP53
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53

    5/261 Interacting proteins for TP53 (ENSP000002693053 P046371, 2) via UniProtKB, MINT, and/or STRING (see all 261)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2STRING: ENSP00000258149 EBI-366083,EBI-389668 MINT-6540920 MINT-6665330 MINT-4793511 MINT-4793467 MINT-6823775 MINT-7013943 MINT-4049616 MINT-4054304 MINT-7905142 MINT-6540905 MINT-6540889 MINT-68742 MINT-7013780 MINT-56681 MINT-58468 MINT-7013791 MINT-68743 MINT-6540807 MINT-7013956 MINT-4545014 MINT-4049631 MINT-6540776 MINT-6801380 MINT-58465 MINT-7013688 MINT-7013802 MINT-6540796 MINT-7905326 MINT-4303990
    MDM4O151511, 2STRING: ENSP00000356151 EBI-366083,EBI-398437 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 MINT-7896820 MINT-7896835
    USP7Q930091, 2STRING: ENSP00000371310 EBI-366083,EBI-302474 MINT-4304022 MINT-14904 MINT-15878 MINT-15877 MINT-15876
    EP300Q094721, 2STRING: ENSP00000263253 EBI-366083,EBI-447295 MINT-69507 MINT-2830826 MINT-7263630 MINT-6628507
    HDAC1Q135471, 2STRING: ENSP00000362649 EBI-366083,EBI-301834 MINT-7893049 MINT-7893085 MINT-7893074 MINT-7893061
    About this table

    5/77 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 77):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060 protein import into nucleus, translocation IEA--
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001302 replicative cell aging IMP19951988
    GO:0001701 in utero embryonic development IEA--
    About this table

    TP53 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TP53 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Enzo Life Sciences drugs & compounds for TP53

    Compounds for TP53 available from Tocris Bioscience
    CompoundAction CAS number
    CP 31398 dihydrochloridep53-stabilizing agent[259199-65-0]
    Pifithrin-alpha hydrobromidep53 inhibitor. Also aryl hydrocarbon receptor agonist[63208-82-2]
    MIRA-1Restores mutant p53 activity; proapoptotic[72835-26-8]
    RITAp53-MDM2 interaction inhibitor; antitumor[213261-59-7]
    RETRA hydrochlorideAntitumor agent; suppresses mutant p53-bearing cancer cells[1036069-26-7]
    About this table


    10/117 Novoseek chemical compound relationships for TP53 gene (see all 117)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 76.9 382 8640471 (4), 7726729 (4), 8434637 (4), 15363320 (4) (see all 99)
    cisplatin 74 1151 12492119 (9), 9811465 (8), 18064040 (7), 14513366 (7) (see all 99)
    noxa 72.7 89 17216584 (4), 17653088 (3), 20160496 (3), 15598651 (3) (see all 52)
    hpvs 71.4 72 20200430 (2), 11002226 (2), 8726818 (2), 9714244 (1) (see all 50)
    estrogen 71 898 14595509 (6), 9744308 (5), 10719737 (4), 15312749 (4) (see all 99)
    progesterone 69.1 712 12416559 (6), 14595509 (5), 9635673 (5), 9744308 (5) (see all 99)
    doxorubicin 67.6 464 15116093 (6), 18263706 (6), 8988061 (5), 11745235 (5) (see all 99)
    aflatoxin b1 63.4 212 16280384 (6), 8921985 (5), 19524575 (5), 1310637 (5) (see all 90)
    5fluorouracil 63.2 456 17634554 (12), 11044365 (7), 14703431 (7), 19810096 (6) (see all 99)
    camptothecin 63.1 172 10536167 (6), 9815856 (5), 19445707 (4), 17709397 (3) (see all 75)
    About this table

    2 PharmGKB drug compound relationships for TP53 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurineCO  PD  PK  FA  GN  12704389 10406363
    methotrexatePD  FA  GN  12704389
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of TP53 Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TP53
    Sigma-Aldrich shRNA Panels and shRNA for TP53
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): TP53
    OriGene shRNA RFP (see all 7): TP53
    OriGene basic RS shRNA (see all 7): TP53
    OriGene siRNA (see all 7): TP53
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TP53 
    miRNA: Sigma-Aldrich microRNA Mimics for TP53
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TP53 
    8/12 SABiosciences Assays for microRNAs that regulate TP53 (see all 12):
    hsa-miR-98 hsa-miR-1294 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
    Clones: Sigma-Aldrich FLAG tag genes for TP53
    OriGene GFP tagged cDNA clones in CMV expression vector: TP53
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): TP53
    OriGene untagged cDNA clones in CMV expression vector (see all 7): TP53
    OriGene 3'-UTR Clone (see all 7): TP53 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TP53 
    Primers: OriGene genome-wide validated SYBR primer pairs: TP53
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TP53: PPH00213A

    REFSEQ mRNAs for TP53 gene (7 alternative transcripts): 

    NM_000546.4  NM_001126112.1  NM_001126113.1  NM_001126114.1  NM_001126115.1  NM_001126116.1  NM_001126117.1  

    Additional cDNA sequence: 

    AB082923.1 AF052180.1 AF307851.1 AK223026.1 AK225838.1 AK297462.1 AK297927.1 AK312568.1 
    AM076970.1 AM076971.1 AM076972.1 AY429684.1 AY627884.1 BC003596.1 BT019622.1 CR608294.1 
    CR624912.1 DQ186648.1 DQ186649.1 DQ186650.1 DQ186651.1 DQ186652.1 DQ191317.1 DQ263704.1 
    DQ286964.1 DQ401704.1 DQ485152.1 DQ648883.1 DQ648884.1 DQ648885.1 DQ648886.1 DQ648887.1 
    EF101867.1 EF101868.1 EF101869.1 FJ207420.1 M14694.1 M14695.1 S66666.1 X01405.1 
    X02469.1 X60010.1 X60011.1 X60012.1 X60013.1 X60014.1 X60015.1 X60016.1 
    X60017.1 X60018.1 X60019.1 X60020.1 

    18 DOTS entries:

    DT.92469229  DT.100788714  DT.120961435  DT.100788713  DT.75152217  DT.40283865  DT.95274968  DT.100712946 
    DT.120961349  DT.100788719  DT.40120491  DT.120961395  DT.100788715  DT.92010563  DT.120961350  DT.120961391 
    DT.120961408  DT.99987012 

    24/112 AceView cDNA sequences (see all 112):

    X60018 S66666 X02469 AA291539 X60016 X60012 BQ066009 BQ057682 
    AI539544 BX952582 CA432254 CR608294 CR624912 AA662570 AW865736 BU673953 
    AA358870 BE886147 AA379547 AY627884 CK904490 BU174921 BE300855 AL524077 

    1 RNAdb entry of non coding RNAs:

    LIT1750   

    highest scoring ESTs for TP53:

    X02469 AA171861 AA296373 AB082923 AF307851 AU076984 AU120569 AU121050 AU129655 AU131952 

    Unigene Cluster for TP53:

    Tumor protein p53
    Hs.654481  [show with all ESTs]
    Unigene Representative Sequence: NM_001126114


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TP53 (see all 9)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -                             -           -     -                           
    SP2:                                                              -                                             
    SP3:                                                              -           -                                 
    SP4:                                                              -           -     -                           
    SP5:                                                                          -     -                           

    About this scheme

    ECgene alternative splicing isoforms for TP53
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396473 ENST00000445888 ENST00000359597 ENST00000508793 ENST00000504290
    ENST00000505014(uc010vug.1) ENST00000504937(uc010cne.1 uc002gii.1)
    ENST00000510385(uc010cnf.1 uc010cng.1) ENST00000414315 ENST00000413465(uc002gig.1 uc010cnj.1)
    ENST00000514944 ENST00000503591 ENST00000269305(uc002gih.2 uc002gim.2 uc002gij.2 uc002gin.2 uc002gio.2 uc010cnk.1)
    ENST00000455263 ENST00000420246(uc010cnh.1 uc010cni.1) ENST00000509690
    ENST00000419024

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TP53 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching TP53 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1974_s_at2, 3 U95-A 1 1.00 1.00 0.82 0.88 X02469 1.00 1.00 1.00 1
    1939_at2, 3 U95-A 1 0.94 1.00 0.74 1.29 M22898 0.20 1.00 0.72 1
    31618_at2, 3 U95-A 1 0.75 1.00 0.54 0.84 S66666 0.60 1.00 0.82 1
    211300_s_at2, 3 U133-A 1 1.00 1.00 -- -- K03199 0.80 1.00 0.91 1
    201746_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000546 0.60 1.00 0.82 1
    211300_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201746_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    TP53 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TP53 gene expression
    TP53 gene electronic northern expression
    TP53 gene sage expression
    About these images

    CGAP SAGE TAG: TTTTGTAGAG

    SOURCE GeneReport for Unigene cluster: Hs.654481

    Expression variation in blood from EXPOLDB for TP53

    Primers: OriGene genome-wide validated SYBR primer pairs: TP53
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TP53: PPH00213A
        SABiosciences Expression via Pathway-Focused PCR Arrays including TP53 (see all 23): PAHS-003A PAHS-004A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TP53 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TP531   -- tumor protein p53 84.3(n)
    83.42(a)
    403869  NM_001003210.1  NP_001003210.1 
    chimpanzee
    (Pan troglodytes)
    TP531   -- tumor protein p53 99.75(n)
    100(a)
    455214  XM_001172091.1  XP_001172091.1 
    cow
    (Bos taurus)
    TP531   -- tumor protein p53 83.9(n)
    82.08(a)
    281542  NM_174201.2  NP_776626.1 
    rat
    (Rattus norvegicus)
    Tp531   -- tumor protein p53 81.44(n)
    78.35(a)
    24842  NM_030989.1  NP_112251.1 
    mouse
    (Mus musculus)
    Trp531 , 5 11 (42.83 cM)5
    transformation related protein 531, 5 80.45(n)1
    78.29(a)1
    220591  NM_011640.11  NP_035770.11 
     AB0178155  AB0178165  (see all 50)
    About this table        Species with no ortholog for TP53

    ENSEMBL Gene Tree for TP53 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TP53 gene
    TP732  TP632  

    TP53 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/356 NCBI SNPs in TP53 are shown (see all 356)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7224941,2
    C,H7583391(+) ATGCAG/CGTGCC 3 -- int111Minor allele frequency- C:0.00NA MN NS EA 1072
    rs8585281,2
    C,F,A,7574936(-) AGAGCG/AAGACT 6 -- int12Minor allele frequency- A:0.07NS WA 182
    rs9161311,2
    --7572436(-) GTCTAG/AAACTT 6 -- ut31 ese34Minor allele frequency- A:0.00MN EA NA 246
    rs9161321,2
    --7572413(-) GGTGCT/CTGTTC 6 -- ut311Minor allele frequency- C:0.00MN 184
    rs10425221,2
    C,F,A,H,7579472(-) TCCCCG/CCGTGG 9 /P /R ref1 mis1 ng5135Minor allele frequency- C:0.44MN NS EA NA WA 3236
    rs10425261,2
    --7572890(-) CTCCCA/TCCCCC 6 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs10425351,2
    H7572292(-) TTGGTC/CG    
       
    /G/GA
    ACCTT
    6 -- ut31 ese34NS EA 404
    rs11609011,2
    F7583532(+) TACAA-/CAAGTACT 3 -- int14Minor allele frequency- CAA:0.14EU NA EA 342
    rs16137491,2
    --7585825(-) ctgggC/Ggcggt 3 -- int10--------
    rs16138381,2
    --7585797(-) ccagcA/Gctttg 3 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for TP53 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TP53: --

    QIAGEN SeqTarget long-range PCR primers for resequencing TP53 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TP53 for disorders           About GeneDecksing

    OMIM: 191170   disorders: 114500  151623  114550  259500  260500  607107  260350  202300  114480  

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637

  • Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or
  • inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally
    stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition
    develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and
    predisposes to the development of esophageal adenocarcinoma
  • Defects in TP53 are involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239]. ESCC is a tumor of the
  • esophagus
  • Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is an autosomal dominant familial
  • cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45
    years with a first degree relative affected by any tumor before 45 years and another first degree relative with any
    tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819
    and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse
    set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53
    germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and
    adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15,
    rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers
  • Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as
  • squamous cell carcinoma of the head and neck
  • Defects in TP53 are a cause of lung cancer [MIM:211980]
  • Defects in TP53 are a cause of choroid plexus papilloma (CPLPA) [MIM:260500]. Choroid plexus papilloma is a
  • slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a
    lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from
    obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a
    choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood
  • Defects in TP53 are a cause of adrenocortical carcinoma (ADCC) [MIM:202300]. ADCC is a rare childhood tumor of
  • the adrenal cortex. It occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome and is a
    component tumor in Li-Fraumeni syndrome

    10/96 Novoseek disease relationships for TP53 gene (see all 96)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 93.8 24003 8777377 (10), 7901994 (9), 8007011 (9), 8324748 (8) (see all 99)
    li-fraumeni syndrome 90.7 344 1373881 (5), 17483435 (3), 10980596 (3), 10484981 (3) (see all 99)
    cancer 90.2 7050 17598983 (10), 18223686 (8), 15055300 (7), 12561442 (7) (see all 99)
    carcinoma 87.5 3357 9110348 (10), 8062281 (9), 16033093 (8), 7927312 (8) (see all 99)
    carcinoma squamous cell 86.8 1909 9127380 (8), 8826924 (7), 10445528 (6), 11255264 (6) (see all 99)
    retinoblastoma 85.1 701 10792093 (8), 9337350 (6), 11306502 (5), 8224613 (5) (see all 99)
    microsatellite instability 85 363 9731891 (6), 9716224 (5), 11290569 (5), 12612901 (5) (see all 99)
    allelic loss 83.7 407 16293976 (5), 7909153 (5), 8467510 (4), 11520271 (4) (see all 99)
    adenocarcinoma 82.7 1551 12823203 (7), 17982662 (7), 9379505 (6), 10674608 (6) (see all 99)
    breast cancer 81.9 2818 7917542 (8), 8679460 (8), 12170762 (7), 15566648 (6) (see all 99)
    About this table

    5 PharmGKB disease relationships for TP53 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, LymphocyticCO  PK  GN  10406363
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    Neoplasms, Radiation-InducedCO  PK  GN  10406363
    Neoplasms, Second PrimaryCO  PK  GN  10406363
    Ovarian NeoplasmsCO  GN  15221786
    About this table

    GeneTests: TP53
    Li-Fraumeni Syndrome

    Locus Specific Mutation Databases (LSDB): TP53
    Human Gene Mutation Database (HGMD): TP53
    Genetic Association Database (GAD): TP53
    Human Genome Epidemiology (HuGE) Navigator: TP53 (996 documents)
    Tumor Gene Database (TGDB): TP53

    Export disorders and mutations for TP53 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/13581 PubMed articles for TP53 gene, integrated from 7 sources (see all 13581):
    (articles sorted by number of sources associating them with TP53)
    1. Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. (PubMed id 6396087)1, 2, 3 Matlashewski G....Benchimol S. (1984)
    2. TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics. (PubMed id 12209590)1, 4, 7 Simao T.A....de Moura-Gallo C.V. (2002)
    3. Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family. (PubMed id 10484981)1, 2, 7 Gueran S.... Imirzalioglu N. (1999)
    4. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. (PubMed id 19536131)1, 2, 7 Lee E.-W.... Song J. (2009)
    5. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. (PubMed id 8875929)1, 2, 7 Kussie P.H.... Pavletich N.P. (1996)
    6. Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. (PubMed id 16314399)1, 4, 7 Ma H....Shen H. (2006)
    7. p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. (PubMed id 16203772)1, 4, 7 Sotamaa K....de la Chapelle A. (2005)
    8. Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk. (PubMed id 12802680)1, 4, 7 Hwang S.J....Strong L.C. (2003)
    9. [p53 gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population] (PubMed id 12921568)1, 4, 7 Zhang J.H....He M. (2003)
    10. Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. (PubMed id 16287156)1, 4, 7 Zhang X....Lin D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7157 HGNC: 11998 AceView: TP53 Ensembl:ENSG00000141510 euGenes: HUgn7157
    ECgene: TP53 Kegg: 7157 H-InvDB: TP53

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TP53 Genetics and Cytogenetics in Oncology and Haematology
    IARC TP53 mutation databasehttp://www-p53.iarc.fr/
    p53 web site at the Institut Curiehttp://p53.free.fr/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TP53
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tp53/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TP53
    Wikipedia http://en.wikipedia.org/wiki/P53

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TP53 gene:
    Search GeneIP for patents involving TP53

    Licensable Technologies for TP53 gene:
     Weizmann Institute:Treatment of Systemic Lupus Erythematosus by Down-Regulating the Autoimmune Response to Autoantigens    (see all 2)
     Salk Institute: Assays for p53 Function in Cells
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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    About This Section

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